{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:16:45Z","timestamp":1794406605795,"version":"4.9.0"},"publisher-location":"Boston, MA","reference-count":81,"publisher":"Springer US","isbn-type":[{"value":"9781461409793","type":"print"},{"value":"9781461409809","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T00:00:00Z","timestamp":1320710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-1-4614-0980-9_9","type":"book-chapter","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T14:53:27Z","timestamp":1324047207000},"page":"201-221","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":169,"title":["Influenza Virus Entry"],"prefix":"10.1007","author":[{"given":"Ming","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"9_CR1_9","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1021\/bi00063a007","volume":"32","author":"DL Bodian","year":"1993","unstructured":"Bodian DL, Yamasaki RB, Buswell RL, Stearns JF, White JM, Kuntz ID (1993) Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochemistry 32:2967\u20132978","journal-title":"Biochemistry"},{"key":"9_CR2_9","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1074\/jbc.275.9.6160","volume":"275","author":"P Bonnafous","year":"2000","unstructured":"Bonnafous P, Stegmann T (2000) Membrane perturbation and fusion pore formation in influenza hemagglutinin-mediated membrane fusion. A new model for fusion. J Biol Chem 275:6160\u20136166","journal-title":"J Biol Chem"},{"key":"9_CR3_9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0014-5793(99)01475-1","volume":"463","author":"C Bottcher","year":"1999","unstructured":"Bottcher C, Ludwig K, Herrmann A, van Heel M, Stark H (1999) Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo-microscopy. FEBS Lett 463:255\u2013259","journal-title":"FEBS Lett"},{"key":"9_CR4_9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1743-422X-5-40","volume":"5","author":"K Bragstad","year":"2008","unstructured":"Bragstad K, Nielsen LP, Fomsgaard A (2008) The evolution of human influenza A viruses from 1999 to 2006: a complete genome study. Virol J 5:40","journal-title":"Virol J"},{"key":"9_CR5_9","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1128\/JVI.70.12.8391-8401.1996","volume":"70","author":"M Bui","year":"1996","unstructured":"Bui M, Whittaker G, Helenius A (1996) Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. J Virol 70:8391\u20138401","journal-title":"J Virol"},{"key":"9_CR6_9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/371037a0","volume":"371","author":"PA Bullough","year":"1994","unstructured":"Bullough PA, Hughson FM, Skehel JJ, Wiley DC (1994) Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371:37\u201343","journal-title":"Nature"},{"key":"9_CR7_9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1042\/BJ20051920","volume":"396","author":"DK Chang","year":"2006","unstructured":"Chang DK, Cheng SF (2006) pH-dependence of intermediate steps of membrane fusion induced by the influenza fusion peptide. Biochem J 396:557\u2013563","journal-title":"Biochem J"},{"key":"9_CR8_9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1741-7007-6-2","volume":"6","author":"DK Chang","year":"2008","unstructured":"Chang DK, Cheng SF, Kantchev EA, Lin CH, Liu YT (2008) Membrane interaction and structure of the transmembrane domain of influenza hemagglutinin and its fusion peptide complex. BMC Biol 6:2","journal-title":"BMC Biol"},{"key":"9_CR9_9","doi-asserted-by":"publisher","first-page":"11790","DOI":"10.1073\/pnas.0803711105","volume":"105","author":"C Chen","year":"2008","unstructured":"Chen C, Zhuang X (2008) Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci USA 105:11790\u201311795","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR10_9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0092-8674(00)81771-7","volume":"95","author":"J Chen","year":"1998","unstructured":"Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC (1998) Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell 95:409\u2013417","journal-title":"Cell"},{"key":"9_CR11_9","doi-asserted-by":"publisher","first-page":"8967","DOI":"10.1073\/pnas.96.16.8967","volume":"96","author":"J