{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T01:05:45Z","timestamp":1725584745214},"publisher-location":"Boston, MA","reference-count":150,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781461350835"},{"type":"electronic","value":"9781461504511"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003]]},"DOI":"10.1007\/978-1-4615-0451-1_1","type":"book-chapter","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T00:11:06Z","timestamp":1307059866000},"page":"3-26","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Genetics of Kidney Cancer"],"prefix":"10.1007","author":[{"given":"Michael","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Othon","family":"Iliopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan, D, and RA Weinberg. 2000. The Hallmarks of Cancer. Cell 100:57\u201370.","journal-title":"Cell"},{"key":"1_CR2","first-page":"124","volume":"27","author":"VE Reuter","year":"2000","unstructured":"Reuter, VE, and JC Presti. 2000. Contemporary approach to the classification of renal epithelial tumors. Seminars in Oncology 27:124\u2013137.","journal-title":"Seminars in Oncology"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/qjmed\/77.2.1151","volume":"77","author":"ER Maher","year":"1990","unstructured":"Maher, ER, JRW Yates, R Harries, C Benjamin, R Harris, AT Moore, and MA Ferguson-Smith. 1990. Clinical features and natural history of von Hippel-Lindau Disease. Quarterly Journal of Medicine 77:1151\u20131163.","journal-title":"Quarterly Journal of Medicine"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0002-9343(64)90107-X","volume":"36","author":"K Melmon","year":"1964","unstructured":"Melmon, K, and S Rosen. 1964. Lindau\u2019s disease. Am J Med 36:595\u2013617.","journal-title":"Am J Med"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.8493574","volume":"260","author":"F Latif","year":"1993","unstructured":"Latif, F, K Tory, J Gnarra, M Yao, F-M Duh, ML Orcutt, T Stackhouse, I Kuzmin, W Modi, L Geil, L Schmidt, F Zhou, H Li, MH Wei, F Chen, G Glenn, P Choyke, MM Walther, Y Weng, D-SR Duan, M Dean, D Glavac, FM Richards, PA Crossey, MA Ferguson-Smith, DL Pasiler, I Chumakov, D Cohen, AC Chinault, ER Maher, WM Linehan, B Zbar, and MI Lerman. 1993. Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene. Science 260:1317\u20131320.","journal-title":"Science"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-198901000-00001","volume":"68","author":"J Lamiell","year":"1989","unstructured":"Lamiell, J, F Salazar, and Y Hsia. 1989. von Hippel-Lindau disease affecting 43 members of a single kindred. Medicine 68:1\u201329.","journal-title":"Medicine"},{"key":"1_CR7","first-page":"1049","volume":"11","author":"S Wizigmann-Voos","year":"1996","unstructured":"Wizigmann-Voos, S, and KH Plate. 1996. Pathology, genetics and cell biology of hemangioblastomas. Histol Histopathol 11:1049\u20131061.","journal-title":"Histol Histopathol"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1046\/j.1365-2796.1998.00337.x","volume":"243","author":"S Richard","year":"1998","unstructured":"Richard, S, C Campello, L Taillandier, F Parker, and F Resche. 1998. Hemangioblastoma of the central nervous system in von Hippel-Lindau disease. J Intern Med 243:547\u2013553.","journal-title":"J Intern Med"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/02688699550041809","volume":"9","author":"RR Sharma","year":"1995","unstructured":"Sharma, RR, IP Cast, and C O\u2019Brien. 1995. Supratentorial haemangioblastoma not associated with Von Hippel Lindau complex or polycythaemia: case report and literature review. Br J Neurosurg 9:81\u201384.","journal-title":"Br J Neurosurg"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1046\/j.1365-2796.1998.00338.x","volume":"243","author":"D Wittebol-Post","year":"1998","unstructured":"Wittebol-Post, D, FJ Hes, and CJM Lips. 1998. The eye in von Hippel-Lindau disease. Long term follow up of screening and treatment recommendations. J Intern Med 243:555\u2013561.","journal-title":"J Intern Med"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/ki.1997.3","volume":"51","author":"HPH Neumann","year":"1997","unstructured":"Neumann, HPH, and B Zbar. 1997. Renal cysts, renal cancer and Von Hippel-Lindau disease. Kidney Int 51:16\u201326.","journal-title":"Kidney Int"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3109\/13816819509059966","volume":"16","author":"EWA Maher","year":"1995","unstructured":"Maher, EWA, and A Moore. 1995. Clinical and molecular genetics of von Hippel-Lindau disease. Ophthalmic Genetics 16:79\u201384.","journal-title":"Ophthalmic Genetics"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0022-5347(01)67602-X","volume":"153","author":"MW McClellan","year":"1995","unstructured":"McClellan, MW, P Choyke, G Weiss, C Manolatos, J Long, R Reiter, RB Alexander, and WM Linehan. 1995. Parenchymal sparing surgery in patients with hereditary renal cell carcinoma. J Urol 153:913\u2013916.","journal-title":"J Urol"},{"key":"1_CR14","first-page":"2251","volume":"59","author":"B Zbar","year":"1999","unstructured":"Zbar, B, W Kaelin, E Maher, and S Richard. 1999. Third International Meeting on von HippelLindau disease. Cancer Res 59:2251\u20132253.","journal-title":"Cancer Res"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1053\/snep.2002.30207","volume":"22","author":"PH Neumann","year":"2002","unstructured":"Neumann, PH, S Hoegerle, T Manz, K Brenner, and 0 Iliopoulos. 2002. How many pathways to pheochromocytoma? Seminars in Nephrology 22:89\u201399.","journal-title":"Seminars in Nephrology"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1056\/NEJM199311183292103","volume":"329","author":"HPH Neumann","year":"1993","unstructured":"Neumann, HPH, DP Berger, G Sigmund, U Blum, D Schmidt, RJ Parmer, B Volk, and G Kirste. 1993. Pheochromocytomas, multiple endocrine neoplasia type 2, and von Hippel-Landau Disease. N Engl J Med 329:1531\u20131538.","journal-title":"N Engl J Med"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1056\/NEJM199906173402404","volume":"340","author":"G Eisenhofer","year":"1999","unstructured":"Eisenhofer, G, JW Lenders, WM Linehan, MM Walther, DS Goldstein, and HR Keiser. 1999. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med 340:1872\u20131879.","journal-title":"N Engl J Med"},{"key":"1_CR18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1148\/radiology.194.3.7862955","volume":"194","author":"PL Choyke","year":"1995","unstructured":"Choyke, PL, GM Glenn, MM Walther, NJ Patrons, WM Linehan, and B Zbar. 1995. von HippelLindau disease: genetic, clinical and imaging features. Radiology 194:629\u2013642.","journal-title":"Radiology"},{"key":"1_CR19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0016-5085(91)90026-H","volume":"101","author":"HP Neumann","year":"1991","unstructured":"Neumann, HP, E Dinkel, H Brambs, B Wimmer, H Friedburg, B Volk, G Sigmund, P Riegler, K Haag, and SP 1991. Pancreatic lesions in the von Hippel-Lindau syndrome. Gastrenterology 101:465\u2013471.","journal-title":"Gastrenterology"},{"issue":"88","key":"1_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4615-6343-3_2","volume":"1996","author":"JS Humphrey","year":"1996","unstructured":"Humphrey, JS, RD Klausner, and WM Linehan. 