{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:39:14Z","timestamp":1777462754517,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":70,"publisher":"Springer New York","isbn-type":[{"value":"9781493910304","type":"print"},{"value":"9781493910311","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-4939-1031-1_2","type":"book-chapter","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T11:23:09Z","timestamp":1405077789000},"page":"5-13","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["sGC-cGMP Signaling: Target for Anticancer Therapy"],"prefix":"10.1007","author":[{"given":"Ka","family":"Bian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferid","family":"Murad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,7]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1023\/A:1020265417394","volume":"19","author":"F Murad","year":"1999","unstructured":"Murad F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep. 1999;19:133\u201354.","journal-title":"Biosci Rep"},{"key":"2_CR2","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1001\/jama.1996.03540140077033","volume":"276","author":"F Murad","year":"1996","unstructured":"Murad F. The 1996 Albert Lasker Medical Research Awards. Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA. 1996;276:1189\u201392.","journal-title":"JAMA"},{"key":"2_CR3","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1161\/01.CIR.95.5.1101","volume":"95","author":"F Murad","year":"1997","unstructured":"Murad F. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle? Circulation. 1997;95:1101\u20133.","journal-title":"Circulation"},{"key":"2_CR4","first-page":"F33","volume":"277","author":"K Bian","year":"1999","unstructured":"Bian K, Davis K, Kuret J, Binder L, Murad F. Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry. Am J Physiol. 1999;277:F33\u201340.","journal-title":"Am J Physiol"},{"key":"2_CR5","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.1073\/pnas.0931291100","volume":"100","author":"K Bian","year":"2003","unstructured":"Bian K, Gao Z, Weisbrodt N, Murad F. The nature of heme\/iron-induced protein tyrosine nitration. Proc Natl Acad Sci U S A. 2003;100:5712\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0891-5849(01)00600-1","volume":"31","author":"K Bian","year":"2001","unstructured":"Bian K, Murad F. Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs. Free Radic Biol Med. 2001;31:421\u20139.","journal-title":"Free Radic Biol Med"},{"key":"2_CR7","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/351714a0","volume":"351","author":"DS Bredt","year":"1991","unstructured":"Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991;351:714\u20138.","journal-title":"Nature"},{"key":"2_CR8","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(94)90266-6","volume":"78","author":"C Nathan","year":"1994","unstructured":"Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994;78:915\u20138.","journal-title":"Cell"},{"key":"2_CR9","first-page":"1","volume":"196","author":"C Nathan","year":"1995","unstructured":"Nathan C. Inducible nitric oxide synthase: regulation subserves function. Curr Top Microbiol Immunol. 1995;196:1\u20134.","journal-title":"Curr Top Microbiol Immunol"},{"key":"2_CR10","doi-asserted-by":"crossref","first-page":"14519","DOI":"10.1016\/S0021-9258(18)42066-2","volume":"267","author":"SP Janssens","year":"1992","unstructured":"Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor\/nitric oxide synthase. J Biol Chem. 1992;267:14519\u201322.","journal-title":"J Biol Chem"},{"key":"2_CR11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0014-5793(92)80697-F","volume":"307","author":"PA Marsden","year":"1992","unstructured":"Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, et al. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 1992;307:287\u201393.","journal-title":"FEBS Lett"},{"key":"2_CR12","doi-asserted-by":"crossref","first-page":"15274","DOI":"10.1016\/S0021-9258(19)49528-8","volume":"267","author":"WC Sessa","year":"1992","unstructured":"Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D\u2019Angelo DD, et al. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem. 1992;267:15274\u20136.","journal-title":"J Biol Chem"},{"key":"2_CR13","doi-asserted-by":"publisher","first-page":"d264","DOI":"10.2741\/997","volume":"8","author":"K Bian","year":"2003","unstructured":"Bian K, Murad F. Nitric oxide (NO)\u2014biogeneration, regulation, and relevance to human diseases. Front Biosci. 2003;8:d264\u201378.","journal-title":"Front Biosci"},{"key":"2_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1530\/JOE-11-0034","volume":"210","author":"CA Ducsay","year":"2011","unstructured":"Ducsay CA, Myers DA. eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia. J Endocrinol. 