{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:44:19Z","timestamp":1794379459882,"version":"4.9.0"},"publisher-location":"New York, NY","reference-count":72,"publisher":"Springer New York","isbn-type":[{"value":"9781441911445","type":"print"},{"value":"9781441911452","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"DOI":"10.1007\/978-1-4419-1145-2_10","type":"book-chapter","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T22:22:51Z","timestamp":1280355771000},"page":"119-127","source":"Crossref","is-referenced-by-count":4,"title":["Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli"],"prefix":"10.1007","author":[{"given":"Alison H.","family":"Trainer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/BF02047300","volume":"36","author":"K.P. Nugent","year":"1993","unstructured":"Nugent KP, Spigelman AD, Phillips RK. Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Dis Colon Rectum 1993; 36:1059\u201362.","journal-title":"Dis Colon Rectum"},{"key":"10_CR2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/BF02150736","volume":"33","author":"M.L. Arvanitis","year":"1990","unstructured":"Arvanitis ML, Jagelman DG, Fazio VW et al. Mortality in patients with familial adenomatous polyposis. Dis Colon Rectum 1990; 33:639\u201342.","journal-title":"Dis Colon Rectum"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/ssu.2980100311","volume":"10","author":"L. Bertario","year":"1994","unstructured":"Bertario L, Presciuttini S, Sala P et al. Causes of death and postsurgical survival in familial adenomatous polyposis: results from the italian registry. Italian registry of familial polyposis writing committee. Semin Surg Oncol 1994; 10:225\u201334.","journal-title":"Semin Surg Oncol"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/0092-8674(93)90538-2","volume":"75","author":"L. Spirio","year":"1993","unstructured":"Spirio L, Calin G, Olschwang S et al. Alleles of the APC gene: an attenuated form of familial polyposis. Cell 1993; 75:951\u20137.","journal-title":"Cell"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1086\/301883","volume":"62","author":"C. Soravia","year":"1998","unstructured":"Soravia C, Berk T, Madlensky L et al. Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 1998; 62:1290\u2013301.","journal-title":"Am J Hum Genet"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1136\/gut.50.6.845","volume":"50","author":"A.L. Moisio","year":"2002","unstructured":"Moisio AL, Jarvinen H, Peltomaki P. Genetic and clinical characterisation of familial adenomatous polyposis: a population based study. Gut 2002; 50:845\u201350.","journal-title":"Gut"},{"key":"10_CR7","first-page":"278","volume":"6","author":"A. Devic","year":"1912","unstructured":"Devic A, Bussy MM. Un cas de polypose adenomateuze generalisee autour de l\u2019intestine. Arch Mal Appar Dig 1912; 6:278\u2013299.","journal-title":"Arch Mal Appar Dig"},{"key":"10_CR8","first-page":"139","volume":"5","author":"E.J. Gardner","year":"1953","unstructured":"Gardner EJ, Richards RC. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 1953; 5:139\u201347.","journal-title":"Am J Hum Genet"},{"key":"10_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/ajmg.1320280217","volume":"28","author":"S. Klemmer","year":"1987","unstructured":"Klemmer S, Pascoe L, DeCosse J. Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet 1987; 28:385\u201392.","journal-title":"Am J Med Genet"},{"key":"10_CR10","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1007\/BF02237046","volume":"41","author":"P.M. Sagar","year":"1998","unstructured":"Sagar PM, Moslein G, Dozois RR. Management of desmoid tumors in patients after ileal pouch-anal anastomosis for familial adenomatous polyposis. Dis Colon Rectum 1998; 41:1350\u20135; discussion 1355-6.","journal-title":"Dis Colon Rectum"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/1097-0215(20010320)95:2<102::AID-IJC1018>3.0.CO;2-8","volume":"95","author":"L. Bertario","year":"2001","unstructured":"Bertario L, Russo A, Sala P et al. Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. Int J Cancer 2001; 95:102\u20137.","journal-title":"Int J Cancer"},{"key":"10_CR12","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1093\/hmg\/5.12.1921","volume":"5","author":"R.J. Scott","year":"1996","unstructured":"Scott RJ, Froggatt NJ, Trembath RC et al. Familial infiltrative fibromatosis (desmoid tumours) (MIMI35290) caused by a recurrent 3\u2032 APC gene mutation. Hum Mol Genet 1996; 5:1921\u20134.","journal-title":"Hum Mol Genet"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1136\/jmg.38.12.861","volume":"38","author":"D. Eccles","year":"2001","unstructured":"Eccles D, Harvey J, Bateman A et al. A novel 3\u2032 mutation in the APC gene in a family presenting with a desmoid tumour. J Med Genet 2001; 38:861\u20133.","journal-title":"J Med Genet"},{"key":"10_CR14","first-page":"1193","volume":"59","author":"D.M. Eccles","year":"1996","unstructured":"Eccles DM, Van Der Luijt R, Breukel C et al. Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. Am J Hum Genet 1996; 59:1193\u2013201.","journal-title":"Am J Hum Genet"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1034\/j.1399-0004.2000.570306.x","volume":"57","author":"J. Couture","year":"2000","unstructured":"Couture J, Mitri A, Lagace R et al. A germline mutation at the extreme 3\u2019 end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. Clin Genet 2000; 57:205\u201312.","journal-title":"Clin Genet"},{"key":"10_CR16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/hmg\/ddl442","volume":"16","author":"A. Latchford","year":"2007","unstructured":"Latchford A,. Volikos E, Johnson V et al. APC mutations in FAP-associated desmoid tumours are nonrandom but not \u2018just right\u2019. Hum Mol Genet 2007; 16:78\u201382.","journal-title":"Hum Mol Genet"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1002\/ijc.23390","volume":"122","author":"M. Miyaki","year":"2008","unstructured":"Miyaki M, Yamaguchi T, Iijima T et al. Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype. Int J Cancer 2008; 122:2491\u20137.","journal-title":"Int J Cancer"},{"key":"10_CR18","first-page":"329","volume":"151","author":"B.A. Alman","year":"1997","unstructured":"Alman BA, Li C, Pajerski ME et al. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol 1997; 151:329\u201334.","journal-title":"Am J Pathol"},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/jcp.52.9.695","volume":"52","author":"K. Shitoh","year":"1999","unstructured":"Shitoh K, Konishi F, Iijima T et al. A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene. J Clin Pathol 1999; 52:695\u20136.","journal-title":"J Clin Pathol"},{"key":"10_CR20","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/bjc.1998.544","volume":"78","author":"M. Giarola","year":"1998","unstructured":"Giarola M, Wells D, Mondini P et al. Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours. Br J Cancer 1998; 78:582\u20137.","journal-title":"Br J Cancer"},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1200\/JCO.2005.02.1923","volume":"24","author":"M. Gega","year":"2006","unstructured":"Gega M, Yanagi H, Yoshikawa R et al. Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. J Clin Oncol 2006; 24:102\u20135.","journal-title":"J Clin Oncol"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S0090-4295(96)00026-X","volume":"47","author":"J.K. Izes","year":"1996","unstructured":"Izes JK, Zinman LN, Larsen CR. Regression of large pelvic desmoid tumor by tamoxifen and sulindac. Urology 1996; 47:756\u20139.","journal-title":"Urology"},{"key":"10_CR23","first-page":"1520","volume":"26","author":"B. Maroy","year":"1997","unstructured":"Maroy B. Desmoid tumor sensitive to tamoxifen. Presse Med 1997; 26, 1520\u20132.","journal-title":"Presse Med"},{"key":"10_CR24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0002-9394(75)90069-0","volume":"79","author":"H. Buettner","year":"1975","unstructured":"Buettner H. Congenital hypertrophy of the retinal pigment epithelium. Am J Ophthalmol 1975; 79:177\u201389.","journal-title":"Am J Ophthalmol"},{"key":"10_CR25","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S0161-6420(92)31736-1","volume":"99","author":"J.A. Shields","year":"1992","unstructured":"Shields