{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T02:44:20Z","timestamp":1767321860274,"version":"3.48.0"},"publisher-location":"New York, NY","reference-count":32,"publisher":"Springer US","isbn-type":[{"value":"9781071650837","type":"print"},{"value":"9781071650844","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5084-4_1","type":"book-chapter","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T02:39:58Z","timestamp":1767321598000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tip-Enhanced Raman Spectroscopy of RNAs"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-7201","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Bonhommeau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-1-0716-0278-2_10","volume-title":"RNA Spectroscopy: methods and protocols","author":"F Geinguenaud","year":"2020","unstructured":"Geinguenaud F, Militello V, Arluison V (2020) Application of FTIR spectroscopy to analyze RNA structure. In: Arluison V, Wien F (eds) RNA Spectroscopy: methods and protocols, vol 2113, pp 119\u2013133. https:\/\/doi.org\/10.1007\/978-1-0716-0278-2_10"},{"issue":"2","key":"1_CR2","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.3390\/s120201657","volume":"12","author":"G Doria","year":"2012","unstructured":"Doria G, Conde J, Veigas B, Giestas L, Almeida C, Assun\u00e7\u00e3o M, Rosa J, Baptista PV (2012) Noble metal nanoparticles for biosensing applications. Sensors 12(2):1657\u20131687. https:\/\/doi.org\/10.3390\/s120201657","journal-title":"Sensors"},{"issue":"25","key":"1_CR3","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.1515\/nanoph-2024-0230","volume":"13","author":"A Micha\u0142owska","year":"2024","unstructured":"Micha\u0142owska A, Kudelski A (2024) Applications of surface enhanced Raman scattering (SERS) spectroscopy for detection of nucleic acids. Nanophotonics 13(25):4577\u20134603. https:\/\/doi.org\/10.1515\/nanoph-2024-0230","journal-title":"Nanophotonics"},{"issue":"7","key":"1_CR4","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1039\/d1cs01039e","volume":"51","author":"S Bonhommeau","year":"2022","unstructured":"Bonhommeau S, Cooney GS, Huang Y (2022) Nanoscale chemical characterization of biomolecules using tip-enhanced Raman spectroscopy. Chem Soc Rev 51(7):2416\u20132430. https:\/\/doi.org\/10.1039\/d1cs01039e","journal-title":"Chem Soc Rev"},{"issue":"14","key":"1_CR5","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1039\/d2nr00274d","volume":"14","author":"P Pienpinijtham","year":"2022","unstructured":"Pienpinijtham P, Kitahama Y, Ozaki Y (2022) Progress of tip-enhanced Raman scattering for the last two decades and its challenges in very recent years. Nanoscale 14(14):5265\u20135288. https:\/\/doi.org\/10.1039\/d2nr00274d","journal-title":"Nanoscale"},{"issue":"19","key":"1_CR6","doi-asserted-by":"publisher","first-page":"4756","DOI":"10.1002\/anie.201205748","volume":"53","author":"S Schl\u00fccker","year":"2014","unstructured":"Schl\u00fccker S (2014) Surface-enhanced Raman spectroscopy: concepts and chemical applications. Angew Chem Int Ed 53(19):4756\u20134795. https:\/\/doi.org\/10.1002\/anie.201205748","journal-title":"Angew Chem Int Ed"},{"issue":"6","key":"1_CR7","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1021\/cr100265f","volume":"111","author":"SM Morton","year":"2011","unstructured":"Morton SM, Silverstein DW, Jensen L (2011) Theoretical studies of Plasmonics using electronic structure methods. Chem Rev 111(6):3962\u20133994. https:\/\/doi.org\/10.1021\/cr100265f","journal-title":"Chem Rev"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/9781119554318.ch6","volume-title":"Microanalysis of atmospheric particles: techniques and applications","author":"S