{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T08:00:04Z","timestamp":1794384004263,"version":"4.9.0"},"publisher-location":"New York, NY","reference-count":56,"publisher":"Springer New York","isbn-type":[{"value":"9781441964472","type":"print"},{"value":"9781441964489","type":"electronic"}],"license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-4419-6448-9_1","type":"book-chapter","created":{"date-parts":[[2011,1,9]],"date-time":"2011-01-09T01:57:34Z","timestamp":1294538254000},"page":"1-8","source":"Crossref","is-referenced-by-count":42,"title":["Triple-A Syndrome"],"prefix":"10.1007","author":[{"given":"Vijaya","family":"Sarathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini S.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/S0140-6736(78)91268-0","volume":"1","author":"J. Allgrove","year":"1978","unstructured":"Allgrove J, Clayden GS, Grant DB et al. Familial glucocorticoid deficiency with achalasia of the cardia and deficient tear production. Lancet 1978; 1:1284\u20131286.","journal-title":"Lancet"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s10067-006-0498-5","volume":"26","author":"A.M. Onat","year":"2007","unstructured":"Onat AM, Pehlivan Y, Buyukhatipoglu H et al. Unusual presentation of triple A syndrome mimicking Sj\u00f6gren\u2019s syndrome. Clin Rheumatol 2007; 26:1749\u20131751.","journal-title":"Clin Rheumatol"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/BF01972967","volume":"154","author":"M. Gazarian","year":"1995","unstructured":"Gazarian M, Cowell CT, Bonney M et al. The \u201c4 A\u201d syndrome: adrenocortical insufficiency associated with achalasia, alacrimia, autonomic and other neurological abnormalities. Eur J Pediatr 1995; 154:18\u201323.","journal-title":"Eur J Pediatr"},{"issue":"58","key":"1_CR4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1212\/WNL.58.6.962","volume":"26","author":"C. Goizet","year":"2002","unstructured":"Goizet C, Catargi B, Tison F et al. Progressive bulbospinal amyotrophy in triple A syndrome with AAAS gene mutation. Neurology 2002; 26(58):962\u2013965.","journal-title":"Neurology"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"5433","DOI":"10.1210\/jc.86.11.5433","volume":"86","author":"F. Sandrini","year":"2001","unstructured":"Sandrini F, Farmakidis C, Kirschner LS et al. Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin. J Clin Endocrinol Metab 2001; 86:5433\u20135437.","journal-title":"J Clin Endocrinol Metab"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1136\/jmg.2003.017962","volume":"41","author":"E. Genin","year":"2004","unstructured":"Genin E, Tullio-Pelet A, Begeot F et al. Estimating the age of rare disease mutations: the example of Triple-A syndrome. J Med Genet 2004; 41:445\u2013449.","journal-title":"J Med Genet"},{"key":"1_CR7","first-page":"353","volume":"50","author":"D. Wied De","year":"1990","unstructured":"De Wied D. Neurotropic effects of ACTH\/MSH neuropeptides. Acta Neurobiol Exp 1990; 50:353\u2013366.","journal-title":"Acta Neurobiol Exp"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1432-1033.1982.tb06826.x","volume":"126","author":"R. Jahn","year":"1982","unstructured":"Jahn R, Padel U, Porsch P-H et al. Adrenocorticotropin hormone and a-melanocyte-stimulating hormone induce secretion and protein phosphorylation in the rat lacrimal gland by activating cAMP dependent pathway. Euro J Biochem 1982; 126:623\u2013629.","journal-title":"Euro J Biochem"},{"key":"1_CR9","first-page":"3","volume":"20","author":"Modebe. Onyechi","year":"2000","unstructured":"Onyechi Modebe. Achalasia-alacrima-acth insensitivity syndrome (Triple a syndrome) in a saudi family. Annals of Saudi Medicine 2000; 20:3\u20134.","journal-title":"Annals of Saudi Medicine"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1093\/hmg\/5.12.2061","volume":"5","author":"A. Weber","year":"1996","unstructured":"Weber A, Wienker TF, Jung M et al. Linkage of the gene for the triple A syndrome to chromosome 12q13 near the type II keratin gene cluster. Hum Mol Genet 1996; 5:2061\u20132066.","journal-title":"Hum Mol Genet"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/hmg\/10.3.283","volume":"10","author":"K. Handschug","year":"2001","unstructured":"Handschug K, Sperling S, Yoon S-JK et al. Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. Hum Mol Genet 2001; 10:283\u2013290.","journal-title":"Hum Mol Genet"},{"key":"1_CR12","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.3748\/wjg.v12.i29.4764","volume":"12","author":"M. Ashis","year":"2006","unstructured":"Ashis Mukhyopadhya, Sumita Danda, Angela Huebner et al. Mutations of the AAAS gene in an Indian family with Allgrove\u2019s syndrome. World J Gastroenterol 2006; 12:4764\u20134766.","journal-title":"World J Gastroenterol"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/81642","volume":"26","author":"A. Tullio-Pelet","year":"2000","unstructured":"Tullio-Pelet A, Salomon R, Hadj-Rabia S et al. Mutant WD-repeat protein in triple-A syndrome. Nat Genet 2000; 26:332\u2013335.","journal-title":"Nat Genet"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1083\/jcb.200206106","volume":"158","author":"J.M. Cronshaw","year":"2002","unstructured":"Cronshaw JM, Krutchinsky AN, Zhang W et al. Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 2002; 158:915\u2013927.","journal-title":"J Cell Biol"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.1073\/pnas.1031047100","volume":"100","author":"J.M. Cronshaw","year":"2003","unstructured":"Cronshaw JM, Matunis MJ. The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome. Proc Natl Acad Sci USA 2003; 100:5823\u20135827.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1073\/pnas.0505598103","volume":"103","author":"M. Hirano","year":"2006","unstructured":"Hirano M, Furiya Y, Asai H et al. ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome. Proc Natl Acad Sci USA 2006; 103:2298\u20132303.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bbrc.2008.07.088","volume":"374","author":"T. Kiriyama","year":"2008","unstructured":"Kiriyama T, Hirano M, Asai H et al. Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress. Biochem Biophys Res Commun 2008; 374:631\u2013634.","journal-title":"Biochem Biophys Res Commun"},{"key":"1_CR18","first-page":"214","volume":"4","author":"A. Soltani","year":"2007","unstructured":"Soltani A, Arab Ameri M, Hasani Ranjbar SH. Allgrove Syndrome: A Case Report: Int J Endocrinol Metab 2007; 4:214\u2013217.","journal-title":"Int J Endocrinol Metab"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1399-0004.2005.00482.x","volume":"68","author":"B.P. Brooks","year":"2005","unstructured":"Brooks BP, Kleta R, Stuart C et al. Genotypic heterogeneity and clinical phenotype in triple A syndrome: a review of the NIH experience 2000\u20132005. Clin Genet 2005; 68:215\u2013221.","journal-title":"Clin Genet"},{"key":"1_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/ajmg.a.10846","volume":"117A","author":"S. Reshmi-Skarja","year":"2003","unstructured":"Reshmi-Skarja S, Huebner A, Handschug K et al. Chromosomal fragility in patients with triple A syndrome. Am J Med Genet 2003; 117A:30\u201336.","journal-title":"Am J Med Genet"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1034\/j.1399-0004.2003.00070.x","volume":"63","author":"I. Prpic","year":"2003","unstructured":"Prpic I, Huebner A, Persic M et al. Triple A syndrome: genotype\u2014phenotype assessment. Clin Genet 2003; 63:415\u2013417.","journal-title":"Clin Genet"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1093\/brain\/awf270","volume":"125","author":"H. Houlden","year":"2002","unstructured":"Houlden H, Smith S, de Carvalho M et al. Clinical and genetic characterization of families with triple A (Allgrove) syndrome. Brain 2002; 125:2681\u20132690.","journal-title":"Brain"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/13816810802502962","volume":"30","author":"C. Villanueva-Mendoza","year":"2009","unstructured":"Villanueva-Mendoza