{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:16:30Z","timestamp":1788304590339,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":28,"publisher":"Springer US","isbn-type":[{"value":"9781071653753","type":"print"},{"value":"9781071653760","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5376-0_11","type":"book-chapter","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:46:18Z","timestamp":1788302778000},"page":"183-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cloning of Antibodies from Patients with Heparin-Induced Thrombocytopenia"],"prefix":"10.1007","author":[{"given":"Lu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Witman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renren","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"12","key":"11_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41577-019-0209-5","volume":"19","author":"JP Julien","year":"2019","unstructured":"Julien JP, Wardemann H (2019) Antibodies against plasmodium falciparum malaria at the molecular level. Nat Rev Immunol 19(12):761\u2013775","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"11_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nri.2017.148","volume":"18","author":"LM Walker","year":"2018","unstructured":"Walker LM, Burton DR (2018) Passive immunotherapy of viral infections: \u2018super-antibodies\u2019 enter the fray. Nat Rev Immunol 18(5):297\u2013308","journal-title":"Nat Rev Immunol"},{"issue":"21","key":"11_CR3","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1182\/blood-2016-11-709873","volume":"129","author":"GM Arepally","year":"2017","unstructured":"Arepally GM (2017) Heparin-induced thrombocytopenia. Blood 129(21):2864\u20132872","journal-title":"Blood"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.med.50.1.129","volume":"50","author":"TE Warkentin","year":"1999","unstructured":"Warkentin TE (1999) Heparin-induced thrombocytopenia: a ten-year retrospective. Annu Rev Med 50:129\u2013147","journal-title":"Annu Rev Med"},{"issue":"5","key":"11_CR5","doi-asserted-by":"publisher","first-page":"e220","DOI":"10.1016\/S2352-3026(18)30046-2","volume":"5","author":"B Dhakal","year":"2018","unstructured":"Dhakal B et al (2018) Disease burden, complication rates, and health-care costs of heparin-induced thrombocytopenia in the USA: a population-based study. Lancet Haematol 5(5):e220\u2013e231","journal-title":"Lancet Haematol"},{"issue":"7","key":"11_CR6","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1055\/s-0037-1602664","volume":"43","author":"AM Pishko","year":"2017","unstructured":"Pishko AM, Cuker A (2017) Heparin-induced thrombocytopenia in cardiac surgery patients. Semin Thromb Hemost 43(7):691\u2013698","journal-title":"Semin Thromb Hemost"},{"issue":"20","key":"11_CR7","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1056\/NEJM199505183322003","volume":"332","author":"TE Warkentin","year":"1995","unstructured":"Warkentin TE et al (1995) Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332(20):1330\u20131335","journal-title":"N Engl J Med"},{"issue":"2","key":"11_CR8","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/bjh.14603","volume":"177","author":"P Staibano","year":"2017","unstructured":"Staibano P et al (2017) The unique immunological features of heparin-induced thrombocytopenia. Br J Haematol 177(2):198\u2013207","journal-title":"Br J Haematol"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.trsl.2020.04.014","volume":"225","author":"GM Arepally","year":"2020","unstructured":"Arepally GM, Cines DB (2020) Pathogenesis of heparin-induced thrombocytopenia. Transl Res 225:131\u2013140","journal-title":"Transl Res"},{"issue":"46","key":"11_CR10","doi-asserted-by":"publisher","first-page":"33060","DOI":"10.1074\/jbc.M113.481598","volume":"288","author":"RI Litvinov","year":"2013","unstructured":"Litvinov RI et al (2013) Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. J Biol Chem 288(46):33060\u201333070","journal-title":"J Biol Chem"},{"issue":"5","key":"11_CR11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/bjh.14955","volume":"179","author":"C Vayne","year":"2017","unstructured":"Vayne C et al (2017) Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin-induced thrombocytopenia antibodies. Br J Haematol 179(5):811\u2013819","journal-title":"Br J Haematol"},{"issue":"12","key":"11_CR12","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1111\/j.1538-7836.2011.04536.x","volume":"9","author":"TE Warkentin","year":"2011","unstructured":"Warkentin TE et al (2011) Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis. J Thromb Haemost 9(12):2498\u20132500","journal-title":"J Thromb Haemost"},{"issue":"12","key":"11_CR13","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1002\/ajh.21032","volume":"82","author":"GK Lo","year":"2007","unstructured":"Lo GK, Sigouin CS, Warkentin TE (2007) What is the potential for overdiagnosis of heparin-induced thrombocytopenia? Am J Hematol 82(12):1037\u20131043","journal-title":"Am J Hematol"},{"key":"11_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1182\/asheducation-2011.1.143","volume":"2011","author":"TE Warkentin","year":"2011","unstructured":"Warkentin TE (2011) How I diagnose and manage HIT. Hematology