{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:19:42Z","timestamp":1725599982914},"publisher-location":"Boston, MA","reference-count":23,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781461377245"},{"type":"electronic","value":"9781461559450"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997]]},"DOI":"10.1007\/978-1-4615-5945-0_14","type":"book-chapter","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T01:06:15Z","timestamp":1312765575000},"page":"217-227","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Acid-Base Alterations and Protein Depletion on Hepatic Nitrogen Metabolism"],"prefix":"10.1007","author":[{"given":"Anton C.","family":"Schoolwerth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"O\u2019Donovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"14_CR1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/B978-0-12-152821-8.50014-1","volume":"21","author":"DE Atkinson","year":"1982","unstructured":"D.E. Atkinson and M. Camien. The role of urea synthesis in the removal of metabolic bicarbonate and the regulation of blood pH. Curr. Top. Cell. Regul. 21:261\u2013302 (1982).","journal-title":"Curr. Top. Cell. Regul."},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0968-0004(84)90293-7","volume":"7","author":"DE Atkinson","year":"1984","unstructured":"D.E. Atkinson and E. Bourke. The role of ureagenesis in pH homeostasis. Trends Biochem. Sci. 7:297\u2013300 (1984).","journal-title":"Trends Biochem. Sci."},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2362.1977.tb01632.x","volume":"7","author":"J Oliver","year":"1977","unstructured":"J. Oliver, A.M. Koelz, J. Costello, and E. Bourke. Acid-base alterations in glutamine metabolism and ureagenesis in perfused muscle and liver of the rat. Eur. J. Clin. Invest. 7:445\u2013449 (1977).","journal-title":"Eur. J. Clin. Invest."},{"key":"14_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0168-8278(85)80063-5","volume":"1","author":"D Haussinger","year":"1984","unstructured":"D. Haussinger, H. Sies, and W. Gerok. Functional heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J. Hepatol. 1:3\u201314 (1984).","journal-title":"J. Hepatol."},{"key":"14_CR5","doi-asserted-by":"crossref","first-page":"F605","DOI":"10.1152\/ajpcell.1986.250.4.C605","volume":"250","author":"ML Halperin","year":"1986","unstructured":"M. L. Halperin, C.B. Chen, S. Cheema-Dhadli, M.L. West, and R.L. Jungas. Is urea formation regulated primarily by acid-base balance in vivo? Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19):F605\u2013F612 (1986).","journal-title":"Am. J. Physiol."},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1432-1033.1987.tb13541.x","volume":"166","author":"C Lenzen","year":"1987","unstructured":"C. Lenzen, S. Soboll, H. Sies, and D. Haussinger. pH control of hepatic glutamine degradation. Role of transport. Eur. J. Biochem. 166:483\u2013488 (1987).","journal-title":"Eur. J. Biochem."},{"key":"14_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1432-1033.1988.tb13911.x","volume":"172","author":"L Boon","year":"1988","unstructured":"L. Boon and A.J. Meijer. Control by pH of urea synthesis in isolated hepatocytes. Eur. J Biochem. 172:465\u2013469, 1988.","journal-title":"Eur. J Biochem."},{"key":"14_CR8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj2920241","volume":"292","author":"B Carey","year":"1993","unstructured":"B. Carey, C.W. Cheung, N.S. Cohen, S. Brusilow, and L. Raijman. Regulation of urea and citrulline synthesis under physiological conditions. Biochem. J. 292:241\u2013247 (1993).","journal-title":"Biochem. J."},{"key":"14_CR9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1432-1033.1988.tb14315.x","volume":"176","author":"V Felipo","year":"1988","unstructured":"V. Felipo, M-D Minana, and S. Grisolia. Long-term ingestion of ammonium increases acetyl glutamate and urea levels without affecting the amount of carbamoyl-phosphate synthase. Eur. J. Biochem. 176:567\u2013571 (1988).","journal-title":"Eur. J. Biochem."},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1432-1033.1980.tb04640.x","volume":"107","author":"HESJ Hensgens","year":"1980","unstructured":"H.E.S.J. Hensgens, A.J. Verhoeven, and A.J. Meijer. The relationship between intramitochondrial n-acetylglutamine activity and carbamoyl phosphate synthetase (ammonia). Eur. J. Biochem. 107:197\u2013205 (1980).","journal-title":"Eur. J. Biochem."},{"key":"14_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1432-1033.1978.tb12250.x","volume":"85","author":"K Shigesada","year":"1978","unstructured":"K. Shigesada, K. Aoyagi, and M. Tatibana. Role of n-acetylglutamate in ureotelism. Variations in acetylglutamate level and its possible significance in control of urea synthesis in mammalian liver. Eur. J. Biochem. 85:385\u2013391 (1978).","journal-title":"Eur. J. Biochem."