{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T18:58:02Z","timestamp":1743015482175,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":39,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071644416"},{"type":"electronic","value":"9781071644423"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4442-3_1","type":"book-chapter","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:17:23Z","timestamp":1741007843000},"page":"3-17","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adoptive Transfer of B Cells In Vivo for Assessment of Their Immune Function"],"prefix":"10.1007","author":[{"given":"Sabelo","family":"Hadebe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1098\/rspl.1899.0121","volume":"66","author":"P Ehrlich","year":"1900","unstructured":"Ehrlich P (1900) Croonian lecture.\u2014on immunity with special reference to cell life. Proc R Soc Lond 66:424","journal-title":"Proc R Soc Lond"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nri.2017.106","volume":"18","author":"LL Lu","year":"2018","unstructured":"Lu LL, Suscovich TJ, Fortune SM, Alter G (2018) Beyond binding: antibody effector functions in infectious diseases. Nat Rev Immunol 18:46\u201361. https:\/\/doi.org\/10.1038\/nri.2017.106","journal-title":"Nat Rev Immunol"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.3389\/fimmu.2020.595535","volume":"11","author":"K Jones","year":"2020","unstructured":"Jones K, Savulescu AF, Brombacher F, Hadebe S (2020) Immunoglobulin M in health and diseases: how far have we come and what next? Front Immunol 11:2858","journal-title":"Front Immunol"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nri2491","volume":"9","author":"S Herzog","year":"2009","unstructured":"Herzog S, Reth M, Jumaa H (2009) Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol 9:195\u2013205. https:\/\/doi.org\/10.1038\/nri2491","journal-title":"Nat Rev Immunol"},{"key":"1_CR5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35074","volume":"7","author":"M Noviski","year":"2018","unstructured":"Noviski M, Mueller JL, Satterthwaite A et al (2018) IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife 7:e35074. https:\/\/doi.org\/10.7554\/eLife.35074","journal-title":"Elife"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"2156 LP \u2013 2159","DOI":"10.1126\/science.286.5447.2156","volume":"286","author":"AF Ochsenbein","year":"1999","unstructured":"Ochsenbein AF, Fehr T, Lutz C et al (1999) Control of early viral and bacterial distribution and disease by natural antibodies. Science (1979) 286:2156 LP \u2013 2159. https:\/\/doi.org\/10.1126\/science.286.5447.2156","journal-title":"Science (1979)"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/31716","volume":"393","author":"C Lutz","year":"1998","unstructured":"Lutz C, Ledermann B, Kosco-Vilbois MH et al (1998) IgD can largely substitute for loss of IgM function in B cells. Nature 393:797\u2013801. https:\/\/doi.org\/10.1038\/31716","journal-title":"Nature"},{"issue":"5","key":"1_CR8","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1073\/pnas.90.5.1887","volume":"90","author":"L Nitschke","year":"1993","unstructured":"Nitschke L, Koscot MH, K\u00f6hler G, Lamers MC (1993) Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and-dependent antigens. Proc Natl Acad Sci USA 90(5):1887\u20131891","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","volume":"19","author":"RR Hardy","year":"2001","unstructured":"Hardy RR, Hayakawa K (2001) B cell development pathways. Annu Rev Immunol 19:595\u2013621. https:\/\/doi.org\/10.1146\/annurev.immunol.19.1.595","journal-title":"Annu Rev Immunol"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"13381","DOI":"10.1038\/ncomms13381","volume":"7","author":"Z Sabouri","year":"2016","unstructured":"Sabouri Z, Perotti S, Spierings E et al (2016) IgD attenuates the IgM-induced anergy response in transitional and mature B cells. Nat Commun 7:13381. https:\/\/doi.org\/10.1038\/ncomms13381","journal-title":"Nat Commun"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/ni.3141","volume":"16","author":"R \u00dcbelhart","year":"2015","unstructured":"\u00dcbelhart R, Hug E, Bach MP et al (2015) Responsiveness of B cells is regulated by the hinge region of IgD. Nat Immunol 16:534\u2013543. https:\/\/doi.org\/10.1038\/ni.3141","journal-title":"Nat Immunol"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4049\/jimmunol.2100726","volume":"208","author":"V Renna","year":"2022","unstructured":"Renna V, Surova E, Khadour A et al (2022) Defective allelic exclusion by IgD in the absence of autoantigen. J Immunol 208:293\u2013302. https:\/\/doi.org\/10.4049\/jimmunol.2100726","journal-title":"J Immunol"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nri2133","volume":"7","author":"JC Cambier","year":"2007","unstructured":"Cambier JC, Gauld SB, Merrell KT, Vilen BJ (2007) B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol 7:633\u2013643. https:\/\/doi.org\/10.1038\/nri2133","journal-title":"Nat Rev Immunol"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","volume":"30","author":"GD Victora","year":"2012","unstructured":"Victora GD, Nussenzweig MC (2012) Germinal centers. Annu Rev Immunol 30:429\u2013457. https:\/\/doi.org\/10.1146\/annurev-immunol-020711-075032","journal-title":"Annu Rev Immunol"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.immuni.2018.08.025","volume":"49","author":"I Stewart","year":"2018","unstructured":"Stewart I, Radtke D, Phillips B et al (2018) Germinal center B cells replace their antigen receptors in dark zones and fail light zone entry when immunoglobulin gene mutations are damaging. Immunity 49:477\u2013489.e7. https:\/\/doi.org\/10.1016\/j.immuni.2018.08.025","journal-title":"Immunity"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","volume":"40","author":"GD Victora","year":"2022","unstructured":"Victora GD, Nussenzweig MC (2022) Germinal centers. Annu Rev Immunol 40:413\u2013442. https:\/\/doi.org\/10.1146\/annurev-immunol-120419-022408","journal-title":"Annu Rev Immunol"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.immuni.2019.07.001","volume":"51","author":"JA Roco","year":"2019","unstructured":"Roco JA, Mesin L, Binder SC et al (2019) Class-switch recombination occurs infrequently in germinal centers. Immunity 51:337\u2013350.e7. https:\/\/doi.org\/10.1016\/j.immuni.2019.07.001","journal-title":"Immunity"},{"key":"1_CR18","doi-asserted-by":"publisher","first-page":"5729 LP\u20135738","DOI":"10.4049\/jimmunol.164.11.5729","volume":"164","author":"SM Shinall","year":"2000","unstructured":"Shinall SM, Gonzalez-Fernandez M, Noelle RJ, Waldschmidt TJ (2000) Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens. J Immunol 164:5729 LP\u20135738. https:\/\/doi.org\/10.4049\/jimmunol.164.11.5729","journal-title":"J Immunol"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","volume":"102","author":"M Muramatsu","year":"2000","unstructured":"Muramatsu M, Kinoshita K, Fagarasan S et al (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553\u2013563. https:\/\/doi.org\/10.1016\/S0092-8674(00)00078-7","journal-title":"Cell"},{"key":"1_CR20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016425118","volume":"118","author":"R Nakagawa","year":"2021","unstructured":"Nakagawa R, Toboso-Navasa A, Schips M et al (2021) Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth. Proc Natl Acad Sci 118:e2016425118. https:\/\/doi.org\/10.1073\/pnas.2016425118","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.immuni.2011.03.024","volume":"34","author":"SM Kerfoot","year":"2011","unstructured":"Kerfoot SM, Yaari G, Patel JR et al (2011) Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34:947\u2013960. https:\/\/doi.org\/10.1016\/j.immuni.2011.03.024","journal-title":"Immunity"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","volume":"102","author":"P Revy","year":"2000","unstructured":"Revy P, Muto T, Levy Y et al (2000) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102:565\u2013575. https:\/\/doi.org\/10.1016\/S0092-8674(00)00079-9","journal-title":"Cell"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cell.2013.01.007","volume":"152","author":"FW Alt","year":"2013","unstructured":"Alt FW, Zhang Y, Meng F et al (2013) Review mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell 152:417\u2013429. https:\/\/doi.org\/10.1016\/j.cell.2013.01.007","journal-title":"Cell"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"287ra70-287ra70","DOI":"10.1126\/scitranslmed.aaa4802","volume":"7","author":"LL Sun","year":"2015","unstructured":"Sun LL, Ellerman D, Mathieu M et al (2015) Anti-CD20\/CD3 T cell\u2013dependent bispecific antibody for the treatment of B cell malignancies. Sci Transl Med 7:287ra70-287ra70. https:\/\/doi.org\/10.1126\/scitranslmed.aaa4802","journal-title":"Sci Transl Med"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.cell.2009.08.041","volume":"139","author":"L Srinivasan","year":"2009","unstructured":"Srinivasan L, Sasaki Y, Calado DP et al (2009) PI3 kinase signals BCR-dependent mature B cell survival. Cell 139:573\u2013586. https:\/\/doi.org\/10.1016\/j.cell.2009.08.041","journal-title":"Cell"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1073\/pnas.0811632106","volume":"106","author":"BL Esplin","year":"2009","unstructured":"Esplin BL, Welner RS, Zhang Q et al (2009) A differentiation pathway for B1 cells in adult bone marrow. Proc Natl Acad Sci U S A 106:5773\u20135778. https:\/\/doi.org\/10.1073\/pnas.0811632106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"E8430","DOI":"10.1073\/pnas.1708125114","volume":"114","author":"R Hurdayal","year":"2017","unstructured":"Hurdayal R, Ndlovu HH, Revaz-Breton M et al (2017) IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases. Proc Natl