Sobanska","year":"2024","unstructured":"Sobanska S, Bonhommeau S, Desmedt A, Talaga D (2024) Raman microspectroscopy of particles. In: Conny JM, Buseck PR (eds) Microanalysis of atmospheric particles: techniques and applications. AGU Books\/Wiley, Hoboken, pp 127\u2013149. https:\/\/doi.org\/10.1002\/9781119554318.ch6"},{"issue":"9","key":"1_CR9","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1002\/anie.200704054","volume":"47","author":"E Bailo","year":"2008","unstructured":"Bailo E, Deckert V (2008) Tip-enhanced Raman spectroscopy of single RNA strands: towards a novel direct-sequencing method. Angew Chem Int Ed 47(9):1658\u20131661. https:\/\/doi.org\/10.1002\/anie.200704054","journal-title":"Angew Chem Int Ed"},{"issue":"2","key":"1_CR10","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1021\/acsphotonics.0c01486","volume":"8","author":"Z He","year":"2021","unstructured":"He Z, Qiu W, Kizer ME, Wang J, Chen W, Sokolov AV, Wang X, Hu J, Scully MO (2021) Resolving the sequence of RNA strands by tip-enhanced Raman spectroscopy. ACS Photonics 8(2):424\u2013430. https:\/\/doi.org\/10.1021\/acsphotonics.0c01486","journal-title":"ACS Photonics"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3762\/bjnano.2.66","volume":"2","author":"R Treffer","year":"2011","unstructured":"Treffer R, Lin X, Bailo E, Deckert-Gaudig T, Deckert V (2011) Distinction of nucleobases \u2013 a tip-enhanced Raman approach. Beilstein J Nanotechnol 2:628\u2013637. https:\/\/doi.org\/10.3762\/bjnano.2.66","journal-title":"Beilstein J Nanotechnol"},{"issue":"2","key":"1_CR12","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1021\/jp410963z","volume":"118","author":"S Najjar","year":"2014","unstructured":"Najjar S, Talaga D, Schu\u00e9 L, Coffinier Y, Szunerits S, Boukherroub R, Servant L, Rodriguez R, Bonhommeau S (2014) Tip-enhanced Raman spectroscopy of combed double-stranded DNA bundles. J Phys Chem C 118(2):1174\u20131181. https:\/\/doi.org\/10.1021\/jp410963z","journal-title":"J Phys Chem C"},{"issue":"11","key":"1_CR13","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1039\/c6an00350h","volume":"141","author":"F Pashaee","year":"2016","unstructured":"Pashaee F, Tabatabaei M, Caetano FA, Ferguson SSG, Lagugn\u00e9-Labarthet F (2016) Tip-enhanced Raman spectroscopy: plasmid-free vs. plasmid-embedded DNA. Analyst 141(11):3251\u20133258. https:\/\/doi.org\/10.1039\/c6an00350h","journal-title":"Analyst"},{"issue":"20","key":"1_CR14","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.1002\/anie.201702263","volume":"56","author":"R Zhang","year":"2017","unstructured":"Zhang R, Zhang X, Wang H, Zhang Y, Jiang S, Hu C, Zhang Y, Luo Y, Dong Z (2017) Distinguishing individual DNA bases in a network by non-resonant tip-enhanced Raman scattering. Angew Chem Int Ed 56(20):5561\u20135564. https:\/\/doi.org\/10.1002\/anie.201702263","journal-title":"Angew Chem Int Ed"},{"issue":"2","key":"1_CR15","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1021\/jacs.8b11506","volume":"141","author":"Z He","year":"2019","unstructured":"He Z, Han Z, Kizer M, Linhardt RJ, Wang X, Sinyukov AM, Wang J, Deckert V, Sokolov AV, Hu J, Scully MO (2019) Tip-enhanced Raman imaging of single-stranded DNA with single base resolution. J Am Chem Soc 141(2):753\u2013757. https:\/\/doi.org\/10.1021\/jacs.8b11506","journal-title":"J Am Chem Soc"},{"issue":"2","key":"1_CR16","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1039\/d1cs00127b","volume":"51","author":"G Limorenko","year":"2022","unstructured":"Limorenko G, Lashuel HA (2022) Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chem Soc Rev 51(2):513\u2013565. https:\/\/doi.org\/10.1039\/d1cs00127b","journal-title":"Chem