Am Soc Hematol Educ Program 2011:143\u2013149","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"3","key":"11_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1160\/TH11-09-0631","volume":"107","author":"MC Morel-Kopp","year":"2012","unstructured":"Morel-Kopp MC et al (2012) Validation of whole blood impedance aggregometry as a new diagnostic tool for HIT: results of a large Australian study. Thromb Haemost 107(3):575\u2013583","journal-title":"Thromb Haemost"},{"issue":"1","key":"11_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1182\/blood.V67.1.27.27","volume":"67","author":"D Sheridan","year":"1986","unstructured":"Sheridan D, Carter C, Kelton JG (1986) A diagnostic test for heparin-induced thrombocytopenia. Blood 67(1):27\u201330","journal-title":"Blood"},{"issue":"3","key":"11_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.chest.2016.02.641","volume":"150","author":"A Padmanabhan","year":"2016","unstructured":"Padmanabhan A et al (2016) A novel PF4-dependent platelet activation assay identifies patients likely to have heparin-induced thrombocytopenia\/thrombosis. Chest 150(3):506\u2013515","journal-title":"Chest"},{"key":"11_CR18","doi-asserted-by":"publisher","unstructured":"Samuelson Bannow BT et al (2020) A prospective, blinded study of a PF4-dependent assay for HIT diagnosis. Blood. https:\/\/doi.org\/10.1182\/blood.2020008195","DOI":"10.1182\/blood.2020008195"},{"issue":"4","key":"11_CR19","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1055\/s-0037-1614536","volume":"81","author":"P Eichler","year":"1999","unstructured":"Eichler P et al (1999) First workshop for detection of heparin-induced antibodies: validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4\/heparin ELISA. Thromb Haemost 81(4):625\u2013629","journal-title":"Thromb Haemost"},{"issue":"10","key":"11_CR20","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1182\/blood-2011-11-376293","volume":"119","author":"A Cuker","year":"2012","unstructured":"Cuker A, Cines DB (2012) How I treat heparin-induced thrombocytopenia. Blood 119(10):2209\u20132218","journal-title":"Blood"},{"issue":"7","key":"11_CR21","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1182\/blood-2008-02-078014","volume":"112","author":"JG Kelton","year":"2008","unstructured":"Kelton JG, Warkentin TE (2008) Heparin-induced thrombocytopenia: a historical perspective. Blood 112(7):2607\u20132616","journal-title":"Blood"},{"issue":"9","key":"11_CR22","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1182\/blood.2022017612","volume":"141","author":"W Zhu","year":"2023","unstructured":"Zhu W et al (2023) Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis. Blood 141(9):1060\u20131069","journal-title":"Blood"},{"issue":"5638","key":"11_CR23","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","volume":"301","author":"H Wardemann","year":"2003","unstructured":"Wardemann H et al (2003) Predominant autoantibody production by early human B cell precursors. Science 301(5638):1374\u20131377","journal-title":"Science"},{"issue":"12","key":"11_CR24","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1038\/nprot1214-2903a","volume":"9","author":"K Smith","year":"2014","unstructured":"Smith K et al (2014) Corrigendum: rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc 9(12):2903","journal-title":"Nat Protoc"},{"issue":"3","key":"11_CR25","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2016.02.010","volume":"44","author":"M Kuraoka","year":"2016","unstructured":"Kuraoka M et al (2016) Complex antigens drive permissive clonal selection in germinal centers. Immunity 44(3):542\u2013552","journal-title":"Immunity"},{"issue":"1","key":"11_CR26","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.immuni.2017.12.009","volume":"48","author":"KR McCarthy","year":"2018","unstructured":"McCarthy KR et al (2018) Memory B cells that cross-react with group 1 and group 2 influenza a viruses are abundant in adult human repertoires. Immunity 48(1):174\u2013184.e9","journal-title":"Immunity"},{"issue":"7","key":"11_CR27","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood-2008-09-177139","volume":"113","author":"XM Luo","year":"2009","unstructured":"Luo XM et al (2009) Engineering human hematopoietic stem\/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood 113(7):1422\u20131431","journal-title":"Blood"},{"issue":"6","key":"11_CR28","first-page":"1322","volume":"114","author":"A Padmanabhan","year":"2015","unstructured":"Padmanabhan A et al (2015) A modified PF4-dependent, CD62p expression assay selectively detects serotonin-releasing antibodies in patients suspected of HIT. Thromb Haemost 114(6):1322\u20131323","journal-title":"Thromb Haemost"}],"container-title":["Methods in Molecular Biology","Methods in Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5376-0_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:46:19Z","timestamp":1788302779000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5376-0_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071653753","9781071653760"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5376-0_11","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 September 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}