{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:18:58Z","timestamp":1788304738672,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":15,"publisher":"Springer US","isbn-type":[{"value":"9781071654996","type":"print"},{"value":"9781071655009","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/978-1-0716-5500-9_26","type":"book-chapter","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:10:39Z","timestamp":1788304239000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hamster Model of Leptospira Infection"],"prefix":"10.1007","author":[{"given":"Mitsumasa","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"26_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1538\/expanim.15-0073","volume":"65","author":"M Matsui","year":"2016","unstructured":"Matsui M, Soupe-Gilbert ME, Picardeau M (2016) Recent advances in leptospirosis research: animal models and vaccine development. Exp Anim 65:23\u201333. https:\/\/doi.org\/10.1538\/expanim.15-0073","journal-title":"Exp Anim"},{"key":"26_CR2","doi-asserted-by":"publisher","first-page":"976","DOI":"10.4269\/ajtmh.2009.09-0191","volume":"81","author":"M Marinho","year":"2009","unstructured":"Marinho M, Ko AI et al. (2009) Infection with Leptospira interrogans induces acute lung injury in a hamster model. Am J Trop Med Hyg 81:976\u2013983. https:\/\/doi.org\/10.4269\/ajtmh.2009.09-0191","journal-title":"Am J Trop Med Hyg"},{"key":"26_CR3","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/1348-0421.12255","volume":"59","author":"M Saito","year":"2015","unstructured":"Saito M, Villanueva SY, Masuzawa T et al. (2015) The usefulness of semi-solid medium in the isolation of highly virulent Leptospira strains from wild rats in an urban area of Fukuoka, Japan. Microbiol Immunol 59:322\u2013330. https:\/\/doi.org\/10.1111\/1348-0421.12255","journal-title":"Microbiol Immunol"},{"key":"26_CR4","doi-asserted-by":"publisher","first-page":"106243","DOI":"10.1016\/j.micpath.2023.106243","volume":"182","author":"T Asoh","year":"2023","unstructured":"Asoh T, Miyahara S, Villanueva SY et al. (2023) Protective role of stratum corneum in percutaneous Leptospira infection in a hamster model. Microb Pathog 182:106243. https:\/\/doi.org\/10.1016\/j.micpath.2023.106243","journal-title":"Microb Pathog"},{"key":"26_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1139\/cjm-2013-0832","volume":"60","author":"T Asoh","year":"2014","unstructured":"Asoh T, Saito M, Villanueva SY et al. (2014) Natural defense by saliva and mucosa against oral infection by Leptospira. Can J Microbiol 60:383\u2013389. https:\/\/doi.org\/10.1139\/cjm-2013-0832","journal-title":"Can J Microbiol"},{"key":"26_CR6","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1080\/22221751.2022.2138320","volume":"11","author":"L Wang","year":"2022","unstructured":"Wang L, Chen Y, Lin X et al. (2022) A hamster model of severe pulmonary hemorrhagic leptospirosis by intranasal inoculation. Emerg Microbes Infect 11:2246\u20132257. https:\/\/doi.org\/10.1080\/22221751.2022.2138320","journal-title":"Emerg Microbes Infect"},{"key":"26_CR7","doi-asserted-by":"publisher","first-page":"e00727","DOI":"10.1128\/IAI.00727-19","volume":"87","author":"Y Nikaido","year":"2019","unstructured":"Nikaido Y, Ogawa M, Fukuda K et al. (2019) Transbronchial invasion and proliferation of Leptospira interrogans in lung without inflammatory cell infiltration in a hamster model. Infect Immun 87:e00727\u201319. https:\/\/doi.org\/10.1128\/IAI.00727-19","journal-title":"Infect Immun"},{"key":"26_CR8","doi-asserted-by":"publisher","first-page":"e0172973","DOI":"10.1371\/journal.pone.0172973","volume":"12","author":"R Ozuru","year":"2017","unstructured":"Ozuru R, Saito M, Kanemaru T et al. (2017) Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters. PLoS