1996. Von Hippel-Lindau syndrome: hereditary cancer arising from inherited mutations of the VHL tumor suppressor gene. Cancer Treat Res 1996 88:13\u201339.","journal-title":"Cancer Treat Res"},{"key":"1_CR21","first-page":"131","volume":"28","author":"O Iliopoulos","year":"2001","unstructured":"Iliopoulos, O. 2001. VHL Disease: Genetic and Clinical Observations. Genetic Disorders of Endocrine Neoplasia. Basel Karger (Dahia PML, Eng C. eds) 28:131\u2013166.","journal-title":"Basel Karger (Dahia PML, Eng C. eds)"},{"key":"1_CR22","first-page":"268","volume":"332","author":"BR Seizinger","year":"1988","unstructured":"Seizinger, BR, GA Rouleau, LJ Ozelius, AH Lane, GE Farmer, JM Lamiell, J Haines, JWM Yuen, D Collins, D Majoor-Krakauer, T Bonner, C Mathew, A Rubenstein, J Halperin, A McConkie- Rosell, JS Green, JA Trofatter, BA Ponder, L Eierman, MI Bowmer, R Schimke, B Oostra, N Aronin, DI Smith, H Drabkin, MH Waziri,WJ Hobbs, R.L Martuza, PM Conneally,YE Hsia, and JF Gusella. 1988. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332:268\u2013269.","journal-title":"Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/hmg\/2.3.279","volume":"2","author":"P Crossey","year":"1993","unstructured":"Crossey, P, E Maher, M Jones, F Richards, F Latif, M Phipps, M Lush, K Foster, K Tory, J Green, B Oostra, J Yates, W Linehan, N Affara, M Lerman, B Zbar, Y Nakamura, and M Ferguson-Smith. 1993. Genetic linkage between von Hippel-Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus. Human Molecular Genetics 2:279\u2013282.","journal-title":"Human Molecular Genetics"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/0888-7543(91)90185-H","volume":"10","author":"E Maher","year":"1991","unstructured":"Maher, E, E Bentley, J Yates, F Latif, M Lerman, B Zbar, N Affara, and M Ferguson-Smith. 1991. Localization of the gene for von Hippel-lindau disease to a small region of chromosome 3p by genetic linkage analysis. Genomics 10:957\u2013960.","journal-title":"Genomics"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"6495","DOI":"10.1073\/pnas.92.14.6459","volume":"92","author":"DR Duan","year":"1995","unstructured":"Duan, DR, JS Humphrey, DYT Chen, Y Weng, J Sukegawa, S Lee, JR Gnarra, WM Linehan, and RD Klausner. 1995. Characterization of the VHL tumor suppressor gene product-localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci (USA) 92:6495\u20136499.","journal-title":"Proc Natl Acad Sci (USA)"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"9102","DOI":"10.1073\/pnas.94.17.9102","volume":"94","author":"J Gnarra","year":"1997","unstructured":"Gnarra, J, J Ward, F Porter, J Wagne, D Devor, A Grinberg, M Emmert-Buck, H Westphal, R Klausner, and W Linehan. 1997. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A 94:9102\u20139107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1006\/geno.2000.6144","volume":"65","author":"ER Woodward","year":"2000","unstructured":"Woodward, ER, A Buchberger, SC Clifford, LD Hurst, NA Affara, and ER Maher. 2000. Comparative sequence analysis of the VHL tumor suppressor gene. Genomics 65:253\u2013265.","journal-title":"Genomics"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1038\/sj.onc.1203611","volume":"19","author":"B Adryan","year":"2000","unstructured":"Adryan, B, H-J Decker, TS Papas, and T Hsu. 2000. Tracheal development and the von HippelLindau tumor suppressor homolog in Drosophila. Oncogene 19:2803\u20132811.","journal-title":"Oncogene"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K","volume":"12","author":"C Stolle","year":"1998","unstructured":"Stolle, C, G Glenn, B Zbar, J Humphrey, P Choyke, M Walther, S Pack, K Hurley, C Andrey, R Klausner, and W Linehan. 1998. Improved detection of germline mutations in the von HippelLindau disease tumor suppressor gene. Hum Mutat3 12:417\u2013423.","journal-title":"Hum Mutat3"},{"key":"1_CR30","first-page":"765","volume":"60","author":"A Prowse","year":"1997","unstructured":"Prowse, A, A Webster, F Richards, S Richard, S Olschwang, F Resche, N Affara, and E Maher. 1997. Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. American Journal of Human Genetics 60:765\u2013761.","journal-title":"American Journal of Human Genetics"},{"key":"1_CR31","first-page":"2089","volume":"149","author":"IA Lubensky","year":"1996","unstructured":"Lubensky, IA, JR Gnarra, P Bertheau, MM Walther, WM Linehan, and Z Zhuang. 1996. Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von HippelLindau disease patients. American Journal of Pathology 149:2089\u20132094.","journal-title":"American Journal of Pathology"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/ng0594-85","volume":"7","author":"JR Gnarra","year":"1994","unstructured":"Gnarra, JR, K Tory, Y Weng, L Schmidt, MH Wei, H Li, F Latif, S Liu, F Chen, F-M Duh, I Lubensky, DR Duan, C Florence, R Pozzatti, MM Walther, NH Bander, HB Grossman, H Brauch, S Pomer, JD Brooks, WB Isaacs, MI Lerman, B Zbar, and WM Linehan. 1994. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genetics 7:85\u201390.","journal-title":"Nature Genetics"},{"key":"1_CR33","first-page":"2852","volume":"54","author":"T Shuin","year":"1994","unstructured":"Shuin, T, K Kondo, S Torigoe, T Kishida, Y Kubota, M Hosaka, Y Nagashima, H Kitamura, F Latif, B Zbar, MI Lerman, and M Yao. 1994. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 54:2852\u20132855.","journal-title":"Cancer Res"},{"key":"1_CR34","first-page":"4845","volume":"54","author":"H Kanno","year":"1994","unstructured":"Kanno, H, K Kondo, S Ito, I Yamamoto, S Fujii, S Torigoe, N Sakai, M Hosaka, T Shuin, and M Yao. 1994. Somatic mutations of the von Hippel-Lindau Tumor supressor gene in sporadic central nervous systems hemangioblastomas. Cancer Research 54:4845\u20134847.","journal-title":"Cancer Research"},{"key":"1_CR35","first-page":"951","volume":"151","author":"AO Vortmeyer","year":"1997","unstructured":"Vortmeyer, AO, IA Lubensky, F Fogt, WM Linehan, U Khettry, and Z Zhuang. 1997. Allelic deletion and mutation of the von Hippel-Lindau tumor suppressor gene in pancreatic microcystic adenomas. Am J Pathol 151:951\u2013956.","journal-title":"Am J Pathol"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/humu.1380050109","volume":"5","author":"F Chen","year":"1995","unstructured":"Chen, F, T Kishida, M Yao, T Hustad, D Glavac, M Dean, JR Gnarra, ML Orcutt, FM Duh, G Glenn, J Green, YE Hsia, J Lamiell, HW Ming, L Schmidt, T Kalman, I Kuzmin, T Stackhouse, F Latif, WM Linehan, M Lerman, and B Zbar. 1995. Germline mutations in the von hippel-lindau disease tumor suppressor gene: correlations with phenotype. Human Mutation 5:66\u201375.","journal-title":"Human Mutation"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1093\/hmg\/3.8.1303","volume":"3","author":"PA Crossey","year":"1994","unstructured":"Crossey, PA, FM Richards, K Foster, JS Green, A Prowse, F Latif, MI Lerman, B Zbar, NA Affara, MA Ferguson-Smith, and ER Maher. 