{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T07:55:40Z","timestamp":1794383740145,"version":"4.9.0"},"publisher-location":"New York, NY","reference-count":94,"publisher":"Springer New York","isbn-type":[{"value":"9781441958181","type":"print"},{"value":"9781441958198","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-4419-5819-8_4","type":"book-chapter","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T21:08:34Z","timestamp":1293743314000},"page":"41-57","source":"Crossref","is-referenced-by-count":7,"title":["Stem Cell Transplantation Methods"],"prefix":"10.1007","author":[{"given":"Kimberly D.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Jandial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"1\u20132","key":"4_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0006-8993(99)01411-0","volume":"831","author":"Y. Takagi","year":"1999","unstructured":"Takagi Y, Nozaki K, Takahashi J et al. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res 1999; 831(1\u20132):283\u20137.","journal-title":"Brain Res"},{"issue":"5","key":"4_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/00005072-199905000-00008","volume":"58","author":"J. Namiki","year":"1999","unstructured":"Namiki J, Tator C. Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury. J Neuropathol Exp Neurol 1999; 58(5):489\u201398.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"20","key":"4_CR3","doi-asserted-by":"publisher","first-page":"13211","DOI":"10.1073\/pnas.192314199","volume":"99","author":"N. Picard-Riera","year":"2002","unstructured":"Picard-Riera N, Decker L, Delarasse C et al. Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci USA 2002; 99(20):13211\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"4_CR4","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1750-3639.2003.tb00031.x","volume":"13","author":"L. Brundin","year":"2003","unstructured":"Brundin L, Brismar H, Danilov A et al. Neural stem cells: a potential source for remyelination in neuroinflammatory disease. Brain Pathol 2003; 13(3):322\u20138.","journal-title":"Brain Pathol"},{"issue":"3","key":"4_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/cne.901360303","volume":"136","author":"J. Altman","year":"1969","unstructured":"Altman J. Autoradiographic and histological studies of postnatal neurogenesis. 3. Dating the time of production and onset of differentiation of cerebellar microneurons in rats. J Comp Neurol 1969; 136(3):269\u201393.","journal-title":"J Comp Neurol"},{"issue":"6","key":"4_CR6","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/jnr.10378","volume":"69","author":"P. Taupin","year":"2002","unstructured":"Taupin P, Gage F. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res 2002; 69(6):745\u20139.","journal-title":"J Neurosci Res"},{"issue":"1\u20132","key":"4_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(97)00588-X","volume":"768","author":"N. Duggal","year":"1997","unstructured":"Duggal N, Schmidt-Kastner R, Hakim A. Nestin expression in reactive astrocytes following focal cerebral ischemia in rats. Brain Res 1997; 768(1\u20132):1\u20139.","journal-title":"Brain Res"},{"issue":"2","key":"4_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.brainresrev.2004.12.011","volume":"48","author":"S. Pluchino","year":"2005","unstructured":"Pluchino S, Zanotti L, Deleidi M et al. Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev 2005; 48(2):211\u20139.","journal-title":"Brain Res Brain Res Rev"},{"key":"4_CR9","doi-asserted-by":"crossref","unstructured":"Lee J, McKercher S, Muller F et al. Neural stem cell transplantation in mouse brain. Curr Protoc Neurosci 2008; Chapter 3:Unit 3.10.","DOI":"10.1002\/0471142301.ns0310s42"},{"issue":"12","key":"4_CR10","doi-asserted-by":"publisher","first-page":"7029","DOI":"10.1073\/pnas.96.12.7029","volume":"96","author":"B. Yandava","year":"1999","unstructured":"Yandava B, Billinghurst L, Snyder E. \u201cGlobal\u201d cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci USA 1999; 96(12):7029\u201334.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nm974","volume":"10","author":"M. Windrem","year":"2004","unstructured":"Windrem M, Nunes M, Rashbaum W et al. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med 2004; 10(1):93\u20137.","journal-title":"Nat Med"},{"issue":"4","key":"4_CR12","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/nm0496-424","volume":"2","author":"H. Lacorazza","year":"1996","unstructured":"Lacorazza H, Flax J, Snyder E et al. Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells. Nat Med 1996; 2(4):424\u20139.","journal-title":"Nat Med"},{"issue":"11","key":"4_CR13","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/3473","volume":"16","author":"J. Flax","year":"1998","unstructured":"Flax J, Aurora S, Yang C et al. Engraftable human neural stem cells respond to developmental cues, replace neurons and express foreign genes. Nat Biotechnol 1998; 16(11):1033\u20139.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nm1548","volume":"13","author":"J. Lee","year":"2007","unstructured":"Lee J, Jeyakumar M, Gonzalez R et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med 2007; 13(4):439\u201347.","journal-title":"Nat Med"},{"issue":"5","key":"4_CR15","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1046\/j.1460-9568.2000.00067.x","volume":"12","author":"J. Auerbach","year":"2000","unstructured":"Auerbach J, Eiden M, McKay R. Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci 2000; 12(5):1696\u2013704.","journal-title":"Eur J Neurosci"},{"issue":"8","key":"4_CR16","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1523\/JNEUROSCI.15-08-05765.1995","volume":"15","author":"S. Ahmed","year":"1995","unstructured":"Ahmed S, Reynolds B, Weiss S. BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors. J Neurosci 1995; 15(8):5765\u201378.","journal-title":"J Neurosci"},{"issue":"2","key":"4_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0014-4886(03)00037-2","volume":"181","author":"P. Lu","year":"2003","unstructured":"Lu P, Jones L, Snyder E et al. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003; 181(2):115\u201329.","journal-title":"Exp Neurol"},{"issue":"9","key":"4_CR18","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/ncb0901-778","volume":"3","author":"J. Toma","year":"2001","unstructured":"Toma J, Akhavan M, Fernandes K et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3(9):778\u201384.","journal-title":"Nat Cell Biol"},{"issue":"8","key":"4_CR19","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.1073\/pnas.94.8.4080","volume":"94","author":"M. Eglitis","year":"1997","unstructured":"Eglitis M, Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA 1997; 94(8):4080\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"4_CR20","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1073\/pnas.95.7.3908","volume":"95","author":"S. Azizi","year":"1998","unstructured":"Azizi S, Stokes D, Augelli B et al. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats\u2014similarities to astrocyte grafts. Proc Natl Acad Sci USA 1998; 95(7):3908\u201313.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1\u20132","key":"4_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0022-510X(01)00557-3","volume":"189","author":"J. Chen","year":"2001","unstructured":"Chen J, Li Y, Wang L et al. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 2001; 189(1\u20132):49\u201357.","journal-title":"J Neurol Sci"},{"issue":"19","key":"4_CR22","doi-asserted-by":"publisher","first-page":"10711","DOI":"10.1073\/pnas.96.19.10711","volume":"96","author":"G. Kopen","year":"1999","unstructured":"Kopen G, Prockop D, Phinney D. Marrow stromal cells migrate throughout forebrain and cerebellum and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999; 96(19):10711\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"4_CR23","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"J. Chen","year":"2001","unstructured":"Chen J, Sanberg P, Li Y et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001; 32(11):2682\u20138.","journal-title":"Stroke"},{"issue":"6","key":"4_CR24","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1161\/01.RES.0000065580.02404.F4","volume":"92","author":"R. Galli","year":"2003","unstructured":"Galli R, Gritti A, Bonfanti L et al. Neural stem cells: an overview. Circ Res 2003; 92(6):598\u2013608.","journal-title":"Circ Res"},{"issue":"8","key":"4_CR25","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1172\/JCI200320098","volume":"112","author":"A. Hallbergson","year":"2003","unstructured":"Hallbergson A, Gnatenco C, Peterson D. Neurogenesis and brain injury: managing a renewable resource for repair. J Clin Invest 2003; 112(8):1128\u201333.","journal-title":"J Clin Invest"},{"issue":"3","key":"4_CR26","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1750-3639.1999.tb00542.x","volume":"9","author":"A. Vescovi","year":"1999","unstructured":"Vescovi A, Snyder E. Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo. Brain Pathol 1999; 9(3):569\u201398.","journal-title":"Brain Pathol"},{"issue":"1","key":"4_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/mcne.2000.0854","volume":"16","author":"F. Rubio","year":"2000","unstructured":"Rubio F, Bueno C, Villa A et al. Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain. Mol Cell Neurosci 2000; 16(1):1\u201313.","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"4_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/exnr.1998.6998","volume":"156","author":"A. Vescovi","year":"1999","unstructured":"Vescovi A, Parati E, Gritti A et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp Neurol 1999; 156(1):71\u201383.","journal-title":"Exp Neurol"},{"issue":"9","key":"4_CR29","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1523\/JNEUROSCI.19-09-03287.1999","volume":"19","author":"A. Gritti","year":"1999","unstructured":"Gritti A, Fr\u00f6lichsthal-Schoeller P, Galli R et al. Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain. J Neurosci 1999; 19(9):3287\u201397.","journal-title":"J Neurosci"},{"issue":"6961","key":"4_CR30","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/nature02060","volume":"425","author":"A. Molofsky","year":"2003","unstructured":"Molofsky A, Pardal R, Iwashita T et al. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 2003; 425(6961):962\u20137.","journal-title":"Nature"},{"issue":"5","key":"4_CR31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/88158","volume":"19","author":"M. Caldwell","year":"2001","unstructured":"Caldwell M, He X, Wilkie N et al. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nat Biotechnol 2001; 19(5):475\u20139.","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4_CR32","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/S0006-291X(03)00879-9","volume":"305","author":"T. Kim","year":"2003","unstructured":"Kim T, Lee H, Lee Y et al. Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell. Biochem Biophys Res Commun 2003; 305(4):1040\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"26","key":"4_CR33","doi-asserted-by":"publisher","first-page":"17089","DOI":"10.1073\/pnas.252589099","volume":"99","author":"U. Englund","year":"2002","unstructured":"Englund U, Bjorklund A, Wictorin K et al. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc Natl Acad Sci USA 2002; 99(26):17089\u201394.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"4_CR34","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0014-4886(03)00271-1","volume":"184","author":"C. Eriksson","year":"2003","unstructured":"Eriksson C, Bj\u00f6rklund A, Wictorin K. Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions. Exp Neurol 2003; 184(2):615\u201335.","journal-title":"Exp Neurol"},{"issue":"1","key":"4_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/exnr.2002.7989","volume":"177","author":"M. Yang","year":"2002","unstructured":"Yang M, Stull N, Berk M et al. Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp Neurol 2002; 177(1):50\u201360.","journal-title":"Exp Neurol"},{"issue":"1","key":"4_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1006\/exnr.2000.7539","volume":"167","author":"Y. Akiyama","year":"2001","unstructured":"Akiyama Y, Honmou O, Kato T et al. Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord. Exp Neurol 2001; 167(1):27\u201339.","journal-title":"Exp Neurol"},{"issue":"1","key":"4_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/glia.10159","volume":"41","author":"T. Ben-Hur","year":"2003","unstructured":"Ben-Hur T, Einstein O, Mizrachi-Kol R et al. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 2003; 41(1):73\u201380.","journal-title":"Glia"},{"issue":"1","key":"4_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/mrm.10511","volume":"50","author":"J. Bulte","year":"2003","unstructured":"Bulte J, Ben-Hur T, Miller B et al. MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magn Reson Med 2003; 50(1):201\u20135.","journal-title":"Magn Reson Med"},{"issue":"6","key":"4_CR39","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1002\/jnr.10346","volume":"69","author":"S. Wu","year":"2002","unstructured":"Wu S, Suzuki Y, Noda T et al. Immunohistochemical and electron microscopic study of invasion and differentiation in spinal cord lesion of neural stem cells grafted through cerebrospinal fluid in rat. J Neurosci Res 2002; 69(6):940\u20135.","journal-title":"J Neurosci Res"},{"issue":"8","key":"4_CR40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1089\/neu.1999.16.689","volume":"16","author":"A. Vescovi","year":"1999","unstructured":"Vescovi A, Gritti A, Galli R et al. Isolation and intracerebral grafting of nontransformed multipotential embryonic human CNS stem cells. J Neurotrauma 1999; 16(8):689\u201393.","journal-title":"J Neurotrauma"},{"issue":"9","key":"4_CR41","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s000180050224","volume":"54","author":"J. Fris\u00e9n","year":"1998","unstructured":"Fris\u00e9n J, Johansson C, Lothian C et al. Central nervous system stem cells in the embryo and adult. Cell Mol Life Sci 1998; 