C, art\u00ednez-Guzm\u00e1n O, Rivera-Parra D et al. Triple A or Allgrove syndrome. A case report with ophthalmic abnormalities and a novel mutation in the AAAS gene. Ophthalmic Genet 2009; 30:45\u201349.","journal-title":"Ophthalmic Genet"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1212\/WNL.0b013e3181a0fe97","volume":"72","author":"H. Houlden","year":"2009","unstructured":"Houlden H. The small, spastic and furrowed tongue of Allgrove syndrome. Neurology 2009; 72:1366.","journal-title":"Neurology"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1038\/ejhg.2008.132","volume":"16","author":"K. Koehler","year":"2008","unstructured":"Koehler K, Brockmann K, Krumbholz M et al. Axonal neuropathy with unusual pattern of amyotrophy and alacrima associated with a novel AAAS mutation p.Leu430Phe. Eur J Hum Genet 2008; 16:1499\u20131506. Epub 2008.","journal-title":"Eur J Hum Genet"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00431-008-0758-2","volume":"168","author":"A. Toromanovic","year":"2009","unstructured":"Toromanovic A, Tahirovic H, Milenkovic T et al. Clinical and molecular genetic findings in a 6-year-old Bosnian boy with triple A syndrome. Eur J Pediatr 2009; 168:317\u2013320. Epub 2008.","journal-title":"Eur J Pediatr"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1507\/endocrj.51.473","volume":"51","author":"S. Kinjo","year":"2004","unstructured":"Kinjo S, Takemoto M, Miyako K et al. Two cases of Allgrove syndrome with mutations in the AAAS gene. Endocr J 2004; 51:473\u2013477.","journal-title":"Endocr J"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1080\/08035250500538999","volume":"95","author":"E.A. Ismail","year":"2006","unstructured":"Ismail EA, Tulliot-Pelet A, Mohsen AM et al. Allgrove syndrome with features of familial dysautonomia: a novel mutation in the AAAS gene. Acta Paediatr 2006; 95:1140\u20131143.","journal-title":"Acta Paediatr"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.metabol.2004.08.013","volume":"54","author":"M. Salehi","year":"2005","unstructured":"Salehi M, Houlden H, Sheikh A et al. The diagnosis of adrenal insufficiency in a patient with Allgrove syndrome and a novel mutation in the ALADIN gene. Metabolism 2005; 54:200\u2013205.","journal-title":"Metabolism"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000161867","volume":"70","author":"A. Salmaggi","year":"2008","unstructured":"Salmaggi A, Zirilli L, Pantaleoni C et al. Late-onset triple A syndrome: a risk of overlooked or delayed diagnosis and management. Horm Res 2008; 70:364\u2013372. Epub 2008.","journal-title":"Horm Res"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000092003","volume":"65","author":"T. Dusek","year":"2006","unstructured":"Dusek T, Korsic M, Koehler K et al. A novel AAAS gene mutation (p.R194X) in a patient with triple A syndrome. Horm Res 2006; 65:171\u2013176. Epub 2006.","journal-title":"Horm Res"},{"key":"1_CR32","first-page":"765","volume":"19","author":"Y.Y. Lam","year":"2006","unstructured":"Lam YY, Lo IF, Shek CC et al. Triple-A syndrome\u2014the first Chinese patient with novel mutations in the AAAS gene. J Pediatr Endocrinol Metab 2006; 19:765\u2013770.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1507\/endocrj.49.49","volume":"49","author":"M. Katsumata","year":"2002","unstructured":"Katsumata M, Hirose H, Kagami M et al. Analysis of the AAAS gene in a Japanese patient with triple A syndrome. Endocr J 2002; 49:49\u201353.","journal-title":"Endocr J"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s00431-007-0640-7","volume":"167","author":"T. Milenkovic","year":"2008","unstructured":"Milenkovic T, Koehler K, Krumbholz M et al. Three siblings with triple A syndrome with a novel frameshift mutation in the AAAS gene and a review of 17 independent patients with the frequent p.Ser263Pro mutation. Eur J Pediatr 2008; 167:1049\u20131055. Epub 2008.","journal-title":"Eur J Pediatr"},{"key":"1_CR35","first-page":"422","volume":"45","author":"C.X. Gong","year":"2007","unstructured":"Gong CX, Wen YR, Zhao XL et al. Allgrove syndrome in the mainland of China: clinical report and mutation analysis. Zhonghua Er Ke Za Zhi 2007; 45:422\u2013425.