1994. Identification of intragenic mutations in the von Hippel-Lindau disease tumor suppressor gene and correlation with disease phenotype. Hum Mol Gen 3:1303\u20131308.","journal-title":"Hum Mol Gen"},{"key":"1_CR38","first-page":"328","volume":"33","author":"E Maher","year":"1996","unstructured":"Maher, E, A Webster, F Richards, J Green, P Crossey, S Payne, and A Moore. 1996. Phenotypic expression in von Hippel-Lindau disease: Correlations with germline VHL gene mutations Journal of Medical Genetics 33:328\u2013332.","journal-title":"Correlations with germline VHL gene mutations Journal of Medical Genetics"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nm0895-822","volume":"1","author":"O Iliopoulos","year":"1995","unstructured":"Iliopoulos O, A Kibel, S Gray, and WG Kaelin. 1995. Tumor Suppression by the Human von HippelLindau Gene Product. Nature Medicine 1:822\u2013826.","journal-title":"Nature Medicine"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"10589","DOI":"10.1073\/pnas.93.20.10589","volume":"93","author":"JR Gnarra","year":"1996","unstructured":"Gnarra, JR, S Zhou, MJ Merrill, J Wagner, A Kunlun, E Papavassiliou, EH Oldfield, RD Klausner, and WM Linehan. 1996. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product. Proc Natl Acad Sci 93:10589\u201310594.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR41","first-page":"226","volume":"58","author":"B Knebelmann","year":"1998","unstructured":"Knebelmann, B, S Ananth, HT Cohen, and VP Sukhatme. 1998. Transforming growth factor a is a target for the von Hippel-Lindau tumor suppressor protein. Cancer Res 58:226\u2013231.","journal-title":"Cancer Res"},{"key":"1_CR42","first-page":"2210","volume":"59","author":"S Ananth","year":"1999","unstructured":"Ananth, S, B Knebehnann, W Gruning, M Dhanabal, G Walz, IE Stillman, and VP Sukhatme. 1999. Transforming growth factor betal is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res 59:2210\u20132216.","journal-title":"Cancer Res"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(00)81957-1","volume":"98","author":"GL Semenza","year":"1999","unstructured":"Semenza, GL. 1999. Perspectives on oxygen sensing. Cell 98:281\u2013284.","journal-title":"Cell"},{"key":"1_CR44","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.1073\/pnas.93.20.10595","volume":"93","author":"O Iliopoulos","year":"1996","unstructured":"Iliopoulos O, C Jiang, AP Levy, WG Kaelin, and MA Goldberg. 1996. Negative Regulation of Hypoxia-Inducible Genes by the von Hippel-Lindau Protein. Proc Natl Acad Sci 93:10595\u201310599.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR45","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1128\/MCB.19.2.1289","volume":"19","author":"M Gorospe","year":"1999","unstructured":"Gorospe, M, JM Egan, B Zbar, M Lerman, L Geil, I Kuzmin, and NJ Holbrook. 1999. Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells. Mol Cell Biol 19:1289\u20131300.","journal-title":"Mol Cell Biol"},{"key":"1_CR46","doi-asserted-by":"publisher","first-page":"5851","DOI":"10.1038\/sj.onc.1203985","volume":"19","author":"AR Schoenfeld","year":"2000","unstructured":"Schoenfeld, AR, T PArris, A Eisenberger, EJ Davidowitz, M De Leon, F Talasazan, P Devarajan, and RD Burk. 2000. The von Hippel Lindau tumor suppressor gene protects cells from UV-mediated apoptosis. Oncogne 19:5851\u20135857.","journal-title":"Oncogne"},{"key":"1_CR47","volume-title":"The von Hippel-Lindau Tumor Suppressor Gene is Required for Cell Cycle Exit Upon Serum Withdrawal","author":"A Pause","year":"1998","unstructured":"Pause A, S Lee, KM Lonergan, and RD Klausner. 1998. The von Hippel-Lindau Tumor Suppressor Gene is Required for Cell Cycle Exit Upon Serum Withdrawal. Proc Natl Acad Sci (USA)."},{"key":"1_CR48","first-page":"1","volume-title":"The von Hippel-Lindau Tumor Suppressor Protein is Required for Proper Assembly of an Extracellular Fibronectin Matrix. Mol Cell","author":"M Ohh","year":"1998","unstructured":"Ohh M, RL Yauch, KM Lonergan, JM Whaley, AO Stemmer-Rachamimov, DN Louis, BJ Gavin, N Kley, WG Kaelin, O Iliopoulos, and WG Kaelin. 1998. The von Hippel-Lindau Tumor Suppressor Protein is Required for Proper Assembly of an Extracellular Fibronectin Matrix. Mol Cell 1:In Press."},{"key":"1_CR49","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1128\/MCB.21.3.865-874.2001","volume":"21","author":"EJ Davidowitz","year":"2001","unstructured":"Davidowitz, EJ, AR Schoenfeld, and RD Burk. 2001. VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol Cell Biol 21:865\u2013874.","journal-title":"Mol Cell Biol"},{"key":"1_CR50","first-page":"4957","volume":"58","author":"B Lieubeau-Teillet","year":"1998","unstructured":"Lieubeau-Teillet, B, J Rak, S Jothy, O Iliopoulos, W Kaelin, and RS Kerbel. 1998. VHL gene mediated growth suppression and induction of differentiation in renal cell carcinoma cell grown as multicellular tumor spheroids. Cancer Research 58:4957\u20134962.","journal-title":"Cancer Research"},{"key":"1_CR51","first-page":"2820","volume":"60","author":"H Kanno","year":"2000","unstructured":"Kanno, H, F Saljooque, I Yamamoto, S Hattori, M Yao, T Shuin, and H-S U. 2000. Role of the von HIppel-Lindau tumor suppressor protein during neuronal differentiation. Cancer Res 60:2820\u20132824.","journal-title":"Cancer Res"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"11661","DOI":"10.1073\/pnas.95.20.11661","volume":"95","author":"O Iliopoulos","year":"1998","unstructured":"Iliopoulos O, M Ohh, and W Kaelin. 1998. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 95: 11661\u201311666.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"8817","DOI":"10.1073\/pnas.95.15.8817","volume":"195","author":"A Schoenfeld","year":"1998","unstructured":"Schoenfeld, A, E Davidowitz, and R Burk. 1998. A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci U S A 195:8817\u20138822.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR54","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/MCB.19.2.1486","volume":"19","author":"S Lee","year":"1999","unstructured":"Lee, S, M Neumann, R Stearman, R Stauber, A Pause, G Pavlakis, and R Klausner. 1999. Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein. Mol Cell Biol 19:1486\u20131497.","journal-title":"Mol Cell Biol"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1126\/science.284.5413.455","volume":"284","author":"CE Stebbins","year":"1999","unstructured":"Stebbins, CE, WG Kaelin, and NP Pavletich. 1999. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 284:455\u2013461.","journal-title":"Science"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"PH Maxwell","year":"1999","unstructured":"Maxwell, PH, RMS Wiesene, GW Chang, SC Clifford, EC Vaux, ME Cockman, CC Wykoff, CW Pugh, ER Maher, and PJ Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxiainducible factors for oxygen-dependent proteolysis. Nature 399:271\u2013275.","journal-title":"Nature"},{"key":"1_CR57","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/S0959-437X(98)80016-6","volume":"8","author":"GL Semenza","year":"1998","unstructured":"Semenza, GL. 1998. Hypoxia-inducible factor 1: master regulator of 02 homeostasis. Curr Opin Genet Dev 8:588\u2013594.","journal-title":"Curr Opin Genet Dev"},{"key":"1_CR58","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1146\/annurev.cellbio.15.1.551","volume":"15","author":"GL Semenza","year":"1999","unstructured":"Semenza, GL. 1999. Regulation of mammalian 02 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:581\u2013578.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1_CR59","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/35017054","volume":"2","author":"M Ohh","year":"2000","unstructured":"Ohh, M, CW Park, M Ivan, MA Hoffman, TY Kim, LE Huang, N Pavletich, V Chau, and WG Kaelin. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423\u2013427.","journal-title":"Nat Cell Biol"},{"key":"1_CR60","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola, P, D Mole, YM Tian, MI Wilson, J Gielbert, LSJ Gaskel, AA Kriegsheim, HF Hebestreit, M Mukherji, CJ Schofield, PH Maxwell, CW Pugh, and PJ Ratcliffe. 2001. Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by 02-Regulated Prolyl Hydroxylation. Science 292:468\u2013472.","journal-title":"Science"},{"key":"1_CR61","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1059817","volume":"292","author":"M Ivan","year":"2001","unstructured":"Ivan, M, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, WS Lane, and WG Kaelin. 2001. HIFla targeted for VHL-mediated destruction by praline hydroxylation: implications for oxygen sensing. Science 292:464\u2013468.","journal-title":"Science"},{"key":"1_CR62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","volume":"107","author":"ACR Epstein","year":"2001","unstructured":"Epstein, ACR, JM Gleadle, and LAEA McNeill. 2001 C. Elegans EGL-9 and mammalian homologs define a family of Dioxygenases that regulate HIF by Prolyl Hydroxylation. Cell 107:43\u201354.","journal-title":"Cell"},{"key":"1_CR63","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S1535-6108(02)00044-2","volume":"1","author":"JK Maranchie","year":"2002","unstructured":"Maranchie, JK, JR Vasselli, J Riss, JS Bonifacino, WM Linehan, and RD Klausner. 2002. The contribution of VHL substrate binding and HIF]-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1:247\u2013255.","journal-title":"Cancer Cell"},{"key":"1_CR64","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1535-6108(02)00043-0","volume":"1","author":"K Kondo","year":"2002","unstructured":"Kondo, K, J Klco, E Nakamura, M Lechpammer, and WG Kaelin. 2002. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1:237\u2013246.","journal-title":"Cancer Cell"},{"key":"1_CR65","doi-asserted-by":"publisher","first-page":"43611","DOI":"10.1074\/jbc.M107880200","volume":"276","author":"H Okuda","year":"2001","unstructured":"Okuda, H, K Saitoh, S Hirai, K Iwai, Y Takaki, M Baba, N Minato, S Ohno, and T Shuin. 2001. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem 276:43611\u201343617.","journal-title":"J Biol Chem"},{"key":"1_CR66","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1074\/jbc.M108269200","volume":"277","author":"Z Li","year":"2002","unstructured":"Li, Z, X Na, D Wang, SR Schoen, EM Messing, and G Wu. 2002. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277:4656\u20134662.","journal-title":"J Biol Chem"},{"key":"1_CR67","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"European Consostrium on Tuberous Sclerosis","year":"1993","unstructured":"European Consostrium on Tuberous Sclerosis: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305\u20131315.","journal-title":"Cell"},{"key":"1_CR68","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"Consortium","year":"1997","unstructured":"Consortium: Identification of the TSC1 gene on chromosome 9q34. Science 277:805\u2013808.","journal-title":"Science"},{"key":"1_CR69","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/(SICI)1098-1004(199911)14:5<412::AID-HUMU7>3.0.CO;2-K","volume":"14","author":"Y Niida","year":"1999","unstructured":"Niida Y, N Lawrence-Smith, A Banwell, E Hammer, J Lewis, RL Beauchamp, K Sims, V Ramesh, and L Ozelius. 1999. Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis. Hum Mutat 14:412\u2013422.","journal-title":"Hum Mutat"},{"key":"1_CR70","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1177\/088307389801301206","volume":"13","author":"ES Roach","year":"1988","unstructured":"Roach, ES, MR Gomez, and H Northurp. 1988. Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurology 13:624\u2013628.","journal-title":"J Child Neurology"},{"key":"1_CR71","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1177\/088307389901400610","volume":"14","author":"ES Roach","year":"1998","unstructured":"Roach, ES, FJ DiMario, and H Northurp. 1998. Tuberous sclerosis consensus conference: recommendations for diagnostic evaluation J Child Neurology 14:401\u2013407.","journal-title":"recommendations for diagnostic evaluation J Child Neurology"},{"key":"1_CR72","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(14)71174-2","volume":"119","author":"IE Zimmer-Galler","year":"1995","unstructured":"Zimmer-Galler, IE, and DM Robertson. 1995. Long-term observation of retinal lesions in tuberous sclerosis. Am J Ophthalmol 119:318\u2013324.","journal-title":"Am J Ophthalmol"},{"key":"1_CR73","first-page":"141","volume":"160","author":"DH Ewalt","year":"1998","unstructured":"Ewalt, DH, E Sheffield, SP Sparagana, MR Delgado, and ES Roach. 1998. Renal lesion growth in children with tuberous sclerosis complex. J Urol 1998 Jul;160(1):141\u2013145 160:141\u2013145.","journal-title":"J Urol 1998 Jul;160(1):141-145"},{"key":"1_CR74","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2208::AID-CNCR21>3.0.CO;2-K","volume":"83","author":"T Al-Saleem","year":"1998","unstructured":"Al-Saleem, T, LL Wessner, BW Scheithauer, K Patterson, ES Roach, SJ Dreyer, K Fujikawa, J Bjornsson, J Bernstein, and EP Henske. 1998. Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer 83:2208\u20132216.","journal-title":"Cancer"},{"key":"1_CR75","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/00000478-200202000-00006","volume":"26","author":"G Martignoni","year":"2002","unstructured":"Martignoni, G, F Bonetti, M Pea, R Tardanico, M Brunelli, and _TN Eble. 2002. Renal disease in adults with TSC2\/PKDI contiguous gene syndrome. Am J Surg Pathol 26:198\u2013205.","journal-title":"Am J Surg Pathol"},{"key":"1_CR76","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/00008480-200208000-00011","volume":"14","author":"DH Siegel","year":"2002","unstructured":"Siegel, DH, and R Howard. 