{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:32:58Z","timestamp":1789939978599,"version":"4.0.1"},"publisher-location":"New York, NY","reference-count":81,"publisher":"Springer New York","isbn-type":[{"value":"9781461461982","type":"print"},{"value":"9781461461999","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-1-4614-6199-9_7","type":"book-chapter","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T05:25:41Z","timestamp":1364880341000},"page":"133-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations"],"prefix":"10.1007","author":[{"given":"Suzy Drummond Carvalho","family":"Bianco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula B.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,16]]},"reference":[{"key":"7_CR00071","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S1054-139X(02)00484-6","volume":"31","author":"TM Plant","year":"2002","unstructured":"Plant TM (2002) Neurophysiology of puberty. J Adolesc Health 31:185\u2013191","journal-title":"J Adolesc Health"},{"key":"7_CR00072","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1210\/er.19.5.521","volume":"19","author":"SB Seminara","year":"1998","unstructured":"Seminara SB, Hayes FJ, Crowley WF Jr (1998) Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann\u2019s syndrome): pathophysiological and genetic considerations. Endocr Rev 19:521\u2013539","journal-title":"Endocr Rev"},{"key":"7_CR00073","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1159\/000098156","volume":"67","author":"SM Cadman","year":"2007","unstructured":"Cadman SM, Kim SH, Hu Y, Gonzalez-Martinez D, Bouloux PM (2007) Molecular pathogenesis of Kallmann\u2019s syndrome. Horm Res 67:231\u2013242","journal-title":"Horm Res"},{"key":"7_CR00074","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.peptides.2008.06.015","volume":"30","author":"YM Chan","year":"2009","unstructured":"Chan YM, Broder-Fingert S, Seminara SB (2009) Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides 30:42\u201348","journal-title":"Peptides"},{"issue":"Suppl 3","key":"7_CR00075","doi-asserted-by":"publisher","first-page":"U83","DOI":"10.1530\/eje.0.151U083","volume":"151","author":"A Iovane","year":"2004","unstructured":"Iovane A, Aumas C, de Roux N (2004) New insights in the genetics of isolated hypogonadotropic hypogonadism. Eur J Endocrinol 151(Suppl 3):U83\u201388","journal-title":"Eur J Endocrinol"},{"key":"7_CR00076","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1056\/NEJMoa073443","volume":"358","author":"MG Teles","year":"2008","unstructured":"Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC (2008) A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 358:709\u2013715","journal-title":"N Engl J Med"},{"key":"7_CR00077","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s11102-007-0061-7","volume":"10","author":"EB Trarbach","year":"2007","unstructured":"Trarbach EB, Silveira LG, Latronico AC (2007) Genetic insights into human isolated gonadotropin deficiency. Pituitary 10:381\u2013391","journal-title":"Pituitary"},{"key":"7_CR00078","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/pnas.1834399100","volume":"100","author":"N de Roux","year":"2003","unstructured":"de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972\u201310976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR00079","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1056\/NEJMoa035322","volume":"349","author":"SB Seminara","year":"2003","unstructured":"Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O\u2019Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH (2003) The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614\u20131627","journal-title":"N Engl J Med"},{"key":"7_CR000710","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1530\/eje.1.02031","volume":"153","author":"F Lanfranco","year":"2005","unstructured":"Lanfranco F, Gromoll J, von Eckardstein S, Herding EM, Nieschlag E, Simoni M (2005) Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol 153:845\u2013852","journal-title":"Eur J Endocrinol"},{"key":"7_CR000711","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1210\/jc.2010-1676","volume":"96","author":"R Nimri","year":"2011","unstructured":"Nimri R, Lebenthal Y, Lazar L, Chevrier L, Phillip M, Bar M, Hernandez-Mora E, de Roux