{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T19:51:03Z","timestamp":1794426663868,"version":"4.9.1"},"publisher-location":"Boston, MA","reference-count":41,"publisher":"Springer US","isbn-type":[{"value":"9781468443844","type":"print"},{"value":"9781468443820","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983]]},"DOI":"10.1007\/978-1-4684-4382-0_10","type":"book-chapter","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T16:30:21Z","timestamp":1343493021000},"page":"249-270","source":"Crossref","is-referenced-by-count":8,"title":["Variation in Response to Mutagens Amongst Normal and Repair-Defective Human Cells"],"prefix":"10.1007","author":[{"given":"Colin F.","family":"Arlett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Harcourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev.ge.12.120178.000523","volume":"12","author":"CF Arlett","year":"1978","unstructured":"Arlett, C. F. and Lehmann, A. R.: Human disorders showing increased sensitivity to the induction of genetic damage. Ann. Rev. Genet., 12: 95 (1978)","journal-title":"Ann. Rev. Genet"},{"key":"10_CR2","unstructured":"Kraemer, K. H.: Xeroderma pigmentosum. in Clinical Dermatology. Ed: by D. J. D.nnis, R. L. Dobson and J. McGuire (Unit 19.7: Vol. 4). Harper and Row, Hagerstown, p. 1 (1978)"},{"key":"10_CR3","first-page":"269","volume":"56","author":"C Sanctis","year":"1932","unstructured":"De Sanctis, C. and Cacchione, A.: L\u2019idiozia xerodermica. Riv. Sper. Freniatr., 56: 269 (1932)","journal-title":"Riv. Sper. Freniatr"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0027-5107(73)90261-3","volume":"17","author":"HF Stich","year":"1973","unstructured":"Stich, H. F., San. R. H. C. and Kawazoe Y. Increased sensitivity of xeroderma pigmentosum cells to some chemical carcinogens and mutagens. Mutation Res., 17: 127 (1973)","journal-title":"Mutation Res"},{"key":"10_CR5","volume-title":"Fundamentals in Cancer Prevention","author":"VM Maher","year":"1976","unstructured":"Maher, V. M., Curren, R. D., Ouellette, L. M., McCormick, J. J. Effect of DNA repair on the frequency of mutations induced in human cells by ultraviolet irradiation and by chemical carcinogens. In Fundamentals in Cancer Prevention. Ed: by. P. N. Magee, S. Takayama, T. Sugimura, T. Matsushima. Tokyo Univ.Press, Tokyo (1976)"},{"key":"10_CR6","first-page":"161","volume-title":"M. Alacevic","author":"CF Arlett","year":"1980","unstructured":"Arlett, C. F.: Mutagenesis in repair-deficient human cell strains. In Progress in Environmental Mutagenesis, Ed. by M. Alacevic, Elsevier, Amsterdam, p. 161 (1980)"},{"key":"10_CR7","first-page":"581","volume-title":"DNA Repair Mechanisms. Ed: by P. C. Hanawalt, E. C. Friedberg and C. F. Fox. Academic Press, New York","author":"JWIM Simons","year":"1978","unstructured":"Simons, J. W. I. M. Effects of liquid holding on cell killing and mutation in normal and repair-deficient human cell strains. In DNA Repair Mechanisms. Ed: by P. C. Hanawalt, E. C. Friedberg and C. F. Fox. Academic Press, New York, p. 581 (1978)"},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1073\/pnas.76.8.3982","volume":"76","author":"TW Glover","year":"1979","unstructured":"Glover, T. W., Chang, C. C., Trosko, J. E., and Li, S. S. L. Ultraviolet light induction of diphtheria toxin-resistant mutants in normal and xeroderma pigmentosum fibroblasts. Proc. Natl. Acad. Sci. USA, 76: 3982 (1979)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10_CR9","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/218652a0","volume":"218","author":"JE Cleaver","year":"1968","unstructured":"Cleaver, J. E. Defective repair replication of DNA in xeroderma pigmentosum. Nature, 218: 652 (1968)","journal-title":"Nature"},{"key":"10_CR10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1073\/pnas.72.1.219","volume":"72","author":"AR Lehmann","year":"1975","unstructured":"Lehmann, A. R., Kirk-Bell, S., Arlett, C. F., Paterson, M. C., Lohman, P. H. M., de Weerd-Kastelein, E. A., Bootsma, D. Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after u.v. irradiation. Proc. Natl. Acad. Sci. USA, 72: 219 (1975)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/258427a0","volume":"258","author":"AMR Taylor","year":"1975","unstructured":"Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., Bridges, B. A. Ataxia telan- giectasia: A human mutant with abnormal radiation sensitivity. Nature, 258: 427 (1975)","journal-title":"Nature"},{"key":"10_CR12","unstructured":"Bridges, B. A., and Harnden, D. G., Eds. Ataxia-telangiectasia: a Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency, John Wiley and Sons, London (in press)"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1259\/0007-1285-48-569-374","volume":"48","author":"PN Cunliffe","year":"1975","unstructured":"Cunliffe, P. N., Mann, J. R., Cameron, A. H., Roberts, K. D., Ward, H. W. C. Radiosensitivity in ataxia telangiectasia. Br. J. Radio1. 