{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T16:30:34Z","timestamp":1742920234713,"version":"3.40.3"},"publisher-location":"Boston, MA","reference-count":42,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781468458794"},{"type":"electronic","value":"9781468458770"}],"license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991]]},"DOI":"10.1007\/978-1-4684-5877-0_13","type":"book-chapter","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T04:19:23Z","timestamp":1341202763000},"page":"121-132","source":"Crossref","is-referenced-by-count":2,"title":["Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hypersensitivity Reactions"],"prefix":"10.1007","author":[{"given":"Jack","family":"Uetrecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"13_CR1","first-page":"39","volume":"12","author":"D Alarcon-Segovia","year":"1972","unstructured":"Alarcon-Segovia, D., Fishbein, E., Reyes, P.A., Dies, H. and Shwadsky, S. (1972). Antinuclear antibodies in patients on anticonvulsant therapy. Clin. Exp. Immunol. 12, 39\u201347.","journal-title":"Clin. Exp. Immunol"},{"key":"13_CR2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0022-3476(70)80130-5","volume":"76","author":"JA Amrhein","year":"1970","unstructured":"Amrhein, J.A., Kenny, F.M. and Ross, D. (1970). Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy. J. Pediat. 76, 54\u201363.","journal-title":"J. Pediat"},{"key":"13_CR3","first-page":"13","volume":"234","author":"DP Aucoin","year":"1985","unstructured":"Aucoin, D.P., Peterson, M.E., and Hurvitz, A.I., (1985). Propylthiouracil-induced immune-mediated disease in the cat. J. Pharmacol. Exp. Ther. 234, 13\u201318.","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1002\/art.1780310517","volume":"31","author":"DP Aucoin","year":"1988","unstructured":"Aucoin, D.P., Rubin, R.L., and Peterson, M.E. (1988). Dose-dependent induction of anti-native DNA antibodies in cats by propylthiouracil. Arthritis Rheum. 31, 688\u2013692.","journal-title":"Arthritis Rheum"},{"key":"13_CR5","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1016\/0006-2952(82)90296-9","volume":"31","author":"H Engler","year":"1982","unstructured":"Engler, H., Taurog, A. and Nakashima, T. (1982). Mechanism of inactivation of thyroid peroxidase by thioureylene drugs. Biochem. Pharmacol. 31, 3801\u20133806.","journal-title":"Biochem. Pharmacol"},{"key":"13_CR6","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1172\/JCI109161","volume":"62","author":"MJ Fritzler","year":"1978","unstructured":"Fritzler, M.J. and Tan, E.M. (1978). Antibodies to histones in drug-induced and idiopathic lupus erythematosus. J. Clin. Invest. 62, 560\u2013567.","journal-title":"J. Clin. Invest"},{"key":"13_CR7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0190-9622(85)80030-X","volume":"12","author":"DC Gorsulowsky","year":"1985","unstructured":"Gorsulowsky, D.C., Bank, P.W., Goldberg, A.D., Lee, T.G., Heinzerling, R.H. and Burnham, T.K. (1985). Antinuclear antibodies as indicators for the procainamide-induced systemic lupus erythematosus-like syndrome and its clinical presentations. J. Am. Acad. Dermatol. 12, 245\u2013253.","journal-title":"J. Am. Acad. Dermatol"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/ijc.2910250116","volume":"25","author":"L Gruciute","year":"1980","unstructured":"Gruciute,L. and Tomatis, L. (1980). Carcinogenicity of dapsone in mice and rats. Int. J. Cancer\n                           25, 123\u2013129.","journal-title":"Int. J. Cancer"},{"key":"13_CR9","first-page":"277A","volume":"23","author":"A Gupta","year":"1988","unstructured":"Gupta, A., Waldhauser, L., Reider, M. (1988). Drug-induced hypothyroidism: the thyroid as a target organ in hypersensitivity reactions. Soc. Ped. Res. 23, 277A.","journal-title":"Soc. Ped. Res"},{"key":"13_CR10","first-page":"A99","volume":"30","author":"A Hofstra","year":"1988","unstructured":"Hofstra, A. and Uetrecht, J. (1988). Oxidation of hydralazine by monocytes as a mechanism of hydralazine-induced lupus. Pharmacologist\n                           30. A99.","journal-title":"Pharmacologist"},{"key":"13_CR11","volume-title":"The Neutrophil: Function and Clinical Disorders","author":"SJ Klebanoff","year":"1978","unstructured":"Klebanoff, S.J. and Clark, r.a. (1978). The Neutrophil: Function and Clinical Disorders, Elsevier\/North-Holland Inc. Amsterdam."