N, Gat-Yablonski G (2011) A novel loss-of-function mutation in GPR54\/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. J Clin Endocrinol Metab 96:E536\u2013545","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000712","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mce.2006.04.019","volume":"254\u2013255","author":"JC Pallais","year":"2006","unstructured":"Pallais JC, Bo-Abbas Y, Pitteloud N, Crowley WF Jr, Seminara SB (2006) Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54. Mol Cell Endocrinol 254\u2013255:70\u201377","journal-title":"Mol Cell Endocrinol"},{"key":"7_CR000713","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1210\/jc.2004-1418","volume":"90","author":"RK Semple","year":"2005","unstructured":"Semple RK, Achermann JC, Ellery J, Farooqi IS, Karet FE, Stanhope RG, O\u2019Rahilly S, Aparicio SA (2005) Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90:1849\u20131855","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000714","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1210\/jc.2006-2147","volume":"92","author":"Y Tenenbaum-Rakover","year":"2007","unstructured":"Tenenbaum-Rakover Y, Commenges-Ducos M, Iovane A, Aumas C, Admoni O, de Roux N (2007) Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. J Clin Endocrinol Metab 92:1137\u20131144","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000715","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1530\/EJE-10-0012","volume":"163","author":"MG Teles","year":"2010","unstructured":"Teles MG, Trarbach EB, Noel SD, Guerra-Junior G, Jorge A, Beneduzzi D, Bianco SD, Mukherjee A, Baptista MT, Costa EM, De Castro M, Mendonca BB, Kaiser UB, Latronico AC (2010) A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol 163:29\u201334","journal-title":"Eur J Endocrinol"},{"key":"7_CR000716","doi-asserted-by":"publisher","first-page":"E1771","DOI":"10.1210\/jc.2011-0518","volume":"96","author":"YM Chan","year":"2011","unstructured":"Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB (2011) GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1\/Kiss1. J Clin Endocrinol Metab 96:E1771\u20131781","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000717","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1210\/jc.2009-2421","volume":"95","author":"LGNS Silveria","year":"2010","unstructured":"Silveria LGNS, Silveira-Neto AP, Abreu AP, Brito VN, Santos MGBS, Kuohung W, Xu S, Gryngarten M, Escobar MEAI, Mendonca BB, Kaiser UB, Latronico AC (2010) Mutations of the KISS1 Gene in Disorders of Puberty. J Clin Endocrinol Metab 95:2276\u20132280","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000718","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1056\/NEJMoa1111184","volume":"366","author":"AK Topaloglu","year":"2012","unstructured":"Topaloglu AK, Tello JA, Kotan LD, Ozbek MN, Yilmaz MB, Erdogan S, Gurbuz F, Temiz F, Millar RP, Yuksel B (2012) Inactivating KISS1 mutation and hypogonadotropic hypogonadism. N Engl J Med 366:629\u2013635","journal-title":"N Engl J Med"},{"issue":"2","key":"7_CR000719","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1530\/EJE-12-0127","volume":"167","author":"O Breuer","year":"2012","unstructured":"Breuer O, Abdulhadi-Atwan M, Zeligson S, Fridman H, Renbaum P, Levy-Lahad E, Zangen DH (2012) A novel severe N-terminal splice site KISS1R gene mutation causes hypogonadotropic hypogonadism but enables a normal development of neonatal external genitalia. Eur J Endocrinol 167(2):209\u201316","journal-title":"Eur J Endocrinol"},{"key":"7_CR000720","doi-asserted-by":"publisher","first-page":"10714","DOI":"10.1073\/pnas.0704114104","volume":"104","author":"X d\u2019Anglemont de Tassigny","year":"2007","unstructured":"d\u2019Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH (2007) Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 104:10714\u201310719","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR000721","doi-asserted-by":"publisher","first-page":"12088","DOI":"10.1523\/JNEUROSCI.2748-07.2007","volume":"27","author":"HM Dungan","year":"2007","unstructured":"Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA (2007) The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone\/luteinizing hormone. J Neurosci 27:12088\u201312095","journal-title":"J