54(9):935\u201345.","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"4_CR42","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1750-3639.1999.tb00538.x","volume":"9","author":"C. Svendsen","year":"1999","unstructured":"Svendsen C, Caldwell M, Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol 1999; 9(3):499\u2013513.","journal-title":"Brain Pathol"},{"issue":"13","key":"4_CR43","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.1073\/pnas.91.13.6143","volume":"91","author":"M. Sims","year":"1994","unstructured":"Sims M, First N. Production of calves by transfer of nuclei from cultured inner cell mass cells. Proc Natl Acad Sci USA 1994; 91(13):6143\u20137.","journal-title":"Natl Acad Sci USA"},{"issue":"5556","key":"4_CR44","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1065637","volume":"295","author":"J. Cibelli","year":"2002","unstructured":"Cibelli J, Grant K, Chapman K et al. Parthenogenetic stem cells in nonhuman primates. Science 2002; 295(5556):819.","journal-title":"Science"},{"issue":"5590","key":"4_CR45","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1126\/science.1074807","volume":"297","author":"A. Wagers","year":"2002","unstructured":"Wagers A, Sherwood R, Christensen J et al. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297(5590):2256\u20139.","journal-title":"Science"},{"issue":"26","key":"4_CR46","doi-asserted-by":"publisher","first-page":"14984","DOI":"10.1073\/pnas.96.26.14984","volume":"96","author":"T. Wakayama","year":"1999","unstructured":"Wakayama T, Rodriguez I, Perry A et al. Mice cloned from embryonic stem cells. Proc Natl Acad Sci USA 1999; 96(26):14984\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6200","key":"4_CR47","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/336688a0","volume":"336","author":"A. Smith","year":"1988","unstructured":"Smith A, Heath J, Donaldson D et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988; 336(6200):688\u201390.","journal-title":"Nature"},{"issue":"4","key":"4_CR48","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/74447","volume":"18","author":"B. Reubinoff","year":"2000","unstructured":"Reubinoff B, Pera M, Fong C et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000; 18(4):399\u2013404.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"4_CR49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0092-8674(00)80956-3","volume":"96","author":"C. Johansson","year":"1999","unstructured":"Johansson C, Momma S, Clarke D et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999; 96(1):25\u201334.","journal-title":"Cell"},{"key":"4_CR50","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0079-6123(02)37023-7","volume":"137","author":"J. McDonald","year":"2002","unstructured":"McDonald J, Howard M. Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination. Prog Brain Res 2002; 137:299\u2013309.","journal-title":"Prog Brain Res"},{"issue":"3","key":"4_CR51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1056\/NEJMra020849","volume":"349","author":"N. Rosenthal","year":"2003","unstructured":"Rosenthal N. Prometheus\u2019s vulture and the stem-cell promise. N Engl J Med 2003; 349(3):267\u201374.","journal-title":"N Engl J Med"},{"issue":"26","key":"4_CR52","doi-asserted-by":"publisher","first-page":"14809","DOI":"10.1073\/pnas.94.26.14809","volume":"94","author":"O. Br\u00fcstle","year":"1997","unstructured":"Br\u00fcstle O, Spiro A, Karram K et al. In vitro-generated neural precursors participate in mammalian brain development. Proc Natl Acad Sci USA 1997; 94(26):14809\u201314.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4_CR53","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1006\/exnr.1997.6674","volume":"149","author":"T. Deacon","year":"1998","unstructured":"Deacon T, Dinsmore J, Costantini L et al. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. Exp Neurol 1998; 149(1):28\u201341.","journal-title":"Exp Neurol"},{"issue":"1","key":"4_CR54","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/rheumatology\/keg024","volume":"42","author":"S. Wakitani","year":"2003","unstructured":"Wakitani S, Takaoka K, Hattori T et al. Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the joint. Rheumatology (Oxford) 2003; 42(1):162\u20135.","journal-title":"Rheumatology (Oxford)"},{"issue":"1\u20132","key":"4_CR55","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/00207459509015295","volume":"81","author":"J. Yanai","year":"1995","unstructured":"Yanai J, Doetchman T, Laufer N et al. Embryonic cultures but not embryos transplanted to the mouse\u2019s brain grow rapidly without immunosuppression. Int J Neurosci 1995; 81(1\u20132):21\u20136.","journal-title":"Int J Neurosci"},{"issue":"6","key":"4_CR56","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/jnr.10363","volume":"69","author":"A. Morizane","year":"2002","unstructured":"Morizane A, Takahashi J, Takagi Y et al. Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity. J Neurosci Res 2002; 69(6):934\u20139.","journal-title":"J Neurosci Res"},{"issue":"12","key":"4_CR57","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nbt1201-1117","volume":"19","author":"L. Studer","year":"2001","unstructured":"Studer L. Stem cells with brainpower. Nat Biotechnol 2001; 19(12):1117\u20138.","journal-title":"Nat Biotechnol"},{"issue":"12","key":"4_CR58","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/nbt1201-1129","volume":"19","author":"S. Zhang","year":"2001","unstructured":"Zhang S, Wernig M, Duncan I et al. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 2001; 19(12):1129\u201333.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"4_CR59","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.expneurol.2004.11.011","volume":"192","author":"Y. Pan","year":"2005","unstructured":"Pan Y, Nastav J, Zhang H et al. Engraftment of freshly isolated or cultured human umbilical cord blood cells and the effect of cyclosporin A on the outcome. Exp Neurol 2005; 192(2):365\u201372.","journal-title":"Exp Neurol"},{"issue":"6520","key":"4_CR60","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/374367a0","volume":"374","author":"E. Snyder","year":"1995","unstructured":"Snyder E, Taylor R, Wolfe J. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 1995; 374(6520):367\u201370.","journal-title":"Nature"},{"issue":"11","key":"4_CR61","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/nbt751","volume":"20","author":"K. Park","year":"2002","unstructured":"Park K, Teng Y, Snyder E. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol 2002; 20(11):1111\u20137.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"4_CR62","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.expneurol.2005.04.018","volume":"194","author":"M. Parker","year":"2005","unstructured":"Parker M, Anderson J, Corliss D et al. Expression profile of an operationally-defined neural stem cell clone. Exp Neurol 2005; 194(2):320\u201332.","journal-title":"Exp Neurol"},{"issue":"3","key":"4_CR63","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/jnr.10659","volume":"73","author":"A. Willing","year":"2003","unstructured":"Willing A, Lixian J, Milliken M et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res 2003; 73(3): 296\u2013307.","journal-title":"J Neurosci Res"},{"issue":"5","key":"4_CR64","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/scd.2005.14.595","volume":"14","author":"M. Vendrame","year":"2005","unstructured":"Vendrame M, Gemma C, de Mesquita D et al. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 2005; 14(5):595\u2013604.","journal-title":"Stem Cells Dev"},{"issue":"1","key":"4_CR65","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.expneurol.2006.03.017","volume":"199","author":"M. Vendrame","year":"2006","unstructured":"Vendrame M, Gemma C, Pennypacker K et al. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol 2006; 199(1):191\u2013200.","journal-title":"Exp Neurol"},{"issue":"4","key":"4_CR66","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1073\/pnas.022438099","volume":"99","author":"L. Bjorklund","year":"2002","unstructured":"Bjorklund L, S\u00e1nchez-Pernaute R, Chung S et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 2002; 99(4):2344\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6893","key":"4_CR67","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature00900","volume":"418","author":"J. Kim","year":"2002","unstructured":"Kim J, Auerbach J, Rodr\u00edguez-G\u00f3mez J et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson\u2019s disease. Nature 2002; 418(6893):50\u20136.","journal-title":"Nature"},{"issue":"6","key":"4_CR68","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1046\/j.1460-9568.1998.00214.x","volume":"10","author":"G. Andsberg","year":"1998","unstructured":"Andsberg G, Kokaia Z, Bj\u00f6rklund A et al. Amelioration of ischaemia-induced neuronal death in the rat striatum by NGF-secreting neural stem cells. Eur J Neurosci 1998; 10(6):2026\u201336.","journal-title":"Eur J Neurosci"},{"issue":"1","key":"4_CR69","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1006\/exnr.2000.7536","volume":"167","author":"Q. Cao","year":"2001","unstructured":"Cao Q, Zhang Y, Howard R et al. Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp Neurol 2001; 167(1):48\u201358.","journal-title":"Exp Neurol"},{"issue":"5","key":"4_CR70","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1073\/pnas.052678899","volume":"99","author":"Y. Teng","year":"2002","unstructured":"Teng Y, Lavik E, Qu X et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002; 99(5):3024\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"4_CR71","doi-asserted-by":"publisher","first-page":"6126","DOI":"10.1073\/pnas.97.11.6126","volume":"97","author":"S. Liu","year":"2000","unstructured":"Liu S, Qu Y, Stewart T et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci USA 2000; 97(11):6126\u201331.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"4_CR72","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1523\/JNEUROSCI.12-11-04565.1992","volume":"12","author":"B. Reynolds","year":"1992","unstructured":"Reynolds B, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 1992; 12(11):4565\u201374.","journal-title":"J Neurosci"},{"issue":"6","key":"4_CR73","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nrn1116","volume":"4","author":"P. Tran","year":"2003","unstructured":"Tran P, Miller R. Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci 2003; 4(6):444\u201355.","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"4_CR74","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1006\/mcne.2001.1037","volume":"18","author":"L. Prestoz","year":"2001","unstructured":"Prestoz L, Relvas J, Hopkins K et al. Association between integrin-dependent migration capacity of neural stem cells in vitro and anatomical repair following transplantation. Mol Cell Neurosci 2001; 18(5):473\u201384.","journal-title":"Mol Cell Neurosci"},{"issue":"3","key":"4_CR75","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/cercor\/13.3.219","volume":"13","author":"R. Schmid","year":"2003","unstructured":"Schmid R, Anton E. Role of integrins in the development of the cerebral cortex. Cereb Cortex 2003; 13(3):219\u201324.","journal-title":"Cereb Cortex"},{"issue":"5258","key":"4_CR76","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1126\/science.272.5258.60","volume":"272","author":"E. Butcher","year":"1996","unstructured":"Butcher E, Picker L. Lymphocyte homing and homeostasis. Science 1996; 272(5258):60\u20136.","journal-title":"Science"},{"issue":"5","key":"4_CR77","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1097\/00005072-199409000-00005","volume":"53","author":"M. Deckert-Schl\u00fcter","year":"1994","unstructured":"Deckert-Schl\u00fcter M, Schl\u00fcter D, Hof H et al. Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, Mac-1, CD43, VLA-4 and MHC class II antigens in murine Toxoplasma encephalitis: a light microscopic and ultrastructural immunohistochemical study. J Neuropathol Exp Neurol 1994; 53(5):457\u201368.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Suppl 2","key":"4_CR78","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1086\/344266","volume":"186","author":"R. Ransohoff","year":"2002","unstructured":"Ransohoff R. The chemokine system in neuroinflammation: an update. J Infect Dis 2002; 186(Suppl 2): S152\u20136.","journal-title":"J Infect Dis"},{"issue":"6","key":"4_CR79","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1046\/j.0305-1846.2003.00507.x","volume":"29","author":"C. Trebst","year":"2003","unstructured":"Trebst C, Staugaitis S, Tucky B et al. Chemokine receptors on infiltrating leucocytes in inflammatory pathologies of the central nervous system (CNS). Neuropathol Appl Neurobiol 2003; 29(6):584\u201395.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4_CR80","first-page":"383","volume-title":"Neural stem cells, second edition methods and protocols","author":"E. Alison","year":"2008","unstructured":"Alison E. Willing SG-D, Paul R. Sanberg and Samuel Saporta. Routes of stem cell administration in the adult rodent. In: Weiner LP, ed. Neural stem cells, second edition methods and protocols 2nd ed. Totowa: Humana Press, 2008:383\u2013401.","edition":"2nd ed."},{"issue":"3","key":"4_CR81","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1055\/s-2000-8335","volume":"43","author":"A. Melada","year":"2000","unstructured":"Melada A, Heinrich Z, Chudy D et al. The difference between ultrasound-guided and stereotactic-guided neurosurgical procedures. Minim Invasive Neurosurg 2000; 43(3):149\u201352.","journal-title":"Minim Invasive Neurosurg"},{"issue":"7","key":"4_CR82","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.4049\/jimmunol.171.7.3426","volume":"171","author":"J. Potian","year":"2003","unstructured":"Potian J, Aviv H, Ponzio N et al. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol 2003; 171(7):3426\u201334.","journal-title":"J Immunol"},{"issue":"52","key":"4_CR83","doi-asserted-by":"publisher","first-page":"18117","DOI":"10.1073\/pnas.0408258102","volume":"101","author":"J. Imitola","year":"2004","unstructured":"Imitola J, Raddassi K, Park K et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 2004; 101(52):18117\u201322.