},{"key":"13_CR12","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/0006-2952(88)90574-6","volume":"37","author":"E Lee","year":"1988","unstructured":"Lee, E., Hirouchi, M., Hosokawa, M., Sayo, H., Kohno, M. and Kariya, K. (1988a). Inactivation of peroxidases of rat bone marrow by repeated administration of propylthiouracil is accompanied by a change in the heme structure. Biochem. Pharmacol. 37, 2151\u20132153.","journal-title":"Biochem. Pharmacol"},{"key":"13_CR13","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3109\/00498258809042236","volume":"18","author":"E Lee","year":"1988","unstructured":"Lee, E., Miki, Y., Hosokawa, M., Sayo, H. and Kariya, K. (1988b). Oxidative metabolism of propylthiouracil by peroxidases from rat bone marrow. Xenobiotica\n                           18, 1135\u20131142.","journal-title":"Xenobiotica"},{"key":"13_CR14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-109-2-127","volume":"109","author":"RI Lehrer","year":"1988","unstructured":"Lehrer, R.I., Ganz, T., Selsted, M.E., Babior, B.M. and Curnutte, J.T. (1988). Neutrophils and host defense. Ann. Intern. Med. 109, 127\u2013142.","journal-title":"Ann. Intern. Med"},{"key":"13_CR15","first-page":"A99","volume":"30","author":"A Li","year":"1988","unstructured":"Li, A. and Uetrecht, J. (1988). Metabolism of isoniazid by activated neutrophils. Pharmacologist\n                           30, A99.","journal-title":"Pharmacologist"},{"key":"13_CR16","first-page":"313","volume-title":"Reviews in Biochemical Toxicology","author":"SJ Moloney","year":"1983","unstructured":"Moloney, S.J. and Prough, R.A. (1983). Biochemical toxicology of hydrazines. In Reviews in Biochemical Toxicology. ( Hodgson, E., Bend, J.R., Philpot, R.M., ed), 313\u2013348. Elsevier, New York."},{"key":"13_CR17","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1073\/pnas.85.4.1232","volume":"85","author":"S Murao","year":"1988","unstructured":"Murao, S., Stevens, F.J., Ito, A. and Huberman, E. (1988). Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties. Proc. Natl. Acad. Sci. USA\n                           85, 1232\u20131236.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0006-2952(87)90706-4","volume":"36","author":"BK Park","year":"1987","unstructured":"Park, B.K., Coleman, J.W. and Kitteringham, N.R. (1987). Drug disposition and drug hypersensitivity. Biochem. Pharmacol. 36, 581\u2013590.","journal-title":"Biochem. Pharmacol"},{"key":"13_CR19","first-page":"1219","volume-title":"Clinical Immunology","author":"CW Parker","year":"1980","unstructured":"Parker, C.W. (1980). Drug allergy. In Clinical Immunology ( Parker C.W. ed), 1219\u20131260. W.B. Saunders, Philadelphia."},{"key":"13_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev.pa.28.040188.002055","volume":"28","author":"LR Pohl","year":"1988","unstructured":"Pohl, L.R., Satoh, H., Christ, D.D. and Kenna, J.G. (1988). the immunologic and metabolic basis of drug hypersensitivities. Ann. Rev. Pharmacol. 28, 367\u2013387.","journal-title":"Ann. Rev. Pharmacol"},{"key":"13_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.pa.19.040179.001021","volume":"19","author":"JL Radomski","year":"1979","unstructured":"Radomski, J.L. (1979). the primary aromatic amines: their biological properties and structur-activity relationships. Ann. Rev. Pharmacol. Toxicol. 