Neurosci"},{"key":"7_CR000722","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.bbrc.2003.11.066","volume":"312","author":"S Funes","year":"2003","unstructured":"Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ, Gustafson EL (2003) The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun 312:1357\u20131363","journal-title":"Biochem Biophys Res Commun"},{"key":"7_CR000723","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1210\/en.2007-0078","volume":"148","author":"R Lapatto","year":"2007","unstructured":"Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB (2007) Kiss1-\/- mice exhibit more variable hypogonadism than Gpr54-\/- mice. Endocrinology 148:4927\u20134936","journal-title":"Endocrinology"},{"key":"7_CR000724","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/REP-10-0432","volume":"141","author":"H Mei","year":"2011","unstructured":"Mei H, Walters C, Carter R, Colledge WH (2011) Gpr54-\/- mice show more pronounced defects in spermatogenesis than Kiss1-\/- mice and improved spermatogenesis with age when exposed to dietary phytoestrogens. Reproduction 141:357\u2013366","journal-title":"Reproduction"},{"key":"7_CR000725","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1210\/jc.2009-2421","volume":"95","author":"LG Silveira","year":"2010","unstructured":"Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC (2010) Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab 95:2276\u20132280","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000726","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000107511","volume":"86","author":"X Luan","year":"2007","unstructured":"Luan X, Yu H, Wei X, Zhou Y, Wang W, Li P, Gan X, Wei D, Xiao J (2007) GPR54 polymorphisms in Chinese girls with central precocious puberty. Neuroendocrinology 86:77\u201383","journal-title":"Neuroendocrinology"},{"key":"7_CR000727","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1530\/EJE-07-0061","volume":"157","author":"X Luan","year":"2007","unstructured":"Luan X, Zhou Y, Wang W, Yu H, Li P, Gan X, Wei D, Xiao J (2007) Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. Eur J Endocrinol 157:113\u2013118","journal-title":"Eur J Endocrinol"},{"key":"7_CR000728","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1210\/en.2004-0395","volume":"145","author":"IS Parhar","year":"2004","unstructured":"Parhar IS, Ogawa S, Sakuma Y (2004) Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology 145:3613\u20133618","journal-title":"Endocrinology"},{"key":"7_CR000729","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1159\/000083140","volume":"80","author":"MS Irwig","year":"2004","unstructured":"Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA (2004) Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264\u2013272","journal-title":"Neuroendocrinology"},{"key":"7_CR000730","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1073\/pnas.0409330102","volume":"102","author":"S Messager","year":"2005","unstructured":"Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA (2005) Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA 102:1761\u20131766","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR000731","unstructured":"Shibata M GR, Shahab M, Plant TM (2005) GnRH neurons in the peripubertal male rhesus monkey (Macaca mulatta) express GPR54: implication for the control of primate puberty. In: 87th Annual Meeting of the Endocrine Society. San Diego, CA"},{"key":"7_CR000732","doi-asserted-by":"publisher","first-page":"11349","DOI":"10.1523\/JNEUROSCI.3328-05.2005","volume":"25","author":"SK Han","year":"2005","unstructured":"Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349\u201311356","journal-title":"J Neurosci"},{"key":"7_CR000733","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.1210\/en.2008-0231","volume":"149","author":"KL Keen","year":"2008","unstructured":"Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E (2008) An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in\u00a0vivo. Endocrinology 149:4151\u20134157","journal-title":"Endocrinology"},{"key":"7_CR000734","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1210\/en.2009-0552","volume":"151","author":"AE Herbison","year":"2010","unstructured":"Herbison AE, de Tassigny X, Doran J, Colledge WH (2010) Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 