{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:07:29Z","timestamp":1766088449774,"version":"3.40.4"},"publisher-location":"New York, NY","reference-count":34,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071644331"},{"type":"electronic","value":"9781071644348"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4434-8_15","type":"book-chapter","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T11:07:42Z","timestamp":1746011262000},"page":"225-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ATR-Infrared Spectroscopy and Acoustic Sensing in Characterization of Blood and Pancreatic Ductal Adenocarcinoma-Derived Extracellular Vesicles"],"prefix":"10.1007","author":[{"given":"Imola Cs.","family":"Szigy\u00e1rt\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasvilla","family":"Sonallya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lor\u00e1nd","family":"Rom\u00e1nszki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Mih\u00e1ly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00edmea","family":"Bebesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Keresztes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Beke-Somfai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"15_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","volume":"21","author":"L Cheng","year":"2022","unstructured":"Cheng L, Hill AF (2022) Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discov 21:379\u2013399","journal-title":"Nat Rev Drug Discov"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"C Th\u00e9ry","year":"2018","unstructured":"Th\u00e9ry C, Witwer KW, Aikawa E et al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 7:1535750","journal-title":"J Extracell Vesicles"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-1-0716-0759-6_10","volume-title":"Cancer cell signaling","author":"W-H Chang","year":"2021","unstructured":"Chang W-H, Cerione RA, Antonyak MA (2021) Extracellular vesicles and their roles in cancer progression. In: Robles-Flores M (ed) Cancer cell signaling. Springer, New York, pp 143\u2013170"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.addr.2020.03.002","volume":"159","author":"T Skotland","year":"2020","unstructured":"Skotland T, Sagini K, Sandvig K et al (2020) An emerging focus on lipids in extracellular vesicles. Adv Drug Deliv Rev 159:308\u2013321","journal-title":"Adv Drug Deliv Rev"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s10555-021-10014-2","volume":"40","author":"M Harmati","year":"2021","unstructured":"Harmati M, Bukva M, B\u00f6r\u00f6czky T et al (2021) The role of the metabolite cargo of extracellular vesicles in tumor progression. Cancer Metastasis Rev 40:1203\u20131221","journal-title":"Cancer Metastasis Rev"},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"D516","DOI":"10.1093\/nar\/gky1029","volume":"47","author":"M Pathan","year":"2019","unstructured":"Pathan M, Fonseka P, Chitti SV et al (2019) Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles. Nucleic Acids Res 47:D516\u2013D519","journal-title":"Nucleic Acids Res"},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jmb.2015.09.019","volume":"428","author":"S Keerthikumar","year":"2016","unstructured":"Keerthikumar S, Chisanga D, Ariyaratne D et al (2016) ExoCarta: a web-based compendium of exosomal cargo. J Mol Biol 428:688\u2013692","journal-title":"J Mol Biol"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrgastro.2017.71","volume":"14","author":"G Szabo","year":"2017","unstructured":"Szabo G, Momen-Heravi F (2017) Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol 14:455\u2013466","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"15_CR9","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","volume":"16","author":"IK Herrmann","year":"2021","unstructured":"Herrmann IK, Wood MJA, Fuhrmann G (2021) Extracellular vesicles as a next-generation drug delivery platform. Nat Nanotechnol 16:748\u2013759","journal-title":"Nat Nanotechnol"},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12951-023-01973-5","volume":"21","author":"S Du","year":"2023","unstructured":"Du S, Guan Y, Xie A et al (2023) Extracellular vesicles: a rising star for therapeutics and drug delivery. J Nanobiotechnol 21:231","journal-title":"J Nanobiotechnol"},{"key":"15_CR11","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3390\/cells9040991","volume":"9","author":"D Tsiapalis","year":"2020","unstructured":"Tsiapalis