One 12:e0172973. https:\/\/doi.org\/10.1371\/journal.pone.0172973","journal-title":"PLoS One"},{"key":"26_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/iep.12084","volume":"95","author":"S Miyahara","year":"2014","unstructured":"Miyahara S, Saito M, Kanemaru T et al. (2014) Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil\u2019s disease. Int J Exp Pathol 95:271\u2013281. https:\/\/doi.org\/10.1111\/iep.12084","journal-title":"Int J Exp Pathol"},{"key":"26_CR10","doi-asserted-by":"publisher","first-page":"e0009410","DOI":"10.1371\/journal.pntd.0009410","volume":"15","author":"T Maruoka","year":"2021","unstructured":"Maruoka T, Nikaido Y, Miyahara S et al. (2021) Correlation between renal distribution of leptospires during the acute phase and chronic renal dysfunction in a hamster model of infection with Leptospira interrogans. PLoS Negl Trop Dis 15:e0009410. https:\/\/doi.org\/10.1371\/journal.pntd.0009410","journal-title":"PLoS Negl Trop Dis"},{"key":"26_CR11","doi-asserted-by":"publisher","first-page":"105481","DOI":"10.1016\/j.micpath.2022.105481","volume":"165","author":"Y Inamasu","year":"2022","unstructured":"Inamasu Y, Nikaido Y, Miyahara S et al. (2022) Dissemination of Leptospira into the intestinal tract resulting in fecal excretion in a hamster model of subcutaneous infection with Leptospira interrogans. Microb Pathog 165:105481. https:\/\/doi.org\/10.1016\/j.micpath.2022.105481","journal-title":"Microb Pathog"},{"key":"26_CR12","doi-asserted-by":"publisher","first-page":"107013","DOI":"10.1016\/j.micpath.2024.107013","volume":"197","author":"T Takigawa","year":"2024","unstructured":"Takigawa T, Miyahara S, Ishii H et al. (2024) Fibrinolytic treatment using recombinant tissue-type plasminogen activator (rt-PA) for staphylococcal infective endocarditis. Microb Pathog 197:107013. https:\/\/doi.org\/10.1016\/j.micpath.2024.107013","journal-title":"Microb Pathog"},{"key":"26_CR13","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1099\/mic.0.073908-0","volume":"160","author":"SY Villanueva","year":"2014","unstructured":"Villanueva SY, Saito M, Tsutsumi Y et al. (2014) High virulence in hamsters of four dominantly prevailing Leptospira serovars isolated from rats in the Philippines. Microbiology 160:418\u2013428. https:\/\/doi.org\/10.1099\/mic.0.073908-0","journal-title":"Microbiology"},{"key":"26_CR14","doi-asserted-by":"publisher","first-page":"e00420","DOI":"10.1128\/iai.00420-23","volume":"92","author":"S Miyahara","year":"2024","unstructured":"Miyahara S, Mori H, Fukuda K et al. (2024) Non-purulent myositis caused by direct invasion of skeletal muscle tissue by Leptospira in a hamster model. Infect Immun 92:e00420\u201323. https:\/\/doi.org\/10.1128\/iai.00420-23","journal-title":"Infect Immun"},{"key":"26_CR15","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1348-0421.2011.00347.x","volume":"55","author":"A Chakraborty","year":"2011","unstructured":"Chakraborty A, Miyahara S, Villanueva SY et al. (2011) A novel combination of selective agents for isolation of Leptospira species. Microbiol Immunol 55:494\u2013501. https:\/\/doi.org\/10.1111\/j.1348-0421.2011.00347.x","journal-title":"Microbiol Immunol"}],"container-title":["Methods in Molecular Biology","Leptospira spp."],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5500-9_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:10:40Z","timestamp":1788304240000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5500-9_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9781071654996","9781071655009"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5500-9_26","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2 September 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}