151:312\u2013321","journal-title":"Endocrinology"},{"key":"7_CR000735","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1210\/en.2012-1221","volume":"153","author":"JR Kurian","year":"2012","unstructured":"Kurian JR, Keen KL, Guerriero KA, Terasawa E (2012) Tonic control of kisspeptin release in prepubertal monkeys: implications to the mechanism of puberty onset. Endocrinology 153:3331\u20133336","journal-title":"Endocrinology"},{"key":"7_CR000736","doi-asserted-by":"publisher","first-page":"8826","DOI":"10.1523\/JNEUROSCI.2099-07.2007","volume":"27","author":"AS Kauffman","year":"2007","unstructured":"Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, Rissman EF (2007) The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci 27:8826\u20138835","journal-title":"J Neurosci"},{"key":"7_CR000737","doi-asserted-by":"publisher","first-page":"34631","DOI":"10.1074\/jbc.M104847200","volume":"276","author":"M Kotani","year":"2001","unstructured":"Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631\u201334636","journal-title":"J Biol Chem"},{"key":"7_CR000738","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1021\/ml1002053","volume":"2","author":"SMR Oishi","year":"2011","unstructured":"Oishi SMR, Tomita K, Setsuda S, Masuda R, Ohno H, Naniwa Y, Ieda N, Inoue N, Ohkura S, Uenoyama Y, Tsukamura H, Maeda K, Hirasawa A, Tsujimoto G, Fijii N (2011) Activation of neuropeptide FF receptors by kisspeptin receptor ligands. ACS Med Chem Lett 2:5","journal-title":"ACS Med Chem Lett"},{"key":"7_CR000739","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ando.2010.02.011","volume":"71","author":"WH Colledge","year":"2010","unstructured":"Colledge WH, d\u2019Anglemont de Tassigny X (2010) The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice. Ann Endocrinol (Paris) 71:198\u2013200","journal-title":"Ann Endocrinol (Paris)"},{"key":"7_CR000740","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1210\/me.2009-0013","volume":"23","author":"M Pampillo","year":"2009","unstructured":"Pampillo M, Camuso N, Taylor JE, Szereszewski JM, Ahow MR, Zajac M, Millar RP, Bhattacharya M, Babwah AV (2009) Regulation of GPR54 signaling by GRK2 and {beta}-arrestin. Mol Endocrinol 23:2060\u20132074","journal-title":"Mol Endocrinol"},{"key":"7_CR000741","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1210\/en.2010-0903","volume":"152","author":"SD Bianco","year":"2011","unstructured":"Bianco SD, Vandepas L, Correa-Medina M, Gereben B, Mukherjee A, Kuohung W, Carroll R, Teles MG, Latronico AC, Kaiser UB (2011) KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology 152:1616\u20131626","journal-title":"Endocrinology"},{"key":"7_CR000742","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0014-5793(99)00009-5","volume":"446","author":"DK Lee","year":"1999","unstructured":"Lee DK, Nguyen T, O\u2019Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-\u00adNguyen AT, George SR, O\u2019Dowd BF (1999) Discovery of a receptor related to the galanin receptors. FEBS Lett 446:103\u2013107","journal-title":"FEBS Lett"},{"key":"7_CR000743","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.peptides.2008.06.016","volume":"30","author":"ML Gottsch","year":"2009","unstructured":"Gottsch ML, Clifton DK, Steiner RA (2009) From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides 30:4\u20139","journal-title":"Peptides"},{"key":"7_CR000744","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/35079135","volume":"411","author":"T Ohtaki","year":"2001","unstructured":"Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613\u2013617","journal-title":"Nature"},{"key":"7_CR000745","doi-asserted-by":"publisher","first-page":"28969","DOI":"10.1074\/jbc.M102743200","volume":"276","author":"AI Muir","year":"2001","unstructured":"Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (2001) AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969\u201328975","journal-title":"J Biol Chem"},{"key":"7_CR000746","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.mce.2006.07.002","volume":"257\u2013258","author":"JM Castellano","year":"2006","unstructured":"Castellano JM, Navarro VM, Fernandez-Fernandez R, Castano JP, Malagon MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M (2006) Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Mol