{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:03:33Z","timestamp":1794441813368,"version":"4.9.1"},"publisher-location":"New York, NY","reference-count":238,"publisher":"Springer New York","isbn-type":[{"value":"9781461461104","type":"print"},{"value":"9781461461111","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-4614-6111-1_3","type":"book-chapter","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T08:30:37Z","timestamp":1362558637000},"page":"45-80","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Genetic Determinants of Susceptibility to Mycobacterial Infections: IRF8, A New Kid on the Block"],"prefix":"10.1007","author":[{"given":"S.","family":"Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"3_CR1","first-page":"283","volume":"13","author":"EL Korenromp","year":"2009","unstructured":"Korenromp EL, Bierrenbach AL, Williams BG, Dye C (2009) The measurement and estimation of tuberculosis mortality. Int J Tuberc Lung Dis 13:283\u2013303","journal-title":"Int J Tuberc Lung Dis"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/S0140-6736(09)60331-7","volume":"373","author":"A Wright","year":"2009","unstructured":"Wright A, Zignol M, VanDeun A, Falzon D, Gerdes SR, Fledman K, Hoffner S, Drobnniewski F, Barrera L, van Soolingen D, Boulabhal F, Paramasivan CN, Kam KM, Mitarai S, Nunn P, Raviglione M (2009) Epidemiology of anti-tuberculosis drug resistance 2002\u20132007: an updated analysis of the Global Project on Anti-tuberculosis Drug Resistance Surveillance. Lancet 373:1861\u20131873","journal-title":"Lancet"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/nrmicro1050","volume":"2","author":"P Onyebujoh","year":"2004","unstructured":"Onyebujoh P, Rook GA (2004) Focus: tuberculosis. Nat Rev Microbiol 2:930\u2013932","journal-title":"Nat Rev Microbiol"},{"key":"3_CR4","first-page":"225","volume":"82","author":"World Health Organization","year":"2007","unstructured":"World Health Organization (2007) Global leprosy situation. Wkly Epidemiol Rec 82:225\u2013232","journal-title":"Wkly Epidemiol Rec"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.jaci.2008.10.037","volume":"122","author":"S Al-Muhsen","year":"2008","unstructured":"Al-Muhsen S, Casanova JL (2008) The genetic heterogeneity of Mendelian susceptibility to mycobacterial diseases. J Allerg Clin Immunol 122:1043\u20131051","journal-title":"J Allerg Clin Immunol"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1146\/annurev.immunol.22.012703.104635","volume":"22","author":"RJ North","year":"2004","unstructured":"North RJ, Jung YJ (2004) Immunity to tuberculosis. Ann Rev Immunol 22:599\u2013623","journal-title":"Ann Rev Immunol"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/S1286-4579(00)01310-1","volume":"2","author":"M Levin","year":"2000","unstructured":"Levin M, Newport M (2000) Inherited predisposition to mycobacterial infection: historical considerations. Microbes Infect 2:1549\u20131552","journal-title":"Microbes Infect"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nrmicro2128","volume":"7","author":"RS Flanagan","year":"2009","unstructured":"Flanagan RS, Cosio G, Grinstein S (2009) Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol 7:355\u2013366","journal-title":"Nat Rev Microbiol"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/35085034","volume":"2","author":"DG Russell","year":"2001","unstructured":"Russell DG (2001) Mycobacterium tuberculosis: here today, and here tomorrow. Nat Rev Mol Cell Biol 2:569\u2013577","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2010.02.030","volume":"140","author":"M Behr","year":"2010","unstructured":"Behr M, Schurr E, Gros P (2010) Screening for responses to a vile visitor. Cell 140:615\u2013618","journal-title":"Cell"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/ni.1654","volume":"9","author":"H Gan","year":"2008","unstructured":"Gan H, Lee J, Ren F, Chen M, Kornfeld H, Remold HG (2008) Mycobacterium tuberculosis blocks cross-linking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nat Immunol 9:1189\u20131197","journal-title":"Nat Immunol"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-642-00302-8_8","volume":"335","author":"V Deretic","year":"2009","unstructured":"Deretic V, Delgado M, Vergne I, Master S, De Haro S, Ponpual M, Singh S (2009) Autophagy in immunity against Mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol 335:169\u2013188","journal-title":"Curr Top Microbiol Immunol"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nm.1928","volume":"15","author":"C Jagannath","year":"2009","unstructured":"Jagannath C, Lindsey DR, Dhandayuthapani S, Xu Y, Hunter RL, Elissa NT (2009) Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med 15:267\u2013276","journal-title":"Nat Med"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.cell.2010.02.012","volume":"140","author":"D Kumar","year":"2010","unstructured":"Kumar D, Nath L, Kamal MA, Varshney A, Jain A, Singh S, Rao KV (2010) Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140:731\u2013742","journal-title":"Cell"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1084\/jem.20080767","volume":"205","author":"M Chen","year":"2008","unstructured":"Chen M, Divangahi M, Gan H, Shin DSJ, Hong S, Lee DM, Serhan CN, Behar SM, Remold HG (2008) Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J Exp Med 205:2791\u20132801","journal-title":"J Exp Med"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/ni.1758","volume":"10","author":"M Divangahi","year":"2009","unstructured":"Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar S, Remold HG (2009) Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nat Immunol 10:899\u2013908","journal-title":"Nat Immunol"},{"key":"3_CR17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","volume":"140","author":"DM Tobin","year":"2010","unstructured":"Tobin DM, Vary JC Jr, Ray JP, Walsh GS, Dunstan SJ, Bang ND, Hagge DA, Khadge S, King MC, Hawn, TR, Moens CB, Ramakrishnan L (2010) The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell 140:717\u2013730","journal-title":"Cell"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.cell.2007.05.059","volume":"129","author":"N Van der Wel","year":"2007","unstructured":"Van der Wel N, Hava D, Houben D, Fluitsma D, van Zon M, Pierson J, Brenner M, Peters PJ (2007) M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129:1287\u20131298","journal-title":"Cell"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1086\/432519","volume":"77","author":"DP Kwiatkowski","year":"2005","unstructured":"Kwiatkowski DP (2005) How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 77:171\u2013192","journal-title":"Am J Hum Genet"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1146\/annurev.genet.40.110405.090546","volume":"40","author":"AV Hill","year":"2006","unstructured":"Hill AV (2006) Aspects of genetic susceptibility to human infectious diseases. Annu Rev Genet 40:469\u2013486","journal-title":"Annu Rev Genet"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/sj.emboj.7601558","volume":"26","author":"JL Casanova","year":"2007","unstructured":"Casanova JL, Abel L (2007) Human genetics of infectious diseases: a unified theory. EMBO J 26:915\u2013922","journal-title":"EMBO J"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev.genom.8.080706.092315","volume":"8","author":"A Fortin","year":"2007","unstructured":"Fortin A, Casanova JL, Abel L, Gros P (2007) Host genetics of mycobacterial diseases in mice and men: the path from BCG-osis to tuberculosis. Annu Rev Genomics Hum Genet 8:163\u2013192","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"27","key":"3_CR23","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1056\/NEJMe0910690","volume":"361","author":"E Schurr","year":"2009","unstructured":"Schurr E, Gros P (2009) A common genetic fingerprint in leprosy and Crohn disease. N Engl J Med 361(27):2666\u20132668","journal-title":"N Engl J Med"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nrg1832","volume":"7","author":"M Lipoldova","year":"2006","unstructured":"Lipoldova M, Demant P (2006) Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat Rev Genet 7:294\u2013305","journal-title":"Nat Rev Genet"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.immunol.26.021607.090304","volume":"28","author":"S Vidal","year":"2008","unstructured":"Vidal S, Malo D, Marquis JF, Gros P (2008) Forward genetic dissection of immunity to infection in the mouse. Annu Rev Immunol 28:81\u2013132","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"3_CR26","doi-asserted-by":"publisher","first-page":"e1001169","DOI":"10.1371\/journal.ppat.1001169","volume":"6","author":"T Di Pietrantonio","year":"2010","unstructured":"Di Pietrantonio T, Hernandez C, Girard M, Verville A, Orlova M, Belley A, Behr MA, Loredo-Osti JC, Schurr E (2010) Strain-specific differences in the genetic control of two closely related mycobacteria. PLoS Pathog 6(10):e1001169","journal-title":"PLoS Pathog"},{"issue":"5","key":"3_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00335-008-9114-0","volume":"19","author":"E Richer","year":"2008","unstructured":"Richer E, Qureshi ST, Vidal SM, Malo D (2008) Chemical mutagenesis: a new strategy against the global threat of infectious diseases. Mamm Genome 19(5):309\u2013317","journal-title":"Mamm Genome"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1128\/IAI.71.1.254-259.2003","volume":"71","author":"CJ Riendeau","year":"2003","unstructured":"Riendeau CJ, Kornfeld H (2003) THP-1 cell apoptosis in response to mycobacterial infection. Infect Immun 71:254\u2013259","journal-title":"Infect Immun"},{"key":"3_CR29","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.4049\/jimmunol.160.11.5448","volume":"160","author":"M Oddo","year":"1998","unstructured":"Oddo M, Renno T, Attinger A, Bakker T, MacDonald HR, Meylan PRA (1998) Fas-ligand induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis. J Immunol 160:5448\u20135454","journal-title":"J Immunol"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","volume":"119","author":"M Gutierrez","year":"2004","unstructured":"Gutierrez M, Master S, Singh S, Taylor G, Colombo M, Deretic V (2004) Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119:753\u2013766","journal-title":"Cell"},{"key":"3_CR31","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1126\/science.1129577","volume":"313","author":"SB Singh","year":"2006","unstructured":"Singh SB, Davis AS, Taylor GA, Deretic V (2006) Human IRGM induces autophagy to eliminate intracellular Mycobacteria. Science 313:1438\u20131441","journal-title":"Science"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nature03419","volume":"434","author":"H Pan","year":"2005","unstructured":"Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I (2005) Ipr1 gene mediates innate immunity to tuberculosis. Nature 434:767\u2013772","journal-title":"Nature"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","volume":"178","author":"AM Cooper","year":"1993","unstructured":"Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM (1993) Disseminated tuberculosis in interferon-g gene disrupted mice. J Exp Med 178:2243\u20132247","journal-title":"J Exp Med"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1084\/jem.186.1.39","volume":"186","author":"AM Cooper","year":"1997","unstructured":"Cooper AM, Magram J, Ferrante J, Orme IM (1997) Interleukin-12 is crucial for the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 186:39\u201345","journal-title":"J Exp Med"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0140-6736(95)91421-8","volume":"346","author":"JL Casanova","year":"1995","unstructured":"Casanova JL, Jouanguy E, Lamhamedi S, Blanche S, Fischer A (1995) Immunological conditions of children with BCG disseminated infection. Lancet 346:581","journal-title":"Lancet"},{"key":"3_CR36","doi-asserted-by":"publisher","first-page":"D514","DOI":"10.1093\/nar\/gki033","volume":"33","author":"A Hamosh","year":"2005","unstructured":"Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA (2005) Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucl Acids Res 33:D514\u2013D517","journal-title":"Nucl Acids Res"},{"key":"3_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1359-6101(00)00010-1","volume":"11","author":"SE Dorman","year":"2000","unstructured":"Dorman SE, Holland SM (2000) Interferon-gamma and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev 11:321\u2013333","journal-title":"Cytokine Growth Factor Rev"},{"key":"3_CR38","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0140-6736(95)90059-4","volume":"345","author":"M Levin","year":"1995","unstructured":"Levin M, Newport MJ, D\u2019Souza S, Kalabalikis P, Brown IN et al (1995) Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene. Lancet 345:79\u201383","journal-title":"Lancet"},{"key":"3_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1399-0004.2010.01510.x","volume":"79","author":"LE Cottle","year":"2011","unstructured":"Cottle LE (2011) Mendelian susceptibility to mycobacterial disease. Clin Genet 79:17\u201322","journal-title":"Clin Genet"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1084\/jem.20052302","volume":"202","author":"A Alcais","year":"2005","unstructured":"Alcais A, Fieschi C, Abel L, Casanova JL (2005) Tuberculosis in children and adults: two distinct genetic diseases. J Exp Med 202:1617\u20131621","journal-title":"J Exp Med"},{"key":"3_CR41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CDLI.8.1.133-137.2001","volume":"8","author":"LM Allende","year":"2001","unstructured":"Allende LM, Lopez-Goyanes A, Paz-Artal E, Corell A, Garcia-Perez MA et al (2001) A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. Clin Diagn Lab Immunol 8:133\u2013137","journal-title":"Clin Diagn Lab Immunol"},{"key":"3_CR42","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1086\/375587","volume":"37","author":"I Caragol","year":"2003","unstructured":"Caragol I, Raspall M, Fieschi C, Feinberg J, Larrosa MN et al (2003) Clinical tuberculosis in 2 of 3 siblings with interleukin-12 receptor beta1 deficiency. Clin Infect Dis 37:302\u2013306","journal-title":"Clin Infect Dis"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1172\/JCI119810","volume":"100","author":"E Jouanguy","year":"1997","unstructured":"Jouanguy E, Lamhamedi-Cherradi S, Altare F, Fondaneche MC, Tuerlinckx D et al (1997) Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J Clin Invest 100:2658\u20132664","journal-title":"J Clin Invest"},{"issue":"6","key":"3_CR44","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1086\/427879","volume":"40","author":"N \u00d6zbek","year":"2005","unstructured":"\u00d6zbek N, Fieschi C, Yilmaz BT, De Beaucoudrey L, Bikmaz YE, Casanova JL (2005) Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis. Clin Infect Dis 40(6):e55\u2013e58","journal-title":"Clin Infect Dis"},{"key":"3_CR45","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1086\/422534","volume":"190","author":"N Remus","year":"2004","unstructured":"Remus N, El Baghdadi J, Fieschi C, Feinberg J, Quintin T et al (2004) Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. J Infect Dis 190:580\u2013587","journal-title":"J Infect Dis"},{"key":"3_CR46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1146\/annurev.immunol.20.081501.125851","volume":"20","author":"JL Casanova","year":"2002","unstructured":"Casanova JL, Abel L (2002) Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol 20:581\u2013620","journal-title":"Annu Rev Immunol"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1086\/425021","volume":"190","author":"C MacLennan","year":"2004","unstructured":"MacLennan C, Fieschi C, Lammas DA, Picard C, Dorman SE et al (2004) Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans. J Infect Dis 190:1755\u20131757","journal-title":"J Infect Dis"},{"key":"3_CR48","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1172\/JCI4950","volume":"102","author":"F Altare","year":"1998","unstructured":"Altare F, Lammas D, Revy P, Jouanguy E, Doffinger R et al (1998) Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection. J Clin Invest 102:2035\u20132040","journal-title":"J Clin Invest"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1126\/science.280.5368.1435","volume":"280","author":"R de Jong","year":"1998","unstructured":"de Jong R, Altare F, Haagen IA, Elferink DG, Boer T et al (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435\u20131438","journal-title":"Science"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1182\/blood-2004-02-0584","volume":"104","author":"C Fieschi","year":"2004","unstructured":"Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J et al (2004) A novel form of complete IL-12\/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors. Blood 104:2095\u20132101","journal-title":"Blood"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10875-006-7830-3","volume":"26","author":"O Sanal","year":"2006","unstructured":"Sanal O, Turul T, De Boer T, Van de Vosse E, Yalcin I et al (2006) Presentation of interleukin-12\/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections. J Clin Immunol 26:1\u20136","journal-title":"J Clin Immunol"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1056\/NEJM199612263352604","volume":"335","author":"E Jouanguy","year":"1996","unstructured":"Jouanguy E, Altare F, Lamhamedi S, Revy P, Emile JF et al (1996) Interferon-gamma receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N Engl J Med 335:1956\u20131961","journal-title":"N Engl J Med"},{"key":"3_CR53","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1056\/NEJM199612263352602","volume":"335","author":"MJ Newport","year":"1996","unstructured":"Newport MJ, Huxley CM, Huston S, Hawrylowicz CM, Oostra BA et al (1996) A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 335:1941\u20131949","journal-title":"N Engl J Med"},{"key":"3_CR54","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1172\/JCI2901","volume":"101","author":"SE Dorman","year":"1998","unstructured":"Dorman SE, Holland SM (1998) Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest 101:2364\u20132369","journal-title":"J Clin Invest"},{"issue":"8","key":"3_CR55","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1371\/journal.pgen.0020131","volume":"2","author":"A Chapgier","year":"2006","unstructured":"Chapgier A, Boisson-Dupuis S, Jouanguy E, Vogt G, Feinberg J et al (2006) Novel STAT1 alleles in otherwise healthy patients with Mycobacterial disease. PLoS Genet 2(8):e131","journal-title":"PLoS Genet"},{"key":"3_CR56","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1126\/science.1061154","volume":"293","author":"S Dupuis","year":"2001","unstructured":"Dupuis S, Dargemont C, Fieschi C, Thomassin N, Rosenzweig S et al (2001) Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science 293:300\u2013303","journal-title":"Science"},{"key":"3_CR57","doi-asserted-by":"publisher","first-page":"5895","DOI":"10.1182\/blood-2010-04-280586","volume":"116","author":"XF Kong","year":"2010","unstructured":"Kong XF, Ciancanelli M, Al-Haijar S, Alsina L, Zumwalt T, Bustamante J, Feinberg J, Audry M, Prando C, Bryant V, Kreins A, Bogunovic D, Halwani R, Zhang XX, Abel L, Chaussabel D, Al-Muhsen S, Casanova JL, Boisson-Dupuis S (2010) A novel form of STAT1 deficiency impairing early but not late responses to interferon. Blood 116:5895\u201358906","journal-title":"Blood"},{"key":"3_CR58","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1084\/jem.20060085","volume":"203","author":"O Filipe-Santos","year":"2006","unstructured":"Filipe-Santos O, Bustamante J, Haverkamp MH, Vinolo E, Ku CL et al (2006) X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. J Exp Med 203:1745\u20131759","journal-title":"J Exp Med"},{"key":"3_CR59","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/ni.1992","volume":"12","author":"J Bustamante","year":"2011","unstructured":"Bustamante J, Arias AA, Vogt G, Picard C, Galicia LB, Prando C, Grant AV, Marchal CC, Hubeau M, Chapgier A, de Beaucoudrey L, Puel A, Feinberg J, Valinetz E, Janniere L, Besse C, Boland A, Brisseau JM, Blanche S, Lortholary O, Fieschi C, Emile JF, Boisson-Dupuis S, Al-Muhsen S, Woda B, Newburger PE, Condino-Neto A, Dinauer MC, Abel L, Casanova JL (2011) Germline CYBB mutations that selectively affect macrophages and kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol 12:213\u2013221","journal-title":"Nat Immunol"},{"key":"3_CR60","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0966-842X(01)02098-4","volume":"9","author":"JR Forbes","year":"2001","unstructured":"Forbes JR, Gros P (2001) Divalent metal transport by Nramp proteins at the interface of host:parasite interactions. Trends Microbiol 9:397\u2013403","journal-title":"Trends Microbiol"},{"key":"3_CR61","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0092-8674(93)90135-D","volume":"73","author":"SM Vidal","year":"1993","unstructured":"Vidal SM, Malo D, Vogan K, Skamene E, Gros P (1993) Natural resistance to infection with intracellular parasites:Isolation of a candidate for Bcg. Cell 73:469\u2013486","journal-title":"Cell"},{"key":"3_CR62","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1084\/jem.182.3.655","volume":"182","author":"S Vidal","year":"1995","unstructured":"Vidal S, Tremblay M, Govoni G, Sebastiani G, Malo D, Olivier M, Skamene E, Jothy S, Gros P (1995) The Ity\/Lsh\/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp 1 gene. J Exp Med 182:655\u2013666","journal-title":"J Exp