{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:51:01Z","timestamp":1790862661953,"version":"4.1.0"},"publisher-location":"Boston, MA","reference-count":66,"publisher":"Springer US","isbn-type":[{"value":"9781461371335","type":"print"},{"value":"9781461547099","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999]]},"DOI":"10.1007\/978-1-4615-4709-9_7","type":"book-chapter","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T23:01:40Z","timestamp":1316127700000},"page":"57-65","source":"Crossref","is-referenced-by-count":25,"title":["Plasma L-Tryptophan Depletion and Aggression"],"prefix":"10.1007","author":[{"given":"Donald M.","family":"Dougherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Gerard","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Bjork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"7_CR1","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1001\/archpsyc.1976.01770100055005","volume":"33","author":"M Asberg","year":"1976","unstructured":"Asberg, M, Traskman, L., and Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor. Arch Gen Psychiat, 33:1193\u20131197.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1749-6632.1986.tb27903.x","volume":"487","author":"M Asberg","year":"1986","unstructured":"Asberg, M., Nordstrom, P., and Traskman-Bendz, L. (1986). Cerebrospinal fluid studies in suicide: an overview. Ann N Acad Sci, 487:243\u2013255.","journal-title":"Ann N Acad Sci"},{"key":"7_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1001\/archpsyc.1979.01780020114013","volume":"36","author":"JC Ballenger","year":"1979","unstructured":"Ballenger, J.C., Goodwin, F.K., Major, L.F., and Brown, G.L. (1979). Alcohol and central serotonin metabolism in man. Arch Gen Psychiat, 36:224\u2013227.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1017\/S0033291700020407","volume":"21","author":"J Bancroft","year":"1991","unstructured":"Bancroft, J., Cook, A., Davidson, D., Bennie, J., and Goodwin, G. (1991). Blunting of neuroendocrine responses to infusion of L-tryptophan in women with perimenstrual mood change. Psychol Med, 21:305\u2013312.","journal-title":"Psychol Med"},{"key":"7_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF01249132","volume":"50","author":"CM Banki","year":"1981","unstructured":"Banki, C.M. (1981). Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J Neural Trans, 50:89\u2013101.","journal-title":"J Neural Trans"},{"key":"7_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0165-1781(83)90072-0","volume":"10","author":"CM Banki","year":"1983","unstructured":"Banki, C.M. and Arato, M. (1983). Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatr Res, 10:253\u2013261.","journal-title":"Psychiatr Res"},{"key":"7_CR7","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/0024-3205(74)90440-8","volume":"14","author":"G Biggio","year":"1974","unstructured":"Biggio, G., Fadda, D., Fanni, P., Tagliamonte, A., and Gessa, G.L. (1974). Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic by a tryptophan-free diet. Life Sci, 14:1321\u20131329.","journal-title":"Life Sci"},{"key":"7_CR8","doi-asserted-by":"crossref","unstructured":"Bjork, J.M., Dougherty, D.M., Moeller, F.G., Cherek, D.R., and Swann, A.C. (in press). The effects of tryptophan depletion and loading in laboratory aggression in men: Time course and a food-restricted control. Psychopharmacol.","DOI":"10.1007\/s002130050858"},{"key":"7_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0741-8329(85)90106-5","volume":"2","author":"S Borg","year":"1985","unstructured":"Borg, S., Kvande, H., Liljeberg, P., Mossberg, D., and Valverius, P. (1985). 5-Hydroxyindoleacetic acid in cere-brospinal fluid in alcoholic patients under different clinical conditions. Alcohol, 2:415\u2013418.","journal-title":"Alcohol"},{"key":"7_CR10","first-page":"131","volume-title":"Psychopharmacology in aggression","author":"GL Brown","year":"1979","unstructured":"Brown, G.L., Ballanger, J.C., Minichiello, M.D., and Goodwin, F.K. (1979). Human aggression and its relationship to cerebrospinal fluid 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and homovaillic acid, in: Psychopharmacology in aggression. (M. Sandler, ed.), pp. 131\u2013148, New York: Raven Press."