Cell Endocrinol 257\u2013258:75\u201383","journal-title":"Mol Cell Endocrinol"},{"key":"7_CR000747","doi-asserted-by":"publisher","first-page":"E1088","DOI":"10.1152\/ajpendo.90240.2008","volume":"294","author":"J Roa","year":"2008","unstructured":"Roa J, Vigo E, Garcia-Galiano D, Castellano JM, Navarro VM, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2008) Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab 294:E1088\u20131096","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7_CR000748","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1210\/en.2005-1550","volume":"147","author":"SB Seminara","year":"2006","unstructured":"Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM (2006) Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-\u00adreleasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 147:2122\u20132126","journal-title":"Endocrinology"},{"key":"7_CR000749","doi-asserted-by":"publisher","first-page":"E1074","DOI":"10.1152\/ajpendo.00040.2006","volume":"291","author":"EL Thompson","year":"2006","unstructured":"Thompson EL, Murphy KG, Patterson M, Bewick GA, Stamp GW, Curtis AE, Cooke JH, Jethwa PH, Todd JF, Ghatei MA, Bloom SR (2006) Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. Am J Physiol Endocrinol Metab 291:E1074\u20131082","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7_CR000750","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1210\/en.2007-0207","volume":"148","author":"S Ramaswamy","year":"2007","unstructured":"Ramaswamy S, Seminara SB, Pohl CR, DiPietro MJ, Crowley WF Jr, Plant TM (2007) Effect of continuous intravenous administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology 148:3364\u20133370","journal-title":"Endocrinology"},{"key":"7_CR000751","doi-asserted-by":"publisher","first-page":"E1228","DOI":"10.1210\/jc.2011-0089","volume":"96","author":"JT George","year":"2011","unstructured":"George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA (2011) Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab 96:E1228\u20131236","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"7_CR000752","doi-asserted-by":"publisher","first-page":"E1458","DOI":"10.1210\/jc.2012-1282","volume":"97","author":"YM Chan","year":"2012","unstructured":"Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB (2012) Kisspeptin administration to women: A window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. J Clin Endocrinol Metab 97(8):E1458\u201367","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000753","doi-asserted-by":"crossref","first-page":"12949","DOI":"10.1016\/S0021-9258(18)98787-9","volume":"266","author":"K Palczewski","year":"1991","unstructured":"Palczewski K, Buczylko J, Kaplan MW, Polans AS, Crabb JW (1991) Mechanism of rhodopsin kinase activation. J Biol Chem 266:12949\u201312955","journal-title":"J Biol Chem"},{"key":"7_CR000754","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1016\/S0021-9258(19)50248-4","volume":"268","author":"VV Gurevich","year":"1993","unstructured":"Gurevich VV, Benovic JL (1993) Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin. J Biol Chem 268:11628\u201311638","journal-title":"J Biol Chem"},{"key":"7_CR000755","first-page":"1","volume":"53","author":"SS Ferguson","year":"2001","unstructured":"Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1\u201324","journal-title":"Pharmacol Rev"},{"key":"7_CR000756","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1161\/01.RES.0000242563.47507.ce","volume":"99","author":"MT Drake","year":"2006","unstructured":"Drake MT, Shenoy SK, Lefkowitz RJ (2006) Trafficking of G protein-coupled receptors. Circ Res 99:570\u2013582","journal-title":"Circ Res"},{"key":"7_CR000757","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.pharmthera.2005.09.008","volume":"110","author":"VV Gurevich","year":"2006","unstructured":"Gurevich VV, Gurevich EV (2006) The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110:465\u2013502","journal-title":"Pharmacol Ther"},{"key":"7_CR000758","doi-asserted-by":"publisher","first-page":"e12964","DOI":"10.1371\/journal.pone.0012964","volume":"5","author":"JM Szereszewski","year":"2010","unstructured":"Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M, Babwah AV (2010) GPR54 regulates ERK1\/2 activity and