{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:35Z","timestamp":1789395635743,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":12,"publisher":"Springer US","isbn-type":[{"value":"9781071655382","type":"print"},{"value":"9781071655399","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2027]]},"DOI":"10.1007\/978-1-0716-5539-9_21","type":"book-chapter","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:39:39Z","timestamp":1789393179000},"page":"337-348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced Image Generation for Cancer and Stem Cell Biology Using Diffusion Models"],"prefix":"10.1007","author":[{"given":"Benjamin L.","family":"Kidder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"6859","key":"21_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414(6859):105\u2013111","journal-title":"Nature"},{"issue":"1","key":"21_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0600-4","volume":"16","author":"PR Prasetyanti","year":"2017","unstructured":"Prasetyanti PR, Medema JP (2017) Intra-tumor heterogeneity from a cancer stem cell perspective. Mol Cancer 16(1):41","journal-title":"Mol Cancer"},{"issue":"3","key":"21_CR3","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/cancers13030376","volume":"13","author":"M Marzagalli","year":"2021","unstructured":"Marzagalli M, Fontana F, Raimondi M, Limonta P (2021) Cancer stem cells\u2014key players in tumor relapse. Cancers 13(3):376","journal-title":"Cancers"},{"issue":"1S","key":"21_CR4","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/MD.0000000000004766","volume":"95","author":"JC Chang","year":"2016","unstructured":"Chang JC (2016) Cancer stem cells: role in tumor growth, recurrence, metastasis, and treatment resistance. Medicine 95(1S):S20\u2013S25","journal-title":"Medicine"},{"issue":"13","key":"21_CR5","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.18632\/oncotarget.4037","volume":"6","author":"A Mitra","year":"2015","unstructured":"Mitra A, Mishra L, Li S (2015) EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget 6(13):10697","journal-title":"Oncotarget"},{"issue":"1","key":"21_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41392-020-00430-1","volume":"6","author":"H-M Zhou","year":"2021","unstructured":"Zhou H-M, Zhang J-G, Zhang X, Li Q (2021) Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents. Signal Transduct Target Ther 6(1):62","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"21_CR7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.cell.2005.08.020","volume":"122","author":"LA Boyer","year":"2005","unstructured":"Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947\u2013956","journal-title":"Cell"},{"issue":"4","key":"21_CR8","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.stem.2012.02.016","volume":"10","author":"Z Wang","year":"2012","unstructured":"Wang Z, Oron E, Nelson B, Razis S, Ivanova N (2012) Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10(4):440\u2013454","journal-title":"Cell Stem Cell"},{"issue":"24","key":"21_CR9","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1038\/emboj.2012.321","volume":"31","author":"P Navarro","year":"2012","unstructured":"Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin NP, Zhang W, Karwacki-Neisius V, Osorno R, Kelly D, Robertson M, Chambers I (2012) OCT4\/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J 31(24):4547\u20134562","journal-title":"EMBO Jl"},{"issue":"9","key":"21_CR10","volume":"32","author":"A Liu","year":"2013","unstructured":"Liu A, Yu X, Liu S (2013) Pluripotency transcription factors and cancer stem cells: small genes make a big difference. Chin J Cancer 32(9):483","journal-title":"Chin J Cancer"},{"key":"21_CR11","doi-asserted-by":"publisher","unstructured":"Kidder BL (2023) Advanced image generation for cancer using diffusion models. bioRxiv:2023.2008.2018.553859. https:\/\/doi.org\/10.1101\/2023.08.18.553859","DOI":"10.1101\/2023.08.18.553859"},{"key":"21_CR12","doi-asserted-by":"crossref","unstructured":"Ruiz N, Li Y, Jampani V, Pritch Y, Rubinstein M, Aberman K (2023) DreamBooth: fine tuning text-to-image diffusion models for subject-driven generation. In: Proceedings of the IEEE\/CVF conference on computer vision and pattern recognition (CVPR 2023). IEEE, pp 22500\u201322510","DOI":"10.1109\/CVPR52729.2023.02155"}],"container-title":["Methods in Molecular Biology","Stem Cell Transcriptional Networks"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5539-9_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:39:42Z","timestamp":1789393182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-5539-9_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"ISBN":["9781071655382","9781071655399"],"references-count":12,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5539-9_21","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"15 September 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}