{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:04:29Z","timestamp":1778605469236,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":45,"publisher":"Springer US","isbn-type":[{"value":"9781071644973","type":"print"},{"value":"9781071644980","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4498-0_4","type":"book-chapter","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:36:55Z","timestamp":1747298215000},"page":"39-55","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MicroRNA Profiling of Blood Extracellular Vesicles in ME\/CFS"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4514-996X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Ljungstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-9083","authenticated-orcid":false,"given":"Lubov","family":"Nathanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-2907","authenticated-orcid":false,"given":"Elisa","family":"Oltra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"issue":"3","key":"4_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3390\/diagnostics9030073","volume":"9","author":"E Sweetman","year":"2019","unstructured":"Sweetman E, Noble A, Edgar C et al (2019) Current research provides insight into the biological basis and diagnostic potential for Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). Diagnostics 9(3):73. https:\/\/doi.org\/10.3390\/diagnostics9030073","journal-title":"Diagnostics"},{"issue":"11","key":"4_CR2","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1001\/jama.2015.1346","volume":"313","author":"EW Clayton","year":"2015","unstructured":"Clayton EW (2015) Beyond myalgic encephalomyelitis\/chronic fatigue syndrome: an IOM report on redefining an illness. JAMA 313(11):1101\u20131102. https:\/\/doi.org\/10.1001\/jama.2015.1346","journal-title":"JAMA"},{"key":"4_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2823-2_1","volume-title":"MicroRnA profiling. Methods in molecular biology","author":"A Vishnoi","year":"2023","unstructured":"Vishnoi A, Rani S (2023) miRNA biogenesis and regulation of diseases: an updated overview. In: Rani S (ed) MicroRnA profiling. Methods in molecular biology, vol 2595. Humana, New York. https:\/\/doi.org\/10.1007\/978-1-0716-2823-2_1"},{"key":"4_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7046-9_4","volume-title":"Bioinformatics in MicroRNA research methods in molecular biology","author":"W Huang","year":"2017","unstructured":"Huang W (2017) MicroRNAs: biomarkers, diagnostics, and therapeutics. In: Huang J et al (eds) Bioinformatics in MicroRNA research methods in molecular biology, vol 1617. Humana, New York. https:\/\/doi.org\/10.1007\/978-1-4939-7046-9_4"},{"issue":"5","key":"4_CR5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.gpb.2012.07.005","volume":"10","author":"Y Li","year":"2012","unstructured":"Li Y, Kowdley KV (2012) MicroRNAs in common human diseases. Genom Proteom Bioinform 10(5):246\u2013253. https:\/\/doi.org\/10.1016\/j.gpb.2012.07.005","journal-title":"Genom Proteom Bioinform"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O'Brien J, Hayder H, Zayed Y et al (2018) Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrin 9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402","journal-title":"Front Endocrin"},{"issue":"4","key":"4_CR7","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.cmet.2019.07.011","volume":"30","author":"MA Mori","year":"2019","unstructured":"Mori MA, Ludwig RG, Garcia-Martin R et al (2019) Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab 30(4):656\u2013673. https:\/\/doi.org\/10.1016\/j.cmet.2019.07.011","journal-title":"Cell Metab"},{"issue":"1","key":"4_CR8","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"C Th\u00e9ry","year":"2018","unstructured":"Th\u00e9ry C, Witwer KW, Aikawa E et al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Ves 7(1):1535750. https:\/\/doi.org\/10.1080\/20013078.2018.1535750","journal-title":"J Extracell Ves"},{"issue":"21","key":"4_CR9","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1161\/CIRCULATIONAHA.113.003058","volume":"127","author":"JE Freedman","year":"2013","unstructured":"Freedman JE, Tanriverdi K (2013) Defining miRNA targets: balancing simplicity with complexity. Circulation 127(21):2075\u20132077. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.003058","journal-title":"Circulation"},{"key":"4_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-944-4_8","volume-title":"PCR protocols. Methods in molecular biology","author":"C Chen","year":"2011","unstructured":"Chen C, Tan R, Wong L et al (2011) Quantitation of microRNAs by real-time RT-qPCR. In: Park D (ed) PCR protocols. Methods in molecular biology, vol 687. Humana, New York. https:\/\/doi.org\/10.1007\/978-1-60761-944-4_8"},{"issue":"1","key":"4_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12987-022-00359-3","volume":"19","author":"HM Ramos-Zald\u00edvar","year":"2022","unstructured":"Ramos-Zald\u00edvar HM, Polakovicova I, Salas-Huenuleo E et al (2022) Extracellular vesicles through the blood-brain barrier: a review. Fluids Barriers CNS 19(1):60. https:\/\/doi.org\/10.1186\/s12987-022-00359-3","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"4_CR12","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/s41598-020-58506-5","volume":"10","author":"E Almenar-P\u00e9rez","year":"2020","unstructured":"Almenar-P\u00e9rez E, Sarr\u00eda L, Nathanson L et al (2020) Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic encephalomyelitis\/chronic fatigue syndrome. Sci Rep 10(1):2064. https:\/\/doi.org\/10.1038\/s41598-020-58506-5","journal-title":"Sci Rep"},{"issue":"8","key":"4_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236439","volume":"15","author":"M Palviainen","year":"2020","unstructured":"Palviainen M, Saraswat M, Varga Z et al (2020) Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo-implications for biomarker discovery. PLoS One 15(8):e0236439. https:\/\/doi.org\/10.1371\/journal.pone.0236439","journal-title":"PLoS One"},{"issue":"6","key":"4_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270634","volume":"17","author":"X Zhang","year":"2022","unstructured":"Zhang X, Takeuchi T, Takeda A et al (2022) Comparison of serum and plasma as a source of blood extracellular vesicles: increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions. PLoS One 17(6):e0270634. https:\/\/doi.org\/10.1371\/journal.pone.0270634","journal-title":"PLoS One"},{"key":"4_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/jex2.88","volume":"2","author":"MS Ma\u0142ys","year":"2023","unstructured":"Ma\u0142ys MS, K\u00f6ller MC, Papp K et al (2023) Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma. J Extracell Biol 2:e88. https:\/\/doi.org\/10.1002\/jex2.88","journal-title":"J Extracell Biol"},{"issue":"4","key":"4_CR16","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.3390\/ijms21041366","volume":"21","author":"T Ovejero","year":"2020","unstructured":"Ovejero T, Sadones O, S\u00e1nchez-Fito T et al (2020) Activation of transposable elements in immune cells of fibromyalgia patients. Int J Molec Sci 21(4):1366. https:\/\/doi.org\/10.3390\/ijms21041366","journal-title":"Int J Molec Sci"},{"key":"4_CR17","doi-asserted-by":"publisher","unstructured":"Witwer KW, Buz\u00e1s EI, Bemis LT et al (2013) Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Ves 2. https:\/\/doi.org\/10.3402\/jev.v2i0.20360","DOI":"10.3402\/jev.v2i0.20360"},{"issue":"10","key":"4_CR18","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1161\/CIRCRESAHA.117.309417","volume":"120","author":"FAW Coumans","year":"2017","unstructured":"Coumans FAW, Brisson AR, Buzas EI et al (2017) Methodological guidelines to study extracellular vesicles. Circ Res 120(10):1632\u20131648. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.309417","journal-title":"Circ Res"},{"issue":"1","key":"4_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170628","volume":"12","author":"I Helwa","year":"2017","unstructured":"Helwa I, Cai J, Drewry MD et al (2017) A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLoS One 12(1):e0170628. https:\/\/doi.org\/10.1371\/journal.pone.0170628","journal-title":"PLoS One"},{"issue":"2","key":"4_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017429","volume":"6","author":"EA Shirdel","year":"2011","unstructured":"Shirdel EA, Xie W, Mak TW et al (2011) NAViGaTing the micronome \u2013 using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One 6(2):e17429. https:\/\/doi.org\/10.1371\/journal.pone.0017429","journal-title":"PLoS One"},{"issue":"12","key":"4_CR21","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.1073\/pnas.1019055108","volume":"108","author":"JD Arroyo","year":"2011","unstructured":"Arroyo JD, Chevillet JR, Kroh EM et al (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108(12):5003\u20135008. https:\/\/doi.org\/10.1073\/pnas.1019055108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"14","key":"4_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12182","volume":"10","author":"KW