{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:12:22Z","timestamp":1749701542889,"version":"3.41.0"},"publisher-location":"New York, NY","reference-count":33,"publisher":"Springer US","isbn-type":[{"value":"9781071645338","type":"print"},{"value":"9781071645345","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4534-5_28","type":"book-chapter","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T14:45:27Z","timestamp":1749653127000},"page":"413-421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Synthetic Nanoparticle to Mimic High-Density Lipoprotein for Reverse Cholesterol Transport"],"prefix":"10.1007","author":[{"given":"Bapurao","family":"Surnar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagesh","family":"Kolishetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanta","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"28_CR1","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1001\/jama.2012.13721","volume":"308","author":"M Mitka","year":"2012","unstructured":"Mitka M (2012) New basic care goals seek to rein in global rise in cardiovascular disease. JAMA 308:1725\u20131726","journal-title":"JAMA"},{"key":"28_CR2","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nature01323","volume":"420","author":"P Libby","year":"2002","unstructured":"Libby P (2002) Inflammation in atherosclerosis. Nature 420:868\u2013874","journal-title":"Nature"},{"key":"28_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature10146","volume":"473","author":"P Libby","year":"2011","unstructured":"Libby P, Ridker PM, Hansson GK (2011) Progress and challenges in translating the biology of atherosclerosis. Nature 473:317\u2013325","journal-title":"Nature"},{"key":"28_CR4","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1161\/CIRCULATIONAHA.112.000116","volume":"127","author":"MD Majmudar","year":"2013","unstructured":"Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M (2013) Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation 127:2038\u20132042","journal-title":"Circulation"},{"key":"28_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrd3444","volume":"10","author":"IF Charo","year":"2011","unstructured":"Charo IF, Taub R (2011) Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov 10:365\u2013376","journal-title":"Nat Rev Drug Discov"},{"key":"28_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/35025203","volume":"407","author":"AJ Lusis","year":"2000","unstructured":"Lusis AJ (2000) Atherosclerosis. Nature 407:233\u2013241","journal-title":"Nature"},{"key":"28_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1586\/14779072.7.2.197","volume":"7","author":"MY Desai","year":"2009","unstructured":"Desai MY, Schoenhagen P (2009) Emergence of targeted molecular imaging in atherosclerotic cardiovascular disease. Expert Rev Cardiovasc Ther 7:197\u2013203","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"28_CR8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1161\/01.ATV.0000054662.44688.9A","volume":"23","author":"JF Oram","year":"2003","unstructured":"Oram JF (2003) HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. Arterioscler Thromb Vasc Biol 23:720\u2013727","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"28_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/00041433-200208000-00004","volume":"13","author":"JF Oram","year":"2002","unstructured":"Oram JF (2002) ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol 13:373\u2013381","journal-title":"Curr Opin Lipidol"},{"key":"28_CR10","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0022-2275(20)32113-1","volume":"40","author":"GH Rothblat","year":"1999","unstructured":"Rothblat GH, de la Llera-Moya M, Atger V, Kellner-Weibel G, Williams DL, Phillips MC (1999) Cell cholesterol efflux: integration of old and new observations provides new insights. J Lipid Res 40:781\u2013796","journal-title":"J Lipid Res"},{"key":"28_CR11","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1152\/physrev.00022.2005","volume":"86","author":"E Ikonen","year":"2006","unstructured":"Ikonen E (2006) Mechanisms for cellular cholesterol transport: defects and human disease. Physiol Rev 86:1237\u20131261","journal-title":"Physiol Rev"},{"key":"28_CR12","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1194\/jlr.R016675","volume":"52","author":"WL