2011;210:259\u201369.","journal-title":"J Endocrinol"},{"key":"2_CR15","first-page":"L925","volume":"276","author":"CB Saqueton","year":"1999","unstructured":"Saqueton CB, Miller RB, Porter VA, Milla CE, Cornfield DN. NO causes perinatal pulmonary vasodilation through K+-channel activation and intracellular Ca2+ release. Am J Physiol. 1999;276:L925\u201332.","journal-title":"Am J Physiol"},{"key":"2_CR16","first-page":"40","volume":"15","author":"WJ Pearce","year":"1991","unstructured":"Pearce WJ, Longo LD. Developmental aspects of endothelial function. Semin Perinatol. 1991;15:40\u20138.","journal-title":"Semin Perinatol"},{"key":"2_CR17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/0006-291X(63)90566-7","volume":"11","author":"DF Ashman","year":"1963","unstructured":"Ashman DF, Lipton R, Melicow MM, Price TD. Isolation of adenosine 3\u2032,5\u2032-monophosphate and guanosine 3\u2032,5\u2032-monophosphate from rat urine. Biochem Biophys Res Commun. 1963;11:330\u20134.","journal-title":"Biochem Biophys Res Commun"},{"key":"2_CR18","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/0005-2787(67)90542-4","volume":"138","author":"TD Price","year":"1967","unstructured":"Price TD, Ashman DF, Melicow MM. Organophosphates of urine, including adenosine 3\u2032,5\u2032-monophosphate and guanosine 3\u2032,5\u2032-monophosphate. Biochim Biophys Acta. 1967;138:452\u201365.","journal-title":"Biochim Biophys Acta"},{"key":"2_CR19","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/BF02431417","volume":"264","author":"E Bohme","year":"1969","unstructured":"Bohme E, Munske K, Schultz G. Formation of cyclic guanosine-3\u2032,5\u2032-monophosphate in various rat tissues. Naunyn Schmiedebergs Arch Pharmakol. 1969;264:220\u20131.","journal-title":"Naunyn Schmiedebergs Arch Pharmakol"},{"key":"2_CR20","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1016\/S0021-9258(18)63473-8","volume":"244","author":"JG Hardman","year":"1969","unstructured":"Hardman JG, Sutherland EW. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3\u2032,5\u2032-monophosphate from guanosine triphosphate. J Biol Chem. 1969;244:6363\u201370.","journal-title":"J Biol Chem"},{"key":"2_CR21","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/0024-3205(69)90189-1","volume":"8","author":"G Schultz","year":"1969","unstructured":"Schultz G, Bohme E, Munske K. Guanyl cyclase. Determination of enzyme activity. Life Sci. 1969;8:1323\u201332.","journal-title":"Life Sci"},{"key":"2_CR22","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/0005-2744(69)90362-3","volume":"191","author":"AA White","year":"1969","unstructured":"White AA, Aurbach GD. Detection of guanyl cyclase in mammalian tissues. Biochim Biophys Acta. 1969;191:686\u201397.","journal-title":"Biochim Biophys Acta"},{"key":"2_CR23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0014-5793(73)80705-7","volume":"34","author":"C Goridis","year":"1973","unstructured":"Goridis C, Morgan IG. Guanyl cyclase in rat brain subcellular fractions. FEBS Lett. 1973;34:71\u20133.","journal-title":"FEBS Lett"},{"key":"2_CR24","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1016\/S0021-9258(19)42144-3","volume":"249","author":"H Kimura","year":"1974","unstructured":"Kimura H, Murad F. Evidence for two different forms of guanylate cyclase in rat heart. J Biol Chem. 1974;249:6910\u20136.","journal-title":"J Biol Chem"},{"key":"2_CR25","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1016\/S0021-9258(18)62703-6","volume":"245","author":"JA Beavo","year":"1970","unstructured":"Beavo JA, Hardman JG, Sutherland EW. Hydrolysis of cyclic guanosine and adenosine 3\u2032,5\u2032-monophosphates by rat and bovine tissues. J Biol Chem. 1970;245:5649\u201355.","journal-title":"J Biol Chem"},{"key":"2_CR26","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/0006-291X(71)90525-0","volume":"42","author":"S Kakiuchi","year":"1971","unstructured":"Kakiuchi S, Yamazaki R, Teshima Y. Cyclic 3\u2032,5\u2032-nucleotide phosphodiesterase, IV. Two enzymes with different properties from brain. Biochem Biophys Res Commun. 1971;42:968\u201374.","journal-title":"Biochem Biophys Res Commun"},{"key":"2_CR27","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0005-2744(71)90231-2","volume":"242","author":"WY Cheung","year":"1971","unstructured":"Cheung WY. Cyclic 3\u2032, 5\u2032-nucleotide phosphodiesterase. Effect of divalent cations. Biochim Biophys Acta. 1971;242:395\u2013409.","journal-title":"Biochim Biophys Acta"},{"key":"2_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/288373a0","volume":"288","author":"RF Furchgott","year":"1980","unstructured":"Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373\u20136.","journal-title":"Nature"},{"key":"2_CR29","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1161\/01.RES.52.3.352","volume":"52","author":"RM Rapoport","year":"1983","unstructured":"Rapoport RM, Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res. 1983;52:352\u20137.","journal-title":"Circ Res"},{"key":"2_CR30","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/306174a0","volume":"306","author":"RM Rapoport","year":"1983","unstructured":"Rapoport RM, Draznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature. 