JA, Shields CL, Shah PG et al. Lack of association among typical congenital hypertrophy of the retinal pigment epithelium, adenomatous polyposis and gardner syndrome. Ophthalmology 1992; 99:1709\u201313.","journal-title":"Ophthalmology"},{"key":"10_CR26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0002-9394(14)75133-5","volume":"90","author":"N.P. Blair","year":"1980","unstructured":"Blair NP, Trempe CL. Hypertrophy of the retinal pigment epithelium associated with Gardner\u2019s syndrome. Am J Ophthalmol 1980; 90:661\u20137.","journal-title":"Am J Ophthalmol"},{"key":"10_CR27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1023\/B:INTE.0000031739.62559.ac","volume":"25","author":"R. Tourino","year":"2004","unstructured":"Tourino R, Conde-Freire R, Cabezas-Agricola JM et al. Value of the congenital hypertrophy of the retinal pigment epithelium in the diagnosis of familial adenomatous polyposis. Int Ophthalmol 2004; 25:101\u201312.","journal-title":"Int Ophthalmol"},{"key":"10_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/BF00171670","volume":"232","author":"D. Schmidt","year":"1994","unstructured":"Schmidt D, Jung CE, Wolff G. Changes in the retinal pigment epithelium close to retinal vessels in familial adenomatous polyposis. Graefes Arch Clin Exp Ophthalmol 1994; 232:96\u2013102.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10792-006-0007-5","volume":"26","author":"R. Tourino","year":"2005","unstructured":"Tourino R, Rodriguez-Ares MT, Lopez-Valladares MJ et al. Fluorescein angiographic features of the congenital hypertrophy of the retinal pigment epithelium in the familial adenomatous polyposis. Int Ophthalmol 2005; 26:59\u201365.","journal-title":"Int Ophthalmol"},{"key":"10_CR30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1442-9071.1993.tb00969.x","volume":"21","author":"M.P. Hennessy","year":"1993","unstructured":"Hennessy MP, Collins F, Coroneo MT. The distinction between multiple retinal pigment epithelial hamartomata (MRPEH) in familial adenomatous polyposis (FAP) and congenital hypertrophy of the retinal pigment epithelium (CHRPE). Aust N Z J Ophthalmol 1993; 21:275\u20136.","journal-title":"Aust N Z J Ophthalmol"},{"key":"10_CR31","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1093\/jjco\/hyd017","volume":"30","author":"M. Enomoto","year":"2000","unstructured":"Enomoto M, Konishi M, Iwama T et al. The relationship between frequencies of extracolonic manifestations and the position ofAPC germline mutation in patients with familial adenomatous polyposis. Jpn J Clin Oncol 2000; 30:82\u20138.","journal-title":"Jpn J Clin Oncol"},{"key":"10_CR32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/gut.40.4.521","volume":"40","author":"F.M. Giardiello","year":"1997","unstructured":"Giardiello FM, Petersen GM, Pianradosi S et al. APC gene mutations and extraintesrinal phenotype of familial adenomatous polyposis. Gut 1997; 40:521\u20135.","journal-title":"Gut"},{"key":"10_CR33","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1054\/bjoc.1999.0925","volume":"82","author":"F. Ficari","year":"2000","unstructured":"Ficari F, Cama A, Valanzano R et al. APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis. Br J Cancer 2000; 82:348\u201353.","journal-title":"Br J Cancer"},{"key":"10_CR34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0030-4220(62)90004-X","volume":"15","author":"M. Fader","year":"1962","unstructured":"Fader M, Kline SN, Spatz SS et al. Gardner\u2019s syndrome (intestinal polyposis, osteomas, sebaceous cysts) and a new dental discovery. Oral Surg Oral Med Oral Pathol 1962; 15:153\u201372.