48: 374 (1975)","journal-title":"Br. J. Radio1"},{"key":"10_CR14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/B978-0-12-322650-1.50125-9","volume-title":"DNA Repair Mechanisms. Ed: by P. C. Hanawalt, E. C. Friedberg and C. F. Fox. Academic Press, New York","author":"CF Arlett","year":"1978","unstructured":"Arlett, C. F. and Harcourt, S. A. Cell killing and mutagenesis in repair-defective human cells. In DNA Repair Mechanisms. Ed: by P. C. Hanawalt, E. C. Friedberg and C. F. Fox. Academic Press, New York, p. 633 (1978)"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.ge.13.120179.001451","volume":"13","author":"MC Paterson","year":"1979","unstructured":"Paterson, M. C. and Smith, P. J. Ataxia-telangiectasia: An inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals. Ann. Rev. Genet. 13: 291 (1979)","journal-title":"Ann. Rev. Genet"},{"key":"10_CR16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0027-5107(76)90060-9","volume":"37","author":"R Cox","year":"1976","unstructured":"Cox, R. and Masson, W. K. X-ray-induced mutation to 6-thioguanine resistance in cultured human fibroblasts. Mutation Res., 37: 125 (1976)","journal-title":"Mutation Res"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0027-5107(75)90209-2","volume":"33","author":"CF Arlett","year":"1975","unstructured":"Arlett, C. F., Harcourt, S. A. and Broughton, B. C. The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet irradiation. Mutation Res., 33: 341 (1975)","journal-title":"Mutation Res"},{"key":"10_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/09553007414551141","volume":"26","author":"R Cox","year":"1974","unstructured":"Cox, R. and Masson, W. K. Changes in radiosensitivity during the in vitro growth of diploid human fibroblasts. Int. J. Radiat. Biol., 26: 293 (1974)","journal-title":"J. Radiat. Biol"},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0027-5107(72)90161-3","volume":"16","author":"CF Arlett","year":"1972","unstructured":"Arlett, C. F. and Harcourt, S. A. Expression time and spontaneous mutability in the estimation of induced mutation frequency following treatment of Chinese hamster cells by ultraviolet light. Mutation Res., 16: 301 (1972)","journal-title":"Mutation Res"},{"key":"10_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0027-5107(74)90021-9","volume":"25","author":"JWIM Simons","year":"1974","unstructured":"Simons, J. W. I. M. Dose response relationships for mutants in mammalian cells in vitro. Mutation Res., 25: 219 (1974)","journal-title":"Mutation Res"},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0027-5107(80)90187-6","volume":"69","author":"AR Lehmann","year":"1980","unstructured":"Lehmann, A. R. and Stevens, S. A rapid procedure for measurement of DNA repair in human fibroblasts and for complementation analysis of xeroderma pigmentosum cells. Mutation Res., 69: 177 (1980)","journal-title":"Mutation Res"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/260441a0","volume":"260","author":"Taylor. A. M. R., Metcalfe, J. A., Oxford, J. M. and Harnden D. G","year":"1976","unstructured":"Taylor. A. M. R., Metcalfe, J. A., Oxford, J. M. and Harnden D. G. Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair? Nature, 260: 441 (1976)","journal-title":"Nature"},{"key":"10_CR23","volume-title":"Baltimore and London (5th ed)","author":"V Mckusick","year":"1978","unstructured":"McKusick, V. A. Mendelian Inheritance in Man: Catalogs of Autosomal Dominent, Autosomal Recessive and X-linked Phenotypes. John Hopkins Univ. Press, Baltimore and London (5th ed), (1978)"},{"key":"10_CR24","volume-title":"University of Birmingham","author":"T Featherstone","year":"1981","unstructured":"Featherstone, T. Ph.D Thesis, University of Birmingham (1981)"},{"key":"10_CR25","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1542\/peds.25.6.997","volume":"25","author":"WB Macdonald","year":"1960","unstructured":"MacDonald, W. B., Fitch, K. D., Lewis, I. C. Cockayne\u2019s syndrome. An heredo-familial disorder of growth and development. Pediatrics, 25: 997 (1960)","journal-title":"Pediatrics"},{"key":"10_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/1523-1747.ep12541290","volume":"70","author":"CF Arlett","year":"1978","unstructured":"Arlett, C. F., Lehmann, A. R., Giannelli, F. and Ramsay, C. A. A human subject with a new defect in repair of ultraviolet damage. J. Invest. Dermatol., 70: 173 (1978)","journal-title":"J. Invest. Dermatol"},{"key":"10_CR27","volume-title":"Ataxia-telangiectasia: a Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency","author":"D Webster","year":"1988","unstructured":"Webster, D., Arlett, C. F., Harcourt, S. A., Teo, I. and