Miller","year":"2011","unstructured":"Miller WL, Bose HS (2011) Early steps in steroidogenesis: intracellular cholesterol trafficking. J Lipid Res 52:2111\u20132135","journal-title":"J Lipid Res"},{"key":"28_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1743-7075-7-47","volume":"7","author":"J Hu","year":"2010","unstructured":"Hu J, Zhang Z, Shen WJ, Azhar S (2010) Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab (Lond) 7:47\u201357","journal-title":"Nutr Metab (Lond)"},{"key":"28_CR14","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.atherosclerosis.2008.09.006","volume":"204","author":"Y Ning","year":"2009","unstructured":"Ning Y, Bai Q, Lu H, Li X, Pandak WM, Zhao F, Chen S, Ren S, Yin L (2009) Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages. Atherosclerosis 204:114\u2013120","journal-title":"Atherosclerosis"},{"key":"28_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrm2336","volume":"9","author":"E Ikonen","year":"2008","unstructured":"Ikonen E (2008) Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol 9:125\u2013138","journal-title":"Nat Rev Mol Cell Biol"},{"key":"28_CR16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/417087a","volume":"417","author":"HS Bose","year":"2002","unstructured":"Bose HS, Lingappa VR, Miller WL (2002) Rapid regulation of steroidogenesis by mitochondrial protein import. Nature 417:87\u201391","journal-title":"Nature"},{"key":"28_CR17","doi-asserted-by":"publisher","first-page":"36596","DOI":"10.1074\/jbc.M006924200","volume":"275","author":"PG Yancey","year":"2000","unstructured":"Yancey PG, de la Llera-Moya M, Swarnakar S, Monzo P, Klein SM, Connelly MA, Johnson WJ, Williams DL, Rothblat GH (2000) High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI. J Biol Chem 275:36596\u201336604","journal-title":"J Biol Chem"},{"key":"28_CR18","doi-asserted-by":"publisher","first-page":"474","DOI":"10.7150\/ijbs.5.474","volume":"5","author":"TF Daniels","year":"2009","unstructured":"Daniels TF, Killinger KM, Michal JJ, Wright RW Jr, Jiang Z (2009) Lipoproteins, cholesterol homeostasis and cardiac health. Int J Biol Sci 5:474\u2013488","journal-title":"Int J Biol Sci"},{"key":"28_CR19","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1021\/bc500517k","volume":"26","author":"BL Sanchez-Gaytan","year":"2015","unstructured":"Sanchez-Gaytan BL, Fay F, Lobatto ME, Tang J, Ouimet M, Kim Y, van der Staay SE, van Rijs SM, Priem B, Zhang L, Fisher EA, Moore KJ, Langer R, Fayad ZA, Mulder WJ (2015) HDL-mimetic PLGA nanoparticle to target atherosclerosis plaque macrophages. Bioconjug Chem 26:443\u2013451","journal-title":"Bioconjug Chem"},{"key":"28_CR20","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1021\/nn506750r","volume":"9","author":"ME Lobatto","year":"2015","unstructured":"Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MP, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ES, Fayad ZA, Mulder WJ (2015) Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS Nano 9:1837\u20131847","journal-title":"ACS Nano"},{"key":"28_CR21","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1038\/ncomms4065","volume":"5","author":"R Duivenvoorden","year":"2014","unstructured":"Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ (2014) A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun 5:3065\u20133072","journal-title":"Nat Commun"},{"key":"28_CR22","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1021\/bc400105j","volume":"24","author":"A Barazza","year":"2013","unstructured":"Barazza A, Blachford C, Even-Or O, Joaquin VA, Briley-Saebo KC, Chen W, Jiang XC, Mulder WJ, Cormode DP, Fayad ZA, Fisher EA (2013) The complex fate in plasma of gadolinium incorporated into high-density lipoproteins used for magnetic imaging of atherosclerotic plaques. Bioconjug Chem 24:1039\u20131048","journal-title":"Bioconjug Chem"},{"key":"28_CR23","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1021\/nl1037903","volume":"10","author":"T Skajaa","year":"2010","unstructured":"Skajaa T, Zhao Y, van den Heuvel DJ, Gerritsen HC, Cormode DP, Koole R, van Schooneveld MM, Post JA, Fisher EA, Fayad ZA, de Mello Donega C, Meijerink A, Mulder WJ (2010) Quantum dot and Cy5.5 labeled nanoparticles to investigate lipoprotein