2002. Molecular advances in genetic skin diseases. Curr Opin Pediatr 14:419\u2013425.","journal-title":"Curr Opin Pediatr"},{"key":"1_CR77","doi-asserted-by":"publisher","first-page":"56S","DOI":"10.1378\/chest.121.3_suppl.56S","volume":"121","author":"G Pacheco-Rodriguez","year":"2002","unstructured":"Pacheco-Rodriguez G, AS Kristof, LA Stevens, Y Zhang, D Crooks, and J Moss. 2002. Giles F. Filley Lecture: Genetics and gene expression in lymphangioleiomyomatosis. Chest 121:56S\u201360S.","journal-title":"Chest"},{"key":"1_CR78","doi-asserted-by":"publisher","first-page":"11413","DOI":"10.1073\/pnas.91.24.11413","volume":"91","author":"RS Yeung","year":"1994","unstructured":"Yeung, RS, G-H Xiao, F Jin, W-C Lee, jfk. Testa, and AG Knudson. 1994. Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. Proc Nat Acad Sci 91:11413\u201311416.","journal-title":"Proc Nat Acad Sci"},{"key":"1_CR79","doi-asserted-by":"publisher","first-page":"15629","DOI":"10.1073\/pnas.95.26.15629","volume":"95","author":"G Rennebeck","year":"1998","unstructured":"Rennebeck, G, EV Kleymenova, R Anderson, RS Yeung, K Artzt, and CL Walker. 1998. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. Proc Natl Acad Sci USA 95: 15629\u201315634.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1_CR80","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0092-8674(00)80657-1","volume":"96","author":"N Ito","year":"1999","unstructured":"Ito, N, and GM Rubin. 1999. Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96:529\u2013539.","journal-title":"Cell"},{"key":"1_CR81","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","volume":"105","author":"N Tapon","year":"2001","unstructured":"Tapon, N, N Ito, BJ Dickson, JE Treisman, and IK Hariharan. 2001. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105:345\u2013355.","journal-title":"Cell"},{"key":"1_CR82","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00019052-200104000-00005","volume":"14","author":"M MacCollin","year":"2001","unstructured":"MacCollin, M, and D Kwiatkowski. 2001. Molecular genetic aspects of the phakomatoses: tuberous sclerosis complex and neurofibromatosis 1. Curr Opin Neurol 14:163\u2013169.","journal-title":"Curr Opin Neurol"},{"key":"1_CR83","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1056\/NEJM199903043400905","volume":"340","author":"J Kwiatkowska","year":"1999","unstructured":"Kwiatkowska, J, J Wigowska-Sowinska, D Napierala, R Slomski, and DJ Kwiatkowski. 1999. Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis. N Engl J Med 340:703\u2013707.","journal-title":"N Engl J Med"},{"key":"1_CR84","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1086\/302322","volume":"64","author":"VM Rose","year":"1999","unstructured":"Rose VM, KS Au, G Pollom, ES Roach, HR Prashner, and H Northrup. 1999. Germ-line mosaicism in tuberous sclerosis: how common? Am J Hum Genet 64:986\u2013992.","journal-title":"Am J Hum Genet"},{"key":"1_CR85","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/ng1294-328","volume":"8","author":"PT Brook-Carter","year":"1994","unstructured":"Brook-Carter, PT, B Peral, and C Ward, et al. 1994. Deletion of the TSC2 and PKDI gene associated with severe infantile polycystic kidney disease-A contiguous gene syndrome. Nat Genet 8:328\u2013332.","journal-title":"Nat Genet"},{"key":"1_CR86","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1086\/316951","volume":"68","author":"SL Dabora","year":"2001","unstructured":"Dabora, SL, S Jozwiak, DN Franz, PS Roberts, A Nieto, J Chung, YS Choy, MP Reeve, E Thiele, JC Egelhoffi, J Kasprzyk-Obara, D Domanska-Pakiela, and DJ Kwiatkowski. 2001. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 68:64\u201380.","journal-title":"Am J Hum Genet"},{"key":"1_CR87","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00431-001-0903-7","volume":"161","author":"N Langkau","year":"2002","unstructured":"Langkau, N, N Martin, R Brandt, K Zugge, S Quast, G Wiegele, A Jauch, M Rehm, A Kuhl, RM Mack-Vette, B Zimmerhackl, and B Janssen. 2002. TSC1 and TSC2 mutations in tuberous sclerosis, the associated phenotypes and a model to explain observed TSC1\/TSC2 frequency ratios. Eur J Pediatr 161:393\u2013402.","journal-title":"Eur J Pediatr"},{"key":"1_CR88","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","volume":"7","author":"M Slegtenhorst Van","year":"1998","unstructured":"Van Slegtenhorst, M, M Nellist, B Nagelkerken, J Cheadle, R Snell, A van den Ouweland, A Reuser, JP Sampson, D Halley, and P Sluijs. 1998. Interaction between hamartin and tuberin, TSC1 and TSC2 gene products. Hum Mol Genet 7:1053\u20131057.","journal-title":"Hum Mol Genet"},{"key":"1_CR89","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/ng0294-193","volume":"6","author":"AJ Green","year":"1994","unstructured":"Green, AJ, M Smith, and JRW Yates. 1994. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet 6:192\u2013196.","journal-title":"Nature Genet"},{"key":"1_CR90","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1136\/jmg.33.11.962","volume":"33","author":"T Sepp","year":"1996","unstructured":"Sepp, T, JR Yates, and AJ Green. 1996. Loss of heterozygosity in tuberous sclerosis hamartomas. J Med Genet 33:962\u2013964.","journal-title":"J Med Genet"},{"key":"1_CR91","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/gcc.2870130411","volume":"13","author":"EP Henske","year":"1995","unstructured":"Henske, EP, HP Neumann, BW Scheithauer, EW Herbst, MP Short, and DJ Kwiatkowski. 1995. Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band l6pl3 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Gene Chromosomes Cancer 13: 295\u2013298.","journal-title":"Gene Chromosomes Cancer"},{"key":"1_CR92","doi-asserted-by":"publisher","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","volume":"97","author":"T Carsillo","year":"2000","unstructured":"Carsillo, T, A Astrinidis, and EP Henske. 2000. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci 97: 6085\u20136090.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR93","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/gcc.2870130411","volume":"13","author":"EP Henske","year":"1995","unstructured":"Henske, EP, HP Neumann, BW Scheithauer, EW Herbst, MP Short, and DJ Kwiatkowski. 1995. Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band l6pl3 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Genes Chromosomes Cancer 13:295\u2013298.","journal-title":"Genes Chromosomes Cancer"},{"key":"1_CR94","doi-asserted-by":"publisher","first-page":"9154","DOI":"10.1073\/pnas.93.17.9154","volume":"93","author":"F Jin","year":"1996","unstructured":"Jin, F, R Wienecke, GH Xiao, JC Maize, JE DeClue, and RS Yeung. 1996. Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Proc Natl Acad Sci 93:9154\u20139159.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR95","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1086\/321972","volume":"69","author":"Y Niida","year":"2001","unstructured":"Niida, Y, AO Stemmer-Rachamimov, M Logrip, D Tapon, R Perez, DJ Kwiatkowski, K Sims, M MacCollin, DN Louis, and V Ramesh. 2001. Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am j Hum Genet 69:493\u2013503.","journal-title":"Am j Hum Genet"},{"key":"1_CR96","first-page":"1206","volume":"59","author":"T Kobayashi","year":"1999","unstructured":"Kobayashi, T, O Minowa, J Kuno, H Mitani, O Hino, and T Noda. 1999. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 59:1206\u20131211.","journal-title":"Cancer Res"},{"key":"1_CR97","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI7319","volume":"104","author":"H Onda","year":"1999","unstructured":"Onda, H, A Lueck, PW Marks, HB Warren, and DJ Kwiatkowski. 1999. Tsc2(+\/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 104:687\u2013695.","journal-title":"J Clin Invest"},{"key":"1_CR98","doi-asserted-by":"publisher","first-page":"8762","DOI":"10.1073\/pnas.151033798","volume":"98","author":"T Kobayashi","year":"2001","unstructured":"Kobayashi, T, O Minowa, Y Sugitani, S Takai, H Mitani, E Kobayashi, T Noda, and O Hino. 2001. A germ-line Tscl mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci 98:8762\u20138767.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR99","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/ncb840","volume":"4","author":"CJ Potter","year":"2002","unstructured":"Potter, CJ, LG Pedraza, and T Xu. 2002. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4:658\u2013665.","journal-title":"Nat Cell Biol"},{"key":"1_CR100","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/ncb847","volume":"4","author":"X Gao","year":"2002","unstructured":"Gao X, Y Zhang, P Arrazola, O Hino, T Kobayashi, RS Yeung, B Ru, and D Pan. 2002. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4:699\u2013704.","journal-title":"Nat Cell Biol"},{"key":"1_CR101","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"K Inoki","year":"2002","unstructured":"Inoki, K, Y Li, T Zhu, J Wu, and KL Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648\u2013657.","journal-title":"Nat Cell Biol"},{"key":"1_CR102","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","volume":"10","author":"BD Manning","year":"2002","unstructured":"Manning, BD, AR Tee, MN Logsdon, J Blenis, and LC Cantley. 2002. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway. Mol Cell 10:151\u2013162.","journal-title":"Mol Cell"},{"key":"1_CR103","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0955-0674(99)80023-4","volume":"11","author":"LM Luttrell","year":"1999","unstructured":"Luttrell LM, Y Daaka, and RJ Lefkowitz. 1999. Regulation of tyrosine kinase cascades by G-proteincoupled receptors. Curr Opin Cell Biol 11:177\u2013183.","journal-title":"Curr Opin Cell Biol"},{"key":"1_CR104","doi-asserted-by":"publisher","first-page":"16409","DOI":"10.1074\/jbc.270.27.16409","volume":"270","author":"R Wienecke","year":"1995","unstructured":"Wienecke, R, A Koning, and J DeClue. 1995. Identification of tuberin, the tuberous sclerosis 2 product. Tuberin possesses specific Rap] GAP activity. J Biol Chem 270:16409\u201316414.","journal-title":"J Biol Chem"},{"key":"1_CR105","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/ijc.2910430313","volume":"43","author":"G Kovacs","year":"1989","unstructured":"Kovacs, G, P Brusa, and W De Riese. 1989. Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinomas. Int J Cancer 43:422\u2013427.","journal-title":"Int J Cancer"},{"issue":"6","key":"1_CR106","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1086\/301888","volume":"62","author":"D Bodmer","year":"1998","unstructured":"Bodmer, D, MJ Eleveld, MJ Ligtenberg, MA Weterman, BA Janssen, DF Smeets, PE de Wit, A van den Berg, E van den Berg, MI Koolen, and A Geurts van Kessel. 1998. An alternative route for multistep tumorigenesis in a novel case of hereditary renal cell cancer and a t(2;3)(q35;q21) chromosome translocation. Am J Hum Genet 62(6):1475\u20131483:1475\u20131483.","journal-title":"Am J Hum Genet"},{"key":"1_CR107","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0165-4608(01)00585-4","volume":"134","author":"D Bodmer","year":"2002","unstructured":"Bodmer, D, M Eleveld, M Ligtenberg, M Weterman, A van der Meijden, M Koolen, C Hulsbergen-van der Kaa, SD Smits A, and A Geurts van Kessel. 2002. Cytogenetic and molecular analysis of early stage renal cell carcinomas in a family with a translocation (2;3)(q35;q21). Cancer Genet Cytogenet 134:6\u201312.","journal-title":"Cancer Genet Cytogenet"},{"key":"1_CR108","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s100380170001","volume":"46","author":"J Podolski","year":"2001","unstructured":"Podolski, J, T Byrski, S Zajaczek, T Druck, DB Zimonjic, NC Popescu, G Kata, A Borowka, J Gronwald, J Lubinski, and RK Huebne. 2001. Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:685\u2013693.","journal-title":"J Hum Genet"},{"key":"1_CR109","doi-asserted-by":"crossref","first-page":"106","DOI":"10.7326\/0003-4819-118-2-199301150-00005","volume":"118","author":"FP Li","year":"1993","unstructured":"Li, FP, HJ Decker, B Zbar, VP Stanton, G Kovacs, BR Seizinger, H Aburatani, AA Sandberg, S Berg, and S Hosoe, et al. 1993. Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Ann Intern Med 118:106\u2013111.","journal-title":"Ann Intern Med"},{"key":"1_CR110","first-page":"191","volume":"1","author":"L Schmidt","year":"1995","unstructured":"Schmidt, L, F Li, RS Brown, S Berg, F Chen, MH Wei, K Tory, MI Lerman, and B Zbar. 1995. Mechanism of Tumorigenesis of Renal Carcinomas Associated with the Constitutional Chromosome 3;8 Translocation. Cancer J Sci Am 1:191.","journal-title":"Cancer J Sci Am"},{"key":"1_CR111","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/gcc.1114","volume":"31","author":"MJ Eleveld","year":"2001","unstructured":"Eleveld, MJ, D Bodmer, G Merkx, A Siepman, SH Sprenger, MA Weterman, MJ Ligtenberg, J Kamp, W Stapper, JW Jeuken, D Smeets, A Smits, and A Geurts Van Kessel. 2001. Molecular analysis of a familial case of renal cell cancer and a t(3;6)(q12;q15). Genes Chromosomes Cancer 31:23\u201332.","journal-title":"Genes Chromosomes Cancer"},{"key":"1_CR112","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/scbi.2000.0151","volume":"10","author":"B Zbar","year":"2000","unstructured":"Zbar, B. 2000. Inherited epithelial tumors of the kidney: old and new disease. Semin Cancer Biol 10:313\u2013318.","journal-title":"Semin Cancer Biol"},{"key":"1_CR113","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0092-8674(00)81034-X","volume":"84","author":"M Ohta","year":"1996","unstructured":"Ohta, M, H Inoue, MG Cotticelli, K Kastury, R Baffa, J Palazzo, Z Siprashvili, M Mori, P McCue, and EA Druck T. 1996. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormalin digestive tract cancers. Cell 84:587\u2013597.","journal-title":"Cell"},{"key":"1_CR114","doi-asserted-by":"publisher","first-page":"13771","DOI":"10.1073\/pnas.94.25.13771","volume":"94","author":"Z Siprashvili","year":"1997","unstructured":"Siprashvili, Z, G Sozzi, LD Barnes, P McCue, AK Robinson, V Eryomin, L Sard, E Tagliabue, A Greco, L Fusetti, G Schwartz, MA Pierotti, CM Croce, and K Huebner. 1997. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A 94:13771\u201313776.