{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:19:27Z","timestamp":1783171167291,"version":"3.54.6"},"publisher-location":"New York, NY","reference-count":12,"publisher":"Springer US","isbn-type":[{"value":"9781071652015","type":"print"},{"value":"9781071652022","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5202-2_15","type":"book-chapter","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:43:55Z","timestamp":1783169035000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatic Discovery of Tumor-Specific Neoantigens Arising from Chimeric RNAs"],"prefix":"10.1007","author":[{"given":"Samir","family":"Lalani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehajroop","family":"Gadh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"15_CR1","doi-asserted-by":"crossref","unstructured":"Robert, C. A decade of immune-checkpoint inhibitors in cancer therapy. Nat Commun 11, 3801 (2020). https:\/\/www.nature.com\/articles\/s41467-020-17670-y","DOI":"10.1038\/s41467-020-17670-y"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1016\/j.cell.2022.06.035","volume":"185","author":"MC Sellars","year":"2022","unstructured":"Sellars MC, Wu CJ, Fritsch EF (2022) Cancer vaccines: building a bridge over troubled waters. Cell 185:2770\u20132788","journal-title":"Cell"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S0140-6736(23)02268-7","volume":"403","author":"JS Weber","year":"2024","unstructured":"Weber JS et al (2024) Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study. Lancet Lond Engl 403:632\u2013644","journal-title":"Lancet Lond Engl"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/s41591-019-0434-2","volume":"25","author":"W Yang","year":"2019","unstructured":"Yang W et al (2019) Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat Med 25:767\u2013775","journal-title":"Nat Med"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.isci.2019.10.028","volume":"21","author":"Z Wei","year":"2019","unstructured":"Wei Z et al (2019) The landscape of tumor fusion neoantigens: a pan-cancer analysis. iScience 21:249\u2013260","journal-title":"iScience"},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/s41587-022-01247-9","volume":"40","author":"D Weber","year":"2022","unstructured":"Weber D et al (2022) Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens. Nat Biotechnol 40:1276\u20131284","journal-title":"Nat Biotechnol"},{"key":"15_CR7","first-page":"1","volume":"8","author":"N Xie","year":"2023","unstructured":"Xie N et al (2023) Neoantigens: promising targets for cancer therapy. Signal Transduct Target Ther 8:1\u201338","journal-title":"Signal Transduct Target Ther"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","volume":"48","author":"B Reynisson","year":"2020","unstructured":"Reynisson B, Alvarez B, Paul S, Peters B, Nielsen M (2020) NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data. Nucleic Acids Res 48:W449\u2013W454","journal-title":"Nucleic Acids Res"},{"key":"15_CR9","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1080\/15476286.2021.1940047","volume":"18","author":"S Singh","year":"2021","unstructured":"Singh S, Li H (2021) Comparative study of bioinformatic tools for the identification of chimeric RNAs from RNA sequencing. RNA Biol 18:254\u2013267","journal-title":"RNA Biol"},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s13059-019-1842-9","volume":"20","author":"BJ Haas","year":"2019","unstructured":"Haas BJ et al (2019) Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods. Genome Biol 20:213.","journal-title":"Genome Biol"},{"key":"15_CR11","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cels.2021.05.021","volume":"12","author":"A Creason","year":"2021","unstructured":"Creason A et al (2021) A community challenge to evaluate RNA-seq, fusion detection, and isoform quantification methods for cancer discovery. Cell Syst 12:827\u2013838. e5","journal-title":"Cell Syst"},{"key":"15_CR12","doi-asserted-by":"publisher","first-page":"100467","DOI":"10.1016\/j.crmeth.2023.100467","volume":"3","author":"BJ Haas","year":"2023","unstructured":"Haas BJ et al (2023) Targeted in silico characterization of fusion transcripts in tumor and normal tissues via FusionInspector. Cell Rep. Methods 3:100467","journal-title":"Cell Rep. Methods"}],"container-title":["Methods in Molecular Biology","Chimeric RNAs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5202-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:43:57Z","timestamp":1783169037000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5202-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071652015","9781071652022"],"references-count":12,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5202-2_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"5 July 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}