biointeractions via Forster resonance energy transfer. Nano Lett 10:5131\u20135138","journal-title":"Nano Lett"},{"key":"28_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.biomaterials.2010.08.078","volume":"32","author":"T Skajaa","year":"2011","unstructured":"Skajaa T, Cormode DP, Jarzyna PA, Delshad A, Blachford C, Barazza A, Fisher EA, Gordon RE, Fayad ZA, Mulder WJ (2011) The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis. Biomaterials 32:206\u2013213","journal-title":"Biomaterials"},{"key":"28_CR25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.2217\/clp.09.38","volume":"4","author":"DP Cormode","year":"2009","unstructured":"Cormode DP, Frias JC, Ma Y, Chen W, Skajaa T, Briley-Saebo K, Barazza A, Williams KJ, Mulder WJ, Fayad ZA, Fisher EA (2009) HDL as a contrast agent for medical imaging. Clin Lipidol 4:493\u2013500","journal-title":"Clin Lipidol"},{"key":"28_CR26","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1096\/fj.09-139865","volume":"24","author":"W Chen","year":"2010","unstructured":"Chen W, Jarzyna PA, van Tilborg GA, Nguyen VA, Cormode DP, Klink A, Griffioen AW, Randolph GJ, Fisher EA, Mulder WJ, Fayad ZA (2010) RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe. FASEB J 24:1689\u20131699","journal-title":"FASEB J"},{"key":"28_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.molmed.2013.12.001","volume":"20","author":"M Schiener","year":"2014","unstructured":"Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O (2014) Nanomedicine-based strategies for treatment of atherosclerosis. Trends Mol Med 20:271\u2013281","journal-title":"Trends Mol Med"},{"key":"28_CR28","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.addr.2016.04.020","volume":"106","author":"CS Thaxton","year":"2016","unstructured":"Thaxton CS, Rink JS, Naha PC, Cormode DP (2016) Lipoproteins and lipoprotein mimetics for imaging and drug delivery. Adv Drug Deliv Rev 106:116\u2013131","journal-title":"Adv Drug Deliv Rev"},{"key":"28_CR29","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biomaterials.2016.05.021","volume":"100","author":"L Foit","year":"2016","unstructured":"Foit L, Thaxton CS (2016) Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding toll-like receptor 4. Biomaterials 100:67\u201375","journal-title":"Biomaterials"},{"key":"28_CR30","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1073\/pnas.1213657110","volume":"110","author":"S Yang","year":"2013","unstructured":"Yang S, Damiano MG, Zhang H, Tripathy S, Luthi AJ, Rink JS, Ugolkov AV, Singh AT, Dave SS, Gordon LI, Thaxton CS (2013) Biomimetic, synthetic HDL nanostructures for lymphoma. Proc Natl Acad Sci USA 110:2511\u20132516","journal-title":"Proc Natl Acad Sci USA"},{"key":"28_CR31","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1073\/pnas.1301929110","volume":"110","author":"S Marrache","year":"2013","unstructured":"Marrache S, Dhar S (2013) Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis. Proc Natl Acad Sci USA 110:9445\u20139450","journal-title":"Proc Natl Acad Sci USA"},{"key":"28_CR32","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1039\/C7NR06295H","volume":"10","author":"B Banik","year":"2017","unstructured":"Banik B, Wen R, Marrache S, Kumar A, Kolishetti N, Howerth EW, Dhar S (2017) Core hydrophobicity tuning of a self-assembled particle results in efficient lipid reduction and favorable organ distribution. Nanoscale 10:366\u2013377","journal-title":"Nanoscale"},{"key":"28_CR33","doi-asserted-by":"publisher","unstructured":"Banik B, Surnar B, Askins B, Banerjee M, Dhar S (2020) Dual targeted synthetic nanoparticle for cardiovascular diseases. ACS Appl. Mater. Interfaces 12:6852-6862. https:\/\/doi.org\/10.1021\/acsami.9b19036","DOI":"10.1021\/acsami.9b19036"}],"container-title":["Methods in Molecular Biology","Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4534-5_28","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T14:45:28Z","timestamp":1749653128000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4534-5_28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9781071645338","9781071645345"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4534-5_28","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"12 June 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}