{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:11:33Z","timestamp":1779127893467,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":28,"publisher":"Springer US","isbn-type":[{"value":"9781071651735","type":"print"},{"value":"9781071651742","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5174-2_14","type":"book-chapter","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:02:24Z","timestamp":1779127344000},"page":"287-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regenerative Medicine in Space: Advancing Bone Repair with Adipose-Derived Stem Cells and Bone-on-Chip Technology"],"prefix":"10.1007","author":[{"given":"Paola","family":"Pontecorvi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"14_CR1","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.3390\/life13071423","volume":"13","author":"R Bonanni","year":"2023","unstructured":"Bonanni R, Cariati I, Marini M et al (2023) Microgravity and musculoskeletal health: what strategies should be used for a great challenge? Life 13:1423","journal-title":"Life"},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.bone.2015.12.057","volume":"87","author":"D Grimm","year":"2016","unstructured":"Grimm D, Grosse J, Wehland M et al (2016) The impact of microgravity on bone in humans. Bone 87:44\u201356","journal-title":"Bone"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"e70316","DOI":"10.1002\/hsr2.70316","volume":"8","author":"J Azariah","year":"2025","unstructured":"Azariah J, Terranova U (2025) Microgravity and cardiovascular health in astronauts: a narrative review. Health Sci Rep 8:e70316","journal-title":"Health Sci Rep"},{"key":"14_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-021-00158-4","volume":"7","author":"OJ Juhl","year":"2021","unstructured":"Juhl OJ, Buettmann EG, Friedman MA et al (2021) Update on the effects of microgravity on the musculoskeletal system. NPJ Microgravity 7:28","journal-title":"NPJ Microgravity"},{"key":"14_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-022-00194-8","volume":"8","author":"J Man","year":"2022","unstructured":"Man J, Graham T, Squires-Donelly G, Laslett AL (2022) The effects of microgravity on bone structure and function. NPJ Microgravity 8:9","journal-title":"NPJ Microgravity"},{"issue":"6","key":"14_CR6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1359\/JBMR.040307","volume":"19","author":"T Lang","year":"2004","unstructured":"Lang T, LeBlanc A, Evans H et al (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J\u00a0Bone Miner Res 19(6):1006\u20131012","journal-title":"J Bone Miner Res"},{"issue":"22","key":"14_CR7","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1089\/scd.2015.0218","volume":"24","author":"EA Blaber","year":"2015","unstructured":"Blaber EA, Finkelstein H, Dvorochkin N et al (2015) Microgravity reduces the differentiation and regenerative potential of embryonic stem cells. Stem Cells Dev 24(22):2605\u20132621","journal-title":"Stem Cells Dev"},{"key":"14_CR8","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1152\/jappl.2000.89.3.1046","volume":"89","author":"PN Colleran","year":"2000","unstructured":"Colleran PN, Wilkerson MK, Bloomfield SA et al (2000) Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 89:1046\u20131054","journal-title":"J Appl Physiol"},{"issue":"15","key":"14_CR9","doi-asserted-by":"publisher","first-page":"8650","DOI":"10.3390\/ijms23158650","volume":"23","author":"RA Baran","year":"2022","unstructured":"Baran RA, Wehland M, Schulz H et al (2022) Microgravity-related changes in bone density and treatment options: a systematic review. Int J Mol Sci 23(15):8650","journal-title":"Int J Mol Sci"},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11914-020-00649-5","volume":"19","author":"EEA Cramer","year":"2021","unstructured":"Cramer EEA, Ito K, Hofmann S (2021) Ex vivo bone models and their potential in preclinical evaluation. Curr Osteoporos Rep 19:75\u201387","journal-title":"Curr Osteoporos Rep"},{"key":"14_CR11","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.3390\/ijms22042011","volume":"22","author":"AG Niculescu","year":"2021","unstructured":"Niculescu AG, Chircov C, B\u00eerc\u0103 AC, Grumezescu AM (2021) Fabrication and applications of microfluidic devices: a review. Int J Mol Sci 22:2011","journal-title":"Int J Mol Sci"},{"key":"14_CR12","doi-asserted-by":"publisher","first-page":"2006796","DOI":"10.1002\/adfm.202006796","volume":"31","author":"A Mansoorifar","year":"2021","unstructured":"Mansoorifar A, Gordon R, Bergan RC, Bertassoni LE (2021) Bone-on-a-chip: microfluidic technologies and microphysiologic models of bone tissue. Adv Funct Mater 31:2006796","journal-title":"Adv Funct Mater"},{"key":"14_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/mi15030370","volume":"15","author":"A Strods","year":"2024","unstructured":"Strods A, Narbute K, Mov\u010d ana V et al (2024) Development of organ-on-a-chip system with continuous flow in simulated microgravity. Micromachines 15:370","journal-title":"Micromachines"},{"key":"14_CR14","first-page":"1","volume":"41","author":"HY Nie","year":"2024","unstructured":"Nie HY, Ge J, Liu KG et al (2024) The effects of microgravity on stem cells and the new insights it brings to tissue engineering and regenerative medicine. Life Sci Space Res 41:1\u201317","journal-title":"Life Sci Space Res"},{"key":"14_CR15","doi-asserted-by":"publisher","first-page":"e10313","DOI":"10.1002\/btm2.10313","volume":"8","author":"K Paek","year":"2023","unstructured":"Paek K, Kim