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR115","first-page":"2946","volume":"158","author":"P Hadaczek","year":"1998","unstructured":"Hadaczek, P, Z Siprashvili, M Marldewski, W Domagala, T Druck, PA McCue,Y Pekarsky, M Ohta, K Huebner, and J Lubinski. 1998. Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res 158:2946\u20132951.","journal-title":"Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res"},{"key":"1_CR116","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1073\/pnas.080063497","volume":"97","author":"LY Fong","year":"2000","unstructured":"Fong LY, V Fidanza, N Zanesi, LF Lock, LD Siracusa, R Mancini, Z Siprashvili, M Ottey, SE Martin, T Druck, P McCue, CM Croce, and K Huebner. 2000. Muir-Tone-like syndrome in Fhitdeficient mice. Proc Natl Acad Sci 97:4742\u20134747.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR117","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1073\/pnas.95.16.9572","volume":"95","author":"RM Gemmill","year":"1998","unstructured":"Gemmill, RM, JD West, F Boldog, N Tanaka, 14 Robinson, DI Smith, F Li, and HA Drabkin. 1998. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A 95:9572\u20139577.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR118","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/hmg\/10.7.757","volume":"10","author":"AE Bale","year":"2001","unstructured":"Bale, AE, and KP Yu. 2001. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 10:757\u2013762.","journal-title":"Hum Mol Genet"},{"key":"1_CR119","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s100380170025","volume":"46","author":"T Druck","year":"2001","unstructured":"Druck, T, J Podolski, T Byrski, L Wyrwicz, S Zajaczek, G Kata, A Borowka, J Lubinski, and K Huebner. 2001. The DIRCI gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:583\u2013589.","journal-title":"J Hum Genet"},{"key":"1_CR120","first-page":"641","volume":"11","author":"D Bodmer","year":"2002","unstructured":"Bodmer, D, M Eleveld, E Kater-Baats, I Janssen, B Janssen, M Weterman, E Schoenmaker, M Nickerson, M Linehan, B Zbar, and AG van Kessel. 2002. Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21). Hum Mol Genet 2002 Mar 15;11(6):641\u2013649; 11:641\u2013649.","journal-title":"Hum Mol Genet 2002 Mar 15;11(6):641-649"},{"key":"1_CR121","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/0003-4819-95-2-182","volume":"95","author":"JJ Goedert","year":"1981","unstructured":"Goedert, JJ, EA McKeen, and JF Fraumeni. 1981. Polymastia and renal adenocarcinoma. Ann Intern Med 95:182\u2013184.","journal-title":"Ann Intern Med"},{"key":"1_CR122","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-4608(95)00185-9","volume":"86","author":"K Mehes","year":"1996","unstructured":"Mehes, K. 1996. Familial association of supernumerary nipple with renal cancer. Cancer Genet Cytogenet 86:129\u2013130.","journal-title":"Cancer Genet Cytogenet"},{"key":"1_CR123","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/S0140-6736(05)61751-5","volume":"349","author":"B Teh","year":"1997","unstructured":"Teh, B, S Giraud, F Sari, S Hii, J Bergerat, LCJ Limacher, and D Nicol. 1997 Familial non-VHL non-papillary clear-cell renal cancer. Lancet 349:848\u2013849.","journal-title":"Lancet"},{"key":"1_CR124","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0065-230X(08)60742-3","volume":"75","author":"B Zbar","year":"1998","unstructured":"Zbar, B, and M Lerman. 1998. Inherited carcinomas of the kidney. Advances Cancer Research 75:163\u2013201.","journal-title":"Advances Cancer Research"},{"key":"1_CR125","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ng0597-68","volume":"16","author":"L Schmidt","year":"1997","unstructured":"Schmidt, L, F Duh, F Chen, T Kishida, G Glenn, P Choyke, S Scherer, Z Zhuang, I Lubensky, M Dean, R Allikmets, A Chidambaram, U Bergerheim, J Feltis, C Casadevall, A Zamarron, M Bernues, S Richard, C Lips, M Walther, L Tsui, L Geil, M Orcutt, T Stackhouse, and BEA Zbar. 1997. Gennline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature Genetics 16:68\u201373.","journal-title":"Nature Genetics"},{"key":"1_CR126","first-page":"66","volume":"20","author":"Z Zhuang","year":"1998","unstructured":"Zhuang, Z, WS Park, S Pack, L Schmidt, AO Vortmeyer, E Pak, T Pham, RJ Weil, S Candidus, IA Lubensky, WM Linehan, B Zbar, and G Weirich. 1998. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998 Sep;20(1):66\u201369; 20:66\u201369.","journal-title":"Nat Genet 1998 Sep;20(1):66-69"},{"key":"1_CR127","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/sj.onc.1201338","volume":"15","author":"FM Duh","year":"1997","unstructured":"Duh, FM, SW Scherer, LC Tsui, MI Lerman, B Zbar, and L Schmidt. 1997. Gene structure of the human MET proto-oncogene. Oncogene 15:1583\u20131586.","journal-title":"Oncogene"},{"key":"1_CR128","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0168-1656(94)90002-7","volume":"37","author":"A Bardelli","year":"1994","unstructured":"Bardelli, A, C Ponzetto, and PM Comoglio. 1994. Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering. J Biotechnol 37:109\u2013122.","journal-title":"J Biotechnol"},{"key":"1_CR129","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.1846706","volume":"251","author":"DP Bottaro","year":"1991","unstructured":"Bottaro, DP, JS Rubin, DL Faletto, AM Chan, TE Kmiecik, GF Vande Woude, and SA Aaronson. 1991. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251:802\u2013804.","journal-title":"Science"},{"key":"1_CR130","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0092-8674(94)90318-2","volume":"77","author":"C Ponzetto","year":"1994","unstructured":"Ponzetto, C, A Bardelli, Z Zhen, F Maina, P dalla Zonca, S Giordano, A Graziani, G Panayotou, and PM Comoglio. 1994. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor\/scatter factor receptor family. Cell 77:261\u2013271.","journal-title":"Cell"},{"key":"1_CR131","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/MCB.11.4.1793","volume":"4","author":"L Naldini","year":"1991","unstructured":"Naldini, L, E Vigna, R Ferracini, P Longati, L Gandino, M Prat, and PM Comoglio. 1991. The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol 4:1793\u20131803.","journal-title":"Mol Cell Biol"},{"key":"1_CR132","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1038\/sj.onc.1203628","volume":"19","author":"N Nakaigawa","year":"2000","unstructured":"Nakaigawa, N, G Weirich, L Schmidt, and B Zbar. 2000. Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src. Oncogene 19:2996\u20133002.","journal-title":"Oncogene"},{"key":"1_CR133","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1073\/pnas.90.2.649","volume":"90","author":"S Giordano","year":"1993","unstructured":"Giordano, S, Z Zhen, E Medico, G Gaudin, F Galimi, and PM Comoglio. 1993. Transfer of motogenic and invasive response to scatter factor\/hepatocyte growth factor by transfection of human MET protooncogene. Proc Natl Acad Sci 90:649\u2013653.