Chen","year":"1999","unstructured":"Chen J, Skehel JJ, Wiley DC (1999) N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc Natl Acad Sci USA 96:8967\u20138972","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR12_9","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1083\/jcb.140.6.1369","volume":"140","author":"LV Chernomordik","year":"1998","unstructured":"Chernomordik LV, Frolov VA, Leikina E, Bronk P, Zimmerberg J (1998) The pathway of membrane fusion catalyzed by influenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation. J Cell Biol 140:1369\u20131382","journal-title":"J Cell Biol"},{"key":"9_CR13_9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nrm1076","volume":"4","author":"PM Colman","year":"2003","unstructured":"Colman PM, Lawrence MC (2003) The structural biology of type I viral membrane fusion. Nat Rev Mol Cell Biol 4:309\u2013319","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9_CR14_9","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/0042-6822(70)90337-5","volume":"42","author":"RW Compans","year":"1970","unstructured":"Compans RW, Klenk HD, Caliguiri LA, Choppin PW (1970) Influenza virus proteins. I. Analysis of polypeptides of the virion and identification of spike glycoproteins. Virology 42:880\u2013889","journal-title":"Virology"},{"key":"9_CR15_9","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0092-8674(85)90157-6","volume":"40","author":"RS Daniels","year":"1985","unstructured":"Daniels RS, Downie JC, Hay AJ, Knossow M, Skehel JJ, Wang ML, Wiley DC (1985) Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell 40:431\u2013439","journal-title":"Cell"},{"key":"9_CR16_9","volume-title":"The PyMOL Molecular Graphics System","author":"WL DeLano","year":"2002","unstructured":"DeLano WL (2002) The PyMOL Molecular Graphics System. DeLano Scientific, Palo Alto, CA"},{"key":"9_CR17_9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0092-8674(87)90499-5","volume":"50","author":"SJ Doxsey","year":"1987","unstructured":"Doxsey SJ, Brodsky FM, Blank GS, Helenius A (1987) Inhibition of endocytosis by anti-clathrin antibodies. Cell 50:453\u2013463","journal-title":"Cell"},{"key":"9_CR18_9","doi-asserted-by":"publisher","first-page":"15382","DOI":"10.1073\/pnas.0807771105","volume":"105","author":"DL Floyd","year":"2008","unstructured":"Floyd DL, Ragains JR, Skehel JJ, Harrison SC, van Oijen AM (2008) Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci USA 105:15382\u201315387","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR19_9","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1126\/science.1093155","volume":"303","author":"SJ Gamblin","year":"2004","unstructured":"Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ (2004) The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science 303:1838\u20131842","journal-title":"Science"},{"issue":"Pt 6","key":"9_CR20_9","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1099\/0022-1317-67-6-1115","volume":"67","author":"Y Ghendon","year":"1986","unstructured":"Ghendon Y, Markushin S, Heider H, Melnikov S, Lotte V (1986) Haemagglutinin of influenza A virus is a target for the antiviral effect of Norakin. J Gen Virol 67(Pt 6):1115\u20131122","journal-title":"J Gen Virol"},{"key":"9_CR21_9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.virusres.2007.07.010","volume":"129","author":"S Giannecchini","year":"2007","unstructured":"Giannecchini S, Campitelli L, Bandini G, Donatelli I, Azzi A (2007) Characterization of human H1N1 influenza virus variants selected in vitro with zanamivir in the presence of sialic acid-containing molecules. Virus Res 129:241\u2013245","journal-title":"Virus Res"},{"key":"9_CR22_9","doi-asserted-by":"publisher","first-page":"11181","DOI":"10.1073\/pnas.201401198","volume":"98","author":"Y Ha","year":"2001","unstructured":"Ha Y, Stevens DJ, Skehel JJ, Wiley DC (2001) X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci USA 98:11181\u201311186","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR23_9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0042-6822(92)90576-B","volume":"189","author":"JE Hanson","year":"1992","unstructured":"Hanson