Med"},{"key":"3_CR63","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1084\/jem.185.4.717","volume":"185","author":"S Gruenheid","year":"1997","unstructured":"Gruenheid S, Pinner E, Desjardins M, Gros P (1997) Natural resistance to infection with intracellular parasites: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med 185:717\u2013730","journal-title":"J Exp Med"},{"key":"3_CR64","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1084\/jem.192.9.1237","volume":"192","author":"N Jabado","year":"2000","unstructured":"Jabado N, Jankowsky A, Dougaparsad S, Picard V, Grinstein S, Gros P (2000) Natural resistance to intracellular infections: Nramp1 functions as a pH-dependent Manganese transporter at the phagosomal membrane. J Exp Med 192:1237\u20131248","journal-title":"J Exp Med"},{"key":"3_CR65","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1084\/jem.188.2.351","volume":"188","author":"DJ Hackam","year":"1998","unstructured":"Hackam DJ, Rotstein OD, Zhang WJ, Gruenheid S, Gros P, Grinstein S (1998) Host resistance to intracellular infections: mutation at Nramp1 impair phagosomal acidification. J Exp Med 188:351\u2013364","journal-title":"J Exp Med"},{"key":"3_CR66","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1074\/jbc.M105508200","volume":"277","author":"P Cuellar-Mata","year":"2002","unstructured":"Cuellar-Mata P, Jabado N, Liu J, Finlay BB, Gros P, Grinstein S (2002) Nramp1 modifies the fusion of Salmonella typhimurium containing vacuoles with cellular endomembranes in macrophages. J Biol Chem 277:2258\u20132265","journal-title":"J Biol Chem"},{"key":"3_CR67","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/sj.gene.6364346","volume":"7","author":"K Turcotte","year":"2006","unstructured":"Turcotte K, Loredo-Osti JC, Fortin P, Schurr E, Morgan K, Gros P (2006) Complex genetic control of susceptibility to Mycobacterium bovis infection in wild-derived Mus spretus mice. Genes Immun 7:684\u2013687","journal-title":"Genes Immun"},{"key":"3_CR68","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1534\/genetics.107.075523","volume":"177","author":"V Sancho-Shimizu","year":"2007","unstructured":"Sancho-Shimizu V, Khan R, Mostowy S, Lariviere L, Wilkinson R, Riendeau N, Behr M, Malo D (2007) Molecular genetic analysis of two loci (Ity2 and Ity3) involved in the host response to infection with Salmonella typhimurium using congenic mice and expression profiling. Genetics 177:1125\u20131139","journal-title":"Genetics"},{"key":"3_CR69","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1084\/jem.20062606","volume":"204","author":"MF Roy","year":"2007","unstructured":"Roy MF, Riendeau N, B\u00e9dard C, H\u00e9lie P, Min-Oo G, Turcotte K, Gros P, Canonne-Hergaux F, Malo D (2007) Pyruvate Kinase deficiency confers susceptibility to Salmonella in mice. J Exp Med 204:2949\u20132961","journal-title":"J Exp Med"},{"key":"3_CR70","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.4049\/jimmunol.179.4.2467","volume":"179","author":"K Turcotte","year":"2007","unstructured":"Turcotte K, Gauthier S, Malo D, Tam M, Stevenson MM, Gros P (2007) Icsbp1\/Irf-8 is required for innate and adaptive immune responses against intracellular pathogens. J Immunol 179:2467\u20132476","journal-title":"J Immunol"},{"issue":"6","key":"3_CR71","doi-asserted-by":"publisher","first-page":"3757","DOI":"10.4049\/jimmunol.0802094","volume":"182","author":"JF Marquis","year":"2009","unstructured":"Marquis JF, LaCourse R, Ryan L, North RJ, Gros P (2009) Genetic and functional characterization of the Trl3 locus in defenses against tuberculosis. J Immunol 182(6):3757\u20133767","journal-title":"J Immunol"},{"key":"3_CR72","first-page":"277","volume-title":"The white plague; tuberculosis, man, and society","author":"RJ Dubos","year":"1952","unstructured":"Dubos RJ, Dubos J (1952) The white plague; tuberculosis, man, and society. Little Brown, Boston, p 277"},{"key":"3_CR73","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/oxfordjournals.aje.a112250","volume":"103","author":"AR Hinman","year":"1976","unstructured":"Hinman AR, Judd JM, Kolnik JP, Daitch PB (1976) Changing risks in tuberculosis. Am J Epidemiol 103:486\u2013497","journal-title":"Am J Epidemiol"},{"key":"3_CR74","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1378\/chest.100.3.678","volume":"100","author":"HL Rieder","year":"1991","unstructured":"Rieder HL, Kelly GD, Bloch AB, Cauthen GM, Snider DE Jr (1991) Tuberculosis diagnosed at death in the United States. Chest 100:678\u2013681","journal-title":"Chest"},{"key":"3_CR75","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJM199002153220702","volume":"322","author":"WW Stead","year":"1990","unstructured":"Stead WW, Senner JW, Reddick WT, Lofgren JP (1990) Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 322:422\u2013427","journal-title":"N Engl J Med"},{"key":"3_CR76","first-page":"28","volume":"32","author":"AG Motulsky","year":"1960","unstructured":"Motulsky AG (1960) Metabolic polymorphisms and the role of infectious diseases in human evolution. Hum Biol 32:28\u201362","journal-title":"Hum Biol"},{"key":"3_CR77","doi-asserted-by":"publisher","first-page":"13227","DOI":"10.1073\/pnas.94.24.13227","volume":"94","author":"AO Sousa","year":"1997","unstructured":"Sousa AO, Salem JI, Lee FK, Vercosa MC, Cruaud P, Bloom BR, Lagrange PH, David HL (1997) An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proc Natl Acad Sci U S A 94:13227\u201313232","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR78","first-page":"621","volume":"117","author":"GW Comstock","year":"1978","unstructured":"Comstock GW (1978) Tuberculosis in twins: a re-analysis of the Prophit survey. Am Rev Respir Dis 117:621\u2013624","journal-title":"Am Rev Respir Dis"},{"key":"3_CR79","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00335-010-9287-1","volume":"22","author":"A Alter","year":"2011","unstructured":"Alter A, Grant A, Abel L, Alcais A, Schurr E (2011) Leprosy as a genetic disease. Mamm Genome 22:19\u201331","journal-title":"Mamm Genome"},{"key":"3_CR80","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1600-065X.2010.00996.x","volume":"240","author":"FO Vannberg","year":"2011","unstructured":"Vannberg FO, Chapman SJ, Hill AV (2011) Human genetic susceptibility to intracellular pathogens. Immunol Rev 240:105\u2013116","journal-title":"Immunol Rev"},{"key":"3_CR81","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1056\/NEJM199803053381002","volume":"338","author":"R Bellamy","year":"1998","unstructured":"Bellamy R, Ruwende C, Corrah T, McAdam KPWJ, Whittle HC, Hill AVS (1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. New Engl J Med 338:640\u2013644","journal-title":"New Engl J Med"},{"key":"3_CR82","first-page":"3","volume":"10","author":"HT Li","year":"2006","unstructured":"Li HT, Zhang TT, Zhou YQ, Huang QH, Huang J (2006) SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis. Int J Tuberc Lung Dis 10:3\u201312","journal-title":"Int J Tuberc Lung Dis"},{"key":"3_CR83","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1086\/303012","volume":"67","author":"CM Greenwood","year":"2000","unstructured":"Greenwood CM, Fujiwara TM, Boothroyd LJ, Miller MA, Frappier D et al (2000) Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family. Am J Hum Genet 67:405\u2013416","journal-title":"Am J Hum Genet"},{"key":"3_CR84","doi-asserted-by":"publisher","first-page":"12183","DOI":"10.1073\/pnas.0503368102","volume":"102","author":"S Malik","year":"2005","unstructured":"Malik S, Abel L, Tooker H, Poon A, Simkin L et al (2005) Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci U S A 102:12183\u201312188","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR85","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1086\/513830","volume":"177","author":"L Abel","year":"1998","unstructured":"Abel L, Sanchez FO, Oberti J, Thuc NV, Hoa LV, Lap VD, Skamene E, Lagrange PH, Schurr E (1998) Susceptibility to leprosy is linked to the human NRAMP1 gene. J Infect Dis 177:133\u2013145","journal-title":"J Infect Dis"},{"key":"3_CR86","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1086\/315174","volume":"181","author":"A Alcais","year":"2000","unstructured":"Alcais A, Sanchez FO, Thuc NY, Lap VD, Oberti J, Lagrange PH, Schurr E, Abel L (2000) Granulomatous reaction to intradermal injection of lepromin (Mitsuda Reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. J Infect Dis 181:302\u2013308","journal-title":"J Infect Dis"},{"key":"3_CR87","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/sj.gene.6364281","volume":"7","author":"Y Stienstra","year":"2006","unstructured":"Stienstra Y, van der Werf TS, Oosterom E, Nolte IM, van der Graaf WT et al (2006) Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism. Genes Immun 7:185\u2013189","journal-title":"Genes Immun"},{"key":"3_CR88","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/sj.gene.6364435","volume":"8","author":"CJ Gallant","year":"2007","unstructured":"Gallant CJ, Malik S, Jabado N, Cellier M, Simkin L, Finlay BB, Graviss EA, Gros P, Musser JM, Schurr E (2007) Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that pre-disposes to increased risk of pediatric tuberculosis disease. Genes Immun 8:691\u2013698","journal-title":"Genes Immun"},{"key":"3_CR89","doi-asserted-by":"publisher","first-page":"10364","DOI":"10.1073\/pnas.0603340103","volume":"103","author":"K Tosh","year":"2006","unstructured":"Tosh K, Campbell SJ, Fielding K, Sillah J, Bah B et al (2006) Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Acad Sci U S A 103:10364\u201310368","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3_CR90","doi-asserted-by":"publisher","first-page":"e16317","DOI":"10.1371\/journal.pone.0016317","volume":"6","author":"KY King","year":"2011","unstructured":"King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA (2011) Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS ONE 6(1):e16317","journal-title":"PLoS ONE"},{"key":"3_CR91","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1126\/science.1088063","volume":"302","author":"JD MacMicking","year":"2003","unstructured":"MacMicking JD, Taylor GA, McKinney JD (2003) Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302:654\u2013659","journal-title":"Science"},{"key":"3_CR92","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.4049\/jimmunol.172.2.1163","volume":"172","author":"CG Feng","year":"2004","unstructured":"Feng CG, Collazo-Custodio CM, Eckhaus M, Hieny S, Belkaid Y et al (2004) Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol 172:1163\u20131168","journal-title":"J Immunol"},{"key":"3_CR93","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4049\/jimmunol.176.2.1090","volume":"176","author":"JC Delgado","year":"2006","unstructured":"Delgado JC, Baena A, Thim S, Goldfeld AE (2006) Aspartic acid homozygosity at codon 57 of HLA-DQ beta is associated with susceptibility to pulmonary tuberculosis in Cambodia. J Immunol 176:1090\u20131097","journal-title":"J Immunol"},{"key":"3_CR94","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1001\/jama.279.3.226","volume":"279","author":"AE Goldfeld","year":"1998","unstructured":"Goldfeld AE, Delgado JC, Thim S, Bozon MV, Uglialoro AM et al (1998) Association of an HLA-DQ allele with clinical tuberculosis. JAMA 279:226\u2013228","journal-title":"JAMA"},{"key":"3_CR95","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1093\/hmg\/ddl193","volume":"15","author":"P Verdu","year":"2006","unstructured":"Verdu P, Barreiro LB, Patin E, Gessain A, Cassar O et al (2006) Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles. Hum Mol Genet 15:2650\u20132658","journal-title":"Hum Mol Genet"},{"key":"3_CR96","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1385\/IR:28:2:109","volume":"28","author":"N Remus","year":"2003","unstructured":"Remus N, Alcais A, Abel L (2003) Human genetics of common mycobacterial infections. Immunol Res 28:109\u2013129","journal-title":"Immunol Res"},{"key":"3_CR97","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1371\/journal.pmed.0030020","volume":"3","author":"LB Barreiro","year":"2006","unstructured":"Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H et al (2006) Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med 3:e20","journal-title":"PLoS Med"},{"key":"3_CR98","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.humimm.2011.04.004","volume":"72","author":"K Kobayashi","year":"2011","unstructured":"Kobayashi K, Yuliwulandari R, Yanai H, Lien LT, Hang NT, Hijikata M, Keicho N, Tokunaga K (2011) Association of CD209 polymorphisms with tuberculosis in an Indonesian population. Hum Immunol 72:741\u2013745","journal-title":"Hum Immunol"},{"key":"3_CR99","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1084\/jem.20050126","volume":"202","author":"PO Flores-Villanueva","year":"2005","unstructured":"Flores-Villanueva PO, Ruiz-Morales JA, Song CH, Flores LM, Jo EK et al (2005) A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. J Exp Med 202:1649\u20131658","journal-title":"J Exp Med"},{"key":"3_CR100","doi-asserted-by":"crossref","unstructured":"Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schroder AK, Schaff B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hartzmann A, Fleischer D, Heussen N, Kleines M, Rink L Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in lack of TLR1 cell surface expression. J Leukoc Biol 90:377\u2013388","DOI":"10.1189\/jlb.0409233"},{"key":"3_CR101","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1164\/rccm.200710-1554OC","volume":"178","author":"GS Cooke","year":"2008","unstructured":"Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV (2008) Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. Am J Respir Crit Care Med 178:203\u2013207","journal-title":"Am J Respir Crit Care Med"},{"key":"3_CR102","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ejhg.2011.1","volume":"19","author":"LA Adams","year":"2011","unstructured":"Adams LA, Moller M, Nebel A, Schreiber S, van der Merwe L, van Helden PD, Hoal EG (2011) Polymorphisms in MCR3 promotor and CTSZ 3\u2019UTR are associated with tuberculosis susceptibility. Eur J Hum Genet 19:676\u2013681","journal-title":"Eur J Hum Genet"},{"key":"3_CR103","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.humimm.2011.02.016","volume":"72","author":"AR Baker","year":"2011","unstructured":"Baker AR, Zalwango S, Malone LL, Igo RP, Qiu F, Nsereko M, Adams MD, Supelak P, Mayania-Kizza H, Boom WH, Stein CM (2011) Genetic susceptibility in tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Hum Immunol 72:426\u2013430","journal-title":"Hum Immunol"},{"key":"3_CR104","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1574-695X.2010.00735.x","volume":"60","author":"J Xiao","year":"2010","unstructured":"Xiao J, Sun L, Yan H, Jiao W, Miao Q, Feng W, Wu X, Gu Y, Jiao A, Guo Y, Peng X, Shen A (2010) Metaanalysis of P2X7 gene polymorphisms and tuberculosis susceptibility. FEMS Immunol Med Microbiol 60:165\u2013170","journal-title":"FEMS Immunol Med Microbiol"},{"key":"3_CR105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/hmg\/ddm378","volume":"17","author":"F Herb","year":"2008","unstructured":"Herb F, Thye T, Niemann S, Browne ENL, Chinbuah MA, Gyapong J, Osei Y, Owusu-Dabo E, Werz O, R\u00fcsch-Gerdes S, Horstmann RD, Meyer CG (2008) ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. Hum Mol Genet 17:1052\u20131060","journal-title":"Hum Mol Genet"},{"key":"3_CR106","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/S0140-6736(03)13491-5","volume":"361","author":"M Rossouw","year":"2003","unstructured":"Rossouw M, Nel HJ, Cooke GS, van Helden PD, Hoal EG (2003) Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene. Lancet 361:1871\u20131872","journal-title":"Lancet"},{"key":"3_CR107","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/sj.gene.6364189","volume":"6","author":"HW Tso","year":"2005","unstructured":"Tso HW, Ip WK, Chong WP, Tam CM, Chiang AK, Lau YL (2005) Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Genes Immun 6:358\u2013363","journal-title":"Genes Immun"},{"key":"3_CR108","doi-asserted-by":"publisher","first-page":"8005","DOI":"10.1073\/pnas.140201897","volume":"97","author":"R Bellamy","year":"2000","unstructured":"Bellamy R, Beyers N, McAdam KP, Ruwende C, Gie R et al (2000) Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. Proc Natl Acad Sci U S A 97:8005\u20138009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR109","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1084\/jem.20060269","volume":"203","author":"JE Baghdadi","year":"2006","unstructured":"Baghdadi JE, Orlova M, Alter A, Ranque B, Chentoufi M et al (2006) An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults. J Exp Med 203:1679\u20131684","journal-title":"J Exp Med"},{"key":"3_CR110","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/gene.2008.81","volume":"10","author":"S Mahasirimongkol","year":"2008","unstructured":"Mahasirimongkol S, Yanai H, Nishida N, Ridruechai C, Matsushita I, Ohashi J, Summanapan S, Yamada N, Moolphate S, Chuchotaworn C, Chaipraset A, Manosuthi W, Kantipong P, Kanitwittaya S, Sura T, Khusmith S, Tokunaga K, Sawanpanyalert P, Keicho N (2008) Genome-wide SNP-based linkage analysis of tuberculosis in Thais. Genes Immun 10:77\u201383","journal-title":"Genes Immun"},{"key":"3_CR111","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/gene.2010.26","volume":"11","author":"C Ridruechai","year":"2010","unstructured":"Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchottaworn C, Manosuthi W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S, Tokunaga K (2010) Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun 11:416\u2013422","journal-title":"Genes Immun"},{"key":"3_CR112","doi-asserted-by":"crossref","unstructured":"Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A, African TB Genetics Consortium, Welcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AV (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet 42:739\u2013741","DOI":"10.1038\/ng.639"},{"key":"3_CR113","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1084\/jem.183.3.1045","volume":"183","author":"E Medina","year":"1996","unstructured":"Medina E, North RJ (1996) Evidence inconsistent with a role for the Bcg gene (Nramp1) in resistance of mice to infection with virulent Mycobacterium tuberculosis. J Exp Med 183:1045\u20131051","journal-title":"J Exp Med"},{"key":"3_CR114","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1046\/j.1365-2567.1998.00419.x","volume":"93","author":"E Medina","year":"1998","unstructured":"Medina E, North RJ (1998) Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility complex haplotype and Nramp1 genotype. Immunology 93:270\u2013274","journal-title":"Immunology"},{"key":"3_CR115","doi-asserted-by":"publisher","first-page":"8560","DOI":"10.1073\/pnas.150227197","volume":"97","author":"I Kramnik","year":"2000","unstructured":"Kramnik I, Dietrich WF, Demant P, Bloom BR (2000) Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 97:8560\u20138565","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"3_CR116","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.4049\/jimmunol.179.10.6919","volume":"179","author":"BS Yan","year":"2007","unstructured":"Yan BS, Pichugin AV, Jobe O, Helming L, Eruslanov EB, Guti\u00e9rrez-Pabello JA et al (2007) Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Gu\u00e9rin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919\u20136932","journal-title":"J Immunol"},{"key":"3_CR117","doi-asserted-by":"publisher","first-page":"6138","DOI":"10.1128\/MCB.20.16.6138-6146.2000","volume":"20","author":"DB Bloch","year":"2000","unstructured":"Bloch DB, Nakajima A, Gulick T, Chiche JD, Orth D, de La Monte SM, Bloch KD (2000) Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol 20:6138\u20136146","journal-title":"Mol Cell Biol"},{"issue":"1","key":"3_CR118","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/gene.2008.68","volume":"10","author":"J Sissons","year":"2009","unstructured":"Sissons J, Yan BS, Pichugin AV, Kirby A, Daly MJ, Kramnik I (2009) Multigenic control of tuberculosis resistance: analysis of a QTL on mouse chromosome 7 and its synergism with sst1. Genes Immun 10(1):37\u201346","journal-title":"Genes Immun"},{"key":"3_CR119","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1054\/tuld.1999.0225","volume":"80","author":"BV Nikonenko","year":"2000","unstructured":"Nikonenko BV, Averbakh MM Jr, Lavebratt C, Schurr E, Apt AS (2000) Comparative analysis of mycobacterial infections in susceptible I\/St and resistant A\/Sn inbred mice. Tuberc Lung Dis 80:15\u201325","journal-title":"Tuberc Lung Dis"},{"key":"3_CR120","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1086\/314843","volume":"180","author":"C Lavebratt","year":"1999","unstructured":"Lavebratt C, Apt AS, Nikonenko BV, Schalling M, Schurr E (1999) Severity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9. J Infect Dis 180:150\u2013155","journal-title":"J Infect Dis"},{"key":"3_CR121","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1128\/IAI.71.1.126-131.2003","volume":"71","author":"F Sanchez","year":"2003","unstructured":"Sanchez F, Radaeva TV, Nikonenko BV, Persson AS, Sengul S et al (2003) Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice. Infect Immun 71:126\u2013131","journal-title":"Infect Immun"},{"key":"3_CR122","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/sj.gene.6364249","volume":"6","author":"AK Kahler","year":"2005","unstructured":"Kahler AK, Persson AS, Sanchez F, Kallstrom