D, O\u2019Driscoll L (2020) Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications. Cells 9:991","journal-title":"Cells"},{"key":"15_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nri3622","volume":"14","author":"PD Robbins","year":"2014","unstructured":"Robbins PD, Morelli AE (2014) Regulation of immune responses by extracellular vesicles. Nat Rev Immunol 14:195\u2013208","journal-title":"Nat Rev Immunol"},{"key":"15_CR13","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nmeth.4185","volume":"14","author":"J Van Deun","year":"2017","unstructured":"EV-TRACK Consortium, Van Deun J, Mestdagh P et al (2017) EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods 14:228\u2013232","journal-title":"Nat Methods"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-1-4939-7253-1_12","volume-title":"Extracellular vesicles","author":"EJK Kowal","year":"2017","unstructured":"Kowal EJK, Ter-Ovanesyan D, Regev A et al (2017) Extracellular vesicle isolation and analysis by western blotting. In: Kuo WP, Jia S (eds) Extracellular vesicles. Springer, New York, pp 143\u2013152"},{"key":"15_CR15","doi-asserted-by":"crossref","unstructured":"Bachurski D, Schuldner M, Nguyen P et al (2019) Extracellular vesicle measurements with nanoparticle tracking analysis \u2013 an accuracy and repeatability comparison between NanoSight NS300 and ZetaView. J Extracell Vesicles 8:1596016","DOI":"10.1080\/20013078.2019.1596016"},{"key":"15_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-1-0716-3203-1_4","volume-title":"Cell-secreted vesicles","author":"ML Corona","year":"2023","unstructured":"Corona ML, Hurbain I, Raposo G et al (2023) Characterization of extracellular vesicles by transmission electron microscopy and immunolabeling electron microscopy. In: Vainio S (ed) Cell-secreted vesicles. Springer, New York, pp 33\u201343"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"12946","DOI":"10.3390\/ijms222312946","volume":"22","author":"K Kogej","year":"2021","unstructured":"Kogej K, Bo\u017ei\u010d D, Kobal B et al (2021) Application of dynamic and static light scattering for size and shape characterization of small extracellular nanoparticles in plasma and ascites of ovarian cancer patients. Int J Mol Sci 22:12946","journal-title":"Int J Mol Sci"},{"key":"15_CR18","doi-asserted-by":"publisher","first-page":"1713526","DOI":"10.1080\/20013078.2020.1713526","volume":"9","author":"JA Welsh","year":"2020","unstructured":"Welsh JA, Van Der Pol E, Arkesteijn GJA et al (2020) MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments. J Extracell Vesicles 9:1713526","journal-title":"J Extracell Vesicles"},{"key":"15_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2021.114168","volume":"622","author":"T Cloet","year":"2021","unstructured":"Cloet T, Momenbeitollahi N, Li H (2021) Recent advances on protein-based quantification of extracellular vesicles. Anal Biochem 622:114168","journal-title":"Anal Biochem"},{"key":"15_CR20","doi-asserted-by":"publisher","first-page":"32945","DOI":"10.3402\/jev.v5.32945","volume":"5","author":"C Gardiner","year":"2016","unstructured":"Gardiner C, Vizio DD, Sahoo S et al (2016) Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. J Extracell Vesicles 5:32945","journal-title":"J Extracell Vesicles"},{"key":"15_CR21","volume":"10","author":"R Vaz","year":"2022","unstructured":"Vaz R, Serrano VM, Casta\u00f1o-Guerrero Y et al (2022) Breaking the classics: next-generation biosensors for the isolation, profiling and detection of extracellular vesicles. Biosens Bioelectron X 10:100115","journal-title":"Biosens Bioelectron X"},{"key":"15_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12014-023-09424-x","volume":"20","author":"AG Birhanu","year":"2023","unstructured":"Birhanu AG (2023) Mass spectrometry-based proteomics as an emerging tool in clinical laboratories. Clin Proteomics 20:32","journal-title":"Clin Proteomics"},{"key":"15_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1839","volume":"15","author":"J Suthar","year":"2023","unstructured":"Suthar J, Taub M, Carney RP et al (2023) Recent developments in biosensing methods for extracellular vesicle protein characterization. WIREs Nanomed Nanobiotechnol 15:e1839","journal-title":"WIREs Nanomed Nanobiotechnol"},{"key":"15_CR24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.bbamem.2016.12.005","volume":"1859","author":"J