{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:57:18Z","timestamp":1760425038211},"publisher-location":"New York, NY","reference-count":70,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781441964472"},{"type":"electronic","value":"9781441964489"}],"license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"DOI":"10.1007\/978-1-4419-6448-9_8","type":"book-chapter","created":{"date-parts":[[2011,1,9]],"date-time":"2011-01-09T06:57:34Z","timestamp":1294556254000},"page":"84-94","source":"Crossref","is-referenced-by-count":12,"title":["Tuberous Sclerosis Complex and DNA Repair"],"prefix":"10.1007","author":[{"given":"Samy L.","family":"Habib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"8_CR1","first-page":"81","volume":"1","author":"D.M. Bourneville","year":"1880","unstructured":"Bourneville DM. Sclerose tubereuse des circonvolutions cerebrales: idiotie et epilepsie hemiplegique. Arch Neurol (Paris) 1880; 1:81\u201391.","journal-title":"Arch Neurol (Paris)"},{"key":"8_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/ng0992-37","volume":"2","author":"R.S. Kandt","year":"1992","unstructured":"Kandt RS, Haines JL, Smith M et al. Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease. Nat Genet 1992; 2:37\u201341.","journal-title":"Nat Genet"},{"key":"8_CR3","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"Consortium.","year":"1993","unstructured":"Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993; 75:1305\u20131315.","journal-title":"Cell"},{"key":"8_CR4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"M. Slegtenhorst Van","year":"1997","unstructured":"Van Slegtenhorst M, de Hoogt R, Hermans C et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997; 277:805\u2013808.","journal-title":"Science"},{"key":"8_CR5","doi-asserted-by":"publisher","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","volume":"97","author":"T. Carsillo","year":"2000","unstructured":"Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci USA 2000; 97:6085\u20136090.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0022-5347(17)43234-4","volume":"138","author":"T.J. Stillwell","year":"1987","unstructured":"Stillwell TJ, Gomez MR, Kelalis PP. Renal lesions in tuberous sclerosis. J Urol 1987; 138:477\u2013481.","journal-title":"J Urol"},{"key":"8_CR7","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2208::AID-CNCR21>3.0.CO;2-K","volume":"83","author":"T. Al-Saleem","year":"1998","unstructured":"Al-Saleem T, Wessner LL, Scheithauer BW et al. Malignant tumors of the kidney, brain and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer 1998; 83:2208\u20132216.","journal-title":"Cancer"},{"key":"8_CR8","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0022-5347(17)50082-8","volume":"132","author":"R.A. Shapiro","year":"1984","unstructured":"Shapiro RA, Skinner DG, Stanley P et al. Renal tumors associated with tuberous sclerosis. the case for aggressive surgical management. J Urol 1984; 132:1170\u20131174.","journal-title":"J Urol"},{"key":"8_CR9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI7319","volume":"104","author":"H. Onda","year":"1999","unstructured":"Onda H, Lueck A, Marks PW et al. Tsc2(+\/\u2212) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 1999; 104:687\u2013695.","journal-title":"J Clin Invest"},{"key":"8_CR10","first-page":"1206","volume":"59","author":"T. Kobayashi","year":"1999","unstructured":"Kobayashi T, Minowa O, Kuno J et al. Renal carcinogenesis, hepatic hemangiomatosis and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 1999; 59:1206\u20131211.","journal-title":"Cancer Res"},{"key":"8_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3835(94)90307-7","volume":"83","author":"O. Hino","year":"1994","unstructured":"Hino O, Mitani H, Katsuyama H et al. A novel cancer predisposition syndrome in the Eker rat model. Cancer Lett 1994; 83:117\u2013121.","journal-title":"Cancer Lett"},{"key":"8_CR12","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1073\/pnas.90.1.327","volume":"90","author":"O. Hino","year":"1993","unstructured":"Hino O, Klein-Szanto AJ, Freed JJ et al. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci USA 1993; 90:327\u2013331.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"15629","DOI":"10.1073\/pnas.95.26.15629","volume":"95","author":"G. Rennebeck","year":"1998","unstructured":"Rennebeck G, Kleymenova EV, Anderson R et al. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryoni c lethality characterized by disrupted neuroepithelial growth and development. Proc Natl Acad Sci USA 1998; 95:15629\u201315634.