1983;306:174\u20136.","journal-title":"Nature"},{"key":"2_CR31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/bj3350125","volume":"335","author":"M Russwurm","year":"1998","unstructured":"Russwurm M, Behrends S, Harteneck C, Koesling D. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem J. 1998;335:125\u201330.","journal-title":"Biochem J"},{"key":"2_CR32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cardiores.2007.06.002","volume":"76","author":"S Nimmegeers","year":"2007","unstructured":"Nimmegeers S, Sips P, Buys E, Brouckaert P, Van de Voorde J. Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res. 2007;76:149\u201359.","journal-title":"Cardiovasc Res"},{"key":"2_CR33","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/334708a0","volume":"334","author":"S Singh","year":"1988","unstructured":"Singh S, Lowe DG, Thorpe DS, Rodriguez H, Kuang WJ, Dangott LJ, et al. Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases. Nature. 1988;334:708\u201312.","journal-title":"Nature"},{"key":"2_CR34","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1126\/science.1672777","volume":"252","author":"KJ Koller","year":"1991","unstructured":"Koller KJ, Lowe DG, Bennett GL, Minamino N, Kangawa K, Matsuo H, et al. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science. 1991;252:120\u20133.","journal-title":"Science"},{"key":"2_CR35","doi-asserted-by":"publisher","first-page":"14827","DOI":"10.1073\/pnas.93.25.14827","volume":"93","author":"SL Carrithers","year":"1996","unstructured":"Carrithers SL, Barber MT, Biswas S, Parkinson SJ, Park PK, Goldstein SD, et al. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc Natl Acad Sci U S A. 1996;93:14827\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR36","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S1050-1738(96)00105-3","volume":"6","author":"M Biel","year":"1996","unstructured":"Biel M, Zong X, Hofmann F. Cyclic nucleotide-gated cation channels molecular diversity, structure, and cellular functions. Trends Cardiovasc Med. 1996;6:274\u201380.","journal-title":"Trends Cardiovasc Med"},{"key":"2_CR37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1096\/fasebj.7.2.7680013","volume":"7","author":"TM Lincoln","year":"1993","unstructured":"Lincoln TM, Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J. 1993;7:328\u201338.","journal-title":"FASEB J"},{"key":"2_CR38","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1476-5381.2011.01729.x","volume":"165","author":"T Keravis","year":"2012","unstructured":"Keravis T, Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol. 2012;165:1288\u2013305.","journal-title":"Br J Pharmacol"},{"key":"2_CR39","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1021\/bi00313a028","volume":"23","author":"K Titani","year":"1984","unstructured":"Titani K, Sasagawa T, Ericsson LH, Kumar S, Smith SB, Krebs EG, et al. Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3\u2032,5\u2032-phosphate dependent protein kinase. Biochemistry. 1984;23:4193\u20139.","journal-title":"Biochemistry"},{"key":"2_CR40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0146-0005(00)80045-2","volume":"24","author":"E Martin","year":"2000","unstructured":"Martin E, Davis K, Bian K, Lee YC, Murad F. Cellular signaling with nitric oxide and cyclic guanosine monophosphate. Semin Perinatol. 2000;24:2\u20136.","journal-title":"Semin Perinatol"},{"key":"2_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1006\/geno.1997.4743","volume":"42","author":"S Orstavik","year":"1997","unstructured":"Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M. Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). Genomics. 1997;42:311\u20138.","journal-title":"Genomics"},{"key":"2_CR42","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1126\/science.162.3861.1484","volume":"162","author":"WL Ryan","year":"1968","unstructured":"Ryan WL, Heidrick ML. Inhibition of cell growth in vitro by adenosine 3\u2032,5\u2032-monophosphate. Science. 1968;162:1484\u20135.","journal-title":"Science"},{"key":"2_CR43","first-page":"307","volume":"5","author":"ND Goldberg","year":"1975","unstructured":"Goldberg ND, Haddox MK, Nicol SE, Glass DB, Sanford CH, Kuehl Jr FA, et al. Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis. Adv Cyclic Nucleotide Res. 1975;5:307\u201330.","journal-title":"Adv Cyclic Nucleotide Res"},{"key":"2_CR44","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1172\/JCI108320","volume":"57","author":"FR DeRubertis","year":"1976","unstructured":"DeRubertis FR, Chayoth R, Field JB. The content and metabolism of cyclic adenosine 3\u2032,5\u2032-monophosphate and cyclic guanosine 3\u2032,5\u2032-monophosphate in adenocarcinoma of the human colon. J Clin Invest. 1976;57:641\u20139.","journal-title":"J Clin Invest"},{"key":"2_CR45","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1073\/pnas.69.10.3024","volume":"69","author":"JW Hadden","year":"1972","unstructured":"Hadden JW, Hadden EM, Haddox MK, Goldberg ND. Guanosine 3\u2032:5\u2032-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. Proc Natl Acad Sci U S A. 1972;69:3024\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000459047","volume":"27","author":"DJ Takemoto","year":"1982","unstructured":"Takemoto DJ, Dunford C, Vaughn D, Kramer KJ, Smith A, Powell RG. Guanylate cyclase activity in human leukemic and normal lymphocytes. Enzyme inhibition and cytotoxicity of plant extracts. Enzyme. 1982;27:179\u201388.","journal-title":"Enzyme"},{"key":"2_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.170677","volume":"190","author":"F Murad","year":"1975","unstructured":"Murad F, Kimura H, Hopkins HA, Looney WB, Kovacs CJ. Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A. Science. 1975;190:58\u201360.","journal-title":"Science"},{"key":"2_CR48","first-page":"1714","volume":"36","author":"WE Criss","year":"1976","unstructured":"Criss WE, Murad F. Urinary excretion of cyclic guanosine 3\u2032:5\u2032-monophosphate and cyclic adenosine 3\u2032:5\u2032-monophosphate in rats bearing transplantable liver and kidney tumors. Cancer Res. 1976;36:1714\u20136.","journal-title":"Cancer Res"},{"key":"2_CR49","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI114081","volume":"83","author":"UC Garg","year":"1989","unstructured":"Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774\u20137.","journal-title":"J Clin Invest"},{"key":"2_CR50","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1006\/bbrc.1994.2304","volume":"203","author":"W Yang","year":"1994","unstructured":"Yang W, Ando J, Korenaga R, Toyo-oka T, Kamiya A. Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial cells. Biochem Biophys Res Commun. 1994;203:1160\u20137.","journal-title":"Biochem Biophys Res Commun"},{"key":"2_CR51","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/0006-8993(92)91678-8","volume":"592","author":"UC Garg","year":"1992","unstructured":"Garg UC, Devi L, Turndorf H, Goldfrank LR, Bansinath M. Effect of nitric oxide on mitogenesis and proliferation of cerebellar glial cells. Brain Res. 1992;592:208\u201312.","journal-title":"Brain Res"},{"key":"2_CR52","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1046\/j.1471-4159.2002.01116.x","volume":"83","author":"M Murillo-Carretero","year":"2002","unstructured":"Murillo-Carretero M, Ruano MJ, Matarredona ER, Villalobo A, Estrada C. Antiproliferative effect of nitric oxide on epidermal growth factor-responsive human neuroblastoma cells. J Neurochem. 2002;83:119\u201331.","journal-title":"J Neurochem"},{"key":"2_CR53","first-page":"787","volume":"123","author":"M Kumazoe","year":"2013","unstructured":"Kumazoe M, Sugihara K, Tsukamoto S, Huang Y, Tsurudome Y, Suzuki T, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J Clin Invest. 2013;123:787\u201399.","journal-title":"J Clin Invest"},{"key":"2_CR54","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1600-0404.1976.tb04371.x","volume":"54","author":"L Frattola","year":"1976","unstructured":"Frattola L, Carenzi A, Cerri C, Kumakura K, Trabucchi M. Regulation of the cyclic guanosine 3\u2032\u20135\u2032 monophosphate system in human brain tumors. Acta Neurol Scand. 1976;54:382\u201390.","journal-title":"Acta Neurol Scand"},{"key":"2_CR55","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1124\/mol.111.073585","volume":"80","author":"H Zhu","year":"2011","unstructured":"Zhu H, Li JT, Zheng F, Martin E, Kots AY, Krumenacker JS, et al. Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma. Mol Pharmacol. 2011;80:1076\u201384.","journal-title":"Mol Pharmacol"},{"key":"2_CR56","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3322\/CA.2007.0010","volume":"58","author":"A Jemal","year":"2008","unstructured":"Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71\u201396.","journal-title":"CA Cancer J Clin"},{"key":"2_CR57","doi-asserted-by":"publisher","first-page":"9208","DOI":"10.1073\/pnas.1633590100","volume":"100","author":"E Martin","year":"2003","unstructured":"Martin E, Sharina I, Kots A, Murad F. A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation. Proc Natl Acad Sci U S A. 2003;100:9208\u201313.