{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:11:15Z","timestamp":1770919875368,"version":"3.50.1"},"publisher-location":"Boston, MA","reference-count":89,"publisher":"Springer US","isbn-type":[{"value":"9781475735895","type":"print"},{"value":"9781475735871","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002]]},"DOI":"10.1007\/978-1-4757-3587-1_12","type":"book-chapter","created":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T22:09:31Z","timestamp":1388354971000},"page":"259-283","source":"Crossref","is-referenced-by-count":12,"title":["Critical Role of Lysophospholipids in the Pathophysiology, Diagnosis, and Management of Ovarian Cancer"],"prefix":"10.1007","author":[{"given":"Gordon B.","family":"Mills","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Eder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muling","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Tanyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazal Haq","family":"Tabassam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lapushin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiangxing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff A.","family":"Parrott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Compton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Tribley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Sharon","family":"Stack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Gaudette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Furui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junken","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"12_CR1","first-page":"47","volume":"119","author":"W Moolenaar","year":"1992","unstructured":"Moolenaar W, Jalink K, and Van Corven E. Lysophosphatidic Acid: A bioactive phospholipid with growth factor-like properties Rev Physiol Biochem Pharmacol 1992; 119: 47\u201365.","journal-title":"E. Lysophosphatidic Acid: A bioactive phospholipid with growth factor-like properties Rev Physiol Biochem Pharmacol"},{"key":"12_CR2","doi-asserted-by":"crossref","first-page":"21360","DOI":"10.1016\/S0021-9258(19)36618-9","volume":"267","author":"G Tigyi","year":"1992","unstructured":"Tigyi G and Miledi R. Lysophosphatidinates bound to serum albumin activate membrane currents in Xenopus Iaevis oocytes and neurite retraction in PC 12 pheochromocytoma cells. J Biol Chem 1992; 267: 21360\u201321367.","journal-title":"J Biol Chem"},{"key":"12_CR3","volume-title":"FASEB J","author":"EJ Goetzl","year":"1998","unstructured":"Goetzl EJ, An S. Diversity of cellular receptors and functions for the lysophospholipid growth factor lysophosphatidic acid and shingosine 1-phosphate. FASEB J 1998."},{"key":"12_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3109\/15419069809040293","volume":"5","author":"GW Nietgen","year":"1998","unstructured":"Nietgen GW, Durieux ME. Intercellular Signaling By Lysophosphatidate recent developments. Cell Adhesions and Comm 1998; 5: 221\u2013235.","journal-title":"Cell Adhesions and Comm"},{"issue":"1","key":"12_CR5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1006\/excr.1999.4702","volume":"253","author":"WH Moolenaar","year":"1999","unstructured":"Moolenaar WH. Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res 1999; 253 (1): 230\u201338.","journal-title":"Exp Cell Res"},{"issue":"2","key":"12_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/BF02738068","volume":"30","author":"J Chun","year":"1999","unstructured":"Chun J, Contos JJ, Munroe D. A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem Biophys 1999; 30 (2): 213\u201342.","journal-title":"Cell Biochem Biophys"},{"issue":"12","key":"12_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0165-6147(99)01401-7","volume":"20","author":"KR Lynch","year":"1999","unstructured":"Lynch KR, Im I. Life on the edg. Trends Pharmacol Sci 1999; 20 (12): 473\u201375.","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"12_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/jcp.1041630303","volume":"163","author":"Y Xu","year":"1995","unstructured":"Xu Y, Casey G, Mills GB. Effect of lysophospholipids on signaling in the human Jurkat T cell line. J Cell Physiol 1995; 163 (3): 441\u2013450.","journal-title":"J Cell