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR14","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0022-5347(17)37087-8","volume":"148","author":"J.I. Everitt","year":"1992","unstructured":"Everitt JI, Goldsworthy TL, Wolf DC et al. Hereditary renal cell carcinoma in the Eker rat: A rodent familial cancer syndrome. J Urol 1992; 148:1932\u20131936.","journal-title":"J Urol"},{"key":"8_CR15","first-page":"99","volume":"4","author":"R. Eker","year":"1981","unstructured":"Eker R, Mossige J, Johannessen JV et al. Hereditary renal adenomas and adenocarcinoma s in rats. Diagn Histopathol 1981; 4:99\u2013110.","journal-title":"Diagn Histopathol"},{"key":"8_CR16","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/0378-4274(95)03506-0","volume":"82\u201383","author":"J.I. Everitt","year":"1995","unstructured":"Everitt JI, Goldsworthy TL, Wolf DC et al. Hereditary renal cell carcinoma in the Eker rat: A unique animal model for the study of cancer susceptibility. Toxicol Lett 1995; 82\u201383:621\u2013625.","journal-title":"Toxicol Lett"},{"key":"8_CR17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0090-4295(91)80261-5","volume":"37","author":"R. Washecka","year":"1991","unstructured":"Washecka R, Hanna M. Malignant renal tumors in tuberous sclerosis. Urology 1991; 37:340\u2013343.","journal-title":"Urology"},{"key":"8_CR18","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0022-3468(96)90689-2","volume":"31","author":"F.M. Robertson","year":"1996","unstructured":"Robertson FM, Cendron M, Klauber GT et al. Renal cell carcinoma in association with tuberous sclerosis in children. J Pediatr Surg 1996; 31:729\u2013730.","journal-title":"J Pediatr Surg"},{"key":"8_CR19","first-page":"1201","volume":"149","author":"J. Bjornsson","year":"1996","unstructured":"Bjornsson J, Short MP, Kwiatkowski DJ et al. Tuberous sclerosis-associated renal cell carcinoma: clinical, pathological and genetic features. Am J Pathol 1996; 149:1201\u20131208.","journal-title":"Am J Pathol"},{"key":"8_CR20","first-page":"539","volume":"12","author":"T.L. Plank","year":"1999","unstructured":"Plank TL, Logginidou H, Klein-Szanto A et al. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1-and TSC2-linked angiomyolipomas. Mod Pathol 1999; 12:539\u2013545.","journal-title":"Mod Pathol"},{"key":"8_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-4598-8-13","volume":"8","author":"S.L. Habib","year":"2009","unstructured":"Habib SL. Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. Mol Cancer 2009; 8:1\u201310.","journal-title":"Mol Cancer"},{"key":"8_CR22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/modpathol.3880286","volume":"14","author":"M.W. Johnson","year":"2001","unstructured":"Johnson MW, Kerfoot C, Bushnell T et al. Hamartin and tuberin expression in human tissues. Mod Pathol 2001; 14:202\u2013210.","journal-title":"Mod Pathol"},{"key":"8_CR23","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1006\/mcbr.2001.0307","volume":"4","author":"D. Lou","year":"2001","unstructured":"Lou D, Griffith N, Noonan DJ. The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependentmanner. Mol Cell Biol Res Commun 2001; 4:374\u2013380.","journal-title":"Mol Cell Biol Res Commun"},{"key":"8_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/35010550","volume":"2","author":"R.F. Lamb","year":"2000","unstructured":"Lamb RF, Roy C, Diefenbach TJ et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol 2000; 2:281\u2013287.","journal-title":"Nat Cell Biol"},{"key":"8_CR25","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"K. Inoki","year":"2003","unstructured":"Inoki K, Li Y, Xu T et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003; 17:1829\u20131834.","journal-title":"Genes Dev"},{"key":"8_CR26","doi-asserted-by":"publisher","first-page":"16409","DOI":"10.1074\/jbc.270.27.16409","volume":"270","author":"R. Wienecke","year":"1995","unstructured":"Wienecke R, Konig A, DeClue JE. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J Biol Chem 1995; 270:16409\u201316414.","journal-title":"J Biol Chem"},{"key":"8_CR27","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1212\/01.WNL.0000140702.08902.D7","volume":"63","author":"F.E. Jansen","year":"2004","unstructured":"Jansen FE, Notenboom RG, Nellist M et al. Differential localization of hamartin and tuberin and increased S6 phosphorylation in a tuber. Neurology 2004; 63:1293\u20131295.","journal-title":"Neurology"},{"key":"8_CR28","doi-asserted-by":"publisher","first-page":"35647","DOI":"10.1074\/jbc.274.50.35647","volume":"274","author":"M. Nellist","year":"1999","unstructured":"Nellist M, van Slegtenhorst MA, Goedbloed M et al. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin. J Biol Chem 1999; 274:35647\u201335652.","journal-title":"J Biol Chem"},{"key":"8_CR29","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","volume":"7","author":"M. Slegtenhorst van","year":"1998","unstructured":"van Slegtenhorst M, Nellist M, Nagelkerken B et al. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 1998; 7:1053\u20137.","journal-title":"Hum Mol Genet"},{"key":"8_CR30","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1093\/hmg\/6.11.1991","volume":"6","author":"M.M. Maheshwar","year":"1997","unstructured":"Maheshwar MM, Cheadle JP, Jones AC et al. The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis. Hum Mol Genet 1997; 6:1991\u20131996.","journal-title":"Hum Mol Genet"},{"key":"8_CR31","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1093\/hmg\/10.25.2889","volume":"10","author":"M. Nellist","year":"2001","unstructured":"Nellist M, Verhaaf B, Goedbloed MA et al. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum Mol Genet 2001; 10:2889\u20132898.","journal-title":"Hum Mol Genet"},{"key":"8_CR32","doi-asserted-by":"publisher","first-page":"7965","DOI":"10.1128\/MCB.24.18.7965-7975.2004","volume":"24","author":"Y. Li","year":"2004","unstructured":"Li Y, Inoki K, Guan KL. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol 2004; 24:7965\u20137975.","journal-title":"Mol Cell Biol"},{"key":"8_CR33","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1073\/pnas.68.4.820","volume":"68","author":"A. Jr. Knudson","year":"1971","unstructured":"Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 68:820\u2013823.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","volume":"10","author":"B.D. Manning","year":"2002","unstructured":"Manning BD, Tee AR, Logsdon MN et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway. Mol Cell 2002; 10:151\u2013162.","journal-title":"Mol Cell"},{"key":"8_CR35","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"J. Huang","year":"2008","unstructured":"Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008; 412:179\u2013190.","journal-title":"Biochem J"},{"key":"8_CR36","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"K. Inoki","year":"2002","unstructured":"Inoki K, Li Y, Zhu T et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4:648\u2013657.","journal-title":"Nat Cell Biol"},{"key":"8_CR37","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1083\/jcb.200507119","volume":"173","author":"S.L. Cai","year":"2006","unstructured":"Cai SL, Tee AR, Short JD et al. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 2006; 173:279\u2013289.","journal-title":"J Cell Biol"},{"key":"8_CR38","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.1074\/jbc.272.10.6097","volume":"272","author":"G.H. Xiao","year":"1997","unstructured":"Xiao GH, Shoarinejad F, Jin F et al. The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J Biol Chem 1997; 272:6097\u20136100.","journal-title":"J Biol Chem"},{"key":"8_CR39","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","volume":"115","author":"K. Inoki","year":"2003","unstructured":"Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115:577\u2013590.","journal-title":"Cell"},{"key":"8_CR40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","volume":"121","author":"L. Ma","year":"2005","unstructured":"Ma L, Chen Z, Erdjument-Bromage H et al. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005; 121:179\u2013193.","journal-title":"Cell"},{"key":"8_CR41","doi-asserted-by":"publisher","first-page":"7106","DOI":"10.1158\/0008-5472.CAN-06-4798","volume":"67","author":"L. Ma","year":"2007","unstructured":"Ma L, Teruya-Feldstein J, Bonner P et al. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res 2007; 67:7106\u20137112.","journal-title":"Cancer Res"},{"key":"8_CR42","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","volume":"13","author":"A. Woods","year":"2003","unstructured":"Woods A, Johnstone SR, Dickerson K et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003; 13:2004\u20132008.","journal-title":"Curr Biol"},{"key":"8_CR43","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1073\/pnas.0308061100","volume":"101","author":"R.J. Shaw","year":"2004","unstructured":"Shaw RJ, Kosmatka M, Bardeesy N et al. Inaugural article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004; 101:3329\u20133335.