{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:40:06Z","timestamp":1743554406892,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":14,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071644171"},{"type":"electronic","value":"9781071644188"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4418-8_8","type":"book-chapter","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T23:55:23Z","timestamp":1743551723000},"page":"137-151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Reverse Engineering Approach to Optimize Chemical Synergy Between Target and Phenotype: Bridging the Cancer and Malaria Indications"],"prefix":"10.1007","author":[{"given":"Jean-Yves","family":"Trosset","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"issue":"6","key":"8_CR1","doi-asserted-by":"crossref","first-page":"e00532","DOI":"10.1002\/prp2.532","volume":"7","author":"J Michael","year":"2019","unstructured":"Michael J, Geisslinger G (2019) Pharmacological plasticity\u2014how do you hit a moving target? Pharmacol Res Perspect 7(6):e00532","journal-title":"Pharmacol Res Perspect"},{"key":"8_CR2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2174\/138620708785739952","volume":"11","author":"E Gregori-puigjane","year":"2008","unstructured":"Gregori-puigjane E, Mestres JA (2008) Ligand-based approach to mining the chemogenomic space of drugs. Comb Chem High Throughput Screen 11:669\u2013676","journal-title":"Comb Chem High Throughput Screen"},{"issue":"7387","key":"8_CR3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature10868","volume":"483","author":"A Prahallad","year":"2012","unstructured":"Prahallad A, Sun C, Huang, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483(7387):100\u2013103","journal-title":"Nature"},{"issue":"3","key":"8_CR4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1158\/2159-8290.CD-11-0341","volume":"2","author":"RB Corcoran","year":"2012","unstructured":"Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Della Pelle P, Dias-Santagata D, Hung KE, Flaherty KT, Piris A, Wargo JA, Settleman J, Mino-Kenudson M, Engelman JA (2012) EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2(3):227\u2013235","journal-title":"Cancer Discov"},{"key":"8_CR5","unstructured":"Trosset JY, Bernot G. (2024) A systemic view of target identification. Same book issue"},{"issue":"1","key":"8_CR6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-virology-091919-102416","volume":"8","author":"K Girdhar","year":"2021","unstructured":"Girdhar K, Powis A, Raisingani A, Chrudinov\u00e1 M, Huang R, Tran T, Sevgi K, Dogru YD, Altindis E (2021) Viruses and metabolism: the effects of viral infections and viral insulins on host metabolism. Annu Rev Virol. 8(1):373\u2013391","journal-title":"Annu Rev Virol."},{"issue":"41","key":"8_CR7","doi-asserted-by":"crossref","first-page":"16708","DOI":"10.1073\/pnas.1205414109","volume":"109","author":"NA Malmquist","year":"2012","unstructured":"Malmquist NA, Moss TA, Mecheri A, Scherf A, Fuchter MJ (2012) Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci USA 109(41):16708\u201316713","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"8_CR8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1021\/acsinfecdis.0c00724","volume":"7","author":"LB Arendse","year":"2021","unstructured":"Arendse LB, Wyllie S, Chibale K, Gilbert IH (2021) Plasmodium kinases as potential drug targets for malaria: challenges and opportunities. ACS Infect Dis. 7(3):518\u2013534","journal-title":"ACS Infect Dis."},{"issue":"1","key":"8_CR9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12936-024-04855-9","volume":"23","author":"T Reyser","year":"2024","unstructured":"Reyser T, Paloque L, Augereau JM, Di Stefano L, Benoit-Vical F (2024) Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum. Malar J. 23(1):44","journal-title":"Malar J."},{"key":"8_CR10","doi-asserted-by":"crossref","unstructured":"Shen S, Clairambault J (2020) Cell plasticity in cancer cell populations. F1000Res Faculty Rev 635","DOI":"10.12688\/f1000research.24803.1"},{"issue":"9","key":"8_CR11","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/cells11091403","volume":"11","author":"VE Kumar","year":"2022","unstructured":"Kumar VE, Nambiar R, De Souza C, Nguyen A, Chien J, Lam KS (2022) Targeting epigenetic modifiers of tumor plasticity and cancer stem cell behavior. Cells 11(9):1403","journal-title":"Cells"},{"issue":"7296","key":"8_CR12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"FJ Gamo","year":"2010","unstructured":"Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DVS, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF (2010) Thousands of chemical starting points for antimalarial lead identification. Nature 465(7296):305\u2013310","journal-title":"Nature"},{"issue":"3","key":"8_CR13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00124455","volume":"9","author":"C McMartin","year":"1995","unstructured":"McMartin C, Bohacek RS (1995) Flexible matching of test ligands to a 3D pharmacophore using a molecular superposition force field: comparison of predicted and experimental conformations of inhibitors of three enzymes. J. Comput. Aided Mol. Design 9(3):237\u2013250","journal-title":"J. Comput. Aided Mol. Design"},{"key":"8_CR14","unstructured":"Journal of Computer-Aided Molecular Design 11(4) 333-344 10.1023\/A:1007907728892"}],"container-title":["Methods in Molecular Biology","Target Identification and Validation in Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4418-8_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T23:58:59Z","timestamp":1743551939000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4418-8_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071644171","9781071644188"],"references-count":14,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4418-8_8","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"1 April 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}