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2415-4-7","volume":"4","author":"B.P. Brooks","year":"2004","unstructured":"Brooks BP, Kleta R, Caruso RC et al. Triple-A syndrome with prominent ophthalmic features and a novel mutation in the AAAS gene: a case report. BMC Ophthalmol 2004; 4:7.","journal-title":"BMC Ophthalmol"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000048093","volume":"56","author":"K. Schmittmann-Ohters","year":"2001","unstructured":"Schmittmann-Ohters K, Huebner A, Richter-Unruh A et al. Clinical and novel molecular findings in a 6.8-year old Turkish boy with triple A syndrome. Horm Res 2001; 56:67\u201372.","journal-title":"Horm Res"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1055\/s-2007-973852","volume":"115","author":"S. Buderus","year":"2007","unstructured":"Buderus S, Utsch B, Huebner A et al. Dysphagia due to triple A syndrome: successful treatment of achalasia by balloon dilatation. Exp Clin Endocrinol Diabetes 2007; 115:533\u2013536.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/mds.10660","volume":"19","author":"A. Roubergue","year":"2004","unstructured":"Roubergue A, Apartis E, Vidailhet M et al. Myoclonus and generalized digestive dysmotility in triple A syndrome with AAAS gene mutation. Mov Disord 2004; 19:344\u2013346.","journal-title":"Mov Disord"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1081\/ERC-200044138","volume":"30","author":"A. Huebner","year":"2004","unstructured":"Huebner A, Kaindl AM, Knobeloch KP et al. The triple A syndrome is due to mutations in ALADIN, a novel member of the nuclear pore complex. Endocr Res 2004; 30:891\u2013899.","journal-title":"Endocr Res"},{"key":"1_CR41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0161-6420(98)94018-0","volume":"105","author":"P.B. Mullaney","year":"1998","unstructured":"Mullaney PB, Weatherhead R, Millar L et al. Keratoconjunctivitis sicca associated with achalasia of the cardia, adrenocortical insufficiency and lacrimal gland degeneration: Keratoconjunctivitis sicca secondary to lacrimal gland degeneration may parallel degenerative changes in esophageal and adrenocortical function. Ophthalmology 1998; 105:643\u2013650.","journal-title":"Ophthalmology"},{"key":"1_CR42","doi-asserted-by":"publisher","first-page":"304","DOI":"10.4103\/0301-4738.33048","volume":"55","author":"K. Babu","year":"2007","unstructured":"Babu K, Murthy KR, Babu N et al. Triple A syndrome with ophthalmic manifestations in two siblings. Indian J Ophthalmol 2007; 55:304\u2013306.","journal-title":"Indian J Ophthalmol"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1210\/er.19.6.828","volume":"19","author":"A.J.L. Clark","year":"1998","unstructured":"Clark AJL, Weber A. Adrenocorticotropin insensitivity syndrome. Endocr Rev 1998; 19:828\u2013843.","journal-title":"Endocr Rev"},{"key":"1_CR44","unstructured":"Elise T, Loeper S, Jung R et al. A patient with the Triple A syndrome presenting with isolated partial adrenal androgen deficiency. 85th annual meeting, Endocrine Society, Philadelphia, PA. 2003;622."},{"key":"1_CR45","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1136\/jnnp.74.5.654","volume":"74","author":"J. Kimber","year":"2003","unstructured":"Kimber J, McLean BN, Prevett M et al. Allgrove or 4 \u201cA\u201d syndrome: an autosomal recessive syndrome causing multisystem neurological disease. J Neurol Neurosurg Psychiatry 2003; 74:654\u2013657.