JE, Sauter NK, Skehel JJ, Wiley DC (1992) Proton nuclear magnetic resonance studies of the binding of sialosides to intact influenza virus. Virology 189:525\u2013533","journal-title":"Virology"},{"key":"9_CR24_9","doi-asserted-by":"publisher","first-page":"19123","DOI":"10.1073\/pnas.0607614103","volume":"103","author":"A Harris","year":"2006","unstructured":"Harris A, Cardone G, Winkler DC, Heymann JB, Brecher M, White JM, Steven AC (2006) Influenza virus pleiomorphy characterized by cryoelectron tomography. Proc Natl Acad Sci USA 103:19123\u201319127","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR25_9","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1098\/rstb.2001.0999","volume":"356","author":"AJ Hay","year":"2001","unstructured":"Hay AJ, Gregory V, Douglas AR, Lin YP (2001) The evolution of human influenza viruses. Philos Trans R Soc Lond B Biol Sci 356:1861\u20131870","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"Suppl 1","key":"9_CR26_9","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1086\/591851","volume":"48","author":"F Hayden","year":"2009","unstructured":"Hayden F (2009) Developing new antiviral agents for influenza treatment: what does the future hold? Clin Infect Dis 48(Suppl 1):S3\u2013S13","journal-title":"Clin Infect Dis"},{"key":"9_CR27_9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/BF01309832","volume":"86","author":"H Heider","year":"1985","unstructured":"Heider H, Markushin S, Schroeder C, Ghendon Y (1985) The influence of Norakin on the reproduction of influenza A and B viruses. Arch Virol 86:283\u2013290","journal-title":"Arch Virol"},{"key":"9_CR28_9","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1128\/JVI.71.11.8808-8820.1997","volume":"71","author":"LR Hoffman","year":"1997","unstructured":"Hoffman LR, Kuntz ID, White JM (1997) Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity. J Virol 71:8808\u20138820","journal-title":"J Virol"},{"key":"9_CR29_9","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/S0006-3495(02)75464-7","volume":"82","author":"Q Huang","year":"2002","unstructured":"Huang Q, Opitz R, Knapp EW, Herrmann A (2002) Protonation and stability of the globular domain of influenza virus hemagglutinin. Biophys J 82:1050\u20131058","journal-title":"Biophys J"},{"key":"9_CR30_9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0005-2736(03)00158-5","volume":"1614","author":"Q Huang","year":"2003","unstructured":"Huang Q, Sivaramakrishna RP, Ludwig K, Korte T, Bottcher C, Herrmann A (2003) Early steps of the conformational change of influenza virus hemagglutinin to a fusion active state: stability and energetics of the hemagglutinin. Biochim Biophys Acta 1614:3\u201313","journal-title":"Biochim Biophys Acta"},{"key":"9_CR31_9","doi-asserted-by":"publisher","first-page":"4433","DOI":"10.1128\/AAC.00334-09","volume":"53","author":"AC Hurt","year":"2009","unstructured":"Hurt AC, Holien JK, Barr IG (2009) In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses. Antimicrob Agents Chemother 53:4433\u20134440","journal-title":"Antimicrob Agents Chemother"},{"key":"9_CR32_9","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.1128\/JVI.02677-05","volume":"80","author":"A Ibricevic","year":"2006","unstructured":"Ibricevic A, Pekosz A, Walter MJ, Newby C, Battaile JT, Brown EG, Holtzman MJ, Brody SL (2006) Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol 80:7469\u20137480","journal-title":"J Virol"},{"key":"9_CR33_9","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0092-8674(94)90344-1","volume":"76","author":"GW Kemble","year":"1994","unstructured":"Kemble GW, Danieli T, White JM (1994) Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell 76:383\u2013391","journal-title":"Cell"},{"key":"9_CR34_9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1046\/j.1398-9219.2003.0140.x","volume":"4","author":"R Khor","year":"2003","unstructured":"Khor R, McElroy LJ, Whittaker GR (2003) The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells. Traffic 4:857\u2013868","journal-title":"Traffic"},{"key":"9_CR35_9","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/3293","volume":"4","author":"JM