{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:05:00Z","timestamp":1775005500767,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":10,"publisher":"Springer US","isbn-type":[{"value":"9781071652176","type":"print"},{"value":"9781071652183","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5218-3_16","type":"book-chapter","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:02:26Z","timestamp":1775001746000},"page":"207-216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Method for Assessing Inhibition Kinetics of Autoantibodies Against ADAMTS13 in Immune-Mediated Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1007","author":[{"given":"Madison","family":"Shay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantine","family":"Halkidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-2141.2005.05420.x","volume":"129","author":"K Kokame","year":"2005","unstructured":"Kokame K, Nobe Y, Kokubo Y et al (2005) FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay. Br J Haematol 129:93\u2013100","journal-title":"Br J Haematol"},{"key":"16_CR2","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1182\/blood-2009-01-195461","volume":"114","author":"TJ Raife","year":"2009","unstructured":"Raife TJ, Cao W, Atkinson BS et al (2009) Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. Blood 114:1666\u20131674","journal-title":"Blood"},{"key":"16_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/ijlh.12718","volume":"40","author":"K Langley","year":"2018","unstructured":"Langley K, Fretwell R, Kitchen S et al (2018) Multiple Centre evaluation study of ADAMTS13 activity and inhibitor assays. Int J Lab Hematol 40:21\u201325","journal-title":"Int J Lab Hematol"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1055\/s-0039-1696718","volume":"119","author":"C Valsecchi","year":"2019","unstructured":"Valsecchi C, Mirabet M, Mancini I et al (2019) Evaluation of a new, rapid, fully automated assay for the measurement of ADAMTS13 activity. Thromb Haemost 119:1767\u20131772","journal-title":"Thromb Haemost"},{"key":"16_CR5","doi-asserted-by":"crossref","unstructured":"Irsara C, Anliker M, Egger AE et al (2023) Evaluation of two fully automated ADAMTS13 activity assays in comparison to manual FRET assay. Int J Lab Hematol","DOI":"10.1111\/ijlh.14090"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1111\/jth.15332","volume":"19","author":"K Halkidis","year":"2021","unstructured":"Halkidis K, Siegel DL, Zheng XL (2021) A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura. J Thromb Haemost 19:1888","journal-title":"J Thromb Haemost"},{"key":"16_CR7","first-page":"2993","volume":"141","author":"K Halkidis","year":"2023","unstructured":"Halkidis K, Meng C, Liu S et al (2023) Mechanisms of inhibition of human monoclonal antibodies in immune thrombotic thrombocytopenic purpura. Blood 141:2993\u20133005","journal-title":"Blood"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0003-9861(83)90225-4","volume":"224","author":"GD Reinhart","year":"1983","unstructured":"Reinhart GD (1983) The determination of thermodynamic allosteric parameters of an enzyme undergoing steady-state turnover. Arch Biochem Biophys 224:389\u2013401","journal-title":"Arch Biochem Biophys"},{"key":"16_CR9","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1111\/trf.13584","volume":"56","author":"EM Ostertag","year":"2016","unstructured":"Ostertag EM, Kacir S, Thiboutot M et al (2016) ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro. Transfusion 56:1763\u20131774","journal-title":"Transfusion"},{"key":"16_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102603","volume":"8","author":"K Halkidis","year":"2024","unstructured":"Halkidis K, Meng C, Pillai VG et al (2024) Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura. Res Pract Thromb Haemost 8:102603","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Methods in Molecular Biology","ADAMTS Proteases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5218-3_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:02:28Z","timestamp":1775001748000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5218-3_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071652176","9781071652183"],"references-count":10,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5218-3_16","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"1 April 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}