{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:07:03Z","timestamp":1779091623426,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":13,"publisher":"Springer US","isbn-type":[{"value":"9781071652527","type":"print"},{"value":"9781071652534","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5253-4_21","type":"book-chapter","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:20:25Z","timestamp":1779088825000},"page":"283-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimentally Induced Epithelial\u2013Mesenchymal Transition of Human Hair Follicle Stem Cells as a Model of Scarring Alopecia Ex Vivo"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-9035","authenticated-orcid":false,"given":"Ilaria","family":"Piccini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"21_CR1","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420\u20131428. https:\/\/doi.org\/10.1172\/JCI39104","journal-title":"J Clin Invest"},{"key":"21_CR2","doi-asserted-by":"publisher","first-page":"e165","DOI":"10.1016\/j.jaad.2018.12.055","volume":"80","author":"M Harries","year":"2019","unstructured":"Harries M, Imanishi H, Paus R (2019) Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias. J Am Acad Dermatol 80:e165\u2013e166. https:\/\/doi.org\/10.1016\/j.jaad.2018.12.055","journal-title":"J Am Acad Dermatol"},{"key":"21_CR3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.molmed.2018.03.007","volume":"24","author":"MJ Harries","year":"2018","unstructured":"Harries MJ, Jimenez F, Izeta A et al (2018) Lichen Planopilaris and frontal Fibrosing alopecia as model epithelial stem cell diseases. Trends Mol Med 24:435\u2013448. https:\/\/doi.org\/10.1016\/j.molmed.2018.03.007","journal-title":"Trends Mol Med"},{"key":"21_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jid.2017.09.047","volume":"138","author":"H Imanishi","year":"2018","unstructured":"Imanishi H, Ansell DM, Ch\u00e9ret J et al (2018) Epithelial-to-mesenchymal stem cell transition in a human organ: lessons from lichen Planopilaris. J Invest Dermatol 138:511\u2013519. https:\/\/doi.org\/10.1016\/j.jid.2017.09.047","journal-title":"J Invest Dermatol"},{"key":"21_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/path.4233","volume":"231","author":"MJ Harries","year":"2013","unstructured":"Harries MJ, Meyer K, Chaudhry I et al (2013) Lichen planopilaris is characterized by immune privilege collapse of the hair follicle\u2019s epithelial stem cell niche. J Pathol 231:236\u2013247. https:\/\/doi.org\/10.1002\/path.4233","journal-title":"J Pathol"},{"key":"21_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jaad.2014.09.058","volume":"75","author":"C Bolduc","year":"2016","unstructured":"Bolduc C, Sperling LC, Shapiro J (2016) Primary cicatricial alopecia. J Am Acad Dermatol 75:1081\u20131099. https:\/\/doi.org\/10.1016\/j.jaad.2014.09.058","journal-title":"J Am Acad Dermatol"},{"key":"21_CR7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-0716-0648-3_9","volume-title":"Molecular Dermatology","author":"J Edelkamp","year":"2020","unstructured":"Edelkamp J, Gherardini J, Bertolini M (2020) Methods to study human hair follicle growth ex vivo: human microdissected hair follicle and human full thickness skin organ culture. In: Botchkareva NV, Westgate GE (eds) Molecular Dermatology. Springer New York, pp 105\u2013119"},{"key":"21_CR8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1600-0625.2009.00939.x","volume":"19","author":"JE Kloepper","year":"2010","unstructured":"Kloepper JE, Sugawara K, Al-Nuaimi Y et al (2010) Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture. Exp Dermatol 19:305\u2013312. https:\/\/doi.org\/10.1111\/j.1600-0625.2009.00939.x","journal-title":"Exp Dermatol"},{"key":"21_CR9","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/exd.12836","volume":"24","author":"EA Langan","year":"2015","unstructured":"Langan EA, Philpott MP, Kloepper JE, Paus R (2015) Human hair follicle organ culture: theory, application and perspectives. Exp Dermatol 24:903\u2013911. https:\/\/doi.org\/10.1111\/exd.12836","journal-title":"Exp Dermatol"},{"key":"21_CR10","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1016\/0923-1811(94)90036-1","volume":"7","author":"MP Philpott","year":"1994","unstructured":"Philpott MP, Sanders D, Westgate GE, Kealey T (1994) Human hair growth in vitro: a model for the study of hair follicle biology. J Dermatol Sci 7:S55\u2013S72. https:\/\/doi.org\/10.1016\/0923-1811(94)90036-1","journal-title":"J Dermatol Sci"},{"key":"21_CR11","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/jid.2008.425","volume":"129","author":"MJ Harries","year":"2009","unstructured":"Harries MJ, Paus R (2009) Scarring alopecia and the PPAR-\u03b3 connection. J Invest Dermatol 129:1066\u20131070. https:\/\/doi.org\/10.1038\/jid.2008.425","journal-title":"J Invest Dermatol"},{"key":"21_CR12","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/jid.2008.369","volume":"129","author":"P Karnik","year":"2009","unstructured":"Karnik P, Tekeste Z, McCormick TS et al (2009) Hair follicle stem cell-specific PPAR\u03b3 deletion causes scarring alopecia. J Invest Dermatol 129:1243\u20131257. https:\/\/doi.org\/10.1038\/jid.2008.369","journal-title":"J Invest Dermatol"},{"key":"21_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1056\/NEJM199908123410706","volume":"341","author":"R Paus","year":"1999","unstructured":"Paus R, Cotsarelis G (1999) The biology of hair follicles. N Engl J Med 341:491\u2013497. https:\/\/doi.org\/10.1056\/NEJM199908123410706","journal-title":"N Engl J Med"}],"container-title":["Methods in Molecular Biology","Molecular Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5253-4_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:20:26Z","timestamp":1779088826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5253-4_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071652527","9781071652534"],"references-count":13,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5253-4_21","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"19 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}