Acad Sci U S A 114:E8430\u2013E8439. https:\/\/doi.org\/10.1073\/pnas.1708125114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2020.100159","volume":"1","author":"E Montecino-Rodriguez","year":"2020","unstructured":"Montecino-Rodriguez E, Dorshkind K (2020) Use of busulfan to condition mice for bone marrow transplantation. STAR Protoc 1:100159. https:\/\/doi.org\/10.1016\/j.xpro.2020.100159","journal-title":"STAR Protoc"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/s1074-7613(04)00107-4","volume":"20","author":"DR Herbert","year":"2004","unstructured":"Herbert DR, Holscher C, Mohrs M et al (2004) Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20:623\u2013635. https:\/\/doi.org\/10.1016\/s1074-7613(04)00107-4","journal-title":"Immunity"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1053\/j.gastro.2011.09.044","volume":"142","author":"JC Hoving","year":"2012","unstructured":"Hoving JC, Kirstein F, Nieuwenhuizen NE et al (2012) B cells that produce immunoglobulin E mediate colitis in BALB\/c mice. Gastroenterology 142:96\u2013108. https:\/\/doi.org\/10.1053\/j.gastro.2011.09.044","journal-title":"Gastroenterology"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"7302","DOI":"10.4049\/jimmunol.162.12.7302","volume":"162","author":"M Mohrs","year":"1999","unstructured":"Mohrs M, Ledermann B, K\u00f6hler G et al (1999) Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol 162:7302\u20137308","journal-title":"J Immunol"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","volume":"282","author":"G Gr\u00fcnig","year":"1998","unstructured":"Gr\u00fcnig G, Warnock M, Wakil AE et al (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Natl Inst Health 282:2261\u20132263. https:\/\/doi.org\/10.1126\/science.282.5397.2261","journal-title":"Natl Inst Health"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/350423a0","volume":"350","author":"D Kitamura","year":"1991","unstructured":"Kitamura D, Roes J, K\u00fchn R, Rajewsky K (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin \u03bc chain gene. Nature 350:423","journal-title":"Nature"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.immuni.2015.11.017","volume":"44","author":"A Ballesteros-Tato","year":"2016","unstructured":"Ballesteros-Tato A, Randall TD, Lund FE et al (2016) T follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite. Immunity 44:259\u2013273. https:\/\/doi.org\/10.1016\/j.immuni.2015.11.017","journal-title":"Immunity"},{"key":"1_CR35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jaci.2016.09.020","volume":"140","author":"M Dullaers","year":"2017","unstructured":"Dullaers M, Schuijs MJ, Willart M et al (2017) House dust mite\u2013driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting. J Allergy Clin Immunol 140:76\u201388.e7. https:\/\/doi.org\/10.1016\/j.jaci.2016.09.020","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jaci.2020.12.635","volume":"148","author":"S Hadebe","year":"2021","unstructured":"Hadebe S, Khumalo J, Mangali S et al (2021) Deletion of IL-4Ra signaling on B cells limits hyperresponsiveness depending on antigen load. J Allergy Clin Immunol 148:99\u2013109.e5. https:\/\/doi.org\/10.1016\/j.jaci.2020.12.635","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"7103 LP \u2013 7107","DOI":"10.4049\/jimmunol.175.11.7103","volume":"175","author":"DP Harris","year":"2005","unstructured":"Harris DP, Goodrich S, Mohrs K et al (2005) Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor \u03b1, and Th2 cells. J Immunol 175:7103 LP \u2013 7107. https:\/\/doi.org\/10.4049\/jimmunol.175.11.7103","journal-title":"J Immunol"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.immuni.2009.01.006","volume":"30","author":"W Wojciechowski","year":"2009","unstructured":"Wojciechowski W, Harris DP, Sprague F et al (2009) Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30:421\u2013433. https:\/\/doi.org\/10.1016\/j.immuni.2009.01.006","journal-title":"Immunity"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.jaci.2020.09.041","volume":"147","author":"A Habener","year":"2021","unstructured":"Habener A, Happle C, Grychtol R et al (2021) Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model. J Allergy Clin Immunol 147:2281\u20132294.e7. https:\/\/doi.org\/10.1016\/j.jaci.2020.09.041","journal-title":"J Allergy Clin Immunol"}],"container-title":["Methods in Molecular Biology","B-Cell Receptor Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4442-3_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:17:25Z","timestamp":1741007845000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4442-3_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071644416","9781071644423"],"references-count":39,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4442-3_1","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"4 March 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}