{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:09:18Z","timestamp":1781831358063,"version":"3.54.5"},"publisher-location":"New York, NY","reference-count":29,"publisher":"Springer New York","isbn-type":[{"value":"9781441902979","type":"print"},{"value":"9781441902986","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-1-4419-0298-6_8","type":"book-chapter","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T23:39:41Z","timestamp":1259797181000},"page":"114-121","source":"Crossref","is-referenced-by-count":39,"title":["Bone Formation Versus Bone Resorption in Ankylosing Spondylitis"],"prefix":"10.1007","author":[{"given":"Georg","family":"Schett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"8_CR1","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1002\/art.21790","volume":"54","author":"J. Braun","year":"2006","unstructured":"Braun J, Landew\u00e9 R, Hermann KG et al. Major reduction in spinal inflammation in patients with ankylosing spondylitis after treatment with infliximab: Results of a multicenter, randomized, double-blind, placebo-controlled magnetic resonance imaging study. Arthritis Rheum 2006; 54:1646\u201352.","journal-title":"Arthritis Rheum"},{"key":"8_CR2","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1002\/art.11325","volume":"48","author":"J. Davis","year":"2003","unstructured":"Davis J, van der Heijde D, Braun J et al. Recombinant human tumor necrosis factor receptor (Etanercept) for treating ankylosing spondylitis A randomized, controlled trial. Arthritis Rheum 2003; 48:3230\u20136","journal-title":"Arthritis Rheum"},{"key":"8_CR3","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1002\/art.21913","volume":"54","author":"D. Heijde van der","year":"2006","unstructured":"van der Heijde D, Kivitz A, Schiff M et al. Efficacy and safety of adalimumab in patients with ankylosing spondylitis: Results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2006:54:2136\u20132.","journal-title":"Arthritis Rheum"},{"key":"8_CR4","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1136\/ard.2007.071159","volume":"66","author":"G. Schett","year":"2007","unstructured":"Schett G, Landew\u00e9 R, Desiree van der Heijde D. TNF blockers and structural remodeling in ankylosing spondylitis-what is reality and what is fiction? Ann Rheum Dis 2007; 66:709\u201311.","journal-title":"Ann Rheum Dis"},{"key":"8_CR5","first-page":"310","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"G. Schett","year":"2006","unstructured":"Schett G, Redlich K, Smolen JS. Inflammation-induced bone loss in the rheumatic diseases. In: Favus MJ, Ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th Edition. Washington D.C.: ASBMR, 2006; 6:310\u2013313.","edition":"6th Edition"},{"key":"8_CR6","first-page":"943","volume":"152","author":"E.M. Gravallese","year":"1998","unstructured":"Gravallese EM, Harada Y, Wang JT et al. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 1998; 152:943\u2013951.","journal-title":"Am J Pathol"},{"key":"8_CR7","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1002\/1529-0131(200110)44:10<2242::AID-ART386>3.0.CO;2-F","volume":"44","author":"M. Boers","year":"2001","unstructured":"Boers M, Kostense PJ, Verhoeven AC et al. Inflammation and damage in an individual joint predict further damage in that joint in patients with early rheumatoid arthritis. Arthritis Rheum 2001; 44:2242\u20136.","journal-title":"Arthritis Rheum"},{"key":"8_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/rheumatology\/39.2.122","volume":"39","author":"D.L. Scott","year":"2000","unstructured":"Scott DL, Pugner K, Kaarela K et al. The links between joint damage and disability in rheumatoid arthritis. Rheumatology (Oxford) 2000; 39:122\u2013132.","journal-title":"Rheumatology (Oxford)"},{"key":"8_CR9","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.122.12.3969","volume":"122","author":"E.E. Storm","year":"1996","unstructured":"Storm EE, Kingsley DM. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 1996; 122:3969\u201379.","journal-title":"Development"},{"key":"8_CR10","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0092-8674(01)00222-7","volume":"104","author":"C. Hartmann","year":"2001","unstructured":"Hartmann C, Tabin CJ. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell 2001; 104:341\u201351.","journal-title":"Cell"},{"key":"8_CR11","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1046\/j.1469-7580.2001.19950503.x","volume":"199","author":"M. Benjamin","year":"2001","unstructured":"Benjamin M, McGonagle D. The anatomical basis for disease localization in seronegative spondylar-thropathy at entheses and related sites. J Anat 2001; 199:503\u2013526.","journal-title":"J Anat"},{"issue":"3","key":"8_CR12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1136\/ard.30.3.213","volume":"30","author":"J. Ball","year":"1971","unstructured":"Ball J. Enthesopathy of rheumatoid and ankylosing spondylitis. Ann Rheum Dis 1971; 30(3):213\u201323.","journal-title":"Ann Rheum Dis"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1172\/JCI23738","volume":"115","author":"R.J. Lories","year":"2005","unstructured":"Lories RJ, Derese I, Luyten FP. Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest 2005; 115:1571\u20139.","journal-title":"J Clin Invest"},{"issue":"9","key":"8_CR14","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1002\/art.22060","volume":"54","author":"H. Appel","year":"2006","unstructured":"Appel H, Kuhne M, Spiekermann S et al. Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum 2006; 54(9):2845\u201351.","journal-title":"Arthritis Rheum"},{"key":"8_CR15","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1002\/art.11328","volume":"48","author":"A. Scharstuhl","year":"2003","unstructured":"Scharstuhl A, Vitters EL, van der Kraan PM et al. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta\/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum 2003; 48:3442\u201351.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"8_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/art.22372","volume":"56","author":"R.J. Lories","year":"2007","unstructured":"Lories RJ, Derese I, de Bari C et al. Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum 2007; 56(2):489\u201397.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"8_CR17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/ard.2003.013599","volume":"63","author":"R.J. Lories","year":"2004","unstructured":"Lories RJ, Matthys P, de Vlam K et al. Ankylosing enthesitis, dactylitis and onychoperiostitis in male DBA\/1 mice: a model of psoriatic arthritis. Ann Rheum Dis 2004; 63(5):595\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"8_CR18","first-page":"3001","volume":"3","author":"J.R. Miller","year":"2002","unstructured":"Miller JR. The Wnts. Genome Biol 2002; 3(1):3001.","journal-title":"Genome Biol"},{"key":"8_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D. Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007; 13:156\u2013163.","journal-title":"Nat Med"},{"key":"8_CR20","doi-asserted-by":"crossref","unstructured":"Lories R, Peeters J, Bakker A et al. Deletion of Frzb affects articular cartilage and biomechanical poperties of the long bones. Arthritis Rheum 2007, in press.","DOI":"10.1002\/art.23137"},{"key":"8_CR21","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nri2094","volume":"7","author":"I. McInnes","year":"2007","unstructured":"McInnes I, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Immunol 2007; 7:429\u2013442.","journal-title":"Nat Immunol"},{"key":"8_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0140-6736(94)91049-9","volume":"344","author":"A.K. Gough","year":"1994","unstructured":"Gough AK, Lilley J, Eyre S et al. Generalized bone loss in patients with early rheumatoid arthritis. Lancet 1994; 344:23\u201327.","journal-title":"Lancet"},{"key":"8_CR23","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/bmj.300.6724.563","volume":"300","author":"S.H. Ralston","year":"1990","unstructured":"Ralston SH, Urquhart GD, Brzeski M et al. Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis. BMJ 1990; 300:563\u2013565.","journal-title":"BMJ"},{"key":"8_CR24","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1001\/archinte.166.22.2495","volume":"166","author":"G. Schett","year":"2006","unstructured":"Schett G, Kiechl S, Weger S et al. High-sensitivity C-reaktive protein and risk of nontraumatic fractures in the bruneck study. Arch Int Med 2006; 166:2495\u2013501.","journal-title":"Arch Int Med"},{"key":"8_CR25","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1186\/ar2035","volume":"22","author":"H. Appel","year":"2006","unstructured":"Appel H, Loddenkemper C, Grozdanovic Z et al. Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther 2006; 22:R143.","journal-title":"Arthritis Res Ther"},{"key":"8_CR26","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/art.22496","volume":"56","author":"E. Jimenez-Boj","year":"2007","unstructured":"Jimenez-Boj E, Nobauer-Huhmann I, Hanslik-Schnabel B et al. Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. Arthritis Rheum 2007; 56:1118\u201324.","journal-title":"Arthritis Rheum"},{"issue":"6","key":"8_CR27","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1359\/JBMR.040205","volume":"19","author":"B. Gortz","year":"2004","unstructured":"Gortz B, Hayer S, Redlich K et al. Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. J Bone Miner Res 2004; 19(6):990\u20138.","journal-title":"J Bone Miner Res"},{"key":"8_CR28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","volume":"8","author":"D.A. Glass","year":"2005","unstructured":"Glass DA, Bialek P, Ahn JD et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005; 8:751\u201364.","journal-title":"Dev Cell"},{"issue":"Suppl II","key":"8_CR29","first-page":"81","volume":"65","author":"D.M. Heijde van der","year":"2006","unstructured":"van der Heijde DM, Landew\u00e9 RB, Ory P et al. Two-year etanercept therapy does not inhibit radiographic progression in patients with ankylosing spondylitis. Ann Rheum Dis 2006; 65(Suppl II):81.","journal-title":"Ann Rheum Dis"}],"container-title":["Advances in Experimental Medicine and Biology","Molecular Mechanisms of Spondyloarthropathies"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4419-0298-6_8.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T07:55:04Z","timestamp":1634284504000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4419-0298-6_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9781441902979","9781441902986"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-1-4419-0298-6_8","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}