H, Apt AS et al (2005) A new coding mutation in the Tnf-alpha leader sequence in tuberculosis-sensitive I\/St mice causes higher secretion levels of soluble TNF-alpha. Genes Immun 6:620\u2013627","journal-title":"Genes Immun"},{"key":"3_CR123","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/sj.gene.6363712","volume":"1","author":"LM Mitsos","year":"2000","unstructured":"Mitsos LM, Cardon L, Fortin A, Ryan L, Lacourse R, North RJ, Gros P (2000) Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun 1:467\u2013477","journal-title":"Genes Immun"},{"key":"3_CR124","doi-asserted-by":"publisher","first-page":"6610","DOI":"10.1073\/pnas.1031727100","volume":"100","author":"L Mitsos","year":"2003","unstructured":"Mitsos L, Cardon LR, Ryan L, Lacourse R, North RJ, Gros P (2003) Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs. Proc Natl Acad Sci U S A 100:6610\u20136615","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3_CR125","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1128\/IAI.00369-07","volume":"76","author":"JF Marquis","year":"2008","unstructured":"Marquis JF, Nantel A, La Course R, Ryan L, North RJ, Gros P (2008) Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis. Infect Immun 76(1):78\u201388","journal-title":"Infect Immun"},{"key":"3_CR126","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/297506a0","volume":"297","author":"E Skamene","year":"1982","unstructured":"Skamene E, Gros P, Forget A, Kongshavn PA, St-Charles C, Taylor BA (1982) Genetic regulation of resistance to intracellular pathogens. Nature 297:506\u2013509","journal-title":"Nature"},{"key":"3_CR127","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1084\/jem.20042170","volume":"201","author":"K Turcotte","year":"2005","unstructured":"Turcotte K, Gauthier S, Tuite A, Mullick A, Malo D, Gros P (2005) A mutation in the Icsbp\/IRF-8 gene causes susceptibility to infections and a CML-like syndrome in BXH-2 mice. J Exp Med 201:881\u2013890","journal-title":"J Exp Med"},{"key":"3_CR128","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1182\/blood-2003-06-1852","volume":"103","author":"K Turcotte","year":"2004","unstructured":"Turcotte K, Gauthier S, Mitsos LM, Shustik C, Copeland NG, Jenkins NA, Fournet JC, Jolicoeur P, Gros P (2004) Genetic control of Myeloproliferation in BXH-2 mice. Blood 103:2343\u20132350","journal-title":"Blood"},{"key":"3_CR129","doi-asserted-by":"publisher","first-page":"34997","DOI":"10.1074\/jbc.M204232200","volume":"277","author":"H Bowen","year":"2002","unstructured":"Bowen H, Biggs TE, Phillpis E, Baker ST, Perry VH, Mann DA, Barton CH (2002) c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promotor. J Biol Chem 277:34997\u201335006","journal-title":"J Biol Chem"},{"key":"3_CR130","doi-asserted-by":"publisher","first-page":"44025","DOI":"10.1074\/jbc.M307954200","volume":"278","author":"M Alter-Koltunoff","year":"2003","unstructured":"Alter-Koltunoff M, Ehrlich S, Dror N, Azriel A, Eilers M, Hauser H et al (2003) Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1 and Miz-1. J Biol Chem 278:44025\u201344032","journal-title":"J Biol Chem"},{"key":"3_CR131","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1074\/jbc.M707704200","volume":"283","author":"M Alter-Koltunoff","year":"2008","unstructured":"Alter-Koltunoff M, Goren S, Nousbeck J, Feng CG, Ozato K, Azriel A, Levi BZ (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem 283:2724\u20132733","journal-title":"J Biol Chem"},{"issue":"5","key":"3_CR132","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.4049\/jimmunol.0800680","volume":"182","author":"JF Marquis","year":"2009","unstructured":"Marquis JF, LaCourse R, Ryan L, North RJ, Gros P (2009) Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IRF8\/ICSBP. J Immunol 182(5):3008\u20133015","journal-title":"J Immunol"},{"key":"3_CR133","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1182\/blood-2007-07-100750","volume":"111","author":"P Tailor","year":"2008","unstructured":"Tailor P, Tamura T, Morse HC 3rd, Ozato K (2008) The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood 111:1942\u20131945","journal-title":"Blood"},{"key":"3_CR134","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.4049\/jimmunol.166.9.5448","volume":"166","author":"H Hochrein","year":"2001","unstructured":"Hochrein H, Shortman K, Vremec D, Scott B, Hertzog P, O\u2019Keefe M (2001) Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol 166:5448\u20135455","journal-title":"J Immunol"},{"key":"3_CR135","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","volume":"26","author":"T Tamura","year":"2008","unstructured":"Tamura T, Yanai H, Savitsky D, Taniguchi T (2008) The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26:535\u2013584","journal-title":"Annu Rev Immunol"},{"key":"3_CR136","doi-asserted-by":"publisher","first-page":"13957","DOI":"10.1074\/jbc.273.22.13957","volume":"272","author":"EA Eklund","year":"1998","unstructured":"Eklund EA, Jalava A, Kabar R (1998) PU.1, interferon regulatory factor 1, and interferon consensus sequence binding protein cooperate to increase gp91phox expression. J Biol Chem 272:13957\u201313965","journal-title":"J Biol Chem"},{"key":"3_CR137","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/jir.2005.25.770","volume":"25","author":"Y Kanno","year":"2005","unstructured":"Kanno Y, Levi BZ, Tamura T, Ozato K (2005) Immune cell-specific amplification of interferon signaling by the IRF-4\/8-PU.1 complex. J Interf Cytokine Res 25:770\u2013779","journal-title":"J Interf Cytokine Res"},{"key":"3_CR138","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.174.5.2573","volume":"174","author":"T Tamura","year":"2005","unstructured":"Tamura T, Tailor P, Yamaoka K, Kong HJ, Tsujimura H, O\u2019Shea JJ, Singh H, Ozato K (2005) IFN regulatory factor 4 and 8 govern dendritic cell subset development and their functional diversity. J Immunol 174:2573\u20132581","journal-title":"J Immunol"},{"key":"3_CR139","first-page":"1577","volume":"81","author":"K Schroder","year":"2007","unstructured":"Schroder K, Lichtinger M, Irvine KM, Brion K, Trieu A et al (2007) PU.1 and ICSBP control constitutive and IFNg-regulated Tlr9 expression in mouse macrophages J Leuk. Biol 81:1577\u20131590","journal-title":"Biol"},{"issue":"11","key":"3_CR140","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.1128\/IAI.01546-08","volume":"77","author":"A Fortier","year":"2009","unstructured":"Fortier A, Doiron K, Saleh M, Grinstein S, Gros P (2009) Restriction of Legionella pneumophila replication in macrophages requires concerted action of transcriptional regulators Irf1, Irf8, and the nod-like receptor Naip5. Infect Immun 77(11):4794\u20134805","journal-title":"Infect Immun"},{"key":"3_CR141","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1073\/pnas.97.1.91","volume":"97","author":"C Contursi","year":"2000","unstructured":"Contursi C, Wang IM, Gabriele L, Gadina M, O\u2019Shea J, Morse HC 3rd, Ozato K (2000) IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNg-responsive promotors in macrophages. Proc Natl Acad Sci U S A 97:91\u201396","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR142","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1084\/jem.186.9.1535","volume":"186","author":"NA Giese","year":"1997","unstructured":"Giese NA, Gabriele L, Doherty TM, Klinman DM, Tadesse-Heath L, Contursi C, Epstein SL, Morse HC 3rd (1997) Interferon consensus sequence binding protein, a transcription factors of the IFN regulatory factor family regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med 186:1535\u20131546","journal-title":"J Exp Med"},{"key":"3_CR143","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0014-5793(02)03556-1","volume":"531","author":"A Masumi","year":"2002","unstructured":"Masumi A, Tamaoki S, Wang IM, Ozaro K, Komuor K (2002) IRF-8\/ICSBP and IRF1 cooperatively stimulate mouse IL-12 promotor activity in macrophages. FEBS Lett 531:348\u2013353","journal-title":"FEBS Lett"},{"key":"3_CR144","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4049\/jimmunol.165.1.271","volume":"165","author":"IM Wang","year":"2000","unstructured":"Wang IM, Contursi C, Masumi A, Ma X, Trinchieri G, Ozato K (2000) An IFNg-inducible transcription factor, IFN consensus sequence binding protein (ICSBP) stimulates IL-12 p40 expression in macrophages. J Immunol 165:271\u2013279","journal-title":"J Immunol"},{"key":"3_CR145","doi-asserted-by":"publisher","first-page":"39372","DOI":"10.1074\/jbc.M306441200","volume":"278","author":"C Zhu","year":"2003","unstructured":"Zhu C, Rao K, Xiong H, Gagnidze K, Li F, Horvath K, Plevy S (2003) Activation of the murine interleukin 12 p40 promotor by functional interaction between NFAT and ICSBP. J Biol Chem 278:39372\u201339382","journal-title":"J Biol Chem"},{"key":"3_CR146","doi-asserted-by":"publisher","first-page":"55609","DOI":"10.1074\/jbc.M406565200","volume":"279","author":"J Liu","year":"2004","unstructured":"Liu J, Guan X, Tamura T, Ozato K, Ma X (2004) Synergistic activation of Interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. J Biol Chem 279:55609\u201355615","journal-title":"J Biol Chem"},{"key":"3_CR147","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.4049\/jimmunol.163.4.2000","volume":"163","author":"YM Kim","year":"1999","unstructured":"Kim YM, Kang HS, Paik SG, Pyun KH, Andersin KL, Torbett BE, Choi I (1999) Roles of IFN consensus sequence binding protein and PU.1 in regulation of IL-18 gene expression. J Immunol 163:2000\u20132007","journal-title":"J Immunol"},{"key":"3_CR148","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1084\/jem.185.5.921","volume":"185","author":"T Fehr","year":"1997","unstructured":"Fehr T, Schoedon G, Odermatt B, Holtschke T, Schneemann M et al (1997) Crucial role of interferon consensus sequence binding protein but neither of intereferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J Exp Med 185:921\u2013931","journal-title":"J Exp Med"},{"key":"3_CR149","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1128\/IAI.68.3.1408-1417.2000","volume":"68","author":"J Hein","year":"2000","unstructured":"Hein J, Kempf VA, Diebold J, Bucheler N, Preger S et al (2000) Interferon consensus sequence binding protein confers resistance against Yersinia enterocolitica. Infect Immun 68:1408\u20131417","journal-title":"Infect Immun"},{"key":"3_CR150","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1084\/jem.186.9.1523","volume":"186","author":"T Scharton-Kersten","year":"1997","unstructured":"Scharton-Kersten T, Contursi C, Masumi A, Sher A, Ozato K (1997) Interferon consensus binding protein-deficient mice display impaired resistance to intracellular infections due to primary defect in interleukin IL12p40 induction. J