},{"key":"7_CR11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1176\/ajp.139.3.399","volume":"139","author":"GL Brown","year":"1982","unstructured":"Brown, G.L., Ebert, M.H., Goyer, P.F., Jimerson, D.C., Klein, W.J., Bunney, W.E., and Goodwin, F.K. (1982a). Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiat, 139:741\u2013746.","journal-title":"Am J Psychiat"},{"key":"7_CR12","first-page":"287","volume":"34","author":"GL Brown","year":"1982","unstructured":"Brown, G.L., Goodwin, F.K., and Bunney, W.E.J. (1982b). Human aggression and suicide: their relationship to neuropsychaitric diagnoses and serotonin metabolism. Adv Biochem Psychopharmacol, 34:287\u2013307. Raven Press.","journal-title":"Adv Biochem Psychopharmacol"},{"key":"7_CR13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1037\/h0046900","volume":"21","author":"AH Buss","year":"1957","unstructured":"Buss, A.H. and Durkee, A. (1957). An inventory for assessing different kinds of hostility. J Consult Clin Psychol, 21:343\u2013349.","journal-title":"J Consult Clin Psychol"},{"key":"7_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/ana.410060109","volume":"6","author":"IJ Butler","year":"1979","unstructured":"Butler, I.J., Koslow, S.H., Seifert, W.E.J., Caprioli, R.M., and Singer, H.S. (1979). Biogenic amine metabolism in Tourette syndrome. Ann Neurol, 6:37\u201339.","journal-title":"Ann Neurol"},{"issue":"2","key":"7_CR15","first-page":"1220","volume":"23","author":"LL Carpenter","year":"1997","unstructured":"Carpenter, L.L., Anderson, G., Pelton, G., Gudin, J., Kirwin, P.D.S., Price, L.H., Heninger, G.R., and McDougal, C.J. (1997). Tryptophan depletion during continuous CSF sampling via indwelling lumbar catheter in healthy human subjects. Soc Neurosci Abstr, 23(2):1220.","journal-title":"Soc Neurosci Abstr"},{"key":"7_CR16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0091-3057(87)90513-2","volume":"28","author":"B Chamberlain","year":"1987","unstructured":"Chamberlain, B., Ervin, F.R., Pihl, R.O., and Young, S.N. (1987). The effects of raising or lowering tryptophan levels on aggression in Vervet monkeys. Pharmacol, Biochem Behav, 28:503\u2013510.","journal-title":"Pharmacol, Biochem Behav"},{"key":"7_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/BF00464569","volume":"77","author":"DS Charney","year":"1982","unstructured":"Charney, D.S., Heninger, G.R., Reinhard, J.F., Sternberg, D.E., and Hafstead, K.M. (1982). The effect of intravenous tryptophan on prolactin and growth hormone and mood in normal subjects. Psychopharmacol, 77:217\u2013222.","journal-title":"Psychopharmacol"},{"key":"7_CR18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/BF02245252","volume":"118","author":"AJ Cleare","year":"1995","unstructured":"Cleare, A.J. and Bond, A.J. (1995). The effect of tryptophan depletion and enhancement on subjective and behavioral aggression in normal male subjects. Psychopharmacol, 118:72\u201381.","journal-title":"Psychopharmacol"},{"key":"7_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1001\/archpsyc.1978.01770260123015","volume":"35","author":"J Cohen","year":"1978","unstructured":"Cohen, J., Shaywitz, B.A., Caparulo, B., Young, J.G., and Bowers, M.B.J. (1978). Chronic, multiple tics of Gilles de la Tourette\u2019s disease: CSF acid monoamine metabolites after probenecid administration. Arch Gen Psychiat, 35:245\u2013250.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR20","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0002-7138(09)61046-3","volume":"18","author":"DJ Cohen","year":"1979","unstructured":"Cohen, D.J., Shaywitz, B.A., Young, J.G., Carbonari, C.M., Nathanson, J.A., Lieberman, D., Bowers, M.B.J., and Maas, J.W. (1979). Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: noreepinephrine, serotonin, and dopamine. J Am Acad Child Adol Psychiat, 18:320\u2013341.","journal-title":"J Am Acad Child Adol Psychiat"},{"issue":"24","key":"7_CR21","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/0024-3205(89)90114-8","volume":"45","author":"PL Delgado","year":"1989","unstructured":"Delgado, P.L., Charney, D.S., Price, L.H., Landis, H., and Heninger, G.R. (1989). Neuroendocrine and behavioral effects of dietary tryptophan restruction in healthy subjects. Life Sci, 45(24):2323\u201332.","journal-title":"Life Sci"},{"key":"7_CR22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1001\/archpsyc.1990.01810170011002","volume":"47","author":"PL Delgado","year":"1990","unstructured":"Delgado, P.L., Charney, D.S., Price, L.H., Aghajanian, G.K., Landis, H., and Heninger, G.R. (1990). Serotonin function and the mechanism of antidepressant action: Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiat, 47:411\u2013418.