Kilby","year":"1998","unstructured":"Kilby JM, Hopkins S, Venetta TM, DiMassimo B, Cloud GA, Lee JY, Alldredge L, Hunter E, Lambert D, Bolognesi D, Matthews T, Johnson MR, Nowak MA, Shaw GM, Saag MS (1998) Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat Med 4:1302\u20131307","journal-title":"Nat Med"},{"key":"9_CR36_9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10719-006-5442-z","volume":"23","author":"T Kogure","year":"2006","unstructured":"Kogure T, Suzuki T, Takahashi T, Miyamoto D, Hidari KI, Guo CT, Ito T, Kawaoka Y, Suzuki Y (2006) Human trachea primary epithelial cells express both sialyl(alpha2-3)Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl(alpha2-6)Gal receptor for human influenza viruses. Glycoconj J 23:101\u2013106","journal-title":"Glycoconj J"},{"key":"9_CR37_9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nature08699","volume":"463","author":"R Konig","year":"2010","unstructured":"Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, Garcia-Sastre A, Young JA, Palese P, Shaw ML, Chanda SK (2010) Human host factors required for influenza virus replication. Nature 463:813\u2013817","journal-title":"Nature"},{"key":"9_CR38_9","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1073\/pnas.0832269100","volume":"100","author":"M Lakadamyali","year":"2003","unstructured":"Lakadamyali M, Rust MJ, Babcock HP, Zhuang X (2003) Visualizing infection of individual influenza viruses. Proc Natl Acad Sci USA 100:9280\u20139285","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR39_9","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1016\/S0021-9258(18)48270-1","volume":"262","author":"JD Lear","year":"1987","unstructured":"Lear JD, DeGrado WF (1987) Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. J Biol Chem 262:6500\u20136505","journal-title":"J Biol Chem"},{"key":"9_CR40_9","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/emboj.2010.13","volume":"29","author":"KK Lee","year":"2010","unstructured":"Lee KK (2010) Architecture of a nascent viral fusion pore. EMBO J 29:1299\u20131311","journal-title":"EMBO J"},{"key":"9_CR41_9","doi-asserted-by":"publisher","first-page":"8378","DOI":"10.1021\/bi010466+","volume":"40","author":"E Leikina","year":"2001","unstructured":"Leikina E, LeDuc DL, Macosko JC, Epand R, Shin YK, Chernomordik LV (2001) The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion. Biochemistry 40:8378\u20138386","journal-title":"Biochemistry"},{"key":"9_CR42_9","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0006-3495(00)76393-4","volume":"79","author":"E Leikina","year":"2000","unstructured":"Leikina E, Markovic I, Chernomordik LV, Kozlov MM (2000) Delay of influenza hemagglutinin refolding into a fusion-competent conformation by receptor binding: a hypothesis. Biophys J 79:1415\u20131427","journal-title":"Biophys J"},{"key":"9_CR43_9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.virol.2009.06.028","volume":"392","author":"T Lin","year":"2009","unstructured":"Lin T, Wang G, Li A, Zhang Q, Wu C, Zhang R, Cai Q, Song W, Yuen KY (2009) The hemagglutinin structure of an avian H1N1 influenza A virus. Virology 392:73\u201381","journal-title":"Virology"},{"key":"9_CR44_9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/JVI.69.2.1099-1106.1995","volume":"69","author":"C Liu","year":"1995","unstructured":"Liu C, Eichelberger MC, Compans RW, Air GM (1995) Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding. J Virol 69:1099\u20131106","journal-title":"J Virol"},{"key":"9_CR45_9","doi-asserted-by":"publisher","first-page":"17175","DOI":"10.1073\/pnas.0906849106","volume":"106","author":"J Liu","year":"2009","unstructured":"Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ (2009) Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957. Proc Natl Acad Sci USA 106:17175\u201317180","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR46_9","doi-asserted-by":"publisher","first-page":"27606","DOI":"10.1074\/jbc.270.46.27606","volume":"270","author":"J Luneberg","year":"1995","unstructured":"Luneberg J, Martin I, Nussler F, Ruysschaert JM, Herrmann A (1995) Structure and topology of the influenza virus fusion peptide in