19, 129\u2013157.","journal-title":"Ann. Rev. Pharmacol. Toxicol"},{"key":"13_CR22","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/0002-9343(83)90885-9","volume":"75","author":"MM Reidenberg","year":"1983","unstructured":"Reidenberg, M.M. (1983). Aromatic amines and the pathogenesis of lupus erythematosus. Am. J. Med. 75, 1037\u20131042.","journal-title":"Am. J. Med"},{"key":"13_CR23","first-page":"833","volume":"242","author":"RL Rubin","year":"1987","unstructured":"Rubin, R.L., Uetrecht, J.P. and Jones, J.E. (1987). Cytotoxicity of oxidative metabolites of procainamide. J. Pharmacol. Exp. Ther. 242, 833\u2013841.","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"13_CR24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1172\/JCI111704","volume":"75","author":"RS Schwartz","year":"1985","unstructured":"Schwartz, R.S. and Stoller, B.D. (1985). Origins of anti-DNA autoantibodies. J. Clin. Invest. 75, 321\u2013327.","journal-title":"J. Clin. Invest"},{"key":"13_CR25","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1172\/JCI109109","volume":"62","author":"O Stendahl","year":"1978","unstructured":"Stendahl, O., Molin, L. and Dahlgren, C. (1978). the inhibition of polymorphonuclear keukocyte cytotoxicity by dapsone: a possible mechanism in the treatment of dermatitis herpetiformis. J. Clin. Invest. 62, 214\u2013220.","journal-title":"J. Clin. Invest"},{"key":"13_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0041-008X(86)90194-8","volume":"82","author":"S Takayama","year":"1986","unstructured":"Takayama, S., Aihara, K., Onodera, T. and Akimoto, T. (1986). Antithyroid effects of propylthiouracil and sulfamonomethoxine in rats and monkeys. Toxicol. Appt. Pharmacol. 82, 191\u2013199.","journal-title":"Toxicol. Appt. Pharmacol"},{"key":"13_CR27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1507\/endocrj1954.28.663","volume":"28","author":"N Takuwa","year":"1981","unstructured":"Takuwa, N., Kojima, I. and Ogata, E. (1981). Lupus-like syndrome\u2013a rare complication in thionamide treatment for Graves\u2019 disease. Endocrinol. Japan. 28, 663\u2013667.","journal-title":"Endocrinol. Japan"},{"key":"13_CR28","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/BF00556891","volume":"27","author":"JA Timbrell","year":"1984","unstructured":"Timbrell, J.A., Facchini, V., Harland, S.J. and Mansilla-Tinoco, R. (1984). Hydralazine-induced lupus: is there a toxic pathway? Eur. J. Clin. Pharmacol. 27, 555\u2013559.","journal-title":"Eur. J. Clin. Pharmacol"},{"key":"13_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0165-6147(89)80012-4","volume":"10","author":"J Uetrecht","year":"1989","unstructured":"Uetrecht, J. (1989). Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes. Trends Pharmacol. Sci. 10, 463\u2013467.","journal-title":"Trends Pharmacol. Sci"},{"key":"13_CR30","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1021\/tx00003a004","volume":"1","author":"J Uetrecht","year":"1988","unstructured":"Uetrecht, J. and Zahid, N. (1988a). N-Chlorination of phenytoin by myeloperoxidase to a reactive metabolite. Chem. Res. Toxicol. 1, 148\u2013151.","journal-title":"Chem. Res. Toxicol"},{"key":"13_CR31","first-page":"A98","volume":"30","author":"J Uetrecht","year":"1988","unstructured":"Uetrecht, J. and Zahid, N. (1988b). Procainamide (PA) is N-chlorinated by myeloperoxidase (MPO)-implications for toxicity. Pharmacologist\n                           30, A98.","journal-title":"Pharmacologist"},{"key":"13_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1021\/tx00001a013","volume":"1","author":"J Uetrecht","year":"1988","unstructured":"Uetrecht, J., Zahid, N. and Rubin, R. (1988a). Metabolism of procainamide to a hydroxylamine by human neutrophils and mononuclear leukocytes. Chem. Res. Toxicol. 