Witwer","year":"2021","unstructured":"Witwer KW, Goberdhan DC, O'Driscoll L et al (2021) Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles. J Extracell Ves 10(14):e12182. https:\/\/doi.org\/10.1002\/jev2.12182","journal-title":"J Extracell Ves"},{"issue":"1 Pt A","key":"4_CR23","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1016\/j.bbagen.2016.07.028","volume":"1861","author":"DLM Rupert","year":"2017","unstructured":"Rupert DLM, Claudio V, L\u00e4sser C et al (2017) Methods for the physical characterization and quantification of extracellular vesicles in biological samples. Biochim Biophys Acta Gen Subj 1861(1 Pt A):3164\u20133179. https:\/\/doi.org\/10.1016\/j.bbagen.2016.07.028","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"4_CR24","unstructured":"Malvern (2012). https:\/\/www.malvernpanalytical.com\/en\/learn\/knowledge-center\/technical-notes\/tn140827-zeta-potential-analysis-using-z-nta"},{"issue":"5259","key":"4_CR25","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK LaemmLi","year":"1970","unstructured":"LaemmLi UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680\u2013685. https:\/\/doi.org\/10.1038\/227680a0","journal-title":"Nature"},{"key":"4_CR26","doi-asserted-by":"publisher","DOI":"10.1385\/0-89603-509-3:167","volume-title":"Vitro neurochemical techniques. Neuromethods","author":"DD Mousseau","year":"1999","unstructured":"Mousseau DD, Raghavendra Rao VL (1999) Western blot analysis. In: Boulton AA, Baker GB, Bateson AN (eds) Vitro neurochemical techniques. Neuromethods, vol 34. Humana Press. https:\/\/doi.org\/10.1385\/0-89603-509-3:167"},{"key":"4_CR27","unstructured":"Nanostring Manual (n.d.). https:\/\/nanostring.com\/resources\/ncounter-mirna-expression-assay-user-manual\/"},{"key":"4_CR28","unstructured":"R Core Team (2013) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. www.R-project.org\/"},{"issue":"D1","key":"4_CR29","doi-asserted-by":"publisher","first-page":"D360","DOI":"10.1093\/nar\/gkx1144","volume":"46","author":"T Tokar","year":"2018","unstructured":"Tokar T, Pastrello C, Rossos AEM et al (2018) mirDIP 4.1-integrative database of human microRNA target predictions. Nucleic Acids Res 46(D1):D360\u2013D370. https:\/\/doi.org\/10.1093\/nar\/gkx1144","journal-title":"Nucleic Acids Res"},{"key":"4_CR30","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","volume":"52","author":"M Milacic","year":"2023","unstructured":"Milacic M, Beavers D, Conley P et al (2023) The Reactome pathway knowledgebase 2024. Nucleic Acids Res 52:D672\u2013D678. https:\/\/doi.org\/10.1093\/nar\/gkad1025","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"4_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"4","key":"4_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3109\/09537104.2012.689038","volume":"24","author":"MD Lanc\u00e9","year":"2013","unstructured":"Lanc\u00e9 MD, Henskens YM, Nelemans P et al (2013) Do blood collection methods influence whole-blood platelet function analysis? Platelets 24(4):275\u2013281. https:\/\/doi.org\/10.3109\/09537104.2012.689038","journal-title":"Platelets"},{"issue":"3","key":"4_CR33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1538-7836.2011.04610.x","volume":"10","author":"R Lacroix","year":"2012","unstructured":"Lacroix R, Judicone C, Poncelet P et al (2012) Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol. J Throm Haem 10(3):437\u2013446. https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04610.x","journal-title":"J Throm Haem"},{"issue":"5","key":"4_CR34","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1080\/09537104.2021.1991569","volume":"33","author":"NC Buntsma","year":"2022","unstructured":"Buntsma NC, G\u0105secka A, Roos YBWEM et al (2022) EDTA stabilizes the concentration of platelet-derived extracellular vesicles during blood collection and handling. Platelets 33(5):764\u2013771. https:\/\/doi.org\/10.1080\/09537104.2021.1991569","journal-title":"Platelets"},{"issue":"4","key":"4_CR35","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.thromres.2010.12.014","volume":"127","author":"L Ayers","year":"2011","unstructured":"Ayers L, Kohler M, Harrison P et al (2011) Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay. Thromb Res 127(4):370\u2013377. https:\/\/doi.org\/10.1016\/j.thromres.2010.12.014","journal-title":"Thromb