Exp Med 186:1523\u20131534","journal-title":"J Exp Med"},{"key":"3_CR151","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.4049\/jimmunol.168.5.2433","volume":"168","author":"J Ko","year":"2002","unstructured":"Ko J, Gendron-Fitzpatrick A, Splitter GA (2002) Susceptibility of IFN regulatory factor-1 and IFN consensus binding protein deficient mice to brucellosis. J Immunol 168:2433\u20132440","journal-title":"J Immunol"},{"key":"3_CR152","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/ncomms1311","volume":"2","author":"X Ouyang","year":"2011","unstructured":"Ouyang X, Zhang R, Yang J, Li Q, Qin L, Zhu C, Liu J, Ning H, Shin MS, Gupta M, Qi CF, He JC, Lira SA, Morse HC 3rd, Ozato K, Mayer L, Xiong H (2011) Transcripton factors IRF8 directs a silencing programme for TH17 cell differentiation. Nat Commun 2:314\u2013325","journal-title":"Nat Commun"},{"key":"3_CR153","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(00)00016-9","volume":"13","author":"T Tamura","year":"2000","unstructured":"Tamura T, Nagamura Inoue T, Shmeltzer Z, Kuwata T, Ozato K (2000) ICSBP directs bipotential progenitor cells to differentiate into mature macrophages. Immunity 13:155\u2013165","journal-title":"Immunity"},{"key":"3_CR154","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12026-008-8055-8","volume":"43","author":"H Wang","year":"2009","unstructured":"Wang H, Morse HC 3rd (2009) IRF8 regulates myeloid and B lymphocyte lineage diversification. Immunol Res 43:109\u2013117","journal-title":"Immunol Res"},{"key":"3_CR155","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1084\/jem.190.3.411","volume":"190","author":"L Gabriele","year":"1999","unstructured":"Gabriele L, Phung J, Fukumoto J, Segal D, Wang IM, Giannakakou P, Giese NA, Ozato K, Morse HC (1999) Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. J Exp Med 190:411\u2013421","journal-title":"J Exp Med"},{"key":"3_CR156","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1158\/0008-5472.CAN-10-2493","volume":"71","author":"X Hu","year":"2011","unstructured":"Hu X, Yang D, Zimmerman M, Liu F, Yang J, Kannan S, Burchert A, Szulc Z, Bielawska A, Ozato K, Bhalla K, Liu K (2011) IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. Cancer Res 71:2882\u20132891","journal-title":"Cancer Res"},{"key":"3_CR157","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1182\/blood-2005-01-0080","volume":"106","author":"T Tamura","year":"2005","unstructured":"Tamura T, Thotakura P, Tanaka TS, Ko MSH, Ozato K (2005) Identification of target genes and a unique cis element regulated by IRF8 in developing macrophages. Blood 106:1938\u20131947","journal-title":"Blood"},{"key":"3_CR158","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.170.3.1131","volume":"170","author":"H Tsujimura","year":"2003","unstructured":"Tsujimura H, Tamura T, Oxato K (2003) IFN consensus sequence binding protein\/IFN regulatory factor 8 drives development of type I IFN producing plasmacytoid dendritic cells. J Immunol 170:1131\u20131135","journal-title":"J Immunol"},{"key":"3_CR159","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1182\/blood-2002-04-1088","volume":"101","author":"J Aliberti","year":"2003","unstructured":"Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A (2003) Essential role for ICSBP in the in vivo development of murine CD8a+ dendritic cells. Blood 101:305\u2013310","journal-title":"Blood"},{"key":"3_CR160","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.20021263","volume":"196","author":"G Schiavoni","year":"2002","unstructured":"Schiavoni G, Mattei F, Sestili P, Borghi P, Venditti M, Morse HC 2nd, Belardelli F, Gabriele L (2002) ICSBP is essential for the development of mouse type I intereferon-producing cells and for the generation and activation of CD8a+ dendritic cells. J Exp Med 196:1415\u20131425","journal-title":"J Exp Med"},{"key":"3_CR161","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.4049\/jimmunol.181.7.4461","volume":"181","author":"V Vila-Del-Sol","year":"2008","unstructured":"Vila-Del-Sol V, Punzon C, Fresno M (2008) IFNg induced TNFa expression is regulated by intereferon regulatory factors 1 and 8 in mouse macrophages. J Immunol 181:4461\u20134470","journal-title":"J Immunol"},{"key":"3_CR162","doi-asserted-by":"publisher","first-page":"19188","DOI":"10.1074\/jbc.M602059200","volume":"281","author":"J Liu","year":"2006","unstructured":"Liu J, Ma X (2006) Intereferon regulatory factor 8 regulates RANTES gene transcription and cooperation with interferon regulatory gactor 1, NF-kB, and PU.1. J Biol Chem 281:19188\u201319195","journal-title":"J Biol Chem"},{"key":"3_CR163","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S1074-7613(00)80444-6","volume":"6","author":"M Lohoff","year":"1997","unstructured":"Lohoff M, Ferrick D, Mittrucker HW, Duncan GS, Bischof S, Rollinghoff M, Mak TW (1997) Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6:681\u2013689","journal-title":"Immunity"},{"key":"3_CR164","doi-asserted-by":"publisher","first-page":"21269","DOI":"10.1074\/jbc.M110.100818","volume":"285","author":"J Zhang","year":"2010","unstructured":"Zhang J, Qian X, Ning H, Yang J, Xiong H, Liu J (2010) Activation of the IL-27p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. J Biol Chem 285:21269\u201321281","journal-title":"J Biol Chem"},{"key":"3_CR165","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.4049\/jimmunol.181.3.1673","volume":"181","author":"A Fragale","year":"2008","unstructured":"Fragale A, Gabriele L, Stellacci E, Borghi P, Perrotti E, Ilari R et al (2008) IFN regulatory factor-1 negatively regulates CD4+CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J Immunol 181:1673\u20131682","journal-title":"J Immunol"},{"key":"3_CR166","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1348-0421.2002.tb02760.x","volume":"46","author":"H Yamada","year":"2002","unstructured":"Yamada H, Mizuno S, Sugawara I (2002) Interferon regulatory factor 1 in mycobacterial infection. Microbiol Immunol 46:751\u2013760","journal-title":"Microbiol Immunol"},{"key":"3_CR167","doi-asserted-by":"publisher","first-page":"7893","DOI":"10.1074\/jbc.M110.165431","volume":"286","author":"MA Smith","year":"2011","unstructured":"Smith MA, Wright G, Wu J, Tailor P, Ozato K, Chen X, Wei S, Piskurich JF, Ting JP, Wight KL (2011) Positive regulatory domain I (PRDM1) and IRF8\/PU.1 counter regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation. J Biol Chem 286:7893\u20137904","journal-title":"J Biol Chem"},{"key":"3_CR168","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/nm.2007","volume":"15","author":"B Zhao","year":"2009","unstructured":"Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R (2009) Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 15:1066\u20131071","journal-title":"Nat Med"},{"key":"3_CR169","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1073\/pnas.0912779107","volume":"107","author":"K Nishikawa","year":"2011","unstructured":"Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H (2011) Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A 107:3117\u20133122","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR170","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1182\/blood-2008-01-129049","volume":"112","author":"H Wang","year":"2008","unstructured":"Wang H, Lee CH, Qi C, Tailor P, Feng J, Abbasi S, Atsumi T, Morse HC (2008) IRF8 regulates B cell lineage specification, commitment, and differentiation. Blood 112:4028\u20134038","journal-title":"Blood"},{"key":"3_CR171","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.4049\/jimmunol.1001950","volume":"186","author":"J Feng","year":"2011","unstructured":"Feng J, Wang H, Shin DM, Masiuk M, Qi CF, Morse HC (2011) IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J Immunol 186:1458\u20131466","journal-title":"J Immunol"},{"key":"3_CR172","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1100066","volume":"365","author":"S Hambleton","year":"2011","unstructured":"Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt T, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova JL, Gros P (2011) Human IRF8 deficiency restricts monocyte and dendritic cell development and anti-mycobacterial immunity. N Engl J Med 365:127\u2013138","journal-title":"N Engl J Med"},{"key":"3_CR173","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.molimm.2006.02.026","volume":"44","author":"N Dror","year":"2007","unstructured":"Dror N, Alter-Koltunoff MA, Azriel A, Amariglio N, Jacob-Hirsh J et al (2007) Identification of IRF8 and IRF1 target genes in activated macrophages. Mol Immunol 44:338\u2013346","journal-title":"Mol Immunol"},{"key":"3_CR174","doi-asserted-by":"publisher","first-page":"7921","DOI":"10.1074\/jbc.M706710200","volume":"283","author":"W Huang","year":"2008","unstructured":"Huang W, Zhu C, Wang H, Horvath E, Eklund EA (2008) The Interferon Consensus Sequence-binding Protein (ICSBP\/IRF8) Represses PTPN13 Gene Transcription in Differentiating Myeloid Cells. J Biol Chem 283:7921\u20137935","journal-title":"J Biol Chem"},{"key":"3_CR175","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1016\/j.molimm.2010.05.289","volume":"47","author":"A Kubosaki","year":"2010","unstructured":"Kubosaki A, Lindgren G, Tagami M, Simon C, Tomaru Y, Miura H, Suzuki T, Arner E, Forrest AR, Irvine KM, Schroder K, Hasegawa Y, Kanamori-Katayama M, Rehli M, Hume DA, Kawai J, Suzuki M, Suzuki H, Hayashizaki Y (2010) The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Mol Immunol 47:2295\u20132302","journal-title":"Mol Immunol"},{"issue":"6","key":"3_CR176","doi-asserted-by":"publisher","first-page":"e1002097","DOI":"10.1371\/journal.pgen.1002097","volume":"7","author":"JF Marquis","year":"2011","unstructured":"Marquis JF, Kapoustina O, Langlais D, Rubby R, Dufour CR, Kim BH, MacMicking JD, Gigure V, Gros P (2011) Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet 7(6):e1002097","journal-title":"PLoS Genet"},{"key":"3_CR177","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"BW Huang","year":"2009","unstructured":"Huang BW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nat Protocols 4:44\u201357","journal-title":"Nat Protocols"},{"key":"3_CR178","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.it.2004.08.010","volume":"25","author":"JD MacMicking","year":"2004","unstructured":"MacMicking JD (2004) IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunol 25:601\u2013609","journal-title":"Trends Immunol"},{"key":"3_CR179","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.4049\/jimmunol.179.11.7729","volume":"179","author":"D Degrandi","year":"2007","unstructured":"Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J et al (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179:7729\u20137740","journal-title":"J