1, 74\u201378.","journal-title":"Chem. Res. Toxicol"},{"key":"13_CR33","first-page":"274","volume":"245","author":"J Uetrecht","year":"1988","unstructured":"Uetrecht, J., Zahid, N. Shear, N.H. and Biggar, W.D. (1988b). Metabolism of dapsone to a hydroxylamine by human neutophils and mononuclear cells. J. Pharmacol. Exp. Ther. 245, 274\u2013279.","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"13_CR34","first-page":"420","volume":"232","author":"JP Uetrecht","year":"1985","unstructured":"Uetrecht, J.P. (1985). reactivity and possible significance of hydroxylamine and nitroso metabolites of procainamide. J. Pharmacol. Exp. Ther. 232, 420\u2013425.","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"13_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1021\/tx00003a001","volume":"1","author":"JP Uetrecht","year":"1988","unstructured":"Uetrecht, J.P. (1988). Mechanism of drug-induced lupus. Chem. Res. Toxicol. 1, 133\u2013143.","journal-title":"Chem. Res. Toxicol"},{"key":"13_CR36","doi-asserted-by":"crossref","unstructured":"Uetrecht, J.P. (1990). Drug metabolism by leukocytes, its role in drug-induced lupus and other idiosyncratic drug reactions. CRC Crit. Rev. Tox, in press.","DOI":"10.3109\/10408449009089863"},{"key":"13_CR37","first-page":"239","volume":"28","author":"JP Uetrecht","year":"1986","unstructured":"Uetrecht, J.P., Shear, N. and Biggar, W. (1986). Dapsone is metabolised by human neutrophils to a hydroxylamine. Pharmacologist\n                           28, 239.","journal-title":"Pharmacologist"},{"key":"13_CR38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.2165\/00003088-198106020-00003","volume":"6","author":"JP Uetrecht","year":"1981","unstructured":"Uetrecht, J.P. and Woosley, R.L. (1981). Acetylator phenotype and lupus erythematosus. Clin. Pharmacokin. 6, 118\u2013134.","journal-title":"Clin. Pharmacokin"},{"key":"13_CR39","first-page":"183","volume":"9","author":"JP Uetrecht","year":"1981","unstructured":"Uetrecht, J.P., Woosley, r.L., Freeman, r.W., Sweetman, B.J. and Oates, J.A. (1981). Metabolism of procainamide in the perfused rat liver. Drug Metab. Disp. 9, 183\u2013187.","journal-title":"Drug Metab. Disp"},{"key":"13_CR40","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1126\/science.2437650","volume":"236","author":"ER Unanue","year":"1987","unstructured":"Unanue, E.R. and allen, P.M. (1987). the basis for the immunoregulatory role of macrophages and other accessory cells. Science\n                           236, 551\u2013557.","journal-title":"Science"},{"key":"13_CR41","first-page":"A1134","volume":"2","author":"L Waldhauser","year":"1988","unstructured":"Waldhauser, L. and Uetrecht, J. (1988). Propylthiouracil (PTU) is metabolized by activated neutrophils-implications for agranulocytosis. FASEB J. 2, A1134.","journal-title":"FASEB J"},{"key":"13_CR42","volume-title":"Dubois Lupus Erythematosus","author":"DJ Wallace","year":"1987","unstructured":"Wallace, D.J. and Dubois, E.L. (1987). Dubois\u2019 Lupus Erythematosus (3rd ed.), Lea and Febiger, Philadelphia.","edition":"3"}],"container-title":["Advances in Experimental Medicine and Biology","Biological Reactive Intermediates IV"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4684-5877-0_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T23:25:10Z","timestamp":1674516310000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4684-5877-0_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"ISBN":["9781468458794","9781468458770"],"references-count":42,"URL":"https:\/\/doi.org\/10.1007\/978-1-4684-5877-0_13","relation":{},"ISSN":["0065-2598"],"issn-type":[{"type":"print","value":"0065-2598"}],"subject":[],"published":{"date-parts":[[1991]]}}}