Res"},{"issue":"2","key":"4_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167969","volume":"12","author":"C Glinge","year":"2017","unstructured":"Glinge C, Clauss S, Boddum K et al (2017) Stability of circulating blood-based MicroRNAs \u2013 pre-analytic methodological considerations. PLoS One 12(2):e0167969. https:\/\/doi.org\/10.1371\/journal.pone.0167969","journal-title":"PLoS One"},{"issue":"2","key":"4_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12162","volume":"11","author":"S Gelibter","year":"2022","unstructured":"Gelibter S, Marostica G, Mandelli A et al (2022) The impact of storage on extracellular vesicles: a systematic study. J Extracell Ves 11(2):e12162. https:\/\/doi.org\/10.1002\/jev2.12162","journal-title":"J Extracell Ves"},{"issue":"5","key":"4_CR38","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3390\/life12050697","volume":"12","author":"A Sivanantham","year":"2022","unstructured":"Sivanantham A, Jin Y (2022) Impact of storage conditions on EV integrity\/surface markers and cargos. Life (Basel) 12(5):697. https:\/\/doi.org\/10.3390\/life12050697","journal-title":"Life (Basel)"},{"issue":"6","key":"4_CR39","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3390\/ijms18061153","volume":"18","author":"R Szatanek","year":"2017","unstructured":"Szatanek R, Baj-Krzyworzeka M, Zimoch J et al (2017) The methods of choice for extracellular vesicles (EVs) characterization. Int J Mol Sci 18(6):1153. https:\/\/doi.org\/10.3390\/ijms18061153","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4_CR40","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1373\/clinchem.2015.239459","volume":"61","author":"H Schwarzenbach","year":"2015","unstructured":"Schwarzenbach H, da Silva AM, Calin G et al (2015) Data normalization strategies for MicroRNA quantification. Clin Chem 61(11):1333\u20131342. https:\/\/doi.org\/10.1373\/clinchem.2015.239459","journal-title":"Clin Chem"},{"issue":"12","key":"4_CR41","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1007\/s10529-010-0380-z","volume":"32","author":"SU Meyer","year":"2010","unstructured":"Meyer SU, Pfaffl MW, Ulbrich SE (2010) Normalization strategies for microRNA profiling experiments: a \u2018normal\u2019 way to a hidden layer of complexity? Biotechnol Lett 32(12):1777\u20131788. https:\/\/doi.org\/10.1007\/s10529-010-0380-z","journal-title":"Biotechnol Lett"},{"issue":"3","key":"4_CR42","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/pharmaceutics11030126","volume":"11","author":"E Almenar-P\u00e9rez","year":"2019","unstructured":"Almenar-P\u00e9rez E, S\u00e1nchez-Fito T, Ovejero T et al (2019) Impact of polypharmacy on candidate biomarker miRNomes for the diagnosis of fibromyalgia and myalgic encephalomyelitis\/chronic fatigue syndrome: striking back on treatments. Pharmaceut 11(3):126. https:\/\/doi.org\/10.3390\/pharmaceutics11030126","journal-title":"Pharmaceut"},{"key":"4_CR43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12920-015-0136-7","volume":"8","author":"S Ameling","year":"2015","unstructured":"Ameling S, Kacprowski T, Chilukoti RK et al (2015) Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study. BMC Med Genom 8:61. https:\/\/doi.org\/10.1186\/s12920-015-0136-7","journal-title":"BMC Med Genom"},{"issue":"6","key":"4_CR44","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.3390\/nu11061326","volume":"11","author":"DC Mantilla-Escalante","year":"2019","unstructured":"Mantilla-Escalante DC, de Las L, Hazas MC, Gil-Zamorano J et al (2019) Postprandial circulating miRNAs in response to a dietary fat challenge. Nutrients 11(6):1326. https:\/\/doi.org\/10.3390\/nu11061326","journal-title":"Nutrients"},{"key":"4_CR45","unstructured":"NINDS (n.d.) Common data elements. Available online, https:\/\/www.commondataelements.ninds.nih.gov\/Myalgic%20Encephalomyelitis\/Chronic%20Fatigue%20Syndrome. Accessed on 24 2023"}],"container-title":["Methods in Molecular Biology","Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4498-0_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:36:57Z","timestamp":1747298217000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4498-0_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071644973","9781071644980"],"references-count":45,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4498-0_4","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"16 May 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}