Soc Rev"},{"issue":"48","key":"1_CR17","doi-asserted-by":"publisher","first-page":"15738","DOI":"10.1002\/anie.201809636","volume":"57","author":"D Talaga","year":"2018","unstructured":"Talaga D, Smeralda W, Lescos L, Hunel J, Lepejova-Caudy N, Cullin C, Bonhommeau S, Lecomte S (2018) PIP2 phospholipid-induced aggregation of tau filaments probed by tip-enhanced Raman spectroscopy. Angew Chem Int Ed 57(48):15738\u201315742. https:\/\/doi.org\/10.1002\/anie.201809636","journal-title":"Angew Chem Int Ed"},{"issue":"27","key":"1_CR18","doi-asserted-by":"publisher","first-page":"5024","DOI":"10.1021\/acs.jpcb.2c02786","volume":"126","author":"D Talaga","year":"2022","unstructured":"Talaga D, Cooney GS, Ury-Thiery V, Fichou Y, Huang Y, Lecomte S, Bonhommeau S (2022) Total internal reflection tip-enhanced Raman spectroscopy of tau fibrils. J Phys Chem B 126(27):5024\u20135032. https:\/\/doi.org\/10.1021\/acs.jpcb.2c02786","journal-title":"J Phys Chem B"},{"issue":"10","key":"1_CR19","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1039\/d3nr06365h","volume":"16","author":"K Sofi\u0144ska","year":"2024","unstructured":"Sofi\u0144ska K, Seweryn S, Skirli\u0144ska-Nosek K, Barbasz J, Lipiec E (2024) Tip-enhanced Raman spectroscopy reveals the structural rearrangements of tau protein aggregates at the growth phase. Nanoscale 16(10):5294\u20135301. https:\/\/doi.org\/10.1039\/d3nr06365h","journal-title":"Nanoscale"},{"issue":"50","key":"1_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314369","volume":"62","author":"GS Cooney","year":"2023","unstructured":"Cooney GS, Talaga D, Ury-Thiery V, Fichou Y, Huang Y, Lecomte S, Bonhommeau S (2023) Chemical imaging of RNA-tau amyloid fibrils at the nanoscale using tip-enhanced Raman spectroscopy. Angew Chem Int Ed 62(50):e202314369. https:\/\/doi.org\/10.1002\/anie.202314369","journal-title":"Angew Chem Int Ed"},{"issue":"15","key":"1_CR21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119952119","volume":"119","author":"R Abskharon","year":"2022","unstructured":"Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS (2022) Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc Natl Acad Sci U S A 119(15):e2119952119. https:\/\/doi.org\/10.1073\/pnas.2119952119","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1_CR22","doi-asserted-by":"publisher","first-page":"3835","DOI":"10.1021\/acs.jpclett.0c00579","volume":"11","author":"D Talaga","year":"2020","unstructured":"Talaga D, Bremner A, Buffeteau T, Vall\u00e9e RAL, Lecomte S, Bonhommeau S (2020) Total internal reflection tip-enhanced Raman spectroscopy of cytochrome C. J Phys Chem Lett 11(10):3835\u20133840. https:\/\/doi.org\/10.1021\/acs.jpclett.0c00579","journal-title":"J Phys Chem Lett"},{"issue":"1","key":"1_CR23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/cphc.201701067","volume":"19","author":"S Bonhommeau","year":"2018","unstructured":"Bonhommeau S, Lecomte S (2018) Tip-enhanced Raman spectroscopy: a tool for nanoscale chemical and structural characterization of biomolecules. ChemPhysChem 19(1):8\u201318. https:\/\/doi.org\/10.1002\/cphc.201701067","journal-title":"ChemPhysChem"},{"issue":"40","key":"1_CR24","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1021\/acs.jpclett.4c02309","volume":"15","author":"Y Huang","year":"2024","unstructured":"Huang Y, Cooney GS, Talaga D, Vall\u00e9e RAL, Quinzi R, Bouffier L, Lecomte S, Bonhommeau S (2024) Nanoscale chemical imaging of amyloid fibrils in water using total-internal-reflection tip-enhanced Raman spectroscopy. J Phys Chem Lett 15(40):10190\u201310197. https:\/\/doi.org\/10.1021\/acs.jpclett.4c02309","journal-title":"J Phys Chem