{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:56:54Z","timestamp":1765231014252,"version":"3.40.4"},"publisher-location":"New York, NY","reference-count":46,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493911325"},{"type":"electronic","value":"9781493911332"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-4939-1133-2_20","type":"book-chapter","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T07:30:51Z","timestamp":1406273451000},"page":"287-309","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retroviral Transduction of Murine and Human Hematopoietic Progenitors and Stem Cells"],"prefix":"10.1007","author":[{"given":"Marioara F.","family":"Ciuculescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Brendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,28]]},"reference":[{"key":"20_CR1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1182\/blood.V90.12.5002","volume":"90","author":"AH Yin","year":"1997","unstructured":"Yin AH, Miraglia S, Zanjani ED et al (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90:5002\u20135012","journal-title":"Blood"},{"key":"20_CR2","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","volume":"121","author":"MJ Kiel","year":"2005","unstructured":"Kiel MJ, Yilmaz OH, Iwashita T et al (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121:1109\u20131121","journal-title":"Cell"},{"key":"20_CR3","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","volume":"183","author":"MA Goodell","year":"1996","unstructured":"Goodell MA, Brose K, Paradis G et al (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183:1797\u20131806","journal-title":"J Exp Med"},{"key":"20_CR4","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.1073\/pnas.87.19.7433","volume":"87","author":"GJ Spangrude","year":"1990","unstructured":"Spangrude GJ, Johnson GR (1990) Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci U S A 87:7433\u20137437","journal-title":"Proc Natl Acad Sci U S A"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/978-3-540-35109-2_8","volume":"178","author":"P Osten","year":"2007","unstructured":"Osten P, Grinevich V, Cetin A (2007) Viral vectors: a wide range of choices and high levels of service. Handb Exp Pharmacol 178:177\u2013202","journal-title":"Handb Exp Pharmacol"},{"key":"20_CR6","volume-title":"Retroviruses","author":"JM Coffin","year":"1997","unstructured":"Coffin JM, Hughes SH, Varmus HE (1997) The interactions of retroviruses and their hosts. In: Coffin JM, Hughes SH, Varmus HE (eds) Retroviruses. Cold Spring Harbor, New York"},{"key":"20_CR7","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1099\/0022-1317-80-12-3049","volume":"80","author":"MA Sommerfelt","year":"1999","unstructured":"Sommerfelt MA (1999) Retrovirus receptors. J Gen Virol 80:3049\u20133064","journal-title":"J Gen Virol"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1128\/MMBR.65.3.371-389.2001","volume":"65","author":"J Overbaugh","year":"2001","unstructured":"Overbaugh J, Miller AD, Eiden MV (2001) Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins. Microbiol Mol Biol Rev 65:371\u2013389, table of contents","journal-title":"Microbiol Mol Biol Rev"},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/2261211a0","volume":"226","author":"HM Temin","year":"1970","unstructured":"Temin HM, Mizutani S (1970) RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226:1211\u20131213","journal-title":"Nature"},{"key":"20_CR10","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1242\/jcs.108.9.3039","volume":"108","author":"C Risco","year":"1995","unstructured":"Risco C, Menendez-Arias L, Copeland TD et al (1995) Intracellular transport of the murine leukemia virus during acute infection of NIH 3T3 cells: nuclear import of nucleocapsid protein and integrase. J Cell Sci 108:3039\u20133050","journal-title":"J Cell Sci"},{"key":"20_CR11","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1128\/JVI.73.11.8919-8925.1999","volume":"73","author":"A Fassati","year":"1999","unstructured":"Fassati A, Goff SP (1999) Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus. J Virol 73:8919\u20138925","journal-title":"J Virol"},{"key":"20_CR12","first-page":"19","volume-title":"Current genomics","author":"GL Buchschacher","year":"2004","unstructured":"Buchschacher GL et al (2004) Safety considerations associated with development and clinical application of lentiviral vector systems for gene transfer. In: Buchschacher G (ed) Current genomics, vol 5. Bentham Science Publishers, Sharjah, UAE, pp 19\u201335"},{"key":"20_CR13","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/v3060677","volume":"3","author":"T Maetzig","year":"2011","unstructured":"Maetzig T, Galla M, Baum C et al (2011) Gammaretroviral vectors: biology, technology and application. Viruses 3:677\u2013713","journal-title":"Viruses"},{"key":"20_CR14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2174\/1566523054546224","volume":"5","author":"J Cronin","year":"2005","unstructured":"Cronin J, Zhang XY, Reiser J (2005) Altering the tropism of lentiviral vectors through pseudotyping. Curr Gene Ther 5:387\u2013398","journal-title":"Curr Gene Ther"},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1126\/science.272.5259.263","volume":"272","author":"L