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1126\/science.173.3992.149","volume":"173","author":"JD Fernstrom","year":"1971","unstructured":"Fernstrom, J.D. and Wurtman, R.J. (1971). Brain serotonin content: Physiological dependence on plasma tryptophan levels. Science, 173:149\u2013152.","journal-title":"Science"},{"key":"7_CR24","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1126\/science.178.4059.414","volume":"178","author":"JD Fernstrom","year":"1972","unstructured":"Fernstrom, J.D. and Wurtman, R.J. (1972). Brain serotonin content: Physiological regulation by plasma neutral amino acids. Science, 178:414\u2013416.","journal-title":"Science"},{"key":"7_CR25","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/j.1471-4159.1974.tb04308.x","volume":"22","author":"GL Gessa","year":"1974","unstructured":"Gessa, G.L., Biggio, G., Fadda, F., Corsini, G.V., and Tagliamonte, A. (1974). Effect of the oral administration of tryptophan-free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism. J Neurochem, 22:869\u2013870.","journal-title":"J Neurochem"},{"key":"7_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/13813459009115733","volume":"98","author":"S Giammanco","year":"1990","unstructured":"Giammanco, S., Ernandes, M., Lopez de Onate, R., and Paderni, M.A. (1990). Short term diet of precooked corn meal almost lacking in tryptophan and interspecific rat-mouse aggressive behavior. Arch Int Physiol, Biochim, Biophys, 98:23\u201326.","journal-title":"Arch Int Physiol, Biochim, Biophys"},{"key":"7_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0006-8993(79)90380-9","volume":"169","author":"JL Gibbons","year":"1979","unstructured":"Gibbons, J.L., Barr, G.A., Bridger, W.H., and Liebowitz, S.F. (1979). Manipulation of dietary tryptophan: effects on mouse killing and brain serotonin in the rat. Brain Res, 169:139\u2013153.","journal-title":"Brain Res"},{"key":"7_CR28","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0091-3057(81)90178-7","volume":"15","author":"JL Gibbons","year":"1981","unstructured":"Gibbons, J.L., Barr, G.A., Bridger, W.H., and Liebowitz, S.F. (1981). L-Tryptophan\u2019s effect on mouse killing, feeding, drinking, locomotion and brain. Pharmacol, Biochem Behav, 15:201\u2013206.","journal-title":"Pharmacol, Biochem Behav"},{"key":"7_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4899-1678-5_12","volume":"7","author":"K Gill","year":"1989","unstructured":"Gill, K. and Amit, Z. (1989). Serotonin uptake blockers and voluntary alcohol consumption: a review of recent studies. Recent Dev Alcohol, 7:225\u2013248.","journal-title":"Recent Dev Alcohol"},{"key":"7_CR30","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0022-3565(25)22806-3","volume":"250","author":"S Gleeson","year":"1989","unstructured":"Gleeson, S., Ahlers, S.T., Mansbach, R.S., Foust, J.M., and Barrett, J.E. (1989). Behavioral studies with anxiolytic drugs, VI: effects on punished responding of drugs interacting with serotonin receptor subtypes. J Pharmacol Exp Ther, 250:809\u2013817.","journal-title":"J Pharmacol Exp Ther"},{"key":"7_CR31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0006-3223(90)90412-U","volume":"28","author":"DC Jimerson","year":"1990","unstructured":"Jimerson, D.C., Lesem, M.D., Kaye, W.H., Hegg, A.P., and Brewerton, T.D. (1990). Eating disorders and depression: Is there a serotonin connection?. Biol Psychiat, 28:443\u2013454.","journal-title":"Biol Psychiat"},{"key":"7_CR32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1001\/archpsyc.1992.01820020052007","volume":"49","author":"DC Jimerson","year":"1992","unstructured":"Jimerson, D.C., Lesem, M.D., Kaye, W.H., and Brewerton, T.D. (1992). Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Arch Gen Psychiat, 49:132\u2013138.