Henderson, L. A new syndrome of immunodeficiency and increased cellular sensitivity to DNA damaging agents. In Ataxia-telangiectasia: a Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency. Ed: by B. A. Bridges and D. G. Harnden. John Wiley and Sons, London (in press)"},{"key":"10_CR28","unstructured":"May, H. M. personal communication"},{"key":"10_CR29","first-page":"904","volume":"37","author":"AR Lehmann","year":"1977","unstructured":"Lehmann, A. R., Kirk-Bell, S., Arlett, C. F., Harcourt, S. A., de Weerd-Kastelein, E. A., Keijzer, W., Hall-Smith, P. Repair of u.v. damage in a variety of human fibroblast cell strains. Cancer Res., 37: 904 (1977)","journal-title":"Cancer Res"},{"key":"10_CR30","first-page":"1415","volume":"62","author":"M Swift","year":"1979","unstructured":"Swift, M. and Chase, C. Cancer in xeroderma pigmentosum families. J. Natl. Cancer Inst., 62: 1415 (1979)","journal-title":"J. Natl. Cancer Inst"},{"key":"10_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0027-5107(79)90087-3","volume":"62","author":"VM Maher","year":"1979","unstructured":"Maher, V. M., Dorney, D. J., Mendrala, A. L., Konze-Thomas, B. and McCormick, J. J. DNA excision-repair processes in human cells can eliminate the cutotoxic and mutagenic consequences of ultraviolet irradiation. Mutation Res., 62: 311 (1979)","journal-title":"Mutation Res"},{"key":"10_CR32","unstructured":"Lehmann, A. R. personal communication"},{"key":"10_CR33","unstructured":"Lehmann, A. R. personal communication"},{"key":"10_CR34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1542\/peds.60.2.135","volume":"60","author":"RD Schmickel","year":"1977","unstructured":"Schmickel, R. D., Chu, E. H. Y., Trosko, J. E. and Chang, C. C. Cockayne syndrome - cellular sensitivity to ultraviolet light. Pediatrics, 60: 135 (1977)","journal-title":"Pediatrics"},{"key":"10_CR35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0027-5107(80)90180-3","volume":"69","author":"RR Marshall","year":"1979","unstructured":"Marshall, R. R., Arlett, C. F., Harcourt, S. A., Broughton, B. C. Increased sensitivity of cell strains from Cockayne\u2019s syndrome to sister-chromatid exchange induction and cell killing by u.v. light. Mutation Res., 69: 107 (1979)","journal-title":"Mutation Res"},{"key":"10_CR36","unstructured":"Lehmann, A. R., Kirk-Bell, S., and Mayne, L. Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne\u2019s syndrome. Cancer Res. 39: 4237."},{"key":"10_CR37","unstructured":"Lehmann, A. R. and Mayne, L. The response of Cockayne syndrome cells to u.v.-irradiation. In Chromosome Damage and Repair. Ed: by E. Seeberg and K. Kleppe. Plenum Press, New York (in press)"},{"key":"10_CR38","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/carcin\/1.9.745","volume":"1","author":"CF Arlett","year":"1980","unstructured":"Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., Ferguson-Smith, M. A. and Morley, W. N. Studies on a new case of xeroderma pigmentosum (XP3BR from complementation group G with cellular sensitivity to ionising radiation. Carcinogenesis 1: 745 (1980)","journal-title":"Carcinogenesis"},{"key":"10_CR39","unstructured":"Simons, J. W. I. M. Studies on survival and mutation in ataxiatelangiectasia cells after X-irradiation under oxic and anoxic conditions. In Ataxia-telangiectasia: a Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency. Ed: by B. A. Bridges and D. G. Harnden. John Wiley and Sons, London (in press)"},{"key":"10_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0027-5107(77)80005-5","volume":"42","author":"MHL Green","year":"1977","unstructured":"Green, M. H. L., Bridges, B. A., Eyfjord, J. E. and Muriel, W. J. Mutagenic DNA repair in Escherichia coli. V. Mutation frequency decline and error-free post-replication repair in an excision-proficient strain. Mutation Res., 42: 33 (1977)","journal-title":"Mutation Res"},{"key":"10_CR41","first-page":"17","volume":"20","author":"EM Witkin","year":"1967","unstructured":"Witkin, E. M. Mutatation-proof and mutation-prone modes of survival in derivatives of Escherichia coli B differing in sensitivity to ultraviolet light. Brookhaven Symposium in Biology, 20: 17 (1967)","journal-title":"Brookhaven Symposium in Biology"}],"container-title":["Induced Mutagenesis"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4684-4382-0_10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T07:59:02Z","timestamp":1642924742000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4684-4382-0_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983]]},"ISBN":["9781468443844","9781468443820"],"references-count":41,"URL":"https:\/\/doi.org\/10.1007\/978-1-4684-4382-0_10","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4684-4382-0","asserted-by":"object"}]},"subject":[],"published":{"date-parts":[[1983]]}}}