lipid bilayers. J Biol Chem 270:27606\u201327614","journal-title":"J Biol Chem"},{"key":"9_CR47_9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1006\/viro.1996.0628","volume":"226","author":"G Luo","year":"1996","unstructured":"Luo G, Colonno R, Krystal M (1996) Characterization of a hemagglutinin-specific inhibitor of influenza A virus. Virology 226:66\u201376","journal-title":"Virology"},{"key":"9_CR48_9","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1128\/JVI.71.5.4062-4070.1997","volume":"71","author":"G Luo","year":"1997","unstructured":"Luo G, Torri A, Harte WE, Danetz S, Cianci C, Tiley L, Day S, Mullaney D, Yu KL, Ouellet C, Dextraze P, Meanwell N, Colonno R, Krystal M (1997) Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus. J Virol 71:4062\u20134070","journal-title":"J Virol"},{"key":"9_CR49_9","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1083\/jcb.91.3.601","volume":"91","author":"KS Matlin","year":"1981","unstructured":"Matlin KS, Reggio H, Helenius A, Simons K (1981) Infectious entry pathway of influenza virus in a canine kidney cell line. J Cell Biol 91:601\u2013613","journal-title":"J Cell Biol"},{"key":"9_CR50_9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.tim.2008.01.008","volume":"16","author":"JM Nicholls","year":"2008","unstructured":"Nicholls JM, Chan RW, Russell RJ, Air GM, Peiris JS (2008) Evolving complexities of influenza virus and its receptors. Trends Microbiol 16:149\u2013157","journal-title":"Trends Microbiol"},{"key":"9_CR51_9","first-page":"47","volume":"9","author":"I Nunes-Correia","year":"2004","unstructured":"Nunes-Correia I, Eulalio A, Nir S, Pedroso de Lima MC (2004) Caveolae as an additional route for influenza virus endocytosis in MDCK cells. Cell Mol Biol Lett 9:47\u201360","journal-title":"Cell Mol Biol Lett"},{"key":"9_CR52_9","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/emboj\/17.1.288","volume":"17","author":"RE O\u2019Neill","year":"1998","unstructured":"O\u2019Neill RE, Talon J, Palese P (1998) The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J 17:288\u2013296","journal-title":"EMBO J"},{"key":"9_CR53_9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0166-3542(94)90050-7","volume":"24","author":"S Ott","year":"1994","unstructured":"Ott S, Wunderli-Allenspach H (1994) Effect of the virostatic Norakin (triperiden) on influenza virus activities. Antiviral Res 24:37\u201342","journal-title":"Antiviral Res"},{"key":"9_CR54_9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF01315569","volume":"102","author":"S Prosch","year":"1988","unstructured":"Prosch S, Heider H, Schroeder C, Kruger DH (1988) Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin. Arch Virol 102:125\u2013129","journal-title":"Arch Virol"},{"key":"9_CR55_9","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1128\/JVI.02596-08","volume":"83","author":"L Qi","year":"2009","unstructured":"Qi L, Kash JC, Dugan VG, Wang R, Jin G, Cunningham RE, Taubenberger JK (2009) Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice. J Virol 83:3754\u20133761","journal-title":"J Virol"},{"key":"9_CR56_9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/23974","volume":"396","author":"PB Rosenthal","year":"1998","unstructured":"Rosenthal PB, Zhang X, Formanowski F, Fitz W, Wong CH, Meier-Ewert H, Skehel JJ, Wiley DC (1998) Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature 396:92\u201396","journal-title":"Nature"},{"key":"9_CR57_9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/viro.1999.0109","volume":"267","author":"AM Roy","year":"2000","unstructured":"Roy AM, Parker JS, Parrish CR, Whittaker GR (2000) Early stages of influenza virus entry into Mv-1 lung cells: involvement of dynamin. Virology 267:17\u201328","journal-title":"Virology"},{"key":"9_CR58_9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nsmb769","volume":"11","author":"MJ Rust","year":"2004","unstructured":"Rust MJ, Lakadamyali M, Zhang F, Zhuang X (2004) Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat Struct Mol Biol 11:567\u2013573","journal-title":"Nat Struct Mol Biol"},{"key":"9_CR59_9","doi-asserted-by":"publisher","first-page":"8388","DOI":"10.1021\/bi00447a018","volume":"28","author":"NK