Physiol"},{"key":"12_CR9","first-page":"933","volume":"309","author":"Y Xu","year":"1995","unstructured":"Xu Y, Fang XF, Casey G, and Mills GB. Lysophospholipids activate ovarian and breast cancer cells Biochem J 1995; 309: 933\u2013940.","journal-title":"Lysophospholipids activate ovarian and breast cancer cells Biochem J"},{"key":"12_CR10","first-page":"1307","volume":"2","author":"A Frankel","year":"1996","unstructured":"Frankel A, and Mills G.B. Peptide and lipid growth factors decrease cisplatin-induced cell death in human ovarian cancer cells Clinical Cancer Res 1996; 2: 1307\u20131313.","journal-title":"Peptide and lipid growth factors decrease cisplatin-induced cell death in human ovarian cancer cells Clinical Cancer Res"},{"key":"12_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/(SICI)1097-0215(19970328)71:1<31::AID-IJC7>3.0.CO;2-4","volume":"71","author":"M Okita","year":"1997","unstructured":"Okita M, Gaudette DC, Mills GB and Holub BJ. Elevated levels of plasma lysophosphatidylcholine (LysoPC) in ovarian cancer patients. Int J Cancer 1997; 71: 31\u201334.","journal-title":"Int J Cancer"},{"key":"12_CR12","first-page":"272","volume":"1368313689","author":"XJ Fang","year":"1997","unstructured":"Fang XJ, Gibson S, Flowers M, Fumi T, Bast RC and Mills GB. Lysophosphatidylcholine stimulates AP-1 and the c-Jun N-terminal kinase activity. J Biol Chem 1997; 272: 1368313689.","journal-title":"J Biol Chem"},{"key":"12_CR13","first-page":"3704","volume":"5","author":"TB Pustilnik","year":"1999","unstructured":"Pustilnik TB, Estrella V, Wiener J, Mao M, Eder A, Watt MAV, Bast RC, and Mills GB. Lysophosphatidic acid induces urokinase secretion in ovarian cancer cells. Clinical Cancer Research 1999; 5: 3704\u201310.","journal-title":"Clinical Cancer Research"},{"key":"12_CR14","volume-title":"Goetzl EJ","author":"YL Hu","year":"2000","unstructured":"Hu YL, Goetzl EJ, Mills GB, Ferrara N, and Jaffe RB. Induction of vascular endothelial growth factor expression by lysophosphatidic acid in normal and neoplastic human ovarian epithelial cells Submitted, 2000."},{"key":"12_CR15","volume-title":"press","author":"M Mao","year":"2000","unstructured":"Mao M, Fang XJ, Lu Y, Lapushin R, Bast RC, and Mills GB. Inhibition of growth factor-induced phosphorylation and activation of PKB\/AKT by atypical PKC4 in breast cancer cells Biochem J. In press, 2000."},{"key":"12_CR16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2000.tb06550.x","volume":"95","author":"XJ Fang","year":"2000","unstructured":"Fang XJ, Gaudette D, Fumi T, Mao M, Estrella V, Eder A, Putstilnik T, Sasagawa T, Lapushin R, Yu S, Jaffe R, Wiener J, Erickson J, and Mills GB. Lysophospholipid growth factors in the initiation, progression, metastases and management of ovarian cancer. Annals of the New York Academy of Science 2000; 95: 188\u2013208.","journal-title":"Annals of the New York Academy of Science"},{"key":"12_CR17","first-page":"1223","volume":"1","author":"Y Xu","year":"1995","unstructured":"Xu Y, Gaudette D, Boynton JD, Frankel A, Fang XJ, Sharma A, Hurteau J, Casey G, Goodbody A, Mellors A, Holub B and Mills GB. Characterization of an ovarian cancer activating factor (OCAF) in ascites from ovarian cancer patients Clin Canc Res 1995; 1: 1223\u20131232.","journal-title":"Characterization of an ovarian cancer activating factor (OCAF) in ascites from ovarian cancer patients Clin Canc Res"},{"key":"12_CR18","unstructured":"Eder A, Sasagawa T, Mao M, Aoiki J, Mills G. Constitutive and LPA induced LPA production: Role of PLD and PLA2 Clinical Cancer Research: In press, 2000."},{"key":"12_CR19","first-page":"2482","volume":"6","author":"XJ Fang","year":"2000","unstructured":"Fang XJ, Yu S, Lapushin R, Lu Y, Furui T, Penn LZ, Stokoe DF, Erickson JR, Bast RC, and Mills GB. Lysophosphatidic acid prevents apoptosis in fibroblasts through Gi Protein-mediated activation of mitogen-activated protein kinase Biochem J 2000; 6: 2482\u20132491.","journal-title":"Lysophosphatidic acid prevents apoptosis in fibroblasts through Gi Protein-mediated activation of mitogen-activated protein kinase Biochem J"},{"key":"12_CR20","volume-title":"Submitted","author":"V Estrella","year":"2000","unstructured":"Estrella V, Pustilnik T, Claret FX, Gallick GE, Mills GB, and Wiener JR. Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38M^PK pathway. Submitted 2000."},{"key":"12_CR21","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1210\/jc.85.9.3370","volume":"85","author":"A Imai","year":"2000","unstructured":"Imai A, Fumi T, Tamaya T, and Mills GB. A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells J. Clin Endrocrinol Metab 2000; 85: 3370\u20133375.","journal-title":"J. Clin Endrocrinol Metab"},{"key":"12_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1749-6632.2000.tb06560.x","volume":"905","author":"JR Erickson","year":"2000","unstructured":"Erickson JR, Espinal G, and Mills GB. Analysis of the Edg2 receptor based on the structure\/activity relationship of LPA. Annals of the New York Academy of Science 2000; 905: 279\u201381.","journal-title":"Annals of the New York Academy of Science"},{"key":"12_CR23","first-page":"4308","volume":"5","author":"T Fumi","year":"1999","unstructured":"Fumi T, LaPushin R, Mao M, Kahn H, Watt SR, Watt MV, Lu Y, Fang XJ, Tsutusi S, Siddik Z, Bast R, and Mills GB. Overexpression of Edg-2\/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid independent manner. Clinical Cancer Research 1999; 5: 4308\u20134318.","journal-title":"Clinical Cancer Research"},{"key":"12_CR24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1749-6632.2000.tb06537.x","volume":"905","author":"S Spiegel","year":"2000","unstructured":"Spiegel S. Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci 2000; 905: 54\u201360.","journal-title":"Ann N Y Acad Sci"},{"key":"12_CR25","first-page":"373","volume":"6","author":"BK Zebrowski","year":"1999","unstructured":"Zebrowski BK, Liu W, Ramirez K, Akagi MD, Mills GB, Ellis LM. Markedly elevated levels of vascular endothelial growth factor in malignant ascites: Ann Surg Oncol 1999; 6: 373\u20138.","journal-title":"Markedly elevated levels of vascular endothelial growth factor in malignant ascites: Ann Surg Oncol"},{"key":"12_CR26","first-page":"59","volume":"53705375","author":"EJ Goetzl","year":"1999","unstructured":"Goetzl EJ, Dolezalova H, Kong Y, Hu YL, Jaffe RB, Kalli KR, Conover CA. Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res 1999; 59: 53705375.","journal-title":"Cancer Res"},{"key":"12_CR27","first-page":"5318","volume":"159","author":"Y Shi","year":"1997","unstructured":"Shi Y, Wang R, Sharma A, Gao C, Wasfy G, Collins M, Penn L, and Mills GB. Dissociation of cytokine signals for proliferation and apoptosis J Immunol 1997; 159: 5318\u20135328.","journal-title":"Dissociation of cytokine signals for proliferation and apoptosis J Immunol"},{"key":"12_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1749-6632.2000.tb06549.x","volume":"905","author":"EJ Goetzl","year":"2000","unstructured":"Goetzl EJ, Lee H, Dolezalova H, Kalli KR, Conover CA, Hu YL, Azuma T, Stossel TP, Karliner JS, Jaffe RB.Mechanisms of lysolipid phosphate effects on cellular survival and proliferation. Ann N Y Acad Sci 2000; 905: 177\u201387.","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"12_CR29","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1074\/jbc.273.3.1506","volume":"273","author":"JR Erickson","year":"1998","unstructured":"Erickson JR, Wu JJ, Goddard JG, et al. Edg-2Nzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem 1998; 273 (3): 1506\u201310.","journal-title":"J Biol Chem"},{"key":"12_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.274.39.27776","volume":"274","author":"K Bandoh","year":"1999","unstructured":"Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K. Molecular cloning and characterization of a novel human G-protein-coupled receptor, Edg7, for lysophosphatidic acid. J Biol Chem 1999; 274: 1\u201310.","journal-title":"J Biol Chem"},{"issue":"12","key":"12_CR31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0014-5793(00)01827-5","volume":"478","author":"K Bandoh","year":"2000","unstructured":"Bandoh K, Aoki J, Taira A, Tsujimoto M, Arai H, Inoue K. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett 2000; 478 (1\u20132): 159\u201365.","journal-title":"FEBS Lett"},{"issue":"6","key":"12_CR32","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1002\/(SICI)1097-4547(19980915)53:6<685::AID-JNR7>3.0.CO;2-1","volume":"53","author":"FW Holtsberg","year":"1998","unstructured":"Holtsberg FW, Steiner MR, Bruce-Keller AJ, Keller JN, Mattson MP, Moyers JC, Steiner SM.Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells. J Neurosci Res 1998; 53 (6): 685\u201396.","journal-title":"J Neurosci Res"},{"issue":"46","key":"12_CR33","doi-asserted-by":"crossref","first-page":"3283541","DOI":"10.1074\/jbc.274.46.32835","volume":"274","author":"M Laffargue","year":"1999","unstructured":"Laffargue M, Raynal P, Yart A, Peres C, Wetzker R, Roche S, Payrastre B, Chap H. An epidermal growth factor receptor\/Gabs signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid. J Biol Chem 1999; 274(46):3283541.","journal-title":"J Biol Chem"},{"issue":"6764","key":"12_CR34","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","volume":"402","author":"N Prenzel","year":"1999","unstructured":"Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402 (6764): 884\u201388.","journal-title":"Nature"},{"issue":"2","key":"12_CR35","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/0264-6021:3450217","volume":"345","author":"M Goppelt-Struebe","year":"2000","unstructured":"Goppelt-Struebe M, Fickel S, Reiser CO. The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42\/44 mitogen-activated protein kinase and to induce prostaglandin G\/H synthase-2 in mesangial cells. Biochem J 2000; 345 (Pt 2): 217\u201324.","journal-title":"Biochem J"},{"key":"12_CR36","first-page":"4732","volume":"59","author":"EJ Goetzl","year":"1999","unstructured":"Goetzl EJ, Dolezalova H, Kong Y, Zeng L. Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. Cancer Research 1999; 59: 4732\u201337.","journal-title":"Cancer Research"},{"key":"12_CR37","doi-asserted-by":"publisher","first-page":"8985","DOI":"10.1073\/pnas.95.15.8985","volume":"95","author":"A Herrlich","year":"1998","unstructured":"Herrlich A, Daub H, Knebel A, Herrlich P, Ullrich A, Schultz G, Gudermann T. Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc nati Acad Sci USA 1998; 95: 8985\u201390.","journal-title":"Proc nati Acad Sci USA"},{"key":"12_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0167-4889(98)90093-3","volume":"1405","author":"CC Chua","year":"1998","unstructured":"Chua CC, Hamdy RC, Chua BHL. Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells. Biochimica et Biophysica Acta 1998; 1405: 29\u201334.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"32","key":"12_CR39","doi-asserted-by":"publisher","first-page":"19443","DOI":"10.1074\/jbc.271.32.19443","volume":"271","author":"LM Luttrell","year":"1996","unstructured":"Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of cSrc tyrosine kinase in G protein-coupled receptor-and G\u00dfy subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 1996; 271 (32): 19443\u201350.","journal-title":"J Biol Chem"},{"key":"12_CR40","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1073\/pnas.91.3.1069","volume":"91","author":"T Nakano","year":"1994","unstructured":"Nakano T, Raines EW, Abraham JA, Klagsbrun M, Ross R. Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes. Proc Natl Acad Sci USA 1994; 91: 1069\u201373.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"12_CR41","doi-asserted-by":"publisher","first-page":"14367","DOI":"10.1073\/pnas.93.25.14367","volume":"93","author":"Z Guo","year":"1996","unstructured":"Guo Z, Liliom K, Fischer DJ, et al. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphadic acid from Xenopus oocytes. Proc Natl Acad Sci USA 1996; 93 (25): 14367\u201372.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"12_CR42","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1083\/jcb.135.4.1071","volume":"135","author":"JH Hecht","year":"1996","unstructured":"Hecht JH, Weiner JA, Post SR, et al. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatadic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 1996; 135 (4): 1071\u201383.","journal-title":"J Cell Biol"},{"key":"12_CR43","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1073\/pnas.95.11.6151","volume":"95","author":"N Fukushima","year":"1998","unstructured":"Fukushima N, Kimura Y, Chun J. A single receptor encoded by vzg-1\/1pA1\/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatic acid. Proc Natl Acad Sci USA 1998; 95: 6151\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR44","doi-asserted-by":"publisher","first-page":"22105","DOI":"10.1074\/jbc.273.34.22105","volume":"273","author":"MJ Lee","year":"1998","unstructured":"Lee MJ, Thangada S, Liu CH, et al. Lysophosphatidic acid stimulates the G-proteincoupled receptor EDG-1 as a low affinity agonist. J Biol Chem 1998; 273: 22105\u201312.","journal-title":"J Biol Chem"},{"key":"12_CR45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1006\/geno.1998.5491","volume":"53","author":"MH Grater","year":"1998","unstructured":"Grater MH, Bernhardt G, Lipp M. EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue. Genomics 1998; 53: 164\u2013169.","journal-title":"Genomics"},{"issue":"5356","key":"12_CR46","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1126\/science.279.5356.1552","volume":"279","author":"MJ Lee","year":"1998","unstructured":"Lee MJ, Van Brocklyn JR, Thangada S, et al. Sphingosine-l-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998; 279 (5356): 1552\u20135.","journal-title":"Science"},{"key":"12_CR47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1124\/mol.54.6.979","volume":"54","author":"DJ Fischer","year":"1998","unstructured":"Fischer DJ, Liliom K, Guo Z, et al. Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes. Mol Pharmocol 1998; 54: 979\u2013988.","journal-title":"Mol Pharmocol"},{"key":"12_CR48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1124\/mol.54.5.881","volume":"54","author":"S An","year":"1998","unstructured":"An S, Bleu T, Zheng Y, et al. Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization. Mol Pharmocol 1998; 54: 881\u2013888.","journal-title":"Mol Pharmocol"},{"key":"12_CR49","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1124\/mol.57.4.753","volume":"57","author":"DS Im","year":"2000","unstructured":"Im DS, Heise CE, Harding MA, George SR, O\u2019Dowd BF, Theodorescu D, Lynch KR. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol Pharmacol 2000; 57: 753\u20139.","journal-title":"Mol Pharmacol"},{"issue":"19","key":"12_CR50","doi-asserted-by":"publisher","first-page":"14281","DOI":"10.1074\/jbc.275.19.14281","volume":"275","author":"DS Im","year":"2000","unstructured":"Im DS, Heise CE, Ancellin N, O\u2019Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR.Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. J Biol Chem 2000; 275 (19): 14281\u20136.","journal-title":"J Biol Chem"},{"issue":"27","key":"12_CR51","first-page":"18997","volume":"274","author":"N Ancellin","year":"1999","unstructured":"Ancellin N, Hla T.Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem 1999; 274 (27): 18997\u20139002.","journal-title":"Hla T.Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem"},{"issue":"39","key":"12_CR52","doi-asserted-by":"publisher","first-page":"27351","DOI":"10.1074\/jbc.274.39.27351","volume":"274","author":"RT Windh","year":"1999","unstructured":"Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR.Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218\/Edg-5 to the G(i),G(q), and G(12) families of heterotrimeric G proteins. J Biol Chem 1999; 274 (39): 27351\u20138.","journal-title":"J Biol Chem"},{"issue":"1","key":"12_CR53","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/bbrc.1999.0886","volume":"260","author":"H Okamoto","year":"1999","unstructured":"Okamoto H, Takuwa N, Yatomi Y, Gonda K, Shigematsu H, Takuwa Y.EDG3 is a functional receptor specific for sphingosine l-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDGI and AGR16. Biochem Biophys Res Commun 1999; 260 (1): 203\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"42","key":"12_CR54","doi-asserted-by":"publisher","first-page":"27104","DOI":"10.1074\/jbc.273.42.27104","volume":"273","author":"H Okamoto","year":"1998","unstructured":"Okamoto H, Takuwa N, Gonda K, Okazaki H, Chang K, Yatomi Y, Shigematsu H, Takuwa Y.EDG1 is a functional sphingosine-l-phosphate receptor that is linked via a Gi\/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, RAS-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J Biol Chem 1998; 273 (42): 27104\u201310.","journal-title":"J Biol Chem"},{"issue":"1","key":"12_CR55","first-page":"1999","volume":"443","author":"K Sato","year":"2530","unstructured":"Sato K, Kon J, Tomura H, Osada M, Murata N, Kuwabara A, Watanabe T, Ohta H, Ui M, Okajima F. Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor. FEBS Lett 1999; 443 (1): 2530.","journal-title":"FEBS Lett"},{"key":"12_CR56","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1749-6632.2000.tb06544.x","volume":"905","author":"MS Beer","year":"2000","unstructured":"Beer MS, Stanton JA, Salim K, Rigby M, Heavens RP, Smith D, Mcallister G. EDG receptors as a therapeutic target in the nervous system. Ann N Y Acad Sci 2000; 905: 118\u201331","journal-title":"Ann N Y Acad Sci"},{"key":"12_CR57","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1749-6632.2000.tb06543.x","volume":"905","author":"J Chun","year":"2000","unstructured":"Chun J, Weiner JA, Fukushima N, Contos JJ, Zhang G, Kimura Y, Dubin A, Ishii I, Hecht JH, Akita C,Kaushal D.Neurobiology of receptor-mediated lysophospholipid signaling. From the first lysophospholipid receptor to roles in nervous system function and development. Ann N Y Acad Sci 2000; 905: 110\u20137.","journal-title":"Ann N Y Acad Sci"},{"key":"12_CR58","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/PL00000747","volume":"57","author":"O Peyruchaud","year":"2000","unstructured":"Peyruchaud O, Mosher DF. Differential stimulation of signaling pathways initiated by Edg2 in response to lysophosphatidic acid or sphingosine-l-phosphate. Cell Mol Life Sci 2000; 57: 1109\u201316.","journal-title":"Cell Mol Life Sci"},{"key":"12_CR59","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1128\/MCB.18.12.7119","volume":"18","author":"S Roche","year":"1998","unstructured":"Roche S, Downward J, Raynal P, Courtneidge SA. A function of phosphatidylinositol 3-kinase \u00df (p85a -p110(3) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal transduction. Molecular and Cellular Biology 1998; 18: 7119\u20137129.","journal-title":"Molecular and Cellular Biology"},{"issue":"8","key":"12_CR60","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1001\/jama.280.8.719","volume":"280","author":"Y Xu","year":"1998","unstructured":"Xu Y, Shen Z, Wiper DW, Wu M, Morton RE, Elson P, Kennedy AW, Belinson J, Markman M, Casey G. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 1998; 280 (8): 719\u2013723.","journal-title":"JAMA"},{"key":"12_CR61","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1006\/gyno.1998.5193","volume":"71","author":"Z Shen","year":"1998","unstructured":"Shen Z, Belinson J, Morton RE, et al. Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells. Gyneco Oncol 1998; 71.364\u20138.","journal-title":"Gyneco Oncol"},{"key":"12_CR62","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/0005-2760(89)90112-4","volume":"1001","author":"JM Gerrard","year":"1989","unstructured":"Gerrard, J.M. and Robinson, P. Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochimica et Biophysica Acta 1989; 1001: 282\u2013285.","journal-title":"Biochimica et Biophysica Acta"},{"key":"12_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1388-1981(99)00063-3","volume":"1439","author":"A Wang","year":"1999","unstructured":"Wang A, Dennis EA. Review mammalian lysophospholipases. Biochimica et Biophysica Acta 1999; 1439: 1\u201316.","journal-title":"Biochimica et Biophysica Acta"},{"key":"12_CR64","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/0092-8674(95)90295-3","volume":"80","author":"O Fourcade","year":"1995","unstructured":"Fourcade O, Simon MF, Viode C, Rugani N, Leballe F, Ragab A, Fournie B, Sarda L, Chap H. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 1995; 80: 919\u201327.","journal-title":"Cell"},{"key":"12_CR65","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1074\/jbc.272.4.2192","volume":"272","author":"T Sato","year":"1997","unstructured":"Sato T, Aoki J, Nagai Y, Dohmae N, Takio K, Doi T, Arai H, Inoue K. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. J Biol Chem. 1997; 272: 2192\u20138.","journal-title":"J Biol Chem"},{"key":"12_CR66","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1388-1981(99)00094-3","volume":"1439","author":"M Waite","year":"1999","unstructured":"Waite M. The PLD superfamily: insights into catalysis. Biochim Biophys Acta 1999; 1439: 187\u201397.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"12_CR67","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1388-1981(99)00011-6","volume":"1437","author":"A Tokumura","year":"1999","unstructured":"Tokumura A, Nishioka Y, Yoshimoto O, Shinomiya J, Fukuzawa K. Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma. Biochim Biophys Acta 1999; 1437 (2): 235\u201345.","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"12_CR68","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1016\/S0021-9258(17)37595-6","volume":"269","author":"H Sugimoto","year":"1994","unstructured":"Sugimoto H, Yamashita S. Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver. J Biol Chem 1994; 269 (8): 6252\u201358.","journal-title":"J Biol Chem"},{"issue":"6749","key":"12_CR69","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/43613","volume":"401","author":"A Schmidt","year":"1999","unstructured":"Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov AV, Witke W, Huttner WB, Soling HD. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature 1999; 401 (6749): 133\u201341.","journal-title":"Nature"},{"issue":"19","key":"12_CR70","doi-asserted-by":"publisher","first-page":"12723","DOI":"10.1074\/jbc.272.19.12723","volume":"272","author":"A Wang","year":"1997","unstructured":"Wang A, Deems RA, Dennis EA. Cloning, expression, and catalytic mechanism of murine lysophospholipase I. J Biol Chem 1997; 272 (19): 12723\u201329.","journal-title":"J Biol Chem"},{"key":"12_CR71","doi-asserted-by":"crossref","first-page":"27520","DOI":"10.1074\/jbc.M003211200","volume":"275","author":"J Xu","year":"2000","unstructured":"Xu J, Love LM, Singh I, Zhang QX, Dewald J, Wang DA, Fischer DJ, Tigyi G, Berthiaume LG, Waggoner DW, Brindley DN. Lipid phosphate phosphatase-1 and Ca2+ control lysophosphatidate signaling through EDG-2 receptors. J Biol Chem 2000; 275: 27520\u201330.","journal-title":"J Biol Chem"},{"issue":"4","key":"12_CR72","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.4049\/jimmunol.162.4.2049","volume":"162","author":"EJ Goetzl","year":"1999","unstructured":"Goetzl EJ, Kong Y, Mei B. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J Immunol 1999; 162 (4): 2049\u201356.","journal-title":"J Immunol"},{"key":"12_CR73","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1749-6632.2000.tb06556.x","volume":"905","author":"J Aoki","year":"2000","unstructured":"Aoki J, Bandoh K, Inoue K A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety. Ann N Y Acad Sci 2000; 905: 263\u20136","journal-title":"Ann N Y Acad Sci"},{"key":"12_CR74","first-page":"1066","volume":"48","author":"GB Mills","year":"1988","unstructured":"Mills, G.B., May, C., McGill, M., Roifman, C., and Mellors, A. A putative new growth factor in ascitic fluid from ovarian cancer patients: Identification, characterization and mechanism of action. Cancer Research 1988; 48: 1066\u201371.","journal-title":"Cancer Research"},{"key":"12_CR75","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1172\/JCI114784","volume":"86","author":"GB Mills","year":"1990","unstructured":"Mills, G.B., May, C., Hill, M., Campbell, S., Shaw, P., and Marks A. Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian cancer cells. J Clin Invest 1990; 86: 851\u2013855.","journal-title":"J Clin Invest"},{"issue":"4","key":"12_CR76","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1023\/A:1008217129273","volume":"9","author":"AM Westermann","year":"1998","unstructured":"Westermann AM, Havik E, Postma FR, Beijnen JH, Dalesio O, Moolenaar WH, Rodenhuis S. Malignant effusions contain lysophosphatidic acid (LPA)-like activity. Ann Oncol 1998; 9 (4): 437\u2013442.","journal-title":"Ann Oncol"},{"key":"12_CR77","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","volume":"9","author":"SM Frisch","year":"1997","unstructured":"Frisch SM and Ruoslahti E. Integrins and anoikis. Current Opinion in Cell Biol 1997; 9: 701\u2013706.","journal-title":"Current Opinion in Cell Biol"},{"issue":"3","key":"12_CR78","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/(SICI)1097-4652(199809)176:3<648::AID-JCP22>3.0.CO;2-U","volume":"176","author":"B Valentinis","year":"1998","unstructured":"Valentinis B, Reiss K, Baserga R. Insulin-like growth factor-I-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase. J Cell Physiol 1998; 176 (3): 648\u2013657.","journal-title":"J Cell Physiol"},{"key":"12_CR79","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<430::AID-IJC21>3.0.CO;2-Q","volume":"85","author":"A