{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:39:44Z","timestamp":1771612784979,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":19,"publisher":"Springer New York","isbn-type":[{"value":"9781461432081","type":"print"},{"value":"9781461432098","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-4614-3209-8_28","type":"book-chapter","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:46:47Z","timestamp":1395647207000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Complement Dysregulation in AMD Mouse Models"],"prefix":"10.1007","author":[{"given":"Jin-Dong","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Una","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marybeth","family":"Groelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph G.","family":"Christenbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bowes Rickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"issue":"3","key":"28_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","volume":"134","author":"DH Anderson","year":"2002","unstructured":"Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134(3):411\u2013431","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"28_CR2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","volume":"20","author":"GS Hageman","year":"2001","unstructured":"Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF (2001) An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch\u2019s membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 20(6):705\u2013732","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"28_CR3","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1006\/exer.2001.1094","volume":"73","author":"LV Johnson","year":"2001","unstructured":"Johnson LV, Leitner WP, Staples MK, Anderson DH (2001) Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp Eye Res 73(6):887\u2013896","journal-title":"Exp Eye Res"},{"key":"28_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/978-1-4419-5635-4_2","volume":"703","author":"PF Zipfel","year":"2010","unstructured":"Zipfel PF, Lauer N, Skerka C (2010) The role of complement in AMD. Adv Exp Med Biol 703:9\u201324","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"28_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","volume":"29","author":"DH Anderson","year":"2010","unstructured":"Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Bowes Rickman C, Bok D, Hageman GS, Johnson LV (2010) The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 29(2):95\u2013112","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"28_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.4049\/jimmunol.176.3.1305","volume":"176","author":"JM Thurman","year":"2006","unstructured":"Thurman JM, Holers VM (2006) The central role of the alternative complement pathway in human disease. J Immunol 176(3):1305\u20131310","journal-title":"J Immunol"},{"issue":"46","key":"28_CR7","doi-asserted-by":"publisher","first-page":"17456","DOI":"10.1073\/pnas.0606234103","volume":"103","author":"PT Johnson","year":"2006","unstructured":"Johnson PT, Betts KE, Radeke MJ, Hageman GS, Anderson DH, Johnson LV (2006) Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A 103(46):17456\u201317461","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"28_CR8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng912","volume":"31","author":"MC Pickering","year":"2002","unstructured":"Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, Botto M (2002) Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet 31(4):424\u2013428","journal-title":"Nat Genet"},{"issue":"42","key":"28_CR9","doi-asserted-by":"publisher","first-page":"16651","DOI":"10.1073\/pnas.0705079104","volume":"104","author":"PJ Coffey","year":"2007","unstructured":"Coffey PJ, Gias C, McDermott CJ, Lundh P, Pickering MC, Sethi C, Bird A, Fitzke FW, Maass A, Chen LL, Holder GE, Luthert PJ, Salt TE, Moss SE, Greenwood J (2007) Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proc Natl Acad Sci U S A 104(42):16651\u201316656","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"28_CR10","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2353\/ajpath.2009.080927","volume":"175","author":"P Lundh von Leithner","year":"2009","unstructured":"Lundh von Leithner P, Kam JH, Bainbridge J, Catchpole I, Gough G, Coffey P, Jeffery G (2009) Complement factor h is critical in the maintenance of retinal perfusion. Am J Pathol 175(1):412\u2013421","journal-title":"Am J Pathol"},{"issue":"6","key":"28_CR11","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/eji.1830230630","volume":"23","author":"S Foley","year":"1993","unstructured":"Foley S, Li B, Dehoff M, Molina H, Holers VM (1993) Mouse Crry\/p65 is a regulator of the alternative pathway of complement activation. Eur J Immunol 23(6):1381\u20131384","journal-title":"Eur J Immunol"},{"issue":"7","key":"28_CR12","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1084\/jem.188.7.1321","volume":"188","author":"RJ Quigg","year":"1998","unstructured":"Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM (1998) Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med 188(7):1321\u20131331","journal-title":"J Exp Med"},{"issue":"16","key":"28_CR13","doi-asserted-by":"publisher","first-page":"10837","DOI":"10.1073\/pnas.162350199","volume":"99","author":"T Wyss-Coray","year":"2002","unstructured":"Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E (2002) Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer\u2019s mice. Proc Natl Acad Sci U S A 99(16):10837\u201310842","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"28_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.visres.2007.07.025","volume":"48","author":"JD Ding","year":"2008","unstructured":"Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C (2008) Targeting age-related macular degeneration with Alzheimer\u2019s disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vision Res 48(3):339\u2013345","journal-title":"Vision Res"},{"issue":"18","key":"28_CR15","doi-asserted-by":"publisher","first-page":"11830","DOI":"10.1073\/pnas.192203399","volume":"99","author":"LV Johnson","year":"2002","unstructured":"Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH (2002) The Alzheimer\u2019s A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A 99(18):11830\u201311835","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28_CR16","unstructured":"Ding JD, Kelly U, Smith SG, Groelle M, Bowes Rickman C (2011) Development and characterization of humanized complement factor H (CFH) transgenic mice. Association for Research in Vision and Ophthalmology:Abstract 958"},{"issue":"11","key":"28_CR17","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1167\/iovs.09-4457","volume":"51","author":"RL Ufret-Vincenty","year":"2010","unstructured":"Ufret-Vincenty RL, Aredo B, Liu X, McMahon A, Chen PW, Sun H, Niederkorn JY, Kedzierski W (2010) Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings. Invest Ophthal Vis Sci 51(11):5878\u20135887","journal-title":"Invest Ophthal Vis Sci"},{"issue":"33","key":"28_CR18","doi-asserted-by":"publisher","first-page":"11900","DOI":"10.1073\/pnas.0503015102","volume":"102","author":"G Malek","year":"2005","unstructured":"Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C (2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A 102(33):11900\u201311905","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"28_CR19","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.1073\/pnas.1100901108","volume":"108","author":"JD Ding","year":"2011","unstructured":"Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M, Mace BE, Sullivan P, Jamison JA, Kelly U, Harrabi O, Bollini SS, Dilley J, Kobayashi D, Kuang B, Li W, Pons J, Lin JC, Rickman CB (2011) Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci U S A 108(28):E279\u2013E287","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Advances in Experimental Medicine and Biology","Retinal Degenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4614-3209-8_28","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T22:29:31Z","timestamp":1675808971000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4614-3209-8_28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9781461432081","9781461432098"],"references-count":19,"URL":"https:\/\/doi.org\/10.1007\/978-1-4614-3209-8_28","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"25 March 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}