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8_CR44","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"K. Inoki","year":"2003","unstructured":"Inoki K, Li Y, Xu T et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes & Dev 2003; 17:1829\u20131834.","journal-title":"Genes & Dev"},{"key":"8_CR45","first-page":"658","volume":"4","author":"S.A. Hawley","year":"2003","unstructured":"Hawley SA, Boudeau J, Reid JL et al. Complexes between the LKB1 tumor suppressor, STRAD\/and MO25\/are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28. growth by directly phosphorylating Tsc2. Nat Cell Biol 2003; 4:658\u2013665.","journal-title":"Nat Cell Biol"},{"key":"8_CR46","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1101\/gad.1199104","volume":"18","author":"M.N. Corradetti","year":"2004","unstructured":"Corradetti MN, Inoki K, Bardeesy N et al. Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004; 18:1533\u20131538.","journal-title":"Genes Dev"},{"key":"8_CR47","doi-asserted-by":"publisher","first-page":"5834","DOI":"10.1128\/MCB.25.14.5834-5845.2005","volume":"25","author":"A. Sofer","year":"2005","unstructured":"Sofer A, Lei K, Johannessen CM et al. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 2005; 25:5834\u20135845.","journal-title":"Mol Cell Biol"},{"key":"8_CR48","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","volume":"110","author":"K. Hara","year":"2002","unstructured":"Hara K, Maruki Y, Long X et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002; 110:177\u2013189.","journal-title":"Cell"},{"key":"8_CR49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/j.1356-9597.2004.00727.x","volume":"9","author":"N. Oshiro","year":"2004","unstructured":"Oshiro N, Yoshino K, Hidayat S et al. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 2004; 9:359\u2013366.","journal-title":"Genes Cells"},{"key":"8_CR50","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","volume":"110","author":"D.H. Kim","year":"2002","unstructured":"Kim DH, Sarbassov DD, Ali SM et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110:163\u2013175.","journal-title":"Cell"},{"key":"8_CR51","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/nature06322","volume":"450","author":"J.T. Cunningham","year":"2007","unstructured":"Cunningham JT, Rodgers JT, Arlow DH et al. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007; 450:736\u2013740.","journal-title":"Nature"},{"key":"8_CR52","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/ncb1183","volume":"6","author":"E. Jacinto","year":"2004","unstructured":"Jacinto E, Loewith R, Schmidt A et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6:1122\u20131128.","journal-title":"Nat Cell Biol"},{"key":"8_CR53","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/modpathol.3800624","volume":"19","author":"V.A. Robb","year":"2006","unstructured":"Robb VA, Astrinidis A, Henske EP. Frequent hyperphosphorylation of ribosomal protein S6 in lymphangioleiomyomatosis-associated angiomyolipomas. Mod Pathol 2006; 19:839\u2013840.","journal-title":"Mod Pathol"},{"key":"8_CR54","first-page":"3075","volume":"51","author":"L.A. Loeb","year":"1991","unstructured":"Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991; 51:3075\u20133079.","journal-title":"Cancer Res"},{"key":"8_CR55","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1038\/sj.onc.1202096","volume":"16","author":"S. Chevillard","year":"1998","unstructured":"Chevillard S, Radicella JP, Levalois C et al. Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. Oncogene 1998; 16:3083\u20133086.","journal-title":"Oncogene"},{"key":"8_CR56","first-page":"902","volume":"63","author":"K. Sakumi","year":"2003","unstructured":"Sakumi K, Tominaga Y, Furuichi M et al. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res 2003; 63:902\u2013905.","journal-title":"Cancer Res"},{"key":"8_CR57","doi-asserted-by":"publisher","first-page":"6006","DOI":"10.1158\/0008-5472.CAN-05-0724","volume":"65","author":"M. Kunisada","year":"2005","unstructured":"Kunisada M, Sakumi K, Tominaga Y et al. 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res 2005; 65:6006\u20136010.","journal-title":"Cancer Res"},{"key":"8_CR58","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1002\/mc.20427","volume":"47","author":"J. Liao","year":"2008","unstructured":"Liao J, Seril DN, Lu GG et al. Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice. Mol Carcinogenesis 2008; 47:638\u2013646.","journal-title":"Mol Carcinogenesis"},{"key":"8_CR59","first-page":"3710","volume":"54","author":"J. Lubinski","year":"1994","unstructured":"Lubinski J, Hadaczek P, Podolski J et al. Common regions of deletions in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res 1994; 54:3710\u20133.","journal-title":"Cancer Res"},{"key":"8_CR60","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1349-7006.1998.tb00635.x","volume":"89","author":"K. Shinmura","year":"1998","unstructured":"Shinmura K, Kohno T, Kasai H et al. Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn J Cancer Res 1998; 89:825\u2013828.","journal-title":"Jpn J Cancer Res"},{"key":"8_CR61","first-page":"669","volume":"8","author":"H. Sugimura","year":"1999","unstructured":"Sugimura H, Kohno T, Wakai K et al. hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 1999; 8:669\u2013674.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"8_CR62","first-page":"4740","volume":"60","author":"M. Audebert","year":"2000","unstructured":"Audebert M, Chevillard S, Levalois C et al. Alterations of DNA repair gene OGG1 in human clear cell carcinomas of the kidney. Cancer Res 2000; 60:4740\u20134744.","journal-title":"Cancer Res"},{"key":"8_CR63","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4161\/cbt.7.1.5120","volume":"7","author":"S.L. Habib","year":"2008","unstructured":"Habib SL, Daniel E, Abboud HE et al. Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis. Cancer Biol Ther 2008; 7:23\u201327.","journal-title":"Cancer Biol Ther"},{"key":"8_CR64","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/ijc.23473","volume":"123","author":"F. Farinati","year":"2008","unstructured":"Farinati F, Cardin R, Bortolami M et al. Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism. Int J Cancer 2008; 123:51\u201355.","journal-title":"Int J Cancer"},{"key":"8_CR65","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/ijc.22748","volume":"121","author":"X. Jiao","year":"2007","unstructured":"Jiao X, Huang J, Wu S et al. hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population. Int J Cancer 2007; 121:501\u2013505.","journal-title":"Int J Cancer"},{"key":"8_CR66","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/1097-0215(20010520)95:3<140::AID-IJC1024>3.0.CO;2-2","volume":"95","author":"D.Y. Xing","year":"2001","unstructured":"Xing DY, Tan W, Song N et al. Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. Int J Cancer 2001; 95:140\u2013143.","journal-title":"Int J Cancer"},{"key":"8_CR67","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1093\/carcin\/23.7.1229","volume":"23","author":"A. Elahi","year":"2002","unstructured":"Elahi A, Zheng Z, Park J et al. The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk. Carcinogenesis 2002; 23:1229\u201312s34.","journal-title":"Carcinogenesis"},{"key":"8_CR68","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/carcin\/24.3.573","volume":"24","author":"S.L. Habib","year":"2003","unstructured":"Habib SL, Phan MN, Patel SK et al. Reduced constitutive 8-oxoguanine-DNA glycocylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis 2003; 24:573\u2013582.","journal-title":"Carcinogenesis"},{"key":"8_CR69","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1476-4598-7-10","volume":"7","author":"S.L. Habib","year":"2008","unstructured":"Habib SL, Simone S, Barnes JJ et al. Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Mol Cancer 2008; 7:10\u201314.","journal-title":"Mol Cancer"},{"key":"8_CR70","doi-asserted-by":"publisher","first-page":"F281","DOI":"10.1152\/ajprenal.00370.2007","volume":"294","author":"S.L. Habib","year":"2008","unstructured":"Habib SL, Riley DJ, Bhandari B et al. Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 2008; 294:F281\u2013F290.","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Advances in Experimental Medicine and Biology","Diseases of DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4419-6448-9_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T14:35:06Z","timestamp":1558103706000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4419-6448-9_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"ISBN":["9781441964472","9781441964489"],"references-count":70,"URL":"https:\/\/doi.org\/10.1007\/978-1-4419-6448-9_8","relation":{},"ISSN":["0065-2598"],"issn-type":[{"type":"print","value":"0065-2598"}],"subject":[],"published":{"date-parts":[[2010]]}}}