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1_CR46","first-page":"61","volume":"10","author":"B.G. Stuckey","year":"1987","unstructured":"Stuckey BG, Mastaglia FL, Reed WD et al. Glucocorticoid insufficiency, achalasia, alacrima with autonomic motor neuropathy. Ann Intern Med 1987; 10:61\u201363.","journal-title":"Ann Intern Med"},{"key":"1_CR47","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1097\/00000478-200305000-00010","volume":"27","author":"K. Khelif","year":"2003","unstructured":"Khelif K. Achalasia of the cardia in Allgrove\u2019s (triple A) syndrome: histopathologic study of 10 cases. Am J Surg Pathol 2003; 27:667\u2013672.","journal-title":"Am J Surg Pathol"},{"key":"1_CR48","first-page":"161","volume":"43","author":"A. Singh","year":"2006","unstructured":"Singh A, Shah A. Esophageal achalasia and alacrima in siblings. Indian Pediatr 2006; 43:161\u2013163.","journal-title":"Indian Pediatr"},{"key":"1_CR49","first-page":"103","volume":"43","author":"R.J. Thomas","year":"1998","unstructured":"Thomas RJ, Sen S, Zachariah N et al. Achalasia cardia in infancy and childhood: an Indian experience. J R Coll Surg Edinb 1998; 43:103\u2013104.","journal-title":"J R Coll Surg Edinb"},{"key":"1_CR50","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1136\/adc.68.6.779","volume":"68","author":"D.B. Grant","year":"1993","unstructured":"Grant DB, Barnes ND, Dumic M et al. Neurological and adrenal dysfunction in the adrenal insufficiency\/ alacrima\/achalasia (3A) syndrome. Arch Dis Child 1993; 68:779\u2013782.","journal-title":"Arch Dis Child"},{"key":"1_CR51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF01958948","volume":"151","author":"D. Grant","year":"1992","unstructured":"Grant D, Dunger D, Smith I et al. Familial glucocorticoid deficiency with achalsia of the cardia associated with a mixed neuropathy, long tract degeneration and mild dementia. Eur J Pediatr 1992; 151:85\u201389.","journal-title":"Eur J Pediatr"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1365-2265.1985.tb00219.x","volume":"23","author":"M. Pombo","year":"1985","unstructured":"Pombo M, Deuesa J, Taborda A et al. Glucocorticoid deficiency with achalasia of the cardia and lack of lacrimation. Clin Endocrinol 1985; 23:237\u2013243.","journal-title":"Clin Endocrinol"},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1507\/endocrj.46.227","volume":"46","author":"A.G. Ozgen","year":"1999","unstructured":"Ozgen AG, Ercan E, Ozutemiz O et al. The 4A syndrome association with osteoporosis. Endocr J 1999; 46:227\u2013230.","journal-title":"Endocr J"},{"key":"1_CR54","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/PL00008361","volume":"159","author":"M. Dumic","year":"2000","unstructured":"Dumic M, Mravak-Stipetic M, Kaic Z et al. Xerostomia in patients with triple A syndrome\u2014a newly recognized finding. Eur J Pediatr 2000; 159:885\u2013888.","journal-title":"Eur J Pediatr"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1440-1673.1994.tb00180.x","volume":"38","author":"P.L. Khong","year":"1994","unstructured":"Khong PL, Peh WC, Low LC et al. Variant of the Triple A syndrome. Australas Radiol 1994; 38:222\u2013224.","journal-title":"Australas Radiol"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12519-009-0010-9","volume":"5","author":"Y. Zhang","year":"2009","unstructured":"Zhang Y, Chun-Di Xu, Zaouche A et al. Diagnosis and management of esophageal achalasia in children: analysis of 13 cases. World J Pediatr 2009; 5:56\u201359.","journal-title":"World J Pediatr"}],"container-title":["Advances in Experimental Medicine and Biology","Diseases of DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4419-6448-9_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T10:37:44Z","timestamp":1558089464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4419-6448-9_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"ISBN":["9781441964472","9781441964489"],"references-count":56,"URL":"https:\/\/doi.org\/10.1007\/978-1-4419-6448-9_1","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4419-6448-9","asserted-by":"object"}]},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}