Ono","year":"2000","unstructured":"Ono A, Maines-Bandiera DL, Roskelley CD, Auersperg N. An ovarian adenocarcinoma line derived from SV40\/E-cadherin-transfected normal human ovarian surface epithelium. Int J Cancer 2000; 85: 430\u2013437.","journal-title":"Int J Cancer"},{"issue":"3","key":"12_CR80","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0014-5793(99)01400-3","volume":"460","author":"G Hong","year":"1999","unstructured":"Hong G, Baudhuin LM, Xu Y. Sphingosine- 1 -phosphate modulates growth and adhesion of ovarian cancer cells. FEBS Lett 1999; 460 (3): 513\u201318.","journal-title":"FEBS Lett"},{"issue":"1","key":"12_CR81","doi-asserted-by":"publisher","first-page":"7884","DOI":"10.1006\/bbrc.1999.0627","volume":"259","author":"A Yoshida","year":"1999","unstructured":"Yoshida A, Ueda H. Activation of Gil by lysophosphatidic acid receptor without ligand in the bacculovirus expression system. Biochem Biophys Res Commun 1999; 259 (1): 7884.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"12_CR82","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/35010529","volume":"2","author":"Y Xu","year":"2000","unstructured":"Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y, Damron DS. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol 2000; 2 (5): 261\u20137.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"12_CR83","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1006\/geno.1996.0377","volume":"35","author":"Y Xu","year":"1996","unstructured":"Xu Y, Casey G. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics. 1996; 35 (2): 397\u2013402.","journal-title":"Genomics"},{"issue":"12","key":"12_CR84","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0014-5793(95)01196-L","volume":"375","author":"S An","year":"1995","unstructured":"An S, Tsai C, Goetzl EJ. Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. FEBS Lett. 1995; 375 (1\u20132): 121\u20134.","journal-title":"FEBS Lett"},{"key":"12_CR85","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1749-6632.2000.tb06554.x","volume":"905","author":"Y Xiao","year":"2000","unstructured":"Xiao Y, Chen Y, Kennedy AW, Belinson J, Xu Y. Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses. Ann N Y Acad Sci 2000; 905: 242\u201359.","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"12_CR86","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3177\/jnsv.44.809","volume":"44","author":"T Sasagawa","year":"1998","unstructured":"Sasagawa T, Suzuki K, Shiota T, Kondo T, Okita M. The significance of plasma lysophospholipids in patients with renal failure on hemodialysis. J Nutr Sci Vitamionol (Tokyo) 1998; 44 (6): 809\u2013818.","journal-title":"J Nutr Sci Vitamionol (Tokyo)"},{"issue":"1","key":"12_CR87","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11745-999-332-5","volume":"34","author":"T Sasagawa","year":"1999","unstructured":"Sasagawa T, Okita M, Murakami J, Kato T, Watanabe A. Abnormal serum lysophospholipids in multiple myeloma patients. Lipids 1999; 34 (1): 17\u201321.","journal-title":"Lipids"},{"key":"12_CR88","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/172460089801300402","volume":"13","author":"RC Bast","year":"1998","unstructured":"Bast, R.C., Xu, F., Yu, Y., Bamhill, S., Zhang, Z., and Mills G.B. CAl25: The past and the future. International Journal of Biological Markers 1998; 13: 179\u201387.","journal-title":"International Journal of Biological Markers"},{"key":"12_CR89","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1749-6632.2000.tb06553.x","volume":"905","author":"WL Santos","year":"2000","unstructured":"Santos WL, Rossi JA, Boggs SD, MacDonald TL. The molecular pharmacology of lysophosphatidate signaling. Ann N Y Acad Sci 2000; 905: 232\u201341.","journal-title":"Ann N Y Acad Sci"}],"container-title":["Ovarian Cancer"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4757-3587-1_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T09:57:50Z","timestamp":1716371870000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4757-3587-1_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"ISBN":["9781475735895","9781475735871"],"references-count":89,"URL":"https:\/\/doi.org\/10.1007\/978-1-4757-3587-1_12","relation":{},"subject":[],"published":{"date-parts":[[2002]]}}}