Naldini","year":"1996","unstructured":"Naldini L, Blomer U, Gallay P et al (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263\u2013267","journal-title":"Science"},{"key":"20_CR16","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1128\/JVI.72.11.8463-8471.1998","volume":"72","author":"T Dull","year":"1998","unstructured":"Dull T, Zufferey R, Kelly M et al (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72:8463\u20138471","journal-title":"J Virol"},{"key":"20_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1089\/108729102753429361","volume":"16","author":"MR Mautino","year":"2002","unstructured":"Mautino MR, Morgan RA (2002) Gene therapy of HIV-1 infection using lentiviral vectors expressing anti-HIV-1 genes. AIDS Patient Care STDS 16:11\u201326","journal-title":"AIDS Patient Care STDS"},{"key":"20_CR18","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.exphem.2006.02.005","volume":"34","author":"A Schambach","year":"2006","unstructured":"Schambach A, Galla M, Modlich U et al (2006) Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol 34:588\u2013592","journal-title":"Exp Hematol"},{"key":"20_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/S0958-1669(99)00010-5","volume":"10","author":"E Martinez-Salas","year":"1999","unstructured":"Martinez-Salas E (1999) Internal ribosome entry site biology and its use in expression vectors. Curr Opin Biotechnol 10:458\u2013464","journal-title":"Curr Opin Biotechnol"},{"key":"20_CR20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1517\/14712598.5.5.627","volume":"5","author":"AL Szymczak","year":"2005","unstructured":"Szymczak AL, Vignali DA (2005) Development of 2A peptide-based strategies in the design of multicistronic vectors. Expert Opin Biol Ther 5:627\u2013638","journal-title":"Expert Opin Biol Ther"},{"key":"20_CR21","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1089\/hum.1997.8.15-1815","volume":"8","author":"B Fehse","year":"1997","unstructured":"Fehse B, Uhde A, Fehse N et al (1997) Selective immunoaffinity-based enrichment of CD34+ cells transduced with retroviral vectors containing an intracytoplasmatically truncated version of the human low-affinity nerve growth factor receptor (deltaLNGFR) gene. Hum Gene Ther 8:1815\u20131824","journal-title":"Hum Gene Ther"},{"key":"20_CR22","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1006\/mthe.2000.0068","volume":"1","author":"B Fehse","year":"2000","unstructured":"Fehse B, Richters A, Putimtseva-Scharf K et al (2000) CD34 splice variant: an attractive marker for selection of gene-modified cells. Mol Ther 1:448\u2013456","journal-title":"Mol Ther"},{"key":"20_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/sj.gt.3302698","volume":"13","author":"A Schambach","year":"2006","unstructured":"Schambach A, Bohne J, Baum C et al (2006) Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression. Gene Ther 13:641\u2013645","journal-title":"Gene Ther"},{"key":"20_CR24","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1128\/JVI.73.4.2886-2892.1999","volume":"73","author":"R Zufferey","year":"1999","unstructured":"Zufferey R, Donello JE, Trono D et al (1999) Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 73:2886\u20132892","journal-title":"J Virol"},{"key":"20_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1021014728217","volume":"26","author":"GL Buchschacher Jr","year":"2001","unstructured":"Buchschacher GL Jr (2001) Introduction to retroviruses and retroviral vectors. Somat Cell Mol Genet 26:1\u201311","journal-title":"Somat Cell Mol Genet"},{"key":"20_CR26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0031-6997(24)01467-4","volume":"52","author":"WS Hu","year":"2000","unstructured":"Hu WS, Pathak VK (2000) Design of retroviral vectors and helper cells for gene therapy. Pharmacol Rev 52:493\u2013511","journal-title":"Pharmacol Rev"},{"key":"20_CR27","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/310476a0","volume":"310","author":"DA Williams","year":"1984","unstructured":"Williams DA, Lemischka IR, Nathan DG et al (1984) Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature 310:476\u2013480","journal-title":"Nature"},{"key":"20_CR28","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1172\/JCI117122","volume":"93","author":"T Moritz","year":"1994","unstructured":"Moritz T, Patel VP, Williams DA (1994) Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. J Clin Invest 93:1451\u20131457","journal-title":"J Clin Invest"},{"key":"20_CR29","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/nm0896-876","volume":"2","author":"H Hanenberg","year":"1996","unstructured":"Hanenberg H, Xiao XL, Dilloo D et al (1996) Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat Med 2:876\u2013882","journal-title":"Nat Med"},{"key":"20_CR30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1006\/mthe.2001.0269","volume":"3","author":"RE Donahue","year":"2001","unstructured":"Donahue RE, Sorrentino BP, Hawley RG et al (2001) Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells. Mol Ther 3:359\u2013367","journal-title":"Mol Ther"},{"key":"20_CR31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1056\/NEJMoa0805817","volume":"360","author":"A Aiuti","year":"2009","unstructured":"Aiuti A, Cattaneo F, Galimberti S et al (2009) Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med 360:447\u2013458","journal-title":"N Engl J Med"},{"key":"20_CR32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1056\/NEJMoa1000164","volume":"363","author":"S Hacein-Bey-Abina","year":"2010","unstructured":"Hacein-Bey-Abina S, Hauer J, Lim A et al (2010) Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363:355\u2013364","journal-title":"N Engl J Med"},{"key":"20_CR33","first-page":"97ra79","volume":"3","author":"HB Gaspar","year":"2011","unstructured":"Gaspar HB, Cooray S, Gilmour KC et al (2011) Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med 3:97ra79","journal-title":"Sci Transl Med"},{"key":"20_CR34","first-page":"97ra80","volume":"3","author":"HB Gaspar","year":"2011","unstructured":"Gaspar HB, Cooray S, Gilmour KC et al (2011) Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Transl Med 3:97ra80","journal-title":"Sci Transl Med"},{"key":"20_CR35","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1056\/NEJMoa1003548","volume":"363","author":"K Boztug","year":"2010","unstructured":"Boztug K, Schmidt M, Schwarzer A et al (2010) Stem-cell gene therapy for the Wiskott-Aldrich syndrome. N Engl J Med 363:1918\u20131927","journal-title":"N Engl J Med"},{"key":"20_CR36","doi-asserted-by":"publisher","first-page":"1233151","DOI":"10.1126\/science.1233151","volume":"341","author":"A Aiuti","year":"2013","unstructured":"Aiuti A, Biasco L, Scaramuzza S et al (2013) Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science 341:1233151","journal-title":"Science"},{"key":"20_CR37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nm1393","volume":"12","author":"MG Ott","year":"2006","unstructured":"Ott MG, Schmidt M, Schwarzwaelder K et al (2006) Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12:401\u2013409","journal-title":"Nat Med"},{"key":"20_CR38","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.1171242","volume":"326","author":"N Cartier","year":"2009","unstructured":"Cartier N, Hacein-Bey-Abina S, Bartholomae CC et al (2009) Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 326:818\u2013823","journal-title":"Science"},{"key":"20_CR39","doi-asserted-by":"publisher","first-page":"1233158","DOI":"10.1126\/science.1233158","volume":"341","author":"A Biffi","year":"2013","unstructured":"Biffi A, Montini E, Lorioli L et al (2013) Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science 341:1233158","journal-title":"Science"},{"key":"20_CR40","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1634\/stemcells.2008-0258","volume":"26","author":"A Ramezani","year":"2008","unstructured":"Ramezani A, Hawley TS, Hawley RG (2008) Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha\/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential. Stem Cells 26:3257\u20133266","journal-title":"Stem Cells"},{"key":"20_CR41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/gt.2011.70","volume":"19","author":"A Gaussin","year":"2012","unstructured":"Gaussin A, Modlich U, Bauche C et al (2012) CTF\/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors. Gene Ther 19:15\u201324","journal-title":"Gene Ther"},{"key":"20_CR42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1089\/humc.2012.244","volume":"24","author":"RM Koldej","year":"2013","unstructured":"Koldej RM, Carney G, Wielgosz MM et al (2013) Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors. Hum Gene Ther Clin Dev 24:77\u201385","journal-title":"Hum Gene Ther Clin Dev"},{"key":"20_CR43","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/stem.1316","volume":"31","author":"N Pfaff","year":"2013","unstructured":"Pfaff N, Lachmann N, Ackermann M et al (2013) A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells 31:488\u2013499","journal-title":"Stem Cells"},{"key":"20_CR44","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1038\/mt.2010.132","volume":"18","author":"F Zhang","year":"2010","unstructured":"Zhang F, Frost AR, Blundell MP et al (2010) A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol Ther 18:1640\u20131649","journal-title":"Mol Ther"},{"key":"20_CR45","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1182\/blood-2006-12-060814","volume":"110","author":"F Zhang","year":"2007","unstructured":"Zhang F, Thornhill SI, Howe SJ et al (2007) Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells. Blood 110:1448\u20131457","journal-title":"Blood"},{"key":"20_CR46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1182\/blood-2010-02-271841","volume":"116","author":"SP McDermott","year":"2010","unstructured":"McDermott SP, Eppert K, Lechman ER et al (2010) Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116:193\u2013200","journal-title":"Blood"}],"container-title":["Methods in Molecular Biology","Hematopoietic Stem Cell Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1133-2_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T23:07:19Z","timestamp":1746313639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1133-2_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9781493911325","9781493911332"],"references-count":46,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1133-2_20","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"28 June 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}