{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:14:09Z","timestamp":1788308049135,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":17,"publisher":"Springer US","isbn-type":[{"value":"9781071653159","type":"print"},{"value":"9781071653166","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5316-6_14","type":"book-chapter","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:29:23Z","timestamp":1788305363000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Efficacy of Drug Efflux Pump Inhibitors Through Growth Curve Analysis"],"prefix":"10.1007","author":[{"given":"Seiji","family":"Yamasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9081-382X","authenticated-orcid":false,"given":"Martijn","family":"Zwama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"14_CR1","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.1128\/JB.183.20.5803-5812.2001","volume":"183","author":"K Nishino","year":"2001","unstructured":"Nishino K, Yamaguchi A (2001) Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol 183:5803\u20135812","journal-title":"J Bacteriol"},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1365-2958.2005.04940.x","volume":"59","author":"K Nishino","year":"2006","unstructured":"Nishino K, Latifi T, Groisman EA (2006) Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Mol Microbiol 59:126\u2013141","journal-title":"Mol Microbiol"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrmicro3380","volume":"13","author":"JM Blair","year":"2015","unstructured":"Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ (2015) Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol 13:42\u201351","journal-title":"Nat Rev Microbiol"},{"key":"14_CR4","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.2217\/fmb.14.66","volume":"9","author":"JM Blair","year":"2014","unstructured":"Blair JM, Richmond GE, Piddock LJ (2014) Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance. Future Microbiol 9:1165\u20131177","journal-title":"Future Microbiol"},{"key":"14_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev.biochem.78.082907.145923","volume":"78","author":"H Nikaido","year":"2009","unstructured":"Nikaido H (2009) Multidrug resistance in bacteria. Annu Rev Biochem 78:119\u2013146","journal-title":"Annu Rev Biochem"},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1469-0691.2004.00763.x","volume":"10","author":"K Poole","year":"2004","unstructured":"Poole K (2004) Efflux-mediated multiresistance in Gram-negative bacteria. Clin Microbiol Infect 10:12\u201326","journal-title":"Clin Microbiol Infect"},{"key":"14_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/jac\/dki171","volume":"56","author":"K Poole","year":"2005","unstructured":"Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56:20\u201351","journal-title":"J Antimicrob Chemother"},{"key":"14_CR8","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.jiac.2016.03.015","volume":"22","author":"S Yamasaki","year":"2016","unstructured":"Yamasaki S, Fujioka T, Hayashi K, Yamasaki S, Hayashi-Nishino M, Nishino K (2016) Phenotype microarray analysis of the drug efflux systems in Salmonella enterica serovar Typhimurium. J Infect Chemother 22:780\u2013784","journal-title":"J Infect Chemother"},{"key":"14_CR9","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1093\/jac\/dks528","volume":"68","author":"S Yamasaki","year":"2013","unstructured":"Yamasaki S, Nagasawa S, Fukushima A, Hayashi-Nishino M, Nishino K (2013) Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium. J Antimicrob Chemother 68:1066\u20131070","journal-title":"J Antimicrob Chemother"},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ijantimicag.2014.12.005","volume":"45","author":"S Yamasaki","year":"2015","unstructured":"Yamasaki S, Wang LY, Hirata T, Hayashi-Nishino M, Nishino K (2015) Multidrug efflux pumps contribute to Escherichia coli biofilm maintenance. Int J Antimicrob Agents 45:439\u2013441","journal-title":"Int J Antimicrob Agents"},{"key":"14_CR11","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1128\/AAC.49.9.3858-3867.2005","volume":"49","author":"RJ Gillis","year":"2005","unstructured":"Gillis RJ, White KG, Choi KH, Wagner VE, Schweizer HP, Iglewski BH (2005) Molecular basis of azithromycin-resistant Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 49:3858\u20133867","journal-title":"Antimicrob Agents Chemother"},{"key":"14_CR12","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1093\/jac\/dks228","volume":"67","author":"S Baugh","year":"2012","unstructured":"Baugh S, Ekanayaka AS, Piddock LJ, Webber MA (2012) Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. J Antimicrob Chemother 67:2409\u20132417","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"14_CR13","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrmicro1464","volume":"4","author":"LJ Piddock","year":"2006","unstructured":"Piddock LJ (2006) Multidrug-resistance efflux pumps \u2013 not just for resistance. Nat Rev Microbiol 4(8):629\u2013636","journal-title":"Nat Rev Microbiol"},{"key":"14_CR14","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.bcp.2005.12.008","volume":"71","author":"O Lomovskaya","year":"2006","unstructured":"Lomovskaya O, Bostian KA (2006) Practical applications and feasibility of efflux pump inhibitors in the clinic\u2013a vision for applied use. Biochem Pharmacol 71:910\u2013918","journal-title":"Biochem Pharmacol"},{"key":"14_CR15","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.bbapap.2008.12.011","volume":"1794","author":"JM Pages","year":"2009","unstructured":"Pages JM, Amaral L (2009) Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim Biophys Acta 1794:826\u2013833","journal-title":"Biochim Biophys Acta"},{"key":"14_CR16","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00672-22","volume":"66","author":"S Yamasaki","year":"2022","unstructured":"Yamasaki S, Koga N, Zwama M, Sakurai K, Nakashima R, Yamaguchi A, Nishino K (2022) Spatial characteristics of the efflux pump MexB determine inhibitor binding. Antimicrob Agents Chemother 66:e0067222","journal-title":"Antimicrob Agents Chemother"},{"key":"14_CR17","doi-asserted-by":"crossref","unstructured":"Yoshida K, Nakayama K, Ohtsuka M, Kuru N, Yokomizo Y, Sakamoto A, Takemura M, Hoshino K, Kanda H, Nitanai H, Namba K, Yoshida K, Imamura Y, Zhang JZ, Lee VJ, Watkins WJ (2007) MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate. Bioorg Med Chem 15:7087\u20137097","DOI":"10.1016\/j.bmc.2007.07.039"}],"container-title":["Methods in Molecular Biology","Bacterial Multidrug Exporters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5316-6_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:29:23Z","timestamp":1788305363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5316-6_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071653159","9781071653166"],"references-count":17,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5316-6_14","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 July 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}