Mih\u00e1ly","year":"2017","unstructured":"Mih\u00e1ly J, De\u00e1k R, Szigy\u00e1rt\u00f3 IC et al (2017) Characterization of extracellular vesicles by IR spectroscopy: fast and simple classification based on amide and CH stretching vibrations. Biochim Biophys Acta Biomembr 1859:459\u2013466","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"15_CR25","doi-asserted-by":"publisher","first-page":"1741174","DOI":"10.1080\/20013078.2020.1741174","volume":"9","author":"L Paolini","year":"2020","unstructured":"Paolini L, Federici S, Consoli G et al (2020) Fourier-transform infrared (FT-IR) spectroscopy fingerprints subpopulations of extracellular vesicles of different sizes and cellular origin. J Extracell Vesicles 9:1741174","journal-title":"J Extracell Vesicles"},{"key":"15_CR26","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1007\/s00216-020-02711-8","volume":"412","author":"V Szentirmai","year":"2020","unstructured":"Szentirmai V, Wacha A, N\u00e9meth C et al (2020) Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection fourier transform infrared (ATR-FTIR) spectroscopy. Anal Bioanal Chem 412:4619\u20134628","journal-title":"Anal Bioanal Chem"},{"key":"15_CR27","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1039\/b304466c","volume":"128","author":"M Thompson","year":"2003","unstructured":"Thompson M, Ballantyne SM, Cheran L-E et al (2003) Electromagnetic excitation of high frequency acoustic waves and detection in the liquid phase. Analyst 128:1048","journal-title":"Analyst"},{"key":"15_CR28","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1038\/s41467-018-04791-8","volume":"9","author":"WM Usman","year":"2018","unstructured":"Usman WM, Pham TC, Kwok YY et al (2018) Efficient RNA drug delivery using red blood cell extracellular vesicles. Nat Commun 9:2359","journal-title":"Nat Commun"},{"key":"15_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12400","volume":"13","author":"R Nieuwland","year":"2024","unstructured":"Nieuwland R, Siljander PR (2024) A beginner\u2019s guide to study extracellular vesicles in human blood plasma and serum. J Extracell Vesicles 13:e12400","journal-title":"J Extracell Vesicles"},{"key":"15_CR30","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/s41598-022-04915-7","volume":"12","author":"T Bebesi","year":"2022","unstructured":"Bebesi T, Kitka D, Ga\u00e1l A et al (2022) Storage conditions determine the characteristics of red blood cell derived extracellular vesicles. Sci Rep 12:977","journal-title":"Sci Rep"},{"key":"15_CR31","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/978-1-4939-6728-5_12","volume-title":"Exosomes and microvesicles","author":"M Aatonen","year":"2017","unstructured":"Aatonen M, Valkonen S, B\u00f6ing A et al (2017) Isolation of platelet-derived extracellular vesicles. In: Hill AF (ed) Exosomes and microvesicles. Springer, New York, pp 177\u2013188"},{"key":"15_CR32","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.snb.2018.08.025","volume":"275","author":"L Rom\u00e1nszki","year":"2018","unstructured":"Rom\u00e1nszki L, Tatarko M, Jiao M et al (2018) Casein probe\u2013based fast plasmin determination in the picomolar range by an ultra-high frequency acoustic wave biosensor. Sens Actuators B Chem 275:206\u2013214","journal-title":"Sens Actuators B Chem"},{"key":"15_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3390\/bios10110173","volume":"10","author":"L Rom\u00e1nszki","year":"2020","unstructured":"Rom\u00e1nszki L, Varga Z, Mih\u00e1ly J et al (2020) Electromagnetic piezoelectric acoustic sensor detection of extracellular vesicles through interaction with detached vesicle proteins. Biosensors 10:173","journal-title":"Biosensors"},{"key":"15_CR34","doi-asserted-by":"publisher","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024 Feb;13(2):e12404. https:\/\/doi.org\/10.1002\/jev2.12404","DOI":"10.1002\/jev2.12404"}],"container-title":["Methods in Molecular Biology","The Surfaceome"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4434-8_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T11:07:43Z","timestamp":1746011263000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4434-8_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071644331","9781071644348"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4434-8_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"1 May 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}