Sauter","year":"1989","unstructured":"Sauter NK, Bednarski MD, Wurzburg BA, Hanson JE, Whitesides GM, Skehel JJ, Wiley DC (1989) Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study. Biochemistry 28:8388\u20138396","journal-title":"Biochemistry"},{"key":"9_CR60_9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.sbi.2009.06.003","volume":"19","author":"R Schauer","year":"2009","unstructured":"Schauer R (2009) Sialic acids as regulators of molecular and cellular interactions. Curr Opin Struct Biol 19:507\u2013514","journal-title":"Curr Opin Struct Biol"},{"key":"9_CR61_9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1083\/jcb.118.2.227","volume":"118","author":"MS Segal","year":"1992","unstructured":"Segal MS, Bye JM, Sambrook JF, Gething MJ (1992) Disulfide bond formation during the folding of influenza virus hemagglutinin. J Cell Biol 118:227\u2013244","journal-title":"J Cell Biol"},{"key":"9_CR62_9","doi-asserted-by":"publisher","first-page":"e7789","DOI":"10.1371\/journal.pone.0007789","volume":"4","author":"J Shen","year":"2009","unstructured":"Shen J, Ma J, Wang Q (2009) Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. PLoS One 4:e7789","journal-title":"PLoS One"},{"key":"9_CR63_9","doi-asserted-by":"publisher","first-page":"10455","DOI":"10.1128\/JVI.76.20.10455-10464.2002","volume":"76","author":"SB Sieczkarski","year":"2002","unstructured":"Sieczkarski SB, Whittaker GR (2002) Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis. J Virol 76:10455\u201310464","journal-title":"J Virol"},{"key":"9_CR64_9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1034\/j.1600-0854.2003.00090.x","volume":"4","author":"SB Sieczkarski","year":"2003","unstructured":"Sieczkarski SB, Whittaker GR (2003) Differential requirements of Rab5 and Rab7 for endocytosis of influenza and other enveloped viruses. Traffic 4:333\u2013343","journal-title":"Traffic"},{"key":"9_CR65_9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1006\/viro.1998.9273","volume":"248","author":"KA Staschke","year":"1998","unstructured":"Staschke KA, Hatch SD, Tang JC, Hornback WJ, Munroe JE, Colacino JM, Muesing MA (1998) Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid. Virology 248:264\u2013274","journal-title":"Virology"},{"key":"9_CR66_9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1126\/science.1124513","volume":"312","author":"J Stevens","year":"2006","unstructured":"Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA (2006) Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312:404\u2013410","journal-title":"Science"},{"key":"9_CR67_9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1093\/glycob\/10.7.649","volume":"10","author":"SJ Stray","year":"2000","unstructured":"Stray SJ, Cummings RD, Air GM (2000) Influenza virus infection of desialylated cells. Glycobiology 10:649\u2013658","journal-title":"Glycobiology"},{"key":"9_CR68_9","doi-asserted-by":"publisher","first-page":"14610","DOI":"10.1073\/pnas.2235620100","volume":"100","author":"M Takeda","year":"2003","unstructured":"Takeda M, Leser GP, Russell CJ, Lamb RA (2003) Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci USA 100:14610\u201314617","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR69_9","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1006\/viro.1996.0139","volume":"217","author":"DK Takemoto","year":"1996","unstructured":"Takemoto DK, Skehel JJ, Wiley DC (1996) A surface plasmon resonance assay for the binding of influenza virus hemagglutinin to its sialic acid receptor. Virology 217:452\u2013458","journal-title":"Virology"},{"key":"9_CR70_9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1021\/bi991594p","volume":"39","author":"SA Tatulian","year":"2000","unstructured":"Tatulian SA, Tamm LK (2000) Secondary structure, orientation, oligomerization, and lipid interactions of the transmembrane domain of influenza hemagglutinin. Biochemistry 39:496\u2013507","journal-title":"Biochemistry"},{"key":"9_CR71_9","doi-asserted-by":"publisher","first-page":"8060","DOI":"10.1128\/JVI.00384-06","volume":"80","author":"CI Thompson","year":"2006","unstructured":"Thompson