Immunol"},{"key":"3_CR180","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.imbio.2007.09.018","volume":"212","author":"AR Shenoy","year":"2007","unstructured":"Shenoy AR, Kim BH, Choi HP, Matsuzawa T, Tiwari S et al (2007) Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology 212:771\u2013784","journal-title":"Immunobiology"},{"key":"3_CR181","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.172.11.6820","volume":"172","author":"H Tsujimura","year":"2004","unstructured":"Tsujimura H, Tamura TH, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, Ozato K (2004) Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8\/IFN consensus sequence binding protein in dendritic cells. J Immunol 172:6820\u20136827","journal-title":"J Immunol"},{"key":"3_CR182","doi-asserted-by":"publisher","first-page":"12013","DOI":"10.1073\/pnas.89.24.12013","volume":"89","author":"JL Flynn","year":"1992","unstructured":"Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR (1992) Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 89:12013\u201312017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR183","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1084\/jem.20090067","volume":"207","author":"A Dorhoi","year":"2010","unstructured":"Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH (2010) The adaptor molecule CARD9 is essential for tuberculosis control. J Exp Med 207:777\u2013792","journal-title":"J Exp Med"},{"key":"3_CR184","doi-asserted-by":"publisher","first-page":"5127","DOI":"10.1128\/IAI.00458-07","volume":"75","author":"S Gandotra","year":"2007","unstructured":"Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S (2007) Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infect Immun 75:5127\u20135134","journal-title":"Infect Immun"},{"key":"3_CR185","doi-asserted-by":"publisher","first-page":"7958","DOI":"10.1073\/pnas.131207398","volume":"98","author":"W Peters","year":"2001","unstructured":"Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD (2001) Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 98:7958\u20137963","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR186","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0008-8749(02)00510-5","volume":"216","author":"BM Saunders","year":"2002","unstructured":"Saunders BM, Frank AA, Orme IM, Cooper AM (2002) CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell Immunol 216:65\u201372","journal-title":"Cell Immunol"},{"key":"3_CR187","doi-asserted-by":"publisher","first-page":"4204","DOI":"10.1073\/pnas.97.8.4204","volume":"97","author":"AO Sousa","year":"2000","unstructured":"Sousa AO, Mazzaccaro RJ, Russell RG, Lee FK, Turner OC, Hong S, Van Kaer L, Bloom BR (2000) Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc Natl Acad Sci U S A 97:4204\u20134208","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR188","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/1471-2334-10-299","volume":"10","author":"M Hawkes","year":"2010","unstructured":"Hawkes M, Li X, Crockett M, Diassiti A, Finney C, Min-Oo G, Liles WC, Liu J, Kain KC (2010) CD36 deficiency attenuates experimental mycobacterial infection. BMC Infect Dis 10:299","journal-title":"BMC Infect Dis"},{"key":"3_CR189","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1046\/j.1365-3083.2003.01266.x","volume":"58","author":"CJ Repique","year":"2003","unstructured":"Repique CJ, Li A, Brickey WJ, Ting JP, Collins FM, Morris SL (2003) Susceptibility of mice deficient in the MHC class II transactivator to infection with Mycobacterium tuberculosis. Scand J Immunol 58:15\u201322","journal-title":"Scand J Immunol"},{"key":"3_CR190","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.4049\/jimmunol.165.5.2596","volume":"165","author":"C Hu","year":"2000","unstructured":"Hu C, Mayadas-Norton T, Tanaka K, Chan J, Salgame P (2000) Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. J Immunol 165:2596\u20132602","journal-title":"J Immunol"},{"key":"3_CR191","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.micinf.2010.10.013","volume":"13","author":"MJ Marakalala","year":"2011","unstructured":"Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD (2011) The Syk\/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes Infect 13:198\u2013201","journal-title":"Microbes Infect"},{"key":"3_CR192","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1002\/eji.200323956","volume":"33","author":"P Seiler","year":"2003","unstructured":"Seiler P, Aichele P, Bandermann S, Hauser AE, Lu B, Gerard NP, Gerard C, Ehlers S, Mollenkopf HJ, Kaufmann SH (2003) Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. Eur J Immunol 33:2676\u20132686","journal-title":"Eur J Immunol"},{"key":"3_CR193","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.imbio.2010.09.010","volume":"216","author":"M Hessmann","year":"2011","unstructured":"Hessmann M, Rausch A, Ruckerl D, Adams PS, Simon M, Gilfillan S, Colonna M, Ehlers S, Holscher C (2011) DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection. Immunobiology 216:639\u2013647","journal-title":"Immunobiology"},{"key":"3_CR194","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.4049\/jimmunol.180.5.3329","volume":"180","author":"PJ Maglione","year":"2008","unstructured":"Maglione PJ, Xu J, Casadevall A, Chan J (2008) Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. J Immunol 180:3329\u20133338","journal-title":"J Immunol"},{"key":"3_CR195","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/iai.65.4.1317-1320.1997","volume":"65","author":"AM Cooper","year":"1997","unstructured":"Cooper AM, D\u2019Souza C, Frank AA, Orme IM (1997) The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms. Infect Immun 65:1317\u20131320","journal-title":"Infect Immun"},{"key":"3_CR196","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1201711","volume":"332","author":"BH Kim","year":"2011","unstructured":"Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD (2011) A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science 332:717\u2013721","journal-title":"Science"},{"key":"3_CR197","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0962-8479(97)90006-X","volume":"78","author":"CM Johnson","year":"1997","unstructured":"Johnson CM, Cooper AM, Frank AA, Bonorino CB, Wysoki LJ, Orme IM (1997) Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. Tuber Lung Dis 78:257\u2013261","journal-title":"Tuber Lung Dis"},{"key":"3_CR198","doi-asserted-by":"publisher","first-page":"e20568","DOI":"10.1371\/journal.pone.0020568","volume":"6","author":"O Liesenfeld","year":"2011","unstructured":"Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Munoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermohlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Konen-Waisman S, Kaufmann SH, Howard JC (2011) The IFN-gamma-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS One 6:e20568","journal-title":"PLoS One"},{"key":"3_CR199","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.1073\/pnas.94.10.5243","volume":"94","author":"JD MacMicking","year":"1997","unstructured":"MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF (1997) Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A 94:5243\u20135248","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR200","doi-asserted-by":"publisher","first-page":"7711","DOI":"10.1128\/IAI.69.12.7711-7717.2001","volume":"69","author":"CA Scanga","year":"2001","unstructured":"Scanga CA, Mohan VP, Tanaka K, Alland D, Flynn JL, Chan J (2001) The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infect Immun 69:7711\u20137717","journal-title":"Infect Immun"},{"key":"3_CR201","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.4049\/jimmunol.176.8.4914","volume":"176","author":"S Ghosh","year":"2006","unstructured":"Ghosh S, Chackerian AA, Parker CM, Ballantyne CM, Behar SM (2006) The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol 176:4914\u20134922","journal-title":"J Immunol"},{"key":"3_CR202","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","volume":"178","author":"JL Flynn","year":"1993","unstructured":"Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178:2249\u20132254","journal-title":"J Exp Med"},{"key":"3_CR203","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1084\/jem.178.4.1435","volume":"178","author":"R Kamijo","year":"1993","unstructured":"Kamijo R, Le J, Shapiro D, Havell EA, Huang S, Aguet M, Bosland M, Vilcek J (1993) Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J Exp Med 178:1435\u20131440","journal-title":"J Exp Med"},{"key":"3_CR204","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/labinvest.3780079","volume":"80","author":"H Yamada","year":"2000","unstructured":"Yamada H, Mizumo S, Horai R, Iwakura Y, Sugawara I (2000) Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha\/beta double-knockout mice. Lab Invest 80:759\u2013767","journal-title":"Lab Invest"},{"key":"3_CR205","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.4049\/jimmunol.0904189","volume":"184","author":"KD Mayer-Barber","year":"2010","unstructured":"Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Nunez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A (2010) Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 184:3326\u20133330","journal-title":"J Immunol"},{"key":"3_CR206","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.4049\/jimmunol.179.2.1178","volume":"179","author":"CM Fremond","year":"2007","unstructured":"Fremond CM, Togbe D, Doz E, Rose S, Vasseur V, Maillet I, Jacobs M, Ryffel B, Quesniaux VF (2007) IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 179:1178\u20131189","journal-title":"J Immunol"},{"key":"3_CR207","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1046\/j.1365-2249.1998.00636.x","volume":"113","author":"RJ North","year":"1998","unstructured":"North RJ (1998) Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113:55\u201358","journal-title":"Clin Exp Immunol"},{"key":"3_CR208","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/iai.65.11.4843-4849.1997","volume":"65","author":"CH Ladel","year":"1997","unstructured":"Ladel CH, Blum C, Dreher A, Reifenberg K, Kopf M, Kaufmann SH (1997) Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect Immun 65:4843\u20134849","journal-title":"Infect Immun"},{"key":"3_CR209","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.168.3.1322","volume":"168","author":"AM Cooper","year":"2002","unstructured":"Cooper AM, Kipnis A, Turner J, Magram J, Ferrante J, Orme IM (2002) Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 168:1322\u20131327","journal-title":"J Immunol"},{"key":"3_CR210","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.4049\/jimmunol.0903332","volume":"184","author":"Y Okamoto Yoshida","year":"2010","unstructured":"Okamoto