{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:44:54Z","timestamp":1792143894800,"version":"4.4.0"},"publisher-location":"New York, NY","reference-count":8,"publisher":"Springer US","isbn-type":[{"value":"9781071655863","type":"print"},{"value":"9781071655870","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2027]]},"DOI":"10.1007\/978-1-0716-5587-0_20","type":"book-chapter","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:54:56Z","timestamp":1792140896000},"page":"317-333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastasis Assessment in Ewing Sarcoma Using Orthotopic Xenografts"],"prefix":"10.1007","author":[{"given":"Roser","family":"L\u00f3pez-Alemany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar M.","family":"Tirado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"issue":"5","key":"20_CR1","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.suc.2016.05.012","volume":"96","author":"RF Williams","year":"2016","unstructured":"Williams RF, Fernandez-Pineda I (2016) Pediatric sarcomas. Surg Clin N Am 96(5):1107\u20131125","journal-title":"Surg Clin N Am"},{"issue":"2","key":"20_CR2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1517\/13543780802715784","volume":"18","author":"R Windsor","year":"2019","unstructured":"Windsor R, Strauss S, Seddon B, Whelan J (2019) Experimental therapies in Ewing\u2019s sarcoma. Expert Opin Investig Drugs 18(2):143\u2013159","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"20_CR3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.stem.2014.02.002","volume":"14","author":"T Oskarsson","year":"2014","unstructured":"Oskarsson T, Batlle E, Massagu\u00e9 J (2014) Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14(3):306\u201321","journal-title":"Cell Stem Cell"},{"key":"20_CR4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s10585-015-9738-x","volume":"32","author":"SD Goldstein","year":"2015","unstructured":"Goldstein SD, Hayashi M, Albert CM, Jackson KW, Loeb DM (2015) An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. Clin Exp Metastasis 32:703\u2013715","journal-title":"Clin Exp Metastasis"},{"issue":"35","key":"20_CR5","doi-asserted-by":"publisher","first-page":"56889","DOI":"10.18632\/oncotarget.10872","volume":"7","author":"L Lagares-Tena","year":"2016","unstructured":"Lagares-Tena L, Garc\u00eda-Moncl\u00fas S, L\u00f3pez-Alemany R, Almacellas-Rabaiget O, Huertas-Mart\u00ednez J, S\u00e1inz-Jaspeado M, Mateo-Lozano S, Rodr\u00edguez-Galindo C, Rello-Varona S, Herrero-Mart\u00edn D, Tirado OM (2016) Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK\/ERK pathway. Oncotarget 7(35):56889\u201356903","journal-title":"Oncotarget"},{"issue":"5","key":"20_CR6","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1002\/ijc.31405","volume":"143","author":"S Garcia-Moncl\u00fas","year":"2018","unstructured":"Garcia-Moncl\u00fas S, L\u00f3pez-Alemany R, Almacellas-Rabaiget O, Herrero-Mart\u00edn D, Huertas-Martinez J, Lagares-Tena L, Alba-Pav\u00f3n P, Hontecillas-Prieto L, Mora J, de \u00c1lava E, Rello-Varona S, Giangrande PH, Tirado OM (2018) EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma. Int J Cancer 143(5):1188\u20131201","journal-title":"Int J Cancer"},{"key":"20_CR7","first-page":"758","volume":"32","author":"L Santana-Viera","year":"2023","unstructured":"Santana-Viera L, Dassie JP, Ros\u00e0s-Lape\u00f1a M, Garcia-Moncl\u00fas S, Chic\u00f3n-Bosch M, Perez-Cap\u00f3 M, Pozo LD, Sancheez-Serra S, Almacellas-Rabaiget O, Maqueda-Marcos S, Lopez-Alemany R, Thiel WH, Giangrande PH,E, Tirado OM (2023) Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors. Mol Oncol 32:758\u2013772","journal-title":"Mol Oncol"},{"issue":"4","key":"20_CR8","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1002\/1878-0261.13788","volume":"19","author":"M Chicon-Bosch","year":"2025","unstructured":"Chicon-Bosch M, Sanchez-Serra S, Ros\u00e0s-Lape\u00f1a M, Costa-Fraga N, Besal\u00fa-Velazquez J, Illa-Bernad\u00ed J, Mate-Lozano S, Cidre-Aranaz F, Grunewald TGP, Diaz-Lagares A, Lopez-Alemany R, Tirado OM (2025) Multi-omics profiling reveals key factors involved in Ewing sarcoma metastasis. Mol Oncol 19(4):1002\u20131878","journal-title":"Mol Oncol"}],"container-title":["Methods in Molecular Biology","Ewing Sarcoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-5587-0_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:54:56Z","timestamp":1792140896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/chapter\/10.1007\/978-1-0716-5587-0_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"ISBN":["9781071655863","9781071655870"],"references-count":8,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-5587-0_20","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"16 October 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}