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR134","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1128\/MCB.19.9.5902","volume":"19","author":"S Koochekpour","year":"1999","unstructured":"Koochekpour, S, M Jeffers, PH Wang, C Gong, GA Taylor, LM Roessler, R Stearman, JR Vasselli, WG Stetler-Stevenson, WG Kaelin, WM Linehan, RD Klausner, JR Gnarra, and GF Vande Woude. 1999. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor\/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 19:5902\u20135912.","journal-title":"Mol Cell Biol"},{"key":"1_CR135","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1073\/pnas.051633798","volume":"98","author":"V Launonen","year":"2001","unstructured":"Launonen, V, O Vierimaa, M Kiuru, J Isola, S Roth, E Pukkala, P Sistonen, R Herva, and LA Aaltonen. 2001. Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci 98:3387\u20133392.","journal-title":"Proc Natl Acad Sci"},{"key":"1_CR136","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1086\/320124","volume":"68","author":"NA Alam","year":"2001","unstructured":"Alam, NA, S Bevan, and MEA Churchman. 2001. Localization of a gene (MCULI) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43. Am J Hum Genet 68:1264\u20131269.","journal-title":"Am J Hum Genet"},{"key":"1_CR137","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/ng844","volume":"30","author":"Consortium TML","year":"2002","unstructured":"Consortium TML. 2002. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30:306\u2013310.","journal-title":"Nat Genet"},{"key":"1_CR138","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng0402-352","volume":"30","author":"P Rustin","year":"2002","unstructured":"Rustin, P. 2002. Mitochondria, from cell death to proliferation. Nat Genet 30:352\u2013353.","journal-title":"Nat Genet"},{"key":"1_CR139","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.287.5454.848","volume":"287","author":"BE Baysal","year":"2000","unstructured":"Baysal, BE, RE Ferrell, JE Willett-Brozick, EC Lawrence, D Myssiorek, A Bosch, A van der Mey, PE Taschner, WS Rubinstein, EN Myers, CW Richard, CJ Cornelisse, P Devilee, and B Devlin. 2000. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848\u2013851.","journal-title":"Science"},{"key":"1_CR140","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/S0140-6736(00)04378-6","volume":"357","author":"D Astuti","year":"2001","unstructured":"Astuti, D, F Douglas, TW Lenard, IA Aligianis, ER Woodward, DG Evans, C Eng, F Latif, and ER Maher. 2001. Germline SDHD mutation in familial phaeochromocytoma. Lancet 357: 1181\u20131182.","journal-title":"Lancet"},{"key":"1_CR141","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/81551","volume":"26","author":"S Nieman","year":"2000","unstructured":"Nieman, S, and U Muller. 2000. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nature Genet 26:268\u2013270.","journal-title":"Nature Genet"},{"key":"1_CR142","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1210\/jc.85.5.1758","volume":"85","author":"CD Malchoff","year":"2000","unstructured":"Malchoff, CD, M Sarfarazi, B Tendler, F Forouhar, G Whalen, V Joshi, A Arnold, and DM Malchoff. 2000. Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metab 85:1758\u20131764.","journal-title":"J Clin Endocrinol Metab"},{"key":"1_CR143","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1001\/archderm.1977.01640120042005","volume":"113","author":"AR Bin","year":"1977","unstructured":"Bin, AR, GR Hogg, and WJ Dube. 1977. Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch Dermatol 113:1674\u20131677.","journal-title":"Arch Dermatol"},{"key":"1_CR144","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1468-3083.1998.tb00952.x","volume":"11","author":"M Scalvenzi","year":"1998","unstructured":"Scalvenzi, M, G Argenziano, E Sammarco, and M Delfmo. 1998. Hereditary multiple fibrofolliculomas, trichodiscomas and acrochordons: syndrome of Birt-Hogg-Dube. J Eur Acad Dermatol Venereol 11:45\u201347.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1_CR145","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1001\/archderm.135.10.1195","volume":"135","author":"JR Toro","year":"1999","unstructured":"Toro, JR, G Glenn, P Duray, T Darling, G Weirich, B Zbar, M Linehan, and ML Turner. 1999. Birt-Hogg-Dube syndrome: a novel marker of kidney neoplasia. Arch Dermatol 135:1195\u20131202.","journal-title":"Arch Dermatol"},{"key":"1_CR146","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/S0190-9622(08)82049-X","volume":"29","author":"JS Roth","year":"1993","unstructured":"Roth, JS, AD Rabinowitz, M Benson, and ME Grossman. 1993. Bilateral renal cell carcinoma in the Birt-Hogg-Dube syndrome. J Am Acad Dermatol 29:1055\u20131056.","journal-title":"J Am Acad Dermatol"},{"key":"1_CR147","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1038\/sj.onc.1204703","volume":"20","author":"SK Khoo","year":"2001","unstructured":"Khoo, SK, M Bradley, FK Wong, MA Hedblad, M Nordenskjold, and BT Teh. 2001. Birt-HoggDube syndrome: mapping of a novel hereditary neoplasia gene to chromosome l7pl 2-ql 1.2. Oncogene 20:5239\u20135242.","journal-title":"Oncogene"},{"key":"1_CR148","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1086\/323744","volume":"69","author":"LS Schmidt","year":"2001","unstructured":"Schmidt, LS, MB Warren, ML Nickerson, G Weirich, V Matrosova, JR Toro, ML Turner, P Duray, M Merino, S Hewitt, CP Pavlovich, G Glenn, CR Greenberg, WM Linehan, and B Zbar. 2001. Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. Am J Hum Genet 69:876\u2013882.","journal-title":"Am J Hum Genet"},{"key":"1_CR149","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0022-5347(01)62888-X","volume":"160","author":"G Weirich","year":"1998","unstructured":"Weirich, G, G Glenn, RK Junke, M Merino, S Storkel, I Lubensky, P Choyke, S Pack, M Amin, MM Walther, WM Lineha, and B Zbar. 1998. Familial renal oncocytoma: clinicopathological study of 5 families. J Urol 160:335\u2013340.","journal-title":"J Urol"},{"key":"1_CR150","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/jcp.55.2.157","volume":"55","author":"X Leroy","year":"2002","unstructured":"Leroy, X, E Leteurtre, PH Mahe, B Gosselin, B Delobel, and MF Croquette. 2002. Renal oncocytoma with a novel chromosomal rearrangement, der(13)t(13;16)(p1 1;p11), associated with a renal cell carcinoma. J Clin Pathol 55:157\u2013158.","journal-title":"J Clin Pathol"}],"container-title":["Cancer Treatment and Research","Kidney Cancer"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4615-0451-1_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T01:57:12Z","timestamp":1553738232000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4615-0451-1_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"ISBN":["9781461350835","9781461504511"],"references-count":150,"URL":"https:\/\/doi.org\/10.1007\/978-1-4615-0451-1_1","relation":{},"ISSN":["0927-3042"],"issn-type":[{"type":"print","value":"0927-3042"}],"subject":[],"published":{"date-parts":[[2003]]}}}