CI, Barclay WS, Zambon MC, Pickles RJ (2006) Infection of human airway epithelium by human and avian strains of influenza a virus. J Virol 80:8060\u20138068","journal-title":"J Virol"},{"key":"9_CR72_9","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1126\/science.1136212","volume":"315","author":"TM Tumpey","year":"2007","unstructured":"Tumpey TM, Maines TR, Van Hoeven N, Glaser L, Solorzano A, Pappas C, Cox NJ, Swayne DE, Palese P, Katz JM, Garcia-Sastre A (2007) A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 315:655\u2013659","journal-title":"Science"},{"key":"9_CR73_9","doi-asserted-by":"publisher","first-page":"6316","DOI":"10.1128\/JVI.74.14.6316-6323.2000","volume":"74","author":"R Wagner","year":"2000","unstructured":"Wagner R, Wolff T, Herwig A, Pleschka S, Klenk HD (2000) Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth: a study by reverse genetics. J Virol 74:6316\u20136323","journal-title":"J Virol"},{"key":"9_CR74_9","doi-asserted-by":"publisher","first-page":"16874","DOI":"10.1073\/pnas.0708363104","volume":"104","author":"Q Wang","year":"2007","unstructured":"Wang Q, Tian X, Chen X, Ma J (2007) Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc Natl Acad Sci USA 104:16874\u201316879","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR75_9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0042-6822(86)90083-8","volume":"149","author":"SA Wharton","year":"1986","unstructured":"Wharton SA, Skehel JJ, Wiley DC (1986) Studies of influenza haemagglutinin-mediated membrane fusion. Virology 149:27\u201335","journal-title":"Virology"},{"key":"9_CR76_9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/300658a0","volume":"300","author":"J White","year":"1982","unstructured":"White J, Helenius A, Gething MJ (1982) Haemagglutinin of influenza virus expressed from a cloned gene promotes membrane fusion. Nature 300:658\u2013659","journal-title":"Nature"},{"key":"9_CR77_9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/289366a0","volume":"289","author":"IA Wilson","year":"1981","unstructured":"Wilson IA, Skehel JJ, Wiley DC (1981) Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289:366\u2013373","journal-title":"Nature"},{"key":"9_CR78_9","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature05264","volume":"444","author":"S Yamada","year":"2006","unstructured":"Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y (2006) Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378\u2013382","journal-title":"Nature"},{"key":"9_CR79_9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-540-92165-3_1","volume":"333","author":"HL Yen","year":"2009","unstructured":"Yen HL, Webster RG (2009) Pandemic influenza as a current threat. Curr Top Microbiol Immunol 333:3\u201324","journal-title":"Curr Top Microbiol Immunol"},{"key":"9_CR80_9","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s007050050552","volume":"144","author":"J Yoshimoto","year":"1999","unstructured":"Yoshimoto J, Kakui M, Iwasaki H, Fujiwara T, Sugimoto H, Hattori N (1999) Identification of a novel HA conformational change inhibitor of human influenza virus. Arch Virol 144:865\u2013878","journal-title":"Arch Virol"},{"key":"9_CR81_9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/rmv.319","volume":"11","author":"MC Zambon","year":"2001","unstructured":"Zambon MC (2001) The pathogenesis of influenza in humans. Rev Med Virol 11:227\u2013241","journal-title":"Rev Med Virol"}],"container-title":["Advances in Experimental Medicine and Biology","Viral Molecular Machines"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4614-0980-9_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T16:50:48Z","timestamp":1640019048000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4614-0980-9_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"ISBN":["9781461409793","9781461409809"],"references-count":81,"URL":"https:\/\/doi.org\/10.1007\/978-1-4614-0980-9_9","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4614-0980-9","asserted-by":"object"}]},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,8]]},"assertion":[{"value":"8 November 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}