},{"key":"14_CR12","doi-asserted-by":"crossref","first-page":"10248","DOI":"10.1016\/S0021-9258(19)70456-6","volume":"255","author":"NS Cohen","year":"1980","unstructured":"N.S. Cohen, S.W. Cheung, and L. Raijman. The effects of ornithine on mitochondrial carbamoyl phosphate synthesis. J. Biol. Chem. 255:10248\u201310255 (1980).","journal-title":"J. Biol. Chem."},{"key":"14_CR13","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-9861(91)90371-O","volume":"285","author":"V Felipo","year":"1991","unstructured":"V. Felipo, M-D Minana, and S. Grisolia. Control of urea synthesis and ammonia utilization in protein deprivation and refeeding. Arch. Biochem. Biophys. 285:351\u2013356 (1991).","journal-title":"Arch. Biochem. Biophys."},{"key":"14_CR14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/oxfordjournals.jbchem.a130769","volume":"77","author":"T Saheki","year":"1975","unstructured":"T. Saheki, M. Tsuda, T. Tanaka, and N. Katunuma. Analysis of regulatory factors for urea synthesis by isolated perfused rat liver. J Biochem. 77:671\u2013678 (1975).","journal-title":"J Biochem"},{"key":"14_CR15","first-page":"459","volume":"237","author":"T Saheki","year":"1977","unstructured":"T. Saheki, T. Katsunuma, and M. Sase. Regulation of urea synthesis in rat liver. Changes in ornithine and n-acetylglutamate concentration in the livers of rats subjected to dietary transitions. J. Biol. Chem. 237:459\u2013468 (1977).","journal-title":"J. Biol. Chem."},{"key":"14_CR16","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0021-9258(19)73959-3","volume":"237","author":"RT Schimke","year":"1962","unstructured":"R.T. Schimke. Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver. J. Biol. Chem. 237:1921\u20131924 (1962)","journal-title":"J. Biol. Chem"},{"key":"14_CR17","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/0003-9861(87)90364-X","volume":"258","author":"R Zaragosa","year":"1987","unstructured":"R. Zaragosa, J. Renu-Piqueras, M. Portoles, J. Hernandez-Yago, A. Jorda, and S. Grisolia. Rats fed prolonged high protein diets show an increase in nitrogen metabolism and liver megamitochondria. Arch. Biochem. Biophys. 258:426\u2013435 (1987).","journal-title":"Arch. Biochem. Biophys."},{"key":"14_CR18","first-page":"F1015","volume":"267","author":"L Boon","year":"1994","unstructured":"L. Boon, P.J.E. Blommaart, A.J. Meijer, W.H. Lamers, and A.C. Schoolwerth. Acute acidosis inhibits amino acid transport: no primary role for the urea cycle in acid-base balance. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36):F1015\u2013F1020 (1994).","journal-title":"Am. J. Physiol"},{"key":"14_CR19","first-page":"F198","volume":"271","author":"L Boon","year":"1996","unstructured":"L. Boon, P.J.E. Blommaart, A.J. Meijer, W.H. Lamers, and A.C. Schoolwerth. Response of hepatic amino acid consumption to chronic metabolic acidosis. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40):F198\u2013F202 (1996).","journal-title":"Am. J. Physiol."},{"key":"14_CR20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000423411","volume":"110","author":"L Boon","year":"1994","unstructured":"L. Boon, P.J.E. Blommaart, A.J. Meijer, W.H. Lamers, and A.C. Schoolwerth. Effect of chronic acidosis on hepatic amino acid uptake and gene regulation: implications for control of acid-base balance. Contr. Nephrol. 110:138\u2013143 (1994).","journal-title":"Contr. Nephrol."},{"key":"14_CR21","first-page":"R858","volume":"251","author":"TC Welbourne","year":"1986","unstructured":"T.C. Welbourne, D. Childress, and G. Givens. Renal regulation of interorgan glutamine flow in metabolic acidosis. Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20):R858\u2013R866 (1986).","journal-title":"Am. J. Physiol"},{"key":"14_CR22","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1172\/JCI112344","volume":"77","author":"RC May","year":"1986","unstructured":"R.C. May, R.A. Kelly, and W.E. Mitch. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid dependent mechanism. J. Clin. Invest. 77:614\u2013621 (1986).","journal-title":"J. Clin. Invest."},{"key":"14_CR23","first-page":"245","volume":"18","author":"RC May","year":"1992","unstructured":"R.C. May, T. Masud, B. Logue, J. Bailey, and B.K. England. Metabolic acidosis accelerates whole body protein degradation and leucine oxidation by a glucocorticoid dependent mechanism. Miner. Electrolyte Metab. 18:245\u2013249 (1992).","journal-title":"Miner. Electrolyte Metab."}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4615-5945-0_14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T22:20:26Z","timestamp":1638224426000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4615-5945-0_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997]]},"ISBN":["9781461377245","9781461559450"],"references-count":23,"URL":"https:\/\/doi.org\/10.1007\/978-1-4615-5945-0_14","relation":{},"ISSN":["0065-2598"],"issn-type":[{"type":"print","value":"0065-2598"}],"subject":[],"published":{"date-parts":[[1997]]}}}