{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T04:01:41Z","timestamp":1749960101216,"version":"3.41.0"},"publisher-location":"New York, NY","reference-count":11,"publisher":"Springer US","isbn-type":[{"value":"9781071645017","type":"print"},{"value":"9781071645024","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4502-4_10","type":"book-chapter","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T06:43:40Z","timestamp":1749883420000},"page":"201-216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activity-Based Protein Profiling of Active Host Cell Serine Hydrolases for Bioprocess Development of Therapeutic Proteins and Vaccines"],"prefix":"10.1007","author":[{"given":"Xuanwen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Tsukidate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa Q.","family":"Stiving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary A.","family":"Schuessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115581","volume":"234","author":"X Li","year":"2023","unstructured":"Li X (2023) Recent applications of quantitative mass spectrometry in biopharmaceutical process development and manufacturing. J Pharm Biomed Anal 234:115581","journal-title":"J Pharm Biomed Anal"},{"key":"10_CR2","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1002\/bit.28658","volume":"121","author":"YH Oh","year":"2024","unstructured":"Oh YH, Becker ML, Mendola KM, Choe LH, Min L, Lee KH, Yigzaw Y, Seay A, Bill J, Li X, Roush DJ, Cramer SM, Menegatti S, Lenhoff AM (2024) Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing. Biotechnol Bioeng 121:1283","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"10_CR3","first-page":"42","volume":"5","author":"X Li","year":"2022","unstructured":"Li X, Wang F, Li H, Richardson DD, Roush DJ (2022) The measurement and control of high-risk host cell proteins for polysorbate degradation in biologics formulation. Antib Ther 5(1):42\u201354","journal-title":"Antib Ther"},{"key":"10_CR4","doi-asserted-by":"crossref","unstructured":"Li X, An Y, Liao J, Xiao L, Swanson M, Martinez-Fonts K, Pavon JA, Sherer EC, Jawa V, Wang F, Gao X, Letarte S, Richardson DD (2021) Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradation during the stability study of a therapeutic recombinant monoclonal antibody product. Biotechnol Prog e3128","DOI":"10.1101\/2020.09.17.302679"},{"issue":"23","key":"10_CR5","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1021\/acs.analchem.1c00042","volume":"93","author":"X Li","year":"2021","unstructured":"Li X, Chandra D, Letarte S, Adam GC, Welch J, Yang RS, Rivera S, Bodea S, Dow A, Chi A, Strulson CA, Richardson DD (2021) Profiling active enzymes for polysorbate degradation in biotherapeutics by activity-based protein profiling. Anal Chem 93(23):8161\u20138169","journal-title":"Anal Chem"},{"issue":"9","key":"10_CR6","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1002\/bit.27016","volume":"116","author":"SW Li","year":"2019","unstructured":"Li SW, Yu B, Byrne G, Wright M, O\u2019Rourke S, Mesa K, Berman PW (2019) Identification and CRISPR\/Cas9 inactivation of the C1s protease responsible for proteolysis of recombinant proteins produced in CHO Cells. Biotechnol Bioeng 116(9):2130\u20132145","journal-title":"Biotechnol Bioeng"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1146\/annurev.biochem.75.101304.124125","volume":"77","author":"BF Cravatt","year":"2008","unstructured":"Cravatt BF, Wright AT, Kozarich JW (2008) Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu Rev Biochem 77:383\u2013414","journal-title":"Annu Rev Biochem"},{"issue":"24","key":"10_CR8","doi-asserted-by":"publisher","first-page":"8625","DOI":"10.1021\/acs.analchem.2c00059","volume":"94","author":"GY Liu","year":"2022","unstructured":"Liu GY, Nie S, Zheng X, Li N (2022) Activity-based protein profiling probe for the detection of enzymes catalyzing polysorbate degradation. Anal Chem 94(24):8625\u20138632","journal-title":"Anal Chem"},{"key":"10_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejpb.2023.04.021","volume":"187","author":"SK Gupta","year":"2023","unstructured":"Gupta SK, Graf T, Edelmann FT, Seelmann H, Reintinger M, Hillringhaus L, Bergmann F, Wiedmann M, Falkenstein R, Wegele H, Yuk IH, Leiss M (2023) A fast and sensitive high-throughput assay to assess polysorbate-degrading hydrolytic activity in biopharmaceuticals. Eur J Pharm Biopharm 187:120\u2013129","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"10_CR10","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.xphs.2023.09.013","volume":"113","author":"A Dehghani","year":"2024","unstructured":"Dehghani A, Binder F, Zorn M, Feigler A, Fischer KI, Felix MN, Happersberger P, Reisinger B (2024) Investigating pH effects on enzymes catalyzing polysorbate degradation by activity-based protein profiling. J Pharm Sci 113(3):744\u2013753","journal-title":"J Pharm Sci"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.copbio.2021.06.026","volume":"71","author":"DG Bracewell","year":"2021","unstructured":"Bracewell DG, Smith V, Delahaye M, Smales CM (2021) Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products. Curr Opin Biotechnol 71:98\u2013104","journal-title":"Curr Opin Biotechnol"}],"container-title":["Methods in Molecular Biology","Activity-Based Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4502-4_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T06:43:42Z","timestamp":1749883422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4502-4_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071645017","9781071645024"],"references-count":11,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4502-4_10","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"15 June 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}