S, Tak S et al (2023) A high-throughput biomimetic bone-on-a-chip platform with artificial intelligence-assisted image analysis for osteoporosis drug testing. Bioeng Transl Med 8:e10313","journal-title":"Bioeng Transl Med"},{"key":"14_CR16","doi-asserted-by":"publisher","first-page":"2101467","DOI":"10.1002\/adem.202101467","volume":"24","author":"VP Galv\u00e1n-Chac\u00f3n","year":"2022","unstructured":"Galv\u00e1n-Chac\u00f3n VP, Zampouka A, Hesse B et al (2022) Bone-on-a-chip: a microscale 3D biomimetic model to study bone regeneration. Adv Eng Mater 24:2101467","journal-title":"Adv Eng Mater"},{"key":"14_CR17","doi-asserted-by":"crossref","unstructured":"Jogdand A, Landolina M, Chen Y (2024) Organs in orbit: how tissue chip technology benefits from microgravity, a perspective. Front Lab Chip Technol 3:1356688","DOI":"10.3389\/frlct.2024.1356688"},{"key":"14_CR18","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.3390\/cells11213356","volume":"11","author":"D Kostina","year":"2022","unstructured":"Kostina D, Lobov A, Klausen P et al (2022) Isolation of human osteoblast cells capable for mineralization and synthetizing bone-related proteins in vitro from adult bone. Cells 11:3356","journal-title":"Cells"},{"key":"14_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-023-01096-w","volume":"22","author":"J Dvorakova","year":"2023","unstructured":"Dvorakova J, Wiesnerova L, Chocholata P et al (2023) Human cells with osteogenic potential in bone tissue research. Biomed Eng Online 22:33","journal-title":"Biomed Eng Online"},{"key":"14_CR20","doi-asserted-by":"publisher","first-page":"1075156","DOI":"10.1155\/2018\/1075156","volume":"2018","author":"S Ceccarelli","year":"2018","unstructured":"Ceccarelli S, Nodale C, Vescarelli E et al (2018) Neuropilin 1 mediates keratinocyte growth factor signaling in adipose-derived stem cells: potential involvement in adipogenesis. Stem Cells Int 2018:1075156","journal-title":"Stem Cells Int"},{"key":"14_CR21","doi-asserted-by":"publisher","first-page":"926180","DOI":"10.3389\/fcell.2022.926180","volume":"10","author":"S Ceccarelli","year":"2022","unstructured":"Ceccarelli S, Gerini G, Megiorni F et al (2022) Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: focus on the role of Akt\/mTOR and Wnt\/\u03b2-catenin pathways on adipogenesis. Front Cell Dev Biol 10:926180","journal-title":"Front Cell Dev Biol"},{"key":"14_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3390\/cells14020135","volume":"14","author":"G Gerini","year":"2025","unstructured":"Gerini G, Traversa A, Cece F et al (2025) Deciphering the transcriptional metabolic profile of adipose-derived stem cells during osteogenic differentiation and epigenetic drug treatment. Cells 14:135","journal-title":"Cells"},{"key":"14_CR23","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/sctm.18-0266","volume":"8","author":"JM Wagner","year":"2019","unstructured":"Wagner JM, Reinkemeier F, Wallner C et al (2019) Adipose-derived stromal cells are capable of restoring bone regeneration after post-traumatic osteomyelitis and modulate B-cell response. Stem Cells Transl Med 8:1084\u20131091","journal-title":"Stem Cells Transl Med"},{"key":"14_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41392-024-01809-0","volume":"9","author":"J Cerneckis","year":"2024","unstructured":"Cerneckis J, Cai H, Shi Y (2024) Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications. Signal Transduct Target Ther 9:112","journal-title":"Signal Transduct Target Ther"},{"key":"14_CR25","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/cells10050975","volume":"10","author":"W Mende","year":"2021","unstructured":"Mende W, G\u00f6tzl R, Kubo Y et al (2021) The role of adipose stem cells in bone regeneration and bone tissue engineering. Cells 10:975","journal-title":"Cells"},{"key":"14_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/jbm.a.37448","volume":"111","author":"P Alam\u00e1n-D\u00edez","year":"2023","unstructured":"Alam\u00e1n-D\u00edez P, Garc\u00eda-Gareta E, Arruebo M, P\u00e9rez M\u00c1 (2023) A bone-on-a-chip collagen hydrogel-based model using pre-differentiated adipose-derived stem cells for personalized bone tissue engineering. J Biomed Mater Res A 111:88\u2013105","journal-title":"J Biomed Mater Res A"},{"key":"14_CR27","doi-asserted-by":"crossref","unstructured":"Ceccarelli S, Pontecorvi P, Anastasiadou E et al (2020) Immunomodulatory effect of adipose-derived stem cells: the cutting edge of clinical application. Front Cell Dev Biol 8:236","DOI":"10.3389\/fcell.2020.00236"},{"key":"14_CR28","doi-asserted-by":"publisher","first-page":"e0257070","DOI":"10.1371\/journal.pone.0257070","volume":"16","author":"E Anastasiadou","year":"2021","unstructured":"Anastasiadou E, Ceccarelli S, Messina E et al (2021) MiR-200c-3p maintains stemness and proliferative potential in adipose-derived stem cells by counteracting senescence mechanisms. PLoS One 16:e0257070","journal-title":"PLoS One"}],"container-title":["Methods in Molecular Biology","Biomedicine and Biotechnology in Space"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5174-2_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:02:26Z","timestamp":1779127346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5174-2_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071651735","9781071651742"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5174-2_14","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"19 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}