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"4_CR84","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1111\/j.1471-4159.2006.03986.x","volume":"97","author":"R. Taylor","year":"2006","unstructured":"Taylor R, Lee J, Palacino J et al. Intrinsic resistance of neural stem cells to toxic metabolites may make them well suited for cell non-autonomous disorders: evidence from a mouse model of Krabbe leukodystrophy. J Neurochem 2006; 97(6):1585\u201399.","journal-title":"J Neurochem"},{"key":"4_CR85","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/978-1-59745-133-8_29","volume":"438","author":"S. Whittemore","year":"2008","unstructured":"Whittemore S, Zhang Y, Shields C et al. Optimizing stem cell grafting into the CNS. Methods Mol Biol 2008; 438:375\u201382.","journal-title":"Methods Mol Biol"},{"issue":"1\u20132","key":"4_CR86","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0006-8993(94)91532-6","volume":"633","author":"G. Nikkhah","year":"1994","unstructured":"Nikkhah G, Cunningham M, J\u00f6dicke A et al. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res 1994; 633(1\u20132):133\u201343.","journal-title":"Brain Res"},{"issue":"2 Pt 1","key":"4_CR87","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/exnr.1997.6503","volume":"145","author":"C. Lundberg","year":"1997","unstructured":"Lundberg C, Mart\u00ednez-Serrano A, Cattaneo E et al. Survival, integration and differentiation of neural stem cell lines after transplantation to the adult rat striatum. Exp Neurol 1997; 145(2 Pt 1):342\u201360.","journal-title":"Exp Neurol"},{"issue":"1","key":"4_CR88","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1006\/exnr.1997.6634","volume":"148","author":"C. Svendsen","year":"1997","unstructured":"Svendsen C, Caldwell M, Shen J et al. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson\u2019s disease. Exp Neurol 1997; 148(1):135\u201346.","journal-title":"Exp Neurol"},{"issue":"2","key":"4_CR89","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0304-3940(03)00174-5","volume":"343","author":"K. Chu","year":"2003","unstructured":"Chu K, Kim M, Jeong S et al. Human neural stem cells can migrate, differentiate and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neurosci Lett 2003; 343(2):129\u201333.","journal-title":"Neurosci Lett"},{"issue":"9","key":"4_CR90","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1161\/01.STR.0000083698.20199.1F","volume":"34","author":"S. Jeong","year":"2003","unstructured":"Jeong S, Chu K, Jung K et al. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke 2003; 34(9):2258\u201363.","journal-title":"Stroke"},{"issue":"23","key":"4_CR91","doi-asserted-by":"publisher","first-page":"12846","DOI":"10.1073\/pnas.97.23.12846","volume":"97","author":"K. Aboody","year":"2000","unstructured":"Aboody K, Brown A, Rainov N et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000; 97(23):12846\u201351.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"18","key":"4_CR92","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1089\/104303403322611782","volume":"14","author":"A. Brown","year":"2003","unstructured":"Brown A, Yang W, Schmidt N et al. Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and nonneural origin. Hum Gene Ther 2003; 14(18):1777\u201385.","journal-title":"Hum Gene Ther"},{"issue":"1\u20132","key":"4_CR93","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0165-3806(02)00273-0","volume":"134","author":"M. Aleksandrova","year":"2002","unstructured":"Aleksandrova M, Saburina I, Poltavtseva R et al. Behavior of human neural progenitor cells transplanted to rat brain. Brain Res Dev Brain Res 2002; 134(1\u20132):143\u20138.","journal-title":"Brain Res Dev Brain Res"},{"issue":"12","key":"4_CR94","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/35104055","volume":"2","author":"M. D\u00f6br\u00f6ssy","year":"2001","unstructured":"D\u00f6br\u00f6ssy M, Dunnett S. The influence of environment and experience on neural grafts. Nat Rev Neurosci 2001; 2(12):871\u20139.","journal-title":"Nat Rev Neurosci"}],"container-title":["Advances in Experimental Medicine and Biology","Frontiers in Brain Repair"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4419-5819-8_4.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T20:11:53Z","timestamp":1619813513000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4419-5819-8_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"ISBN":["9781441958181","9781441958198"],"references-count":94,"URL":"https:\/\/doi.org\/10.1007\/978-1-4419-5819-8_4","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4419-5819-8","asserted-by":"object"}]},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}