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR58","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1593\/neo.08928","volume":"10","author":"V Mathieu","year":"2008","unstructured":"Mathieu V, De Neve N, Le Mercier M, Dewelle J, Gaussin JF, Dehoux M, et al. Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. Neoplasia. 2008;10:1383\u201392.","journal-title":"Neoplasia"},{"key":"2_CR59","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1200\/JCO.2006.06.8015","volume":"25","author":"J Subramanian","year":"2007","unstructured":"Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol. 2007;25:561\u201370.","journal-title":"J Clin Oncol"},{"key":"2_CR60","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1097\/JTO.0b013e31818b06e3","volume":"3","author":"WD Travis","year":"2008","unstructured":"Travis WD, Giroux DJ, Chansky K, Crowley J, Asamura H, Brambilla E, et al. The IASLC Lung Cancer Staging Project: proposals for the inclusion of broncho-pulmonary carcinoid tumors in the forthcoming (seventh) edition of the TNM Classification for Lung Cancer. J Thorac Oncol. 2008;3:1213\u201323.","journal-title":"J Thorac Oncol"},{"key":"2_CR61","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","volume":"123","author":"B Gyorffy","year":"2010","unstructured":"Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 2010;123:725\u201331.","journal-title":"Breast Cancer Res Treat"},{"key":"2_CR62","doi-asserted-by":"publisher","first-page":"218","DOI":"10.11607\/ijp.3406","volume":"26","author":"DM Layton","year":"2013","unstructured":"Layton DM. Understanding Kaplan-Meier and survival statistics. Int J Prosthodont. 2013;26:218\u201326.","journal-title":"Int J Prosthodont"},{"key":"2_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.niox.2005.06.010","volume":"14","author":"JS Krumenacker","year":"2006","unstructured":"Krumenacker JS, Katsuki S, Kots A, Murad F. Differential expression of genes involved in cGMP-dependent nitric oxide signaling in murine embryonic stem (ES) cells and ES cell-derived cardiomyocytes. Nitric Oxide. 2006;14:1\u201311.","journal-title":"Nitric Oxide"},{"key":"2_CR64","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1089\/scd.2006.15.779","volume":"15","author":"K Mujoo","year":"2006","unstructured":"Mujoo K, Krumenacker JS, Wada Y, Murad F. Differential expression of nitric oxide signaling components in undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev. 2006;15:779\u201387.","journal-title":"Stem Cells Dev"},{"key":"2_CR65","doi-asserted-by":"publisher","first-page":"9392","DOI":"10.1038\/sj.onc.1208311","volume":"23","author":"X Yuan","year":"2004","unstructured":"Yuan X, Curtin J, Xiong Y, Liu G, Waschsmann-Hogiu S, Farkas DL, et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene. 2004;23:9392\u2013400.","journal-title":"Oncogene"},{"key":"2_CR66","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396\u2013401.","journal-title":"Nature"},{"key":"2_CR67","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/1471-2164-6-151","volume":"6","author":"X Cui","year":"2005","unstructured":"Cui X, Zhang J, Ma P, Myers DE, Goldberg IG, Sittler KJ, et al. cGMP-independent nitric oxide signaling and regulation of the cell cycle. BMC Genomics. 2005;6:151.","journal-title":"BMC Genomics"},{"key":"2_CR68","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.2741\/1616","volume":"10","author":"RB Pilz","year":"2005","unstructured":"Pilz RB, Broderick KE. Role of cyclic GMP in gene regulation. Front Biosci. 2005;10:1239\u201368.","journal-title":"Front Biosci"},{"key":"2_CR69","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1128\/MCB.17.9.5244","volume":"17","author":"T Gudi","year":"1997","unstructured":"Gudi T, Lohmann SM, Pilz RB. Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal. Mol Cell Biol. 1997;17:5244\u201354.","journal-title":"Mol Cell Biol"},{"key":"2_CR70","doi-asserted-by":"publisher","first-page":"16004","DOI":"10.1074\/jbc.M112.432294","volume":"288","author":"JR Hickok","year":"2013","unstructured":"Hickok JR, Vasudevan D, Antholine WE, Thomas DD. Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. J Biol Chem. 2013;288:16004\u201315.","journal-title":"J Biol Chem"}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Fetal and Neonatal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1031-1_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T17:50:31Z","timestamp":1676397031000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1031-1_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9781493910304","9781493910311"],"references-count":70,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1031-1_2","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"7 June 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}