Yoshida Y, Umemura M, Yahagi A, O\u2019Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G (2010) Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol 184:4414\u20134422","journal-title":"J Immunol"},{"key":"3_CR211","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1128\/IAI.67.5.2585-2589.1999","volume":"67","author":"I Sugawara","year":"1999","unstructured":"Sugawara I, Yamada H, Kaneko H, Mizuno S, Takeda K, Akira S (1999) Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun 67:2585\u20132589","journal-title":"Infect Immun"},{"key":"3_CR212","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/eji.200939583","volume":"40","author":"BE Schneider","year":"2010","unstructured":"Schneider BE, Korbel D, Hagens K, Koch M, Raupach B, Enders J, Kaufmann SH, Mittrucker HW, Schaible UE (2010) A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur J Immunol 40:396\u2013405","journal-title":"Eur J Immunol"},{"key":"3_CR213","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.175.2.788","volume":"175","author":"SA Khader","year":"2005","unstructured":"Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM (2005) IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 175:788\u2013795","journal-title":"J Immunol"},{"key":"3_CR214","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.4049\/jimmunol.174.6.3534","volume":"174","author":"C Holscher","year":"2005","unstructured":"Holscher C, Holscher A, Ruckerl D, Yoshimoto T, Yoshida H, Mak T, Saris C, Ehlers S (2005) The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 174:3534\u20133544","journal-title":"J Immunol"},{"key":"3_CR215","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1046\/j.1365-2567.1999.00877.x","volume":"98","author":"BM Saunders","year":"1999","unstructured":"Saunders BM, Frank AA, Orme IM (1999) Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis. Immunology 98:324\u2013328","journal-title":"Immunology"},{"key":"3_CR216","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1128\/IAI.66.4.1666-1670.1998","volume":"66","author":"CM Johnson","year":"1998","unstructured":"Johnson CM, Cooper AM, Frank AA, Orme IM (1998) Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis-infected mice with a disruption in the intracellular adhesion molecule 1 gene. Infect Immun 66:1666\u20131670","journal-title":"Infect Immun"},{"key":"3_CR217","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1084\/jem.187.4.601","volume":"187","author":"B Lu","year":"1998","unstructured":"Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ (1998) Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187:601\u2013608","journal-title":"J Exp Med"},{"key":"3_CR218","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1046\/j.1365-2249.2002.01952.x","volume":"130","author":"A Verbon","year":"2002","unstructured":"Verbon A, Leemans JC, Weijer S, Florquin S, Van Der Poll T (2002) Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis. Clin Exp Immunol 130:32\u201336","journal-title":"Clin Exp Immunol"},{"key":"3_CR219","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1348-0421.2003.tb03404.x","volume":"47","author":"I Sugawara","year":"2003","unstructured":"Sugawara I, Yamada H, Li C, Mizuno S, Takeuchi O, Akira S (2003a) Mycobacterial infection in TLR2 and TLR6 knockout mice. Microbiol Immunol 47:327\u2013336","journal-title":"Microbiol Immunol"},{"key":"3_CR220","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1128\/IAI.72.4.2400-2404.2004","volume":"72","author":"CA Scanga","year":"2004","unstructured":"Scanga CA, Bafica A, Feng CG, Cheever AW, Hieny S, Sher A (2004) MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infect Immun 72:2400\u20132404","journal-title":"Infect Immun"},{"key":"3_CR221","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.imbio.2010.05.015","volume":"215","author":"K Walter","year":"2010","unstructured":"Walter K, Holscher C, Tschopp J, Ehlers S (2010) NALP3 is not necessary for early protection against experimental tuberculosis. Immunobiology 215:804\u2013811","journal-title":"Immunobiology"},{"key":"3_CR222","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1128\/IAI.67.11.5811-5814.1999","volume":"67","author":"RJ North","year":"1999","unstructured":"North RJ, LaCourse R, Ryan L, Gros P (1999) Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice. Infect Immun 67:5811\u20135814","journal-title":"Infect Immun"},{"key":"3_CR223","doi-asserted-by":"publisher","first-page":"7100","DOI":"10.1128\/IAI.69.11.7100-7105.2001","volume":"69","author":"H Yamada","year":"2001","unstructured":"Yamada H, Mizuno S, Reza-Gholizadeh M, Sugawara I (2001) Relative importance of NF-kappaB p50 in mycobacterial infection. Infect Immun 69:7100\u20137105","journal-title":"Infect Immun"},{"key":"3_CR224","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.4049\/jimmunol.181.10.7157","volume":"181","author":"M Divangahi","year":"2008","unstructured":"Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA (2008) NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J Immunol 181:7157\u20137165","journal-title":"J Immunol"},{"key":"3_CR225","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1128\/IAI.68.3.1231-1234.2000","volume":"68","author":"AM Cooper","year":"2000","unstructured":"Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM (2000) Transient loss of resistance to pulmonary tuberculosis in p47(phox-\/-) mice. Infect Immun 68:1231\u20131234","journal-title":"Infect Immun"},{"key":"3_CR226","doi-asserted-by":"publisher","first-page":"13402","DOI":"10.1073\/pnas.1007394107","volume":"107","author":"E Lazar-Molnar","year":"2010","unstructured":"Lazar-Molnar E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR Jr (2010) Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Proc Natl Acad Sci U S A 107:13402\u201313407","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR227","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1620\/tjem.202.41","volume":"202","author":"I Sugawara","year":"2004","unstructured":"Sugawara I, Yamada H, Mizuno S (2004) STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection. Tohoku J Exp Med 202:41\u201350","journal-title":"Tohoku J Exp Med"},{"key":"3_CR228","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1128\/IAI.00286-10","volume":"79","author":"MP Lemos","year":"2011","unstructured":"Lemos MP, McKinney J, Rhee KY (2011) Dispensability of surfactant proteins A and D in immune control of Mycobacterium tuberculosis infection following aerosol challenge of mice. Infect Immun 79:1077\u20131085","journal-title":"Infect Immun"},{"key":"3_CR229","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1084\/jem.193.3.271","volume":"193","author":"T Mogues","year":"2001","unstructured":"Mogues T, Goodrich ME, Ryan L, LaCourse R, North RJ (2001) The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J Exp Med 193:271\u2013280","journal-title":"J Exp Med"},{"key":"3_CR230","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1002\/eji.1830251025","volume":"25","author":"CH Ladel","year":"1995","unstructured":"Ladel CH, Blum C, Dreher A, Reifenberg K, Kaufmann SH (1995) Protective role of gamma\/delta T cells and alpha\/beta T cells in tuberculosis. Eur J Immunol 25:2877\u20132881","journal-title":"Eur J Immunol"},{"key":"3_CR231","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1348-0421.2003.tb03404.x","volume":"47","author":"I Sugawara","year":"2003","unstructured":"Sugawara I, Yamada H, Li C, Mizuno S, Takeuchi O, Akira S (2003b) Mycobacterial infection in TLR2 and TLR6 knockout mice. Microbiol Immunol 47:327\u2013336","journal-title":"Microbiol Immunol"},{"key":"3_CR232","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1084\/jem.20051782","volume":"202","author":"A Bafica","year":"2005","unstructured":"Bafica A, Scanga CA, Feng CG, Leifer C, Cheever A, Sher A (2005a) TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med 202:1715\u20131724","journal-title":"J Exp Med"},{"key":"3_CR233","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/eji.200736458","volume":"38","author":"C Holscher","year":"2008","unstructured":"Holscher C, Reiling N, Schaible UE, Holscher A, Bathmann C, Korbel D, Lenz I, Sonntag T, Kroger S, Akira S, Mossmann H, Kirschning CJ, Wagner H, Freudenberg M, Ehlers S (2008) Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9. Eur J Immunol 38:680\u2013694","journal-title":"Eur J Immunol"},{"key":"3_CR234","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/intimm\/dxh052","volume":"16","author":"J Branger","year":"2004","unstructured":"Branger J, Leemans JC, Florquin S, Weijer S, Speelman P, Van Der Poll T (2004) Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice. Int Immunol 16:509\u2013516","journal-title":"Int Immunol"},{"key":"3_CR235","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1084\/jem.189.12.1973","volume":"189","author":"SM Behar","year":"1999","unstructured":"Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB (1999) Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med 189:1973\u20131980","journal-title":"J Exp Med"},{"key":"3_CR236","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.4049\/jimmunol.162.6.3504","volume":"162","author":"AG Bean","year":"1999","unstructured":"Bean AG, Roach DR, Briscoe H, France MP, Korner H, Sedgwick JD, Britton WJ (1999) Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol 162:3504\u20133511","journal-title":"J Immunol"},{"key":"3_CR237","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000028116","volume":"68","author":"M Jacobs","year":"2000","unstructured":"Jacobs M, Brown N, Allie N, Chetty K, Ryffel B (2000) Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity. Pathobiology 68:68\u201375","journal-title":"Pathobiology"},{"key":"3_CR238","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1172\/JCI23949","volume":"115","author":"A Bafica","year":"2005","unstructured":"Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti J (2005b) Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J Clin Invest 115:1601\u20131606","journal-title":"J Clin Invest"}],"container-title":["Advances in Experimental Medicine and Biology","The New Paradigm of Immunity to Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4614-6111-1_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T09:27:13Z","timestamp":1676280433000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4614-6111-1_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781461461104","9781461461111"],"references-count":238,"URL":"https:\/\/doi.org\/10.1007\/978-1-4614-6111-1_3","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4614-6111-1","asserted-by":"object"}]},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"7 March 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}