hypothalamic gene expression in a Galpha(q\/11) and beta-arrestin-dependent manner. PLoS One 5:e12964","journal-title":"PLoS One"},{"key":"7_CR000759","doi-asserted-by":"publisher","first-page":"12345","DOI":"10.1074\/jbc.M008054200","volume":"276","author":"K Chaturvedi","year":"2001","unstructured":"Chaturvedi K, Bandari P, Chinen N, Howells RD (2001) Proteasome involvement in agonist-\u00adinduced down-regulation of mu and delta opioid receptors. J Biol Chem 276:12345\u201312355","journal-title":"J Biol Chem"},{"key":"7_CR000760","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1126\/science.1063866","volume":"294","author":"SK Shenoy","year":"2001","unstructured":"Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294:1307\u20131313","journal-title":"Science"},{"key":"7_CR000761","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2265.2009.03687.x","volume":"72","author":"RK Semple","year":"2010","unstructured":"Semple RK, Topaloglu AK (2010) The recent genetics of hypogonadotrophic hypogonadism\u00a0-\u00a0novel insights and new questions. Clin Endocrinol (Oxf) 72:427\u2013435","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7_CR000762","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1210\/jc.2009-2582","volume":"95","author":"GP Sykiotis","year":"2010","unstructured":"Sykiotis GP, Hoang XH, Avbelj M, Hayes FJ, Thambundit A, Dwyer A, Au M, Plummer L, Crowley WF Jr, Pitteloud N (2010) Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. J Clin Endocrinol Metab 95:3019\u20133027","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000763","volume-title":"GeneReviews\u2122","author":"JC Pallais","year":"1993","unstructured":"Pallais JC, Au M, Pitteloud N, Seminara S, Crowley WF (1993) Isolated gonadotropin-\u00adreleasing hormone (GnRH) deficiency overview. In: Bird TD, Dolan CR, Stephens K, Adam MP, Pagon RA (eds) GeneReviews\u2122. University of Washington, Seattle"},{"key":"7_CR000764","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1007\/s00018-005-5604-3","volume":"63","author":"A Cariboni","year":"2006","unstructured":"Cariboni A, Maggi R (2006) Kallmann\u2019s syndrome, a neuronal migration defect. Cell Mol Life Sci 63:2512\u20132526","journal-title":"Cell Mol Life Sci"},{"key":"7_CR000765","first-page":"249","volume":"22","author":"AL Mitchell","year":"2011","unstructured":"Mitchell AL, Dwyer A, Pitteloud N, Quinton R (2011) Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. Trends Endocrinol Metab 22:249\u2013258","journal-title":"Trends Endocrinol Metab"},{"key":"7_CR000766","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nrendo.2009.177","volume":"5","author":"SD Bianco","year":"2009","unstructured":"Bianco SD, Kaiser UB (2009) The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol 5:569\u2013576","journal-title":"Nat Rev Endocrinol"},{"key":"7_CR000767","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mce.2011.05.043","volume":"346","author":"F Wahab","year":"2011","unstructured":"Wahab F, Quinton R, Seminara SB (2011) The kisspeptin signaling pathway and its role in human isolated GnRH deficiency. Mol Cell Endocrinol 346:29\u201336","journal-title":"Mol Cell Endocrinol"},{"key":"7_CR000768","doi-asserted-by":"publisher","first-page":"31068","DOI":"10.1074\/jbc.M805251200","volume":"283","author":"JL Wacker","year":"2008","unstructured":"Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, Hague C (2008) Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem 283:31068\u201331078","journal-title":"J Biol Chem"},{"key":"7_CR000769","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.peptides.2008.05.006","volume":"30","author":"WH Colledge","year":"2009","unstructured":"Colledge WH (2009) Transgenic mouse models to study Gpr54\/kisspeptin physiology. Peptides 30:34\u201341","journal-title":"Peptides"},{"key":"7_CR000770","doi-asserted-by":"publisher","first-page":"8691","DOI":"10.1523\/JNEUROSCI.1775-08.2008","volume":"28","author":"J Clarkson","year":"2008","unstructured":"Clarkson J, d\u2019Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE (2008) Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 28:8691\u20138697","journal-title":"J Neurosci"},{"key":"7_CR000771","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1210\/jc.84.2.411","volume":"84","author":"KO