Lett"},{"issue":"15","key":"1_CR25","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.69.155418","volume":"69","author":"H Watanabe","year":"2004","unstructured":"Watanabe H, Ishida Y, Hayazawa N, Inouye Y, Kawata S (2004) Tip-enhanced near-field Raman analysis of tip-pressurized adenine molecule. Phys Rev B 69(15):155418. https:\/\/doi.org\/10.1103\/PhysRevB.69.155418","journal-title":"Phys Rev B"},{"issue":"1\u20133","key":"1_CR26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/jrs.1480","volume":"37","author":"A Rasmussen","year":"2006","unstructured":"Rasmussen A, Deckert V (2006) Surface- and tip-enhanced Raman scattering of DNA components. J Raman Spectrosc 37(1\u20133):311\u2013317. https:\/\/doi.org\/10.1002\/jrs.1480","journal-title":"J Raman Spectrosc"},{"issue":"21","key":"1_CR27","doi-asserted-by":"publisher","first-page":"6708","DOI":"10.1021\/ja071107q","volume":"129","author":"KF Domke","year":"2007","unstructured":"Domke KF, Zhang D, Pettinger B (2007) Tip-enhanced Raman spectra of picomole quantities of DNA nucleobases at Au(111). J Am Chem Soc 129(21):6708\u20136709. https:\/\/doi.org\/10.1021\/ja071107q","journal-title":"J Am Chem Soc"},{"issue":"6","key":"1_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1021\/jp011986h","volume":"106","author":"B Giese","year":"2002","unstructured":"Giese B, McNaughton D (2002) Surface-enhanced Raman spectroscopic and density functional theory study of adenine adsorption to silver surfaces. J Phys Chem B 106(6):101\u2013112. https:\/\/doi.org\/10.1021\/jp011986h","journal-title":"J Phys Chem B"},{"issue":"3","key":"1_CR29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.saa.2005.06.013","volume":"63","author":"Y Badr","year":"2006","unstructured":"Badr Y, Mahmoud MA (2006) Effect of silver nanowires on the surface-enhanced Raman spectra (SERS) of the RNA bases. Spectrochim Acta A Mol Biomol Spectrosc 63(3):639\u2013645. https:\/\/doi.org\/10.1016\/j.saa.2005.06.013","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"issue":"3","key":"1_CR30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/jrs.1250170311","volume":"17","author":"C Otto","year":"1986","unstructured":"Otto C, van den Tweel TJJ, de Mul FFM, Greve J (1986) Surface-enhanced Raman spectroscopy of DNA bases. J Raman Spectrosc 17(3):289\u2013298. https:\/\/doi.org\/10.1002\/jrs.1250170311","journal-title":"J Raman Spectrosc"},{"issue":"1","key":"1_CR31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0006-3495(94)80767-2","volume":"66","author":"Y Guan","year":"1994","unstructured":"Guan Y, Wurrey CJ, Thomas GJ Jr (1994) Vibrational analysis of nucleic acids. 1. The phosphodiester group in dimethyl phosphate model compounds: (CH3O)2PO2\u2212, (CD3O)2PO2\u2212, and (13CH3O)2PO2\u2212. Biophys J 66(1):225\u2013235. https:\/\/doi.org\/10.1016\/S0006-3495(94)80767-2","journal-title":"Biophys J"},{"key":"1_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/srep33575","volume":"6","author":"T Deckert-Gaudig","year":"2016","unstructured":"Deckert-Gaudig T, Kurouski D, Hedegaard MAB, Singh P, Lednev IK, Deckert V (2016) Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils. Sci Rep 6:33575. https:\/\/doi.org\/10.1038\/srep33575","journal-title":"Sci Rep"}],"container-title":["Methods in Molecular Biology","RNA Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5084-4_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T02:39:58Z","timestamp":1767321598000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5084-4_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071650837","9781071650844"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5084-4_1","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 January 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}