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10_CR35","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/0266-4356(86)90054-9","volume":"24","author":"J. Wolf","year":"1986","unstructured":"Wolf J, Jarvinen HJ, Hietanen J. Gardner\u2019s dento-maxillary stigmas in patients with familial adenomatosis coli. Br I Oral Maxillofac Surg 1986; 24:410\u20136.","journal-title":"Br I Oral Maxillofac Surg"},{"key":"10_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3109\/00016358709094355","volume":"45","author":"J.O. Sondergaard","year":"1987","unstructured":"Sondergaard JO, Bulow S, Jarvinen H et al. Dental anomalies in familial adenomatous polyposis coli. Acta Odontol Scand 1987; 45:61\u20133.","journal-title":"Acta Odontol Scand"},{"key":"10_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000102681","volume":"186","author":"R.N. D\u2019Souza","year":"2007","unstructured":"D\u2019Souza RN, Klein OD. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs 2007; 186:60\u20139.","journal-title":"Cells Tissues Organs"},{"key":"10_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ydbio.2007.10.016","volume":"313","author":"F. Liu","year":"2008","unstructured":"Liu F, Chu EY, Watt B et al. Wnt\/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 2008; 313:210\u201324.","journal-title":"Dev Biol"},{"key":"10_CR39","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/dev.125.21.4325","volume":"125","author":"M. Bei","year":"1998","unstructured":"Bei M, Maas R. FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. Development 1998; 125:4325\u201333.","journal-title":"Development"},{"key":"10_CR40","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S1010-5182(89)80104-0","volume":"17","author":"K. Kubo","year":"1989","unstructured":"Kubo K, Miyatani H, Takenoshita Y et al. Widespread radiopacity of jaw bones in familial adenomatosis coli. J Craniomaxillofac Surg 1989; 17:350\u20133.","journal-title":"J Craniomaxillofac Surg"},{"key":"10_CR41","first-page":"1151","volume":"57","author":"D.R. Davies","year":"1995","unstructured":"Davies DR, Armstrong JG, Thakker N et al. Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene. Am J Hum Genet 1995; 57:1151\u20138.","journal-title":"Am J Hum Genet"},{"key":"10_CR42","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S0901-5027(05)80641-1","volume":"22","author":"T. Takeuchi","year":"1993","unstructured":"Takeuchi T, Takenoshita Y, Kubo K et al. Natural course of jaw lesions in patients with familial adenomatosis coli (Gardner\u2019s syndrome). Int J Oral Maxillofac Surg 1993; 22:226\u201330.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10_CR43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/bjs.1800620111","volume":"62","author":"J. Utsunomiya","year":"1975","unstructured":"Utsunomiya J, Nakamura T. The occult osteomatous changes in the mandible in patients with familial polyposis coli. Br J Surg 1975; 62:45\u201351.","journal-title":"Br J Surg"},{"key":"10_CR44","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1136\/jmg.32.6.458","volume":"32","author":"N. Thakker","year":"1995","unstructured":"Thakker N, Davies R, Horner K et al. The dental phenotype in familial adenomatous polyposis: diagnostic application of a weighted scoring system for changes on dental panoramic radiographs. J Med Genet 1995; 32:458\u201364.","journal-title":"J Med Genet"},{"key":"10_CR45","first-page":"201","volume":"14","author":"C. Ullbro","year":"1990","unstructured":"Ullbro C, AIm T, Ericson S et al. Occult radiopaque jaw lesions in familial adenomatous polyposis. Swed Dent J 1990; 14:201\u201312.","journal-title":"Swed Dent J"},{"key":"10_CR46","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0030-4220(93)90213-N","volume":"76","author":"K. Yuasa","year":"1993","unstructured":"Yuasa K, Yonetsu K, Kanda S et al. Computed tomography of the jaws in familial adenomatosis coli. Oral Surg Oral Med Oral Pathol 1993; 76:251\u20135.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10_CR47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1259\/dmfr.21.2.1327886","volume":"21","author":"F. Halling","year":"1992","unstructured":"Halling F, Merten HA, Lepsien G et al. Clinical and radiological findings in Gardner\u2019s syndrome: a case report and follow-up study. Dentomaxillofac Radiol 1992; 21:93\u20138.","journal-title":"Dentomaxillofac Radiol"},{"key":"10_CR48","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1002\/cncr.22475","volume":"109","author":"T.M. Attard","year":"2007","unstructured":"Attard TM, Giglio P, Koppula S et al. Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Cancer 2007; 109:761\u20136.","journal-title":"Cancer"},{"key":"10_CR49","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1056\/NEJM199503303321302","volume":"332","author":"S.R. Hamilton","year":"1995","unstructured":"Hamilton SR, Liu B, Parsons RE et al. The molecular basis of Turcot\u2019s syndrome. N Engl J Med 1995; 332:839\u201347.","journal-title":"N Engl J Med"},{"key":"10_CR50","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/gcc.2870090304","volume":"9","author":"T. Mori","year":"1994","unstructured":"Mori T, Nagase H, Horii A et al. Germ-line and somatic mutations of the APC gene in patients with turcot syndrome and analysis of APC mutations in brain tumors. Genes Chromosomes Cancer 1994; 9:168\u201372.","journal-title":"Genes Chromosomes Cancer"},{"key":"10_CR51","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0002-9440(10)64747-5","volume":"156","author":"H. Huang","year":"2000","unstructured":"Huang H, Mahler-Araujo BM, Sankila A et al. APC mutations in sporadic medulloblastomas. Am J Pathol 2000; 156:433\u20137.","journal-title":"Am J Pathol"},{"key":"10_CR52","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1056\/NEJM199508243330817","volume":"333","author":"W.H. Yong","year":"1995","unstructured":"Yong WH, Raffel C, von Deimling A et al. The APC gene in Turcot\u2019s syndrome. N Engl J Med 1995; 333:524.","journal-title":"N Engl J Med"},{"key":"10_CR53","first-page":"7039","volume":"61","author":"R.P. Dahmen","year":"2001","unstructured":"Dahmen RP, Koch A, Denkhaus D et al. Deletions ofAXIN1, a component of the WNT\/wingless pathway, in sporadic medulloblastomas. Cancer Res 2001; 61:7039\u201343.","journal-title":"Cancer Res"},{"key":"10_CR54","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/sj.onc.1206156","volume":"22","author":"N. Baeza","year":"2003","unstructured":"Baeza N, Masuoka J, Kleihues P et al. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003; 22:632\u20136.","journal-title":"Oncogene"},{"key":"10_CR55","first-page":"896","volume":"58","author":"R.H. Zurawel","year":"1998","unstructured":"Zurawel RH, Chiappa SA, Allen C et al. Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res 1998; 58:896\u20139.","journal-title":"Cancer Res"},{"key":"10_CR56","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1136\/gut.39.6.867","volume":"39","author":"F.M. Giardiello","year":"1996","unstructured":"Giardiello FM, Petersen GM, Brensinger JD et al. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1996; 39:867\u20139.","journal-title":"Gut"},{"key":"10_CR57","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jpeds.2005.04.019","volume":"147","author":"B.A. Hirschman","year":"2005","unstructured":"Hirschman BA, Pollock BH, Tomlinson GE. The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds. J Pediatr 2005; 147:263\u20136.","journal-title":"J Pediatr"},{"key":"10_CR58","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1136\/gut.41.3.417","volume":"41","author":"F. Cetta","year":"1997","unstructured":"Cetta F, Montalto G, Petracci M. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1997; 41:417.","journal-title":"Gut"},{"key":"10_CR59","first-page":"901","volume":"7","author":"H. Takayasu","year":"2001","unstructured":"Takayasu H, Horie H, Hiyama E et al. Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma. Clin Cancer Res 2001; 7:901\u20138.","journal-title":"Clin Cancer Res"},{"key":"10_CR60","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/mpo.10180","volume":"39","author":"M.A. Buendia","year":"2002","unstructured":"Buendia MA. Genetic alterations in hepatoblastoma and hepatocellular carcinoma: common and distinctive aspects. Med Pediatr Oncol 2002; 39:530\u20135.","journal-title":"Med Pediatr Oncol"},{"key":"10_CR61","first-page":"5007","volume":"55","author":"H. Kurahashi","year":"1995","unstructured":"Kurahashi H, Takami K, Oue T et al. Biallelic inactivation of the APC gene in hepatoblastoma. Cancer Res 1995; 55:5007\u201311.","journal-title":"Cancer Res"},{"key":"10_CR62","first-page":"121","volume":"11","author":"T. Inukai","year":"2004","unstructured":"Inukai T, Furuuchi K, Sugita K et al. Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient. Oncol Rep 2004; 11:121\u20136.","journal-title":"Oncol Rep"},{"key":"10_CR63","first-page":"3320","volume":"56","author":"H. Oda","year":"1996","unstructured":"Oda H, Imai Y, Nakatsuru Y et al. Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res 1996; 56:3320\u20133.","journal-title":"Cancer Res"},{"key":"10_CR64","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1023\/A:1025762706854","volume":"2","author":"B. Truta","year":"2003","unstructured":"Truta B, Allen BA, Conrad PG et al. Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. Fam Cancer 2003; 2:95\u20139.","journal-title":"Fam Cancer"},{"key":"10_CR65","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0002-9440(10)65259-5","volume":"154","author":"C. Soravia","year":"1999","unstructured":"Soravia C, Sugg SL, Berk T et al. Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological and molecular genetics study. Am J Pathol 1999; 154:127\u201335.","journal-title":"Am J Pathol"},{"key":"10_CR66","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1210\/jc.86.1.427","volume":"86","author":"F. Cetta","year":"2001","unstructured":"Cetta F, Curia MC, Montalto G et al. Thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene. J Clin Endocrinol Metab 2001; 86:427\u201332.","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR67","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/path.1225","volume":"199","author":"B. Xu","year":"2003","unstructured":"Xu B, Yoshimoto K, Miyauchi A et al. Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-eaten in gene. J Pathol 2003; 199:58\u201367.","journal-title":"J Pathol"},{"key":"10_CR68","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1210\/jc.83.3.1003","volume":"83","author":"F. Cetta","year":"1998","unstructured":"Cetta F, Chiappetta G, Melillo RM et al. The ret\/ptcl oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. J Clin Endocrinol Metab 1998; 83:1003\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"10_CR69","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1365-2559.1997.2390858.x","volume":"31","author":"F. Cetta","year":"1997","unstructured":"Cetta F, Toti P, Petracci M et al. Thyroid carcinoma associated with familial adenomatous polyposis. Histopathology 1997; 31:231\u20136.","journal-title":"Histopathology"},{"key":"10_CR70","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/00125480-200111000-00005","volume":"8","author":"G. Tallini","year":"2001","unstructured":"Tallini G, Asa SL. RET oncogene activation in papillary thyroid carcinoma. Adv Anat Pathol 2001; 8:345\u201354.","journal-title":"Adv Anat Pathol"},{"key":"10_CR71","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1136\/jmg.30.5.369","volume":"30","author":"S.V. Hodgson","year":"1993","unstructured":"Hodgson SV, Coonar AS, Hanson PJ et al. Two cases of 5q deletions in patients with familial adenomatous polyposis: possible link with Caroli\u2019s disease. J Med Genet 1993; 30:369\u201375.","journal-title":"J Med Genet"},{"key":"10_CR72","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/sj.ejhg.5200350","volume":"7","author":"G. Calin","year":"1999","unstructured":"Calin G, Wijnen J, Van Der Klift H et al. Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association? Eur J Hum Genet 1999; 7:609\u201314.","journal-title":"Eur J Hum Genet"}],"container-title":["Advances in Experimental Medicine and Biology","APC Proteins"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4419-1145-2_10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T01:50:21Z","timestamp":1635817821000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4419-1145-2_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"ISBN":["9781441911445","9781441911452"],"references-count":72,"URL":"https:\/\/doi.org\/10.1007\/978-1-4419-1145-2_10","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4419-1145-2","asserted-by":"object"}]},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}