Klein","year":"1999","unstructured":"Klein KO (1999) Precocious puberty: who has it? Who should be treated? J Clin Endocrinol Metab 84:411\u2013414","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000772","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1210\/jc.86.6.2364","volume":"86","author":"MR Palmert","year":"2001","unstructured":"Palmert MR, Boepple PA (2001) Variation in the timing of puberty: clinical spectrum and genetic investigation. J Clin Endocrinol Metab 86:2364\u20132368","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000773","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1096-7192(03)00107-0","volume":"80","author":"MR Palmert","year":"2003","unstructured":"Palmert MR, Hirschhorn JN (2003) Genetic approaches to stature, pubertal timing, and other complex traits. Mol Genet Metab 80:1\u201310","journal-title":"Mol Genet Metab"},{"key":"7_CR000774","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1210\/er.2002-0019","volume":"24","author":"AS Parent","year":"2003","unstructured":"Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24:668\u2013693","journal-title":"Endocr Rev"},{"key":"7_CR000775","doi-asserted-by":"publisher","first-page":"e932","DOI":"10.1542\/peds.2008-2491","volume":"123","author":"L Aksglaede","year":"2009","unstructured":"Aksglaede L, Sorensen K, Petersen JH, Skakkebaek NE, Juul A (2009) Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 123:e932\u2013939","journal-title":"Pediatrics"},{"key":"7_CR000776","doi-asserted-by":"publisher","first-page":"E583","DOI":"10.1542\/peds.2009-3079","volume":"126","author":"FM Biro","year":"2010","unstructured":"Biro FM, Galvez MP, Greenspan LC, Succop PA, Vangeepuram N, Pinney SM, Teitelbaum S, Windham GC, Kushi LH, Wolff MS (2010) Pubertal Assessment Method and Baseline Characteristics in a Mixed Longitudinal Study of Girls. Pediatrics 126:E583\u2013E590","journal-title":"Pediatrics"},{"key":"7_CR000777","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1210\/jc.2003-030361","volume":"89","author":"L de Vries","year":"2004","unstructured":"de Vries L, Kauschansky A, Shohat M, Phillip M (2004) Familial central precocious puberty suggests autosomal dominant inheritance. J Clin Endocrinol Metab 89:1794\u20131800","journal-title":"J Clin Endocrinol Metab"},{"key":"7_CR000778","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2431-8-27","volume":"8","author":"G Prete","year":"2008","unstructured":"Prete G, Couto-Silva AC, Trivin C, Brauner R (2008) Idiopathic central precocious puberty in girls: presentation factors. BMC Pediatr 8:27","journal-title":"BMC Pediatr"},{"key":"7_CR000779","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1542\/peds.2005-0012","volume":"116","author":"G Teilmann","year":"2005","unstructured":"Teilmann G, Pedersen CB, Jensen TK, Skakkebaek NE, Juul A (2005) Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries. Pediatrics 116:1323\u20131328","journal-title":"Pediatrics"},{"issue":"1\u20132","key":"7_CR000780","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mce.2011.05.019","volume":"346","author":"MG Teles","year":"2011","unstructured":"Teles MG, Silveira LF, Tusset C, Latronico AC (2011) New genetic factors implicated in human GnRH-dependent precocious puberty: the role of kisspeptin system. Mol Cell Endocrinol 346(1\u20132):84\u201390","journal-title":"Mol Cell Endocrinol"},{"key":"7_CR000781","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1210\/me.2006-0138","volume":"20","author":"C Galet","year":"2006","unstructured":"Galet C, Ascoli M (2006) A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation. Mol Endocrinol 20:2931\u20132945","journal-title":"Mol Endocrinol"}],"container-title":["Advances in Experimental Medicine and Biology","Kisspeptin Signaling in Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4614-6199-9_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T10:19:23Z","timestamp":1676801963000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4614-6199-9_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9781461461982","9781461461999"],"references-count":81,"URL":"https:\/\/doi.org\/10.1007\/978-1-4614-6199-9_7","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"16 February 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}