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0091-3057(80)90351-2","volume":"12","author":"KM Kantak","year":"1980","unstructured":"Kantak, K.M., Hegstrand, L.R., Whitman, J., and Eichelman, B. (1980). Effects of dietary supplements and a tryptophan free diet on aggressive behaviour in rats. Pharmacol, Biochem Behav, 12:173\u2013180.","journal-title":"Pharmacol, Biochem Behav"},{"key":"7_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0165-1781(89)90203-5","volume":"28","author":"MJ Kruesi","year":"1989","unstructured":"Kruesi, M.J. (1989). Cruelty to animals and CSF 5-HIAA (letter). Psychiatr Res, 28:115\u2013116.","journal-title":"Psychiatr Res"},{"key":"7_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1001\/archpsyc.1990.01810170019003","volume":"47","author":"MJ Kruesi","year":"1990","unstructured":"Kruesi, M.J., Rapoport, J.L., Hamburger, S., Hibbs, E., Potter, W.Z., Lenane, M., and Brown, G.L. (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiat, 47:419\u2013426.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1001\/archpsyc.1992.01820060009001","volume":"49","author":"MJ Kruesi","year":"1992","unstructured":"Kruesi, M.J., Hibbs, E.D., Zahn, T.P., Keysor, C.S., Manburger, S.D., Bartko, J.J., and Rapoport, J.L. (1992). A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders: prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomic measures? Arch Gen Psychiat, 49:429\u2013435.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1600-0447.1985.tb01279.x","volume":"71","author":"L Lidberg","year":"1985","unstructured":"Lidberg, L., Tuck, J.R., Asberg, M., Scalia-Tomba, G.P., and Bertilsson, L. (1985). Acta Psychiatr Scand, 71:230\u2013236.","journal-title":"Acta Psychiatr Scand"},{"key":"7_CR38","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1001\/archpsyc.1991.01810290049010","volume":"48","author":"R Limson","year":"1991","unstructured":"Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B., and Linnoila, M. (1991). Personality and cerebrospinal fluid monomine metabolites in alcoholics and controls. Arch Gen Psychiat, 48:437\u2013441.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR39","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/0024-3205(83)90344-2","volume":"33","author":"M Linnoila","year":"1983","unstructured":"Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., and Goodwin, F.K. (1983). Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci, 33:2609\u20132614.","journal-title":"Life Sci"},{"key":"7_CR40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4899-1678-5_10","volume":"7","author":"WJ McBride","year":"1989","unstructured":"McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.K. (1989). Serotonin and ethanol preference. Recent Dev Alcohol, 7:187\u2013209.","journal-title":"Recent Dev Alcohol"},{"key":"7_CR41","first-page":"399","volume":"25","author":"KA Miczek","year":"1989","unstructured":"Miczek, K.A., Mos, J., and Olivier, B. (1989). Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol Bull, 25:399\u2013403.","journal-title":"Psychopharmacol Bull"},{"key":"7_CR42","first-page":"117","volume-title":"Behavioral Pharmacology of 5-HT.","author":"KA Miczek","year":"1990","unstructured":"Miczek, K.A. and Donat, P. (1990). Brain 5-HT system and inhibition of aggressive behavior, in: Behavioral Pharmacology of 5-HT. (T. Archer, P. Bevan, A. Cools, and N.J. Hillsdale [nteds.), pp. 117\u2013144, New Jersey: Lawrence Erlbaum Assoc."},{"key":"7_CR43","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF02246343","volume":"126","author":"FG Moeller","year":"1996","unstructured":"Moeller, F.G., Dougherty, D.M., Swann, A.C., Collins, D., Davis, M., and Cherek, D.R. (1996). Tryptophan depletion and aggressive responding in healthy males. Psychopharmacol, 126:97\u2013103.","journal-title":"Psychopharmacol"},{"key":"7_CR44","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0306-9877(87)90055-7","volume":"23","author":"HB Moss","year":"1987","unstructured":"Moss, H.B. (1987). Serotonergic activity and disinhibitory psychopathy in alcoholism. Med Hypotheses, 23:353\u2013361.","journal-title":"Med Hypotheses"},{"key":"7_CR45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0091-3057(89)90434-6","volume":"33","author":"EV Naumenko","year":"1989","unstructured":"Naumenko, E.V., Popova, N.K., Nikulina, E.M., Dygalo, N.N., Shishkina, G.T., Borodin, P.M., and Markel, A.L. (1989). Behavior, adrenocortical activity, and brain monoamines in Norway rats selected for reduced aggressiveness towards man. Pharmacol, Biochem Behav, 33:85\u201391.","journal-title":"Pharmacol, Biochem Behav"},{"key":"7_CR46","doi-asserted-by":"publisher","first-page":"5308","DOI":"10.1073\/pnas.94.10.5308","volume":"94","author":"S Nishizawa","year":"1997","unstructured":"Nishizawa, S., Benkelfat, C., Young, S.N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., and Diksic, M. (1997). Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci, 94:5308\u20135313.","journal-title":"Proc Natl Acad Sci"},{"key":"7_CR47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1365-2265.1991.tb03768.x","volume":"34","author":"V OKeane","year":"1990","unstructured":"O\u2019Keane, V., O\u2019Hanlon, M., Webb, M., and Dinan, T. (1990). d-Fenfluramine\/prolactin response throughout the menstrual cycle: evidence for an estrogen-induced alteration. Clin Endocrinol (Oxf.), 34:289\u2013292.","journal-title":"Clin Endocrinol"},{"key":"7_CR48","first-page":"203","volume":"361","author":"B Olivier","year":"1990","unstructured":"Olivier, B. and Mos, J. (1990). Serenics, serotonin and aggression. Prog Clin Biol Res, 361:203\u2013230.","journal-title":"Prog Clin Biol Res"},{"key":"7_CR49","unstructured":"Olivier, B., Mos, J., Tulp, M., Schipper, J., and Bevan, P. (1990). Modulatory action of serotonin in aggressive behavior, in: Behavioral pharmacology of 5-HT, (T. Archer, P. Bevan, A. Cools, and N. J. Hillsdale, e s.), pp. 89\u2013115, New Jersey: Lawrence Erlbaum Assoc."},{"key":"7_CR50","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/BF02245849","volume":"119","author":"RO Pihl","year":"1995","unstructured":"Pihl, R.O., Young, S.N., Harden, P., Plotnick, S., Chamberlain, B., and Ervin, F.R. (1995). Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacol, 119:353\u2013360.","journal-title":"Psychopharmacol"},{"key":"7_CR51","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/1098-2337(1991)17:4<207::AID-AB2480170403>3.0.CO;2-2","volume":"17","author":"NK Popova","year":"1991","unstructured":"Popova, N.K., Kulikov, A.V., Nikulina, E.M., Kozlachkova, E.Y., and Maslova, G.B. (1991). Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness towards man. Aggress Behav, 17:207\u2013213.","journal-title":"Aggress Behav"},{"key":"7_CR52","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/0091-3057(91)90080-L","volume":"40","author":"NK Popova","year":"1991","unstructured":"Popova, N.K., Voitenko, N.N., Kulikov, A.V., and Avgustinovich, D.F. (1991). Evidence for the involvement of central serotonin in the mechanism of domestication of silver foxes. Pharmacol, Biochem Behav, 40:751\u2013756.","journal-title":"Pharmacol, Biochem Behav"},{"key":"7_CR53","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/0014-4886(80)90089-8","volume":"68","author":"MJ Raleigh","year":"1980","unstructured":"Raleigh, M.J., Brammer, G.L., Yuwiler, A., Flannery, J.W., and McGuire, M.T. (1980). Serotonergic influences on the social behavior of Vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol, 68:322\u2013334.","journal-title":"Exp Neurol"},{"key":"7_CR54","first-page":"185","volume":"131","author":"MJ Raleigh","year":"1983","unstructured":"Raleigh, M.J., Brammer, G.L., and McGuire, M.T. (1983). Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in Vervet monkeys (Cercopithecus aethiops sabaeus). Prog Clin Biol Res, 131:185\u2013197.","journal-title":"Prog Clin Biol Res"},{"key":"7_CR55","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/0006-8993(85)90445-7","volume":"348","author":"MJ Raleigh","year":"1985","unstructured":"Raleigh, M.J., Brammer, G.L., McGuire, M.T., and Yuwiler, A. (1985). Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Res, 348:274\u2013282.","journal-title":"Brain Res"},{"key":"7_CR56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0162-3095(86)90048-8","volume":"7","author":"MJ Raleigh","year":"1986","unstructured":"Raleigh, M.J. and McGuire, M.T. (1986). Animal analogs of ostracism: biological mechanisms and social consequences. Ethology Sociobiol, 7:53\u201366.","journal-title":"Ethology Sociobiol"},{"key":"7_CR57","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0006-8993(91)90001-C","volume":"559","author":"MJ Raleigh","year":"1991","unstructured":"Raleigh, M.J., McGuire, M.T., Brammer, G.L., Pollack, D.B., and Yuwiler, A. (1991). Serotonergic mechanisms promote dominance acquisition in adult male Vervet monkeys. Brain Res, 559:181\u2013190.","journal-title":"Brain Res"},{"key":"7_CR58","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0278-5846(89)90138-3","volume":"13","author":"A Roy","year":"1989","unstructured":"Roy, A. and Linnoila, M. (1989). CSF studies on alcoholism and related behaviors. Prog. Neuropsychopharmacol Biol Psychiat, 13:505\u2013511.","journal-title":"Prog. Neuropsychopharmacol Biol Psychiat"},{"key":"7_CR59","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/1098-2337(1986)12:6<393::AID-AB2480120602>3.0.CO;2-L","volume":"12","author":"SE Smith","year":"1986","unstructured":"Smith, S.E., Pihl, R.O., Young, S.N., and Ervin, F.R. (1986). Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggress Behav., 12:393\u2013407.","journal-title":"Aggress Behav."},{"key":"7_CR60","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archpsyc.1987.01800150053007","volume":"44","author":"M Virkkunen","year":"1987","unstructured":"Virkkunen, M., Nuutila, A., Goodwin, F.K., and Linnoila, M. (1987). Cerebrospinal fluid monomine metabolite levels in male arsonists. Arch Gen Psychiat, 44:241\u2013247.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR61","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1001\/archpsyc.1994.03950010028004","volume":"51","author":"M Virkkunen","year":"1994","unstructured":"Virkkunen, M., Kallio, E., Rawlings, R., Tokola, R., Poland, R.E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.L., and Linnoila, M. (1994). Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiat, 51:28\u201333.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR62","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1001\/archpsyc.1994.03950010020003","volume":"51","author":"M Virkkunen","year":"1994","unstructured":"Virkkunen, M., Rawlings, R., Tokola, R., Poland, R.E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.L., and Linnoila, M. (1994). CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiat, 51:20\u201327.","journal-title":"Arch Gen Psychiat"},{"key":"7_CR63","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/0024-3205(95)00103-4","volume":"56","author":"BE Wolfe","year":"1995","unstructured":"Wolfe, B.E., Metzger, E.D., and Jimerson, D.C. (1995). Comparison of the effects of amino acid mixture and placebo on plasma tryptophan to large neutral amino acid ratio. Life Sci, 56:1395\u20131400.","journal-title":"Life Sci"},{"key":"7_CR64","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1136\/jnnp.44.4.323","volume":"44","author":"SN Young","year":"1981","unstructured":"Young, S.N. and Gauthier, S. (1981). Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid, and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid. J Neurol, Neurosurg Psychiat, 44:323\u2013327.","journal-title":"J Neurol, Neurosurg Psychiat"},{"key":"7_CR65","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF00431803","volume":"87","author":"SN Young","year":"1985","unstructured":"Young, S.N., Smith, S., Pihl, R.O., and Ervin, F.R. (1985). Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacol, 87:173\u2013177.","journal-title":"Psychopharmacol"},{"key":"7_CR66","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/BF00441950","volume":"98","author":"SN Young","year":"1989","unstructured":"Young, S.N., Ervin, F.R., Pihl, R.O., and Finn, P. (1989). Biochemical aspects of tryptophan depletion in primates. Psychopharmacol, 98:508\u2013511.","journal-title":"Psychopharmacol"}],"container-title":["Advances in Experimental Medicine and Biology","Tryptophan, Serotonin, and Melatonin"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4615-4709-9_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T07:29:00Z","timestamp":1741678140000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4615-4709-9_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"ISBN":["9781461371335","9781461547099"],"references-count":66,"URL":"https:\/\/doi.org\/10.1007\/978-1-4615-4709-9_7","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[1999]]}}}