{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:49:31Z","timestamp":1794484171552,"version":"4.9.1"},"publisher-location":"New York, NY","reference-count":12,"publisher":"Springer New York","isbn-type":[{"value":"9781493914524","type":"print"},{"value":"9781493914531","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-1-4939-1453-1_23","type":"book-chapter","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T03:56:51Z","timestamp":1409371011000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improvement of Neurological Dysfunctions in Aphakia Mice, a Model of Parkinson\u2019s Disease, after Transplantation of ES Cell-Derived Dopaminergic Neuronal Precursors"],"prefix":"10.1007","author":[{"given":"Sangmi","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisook","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"23_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0169-328X(03)00162-1","volume":"114","author":"DY Hwang","year":"2003","unstructured":"Hwang DY, Ardayfio P, Kang UJ, Semina EV, Kim KS (2003) Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Res Mol Brain Res 114:123\u2013131","journal-title":"Brain Res Mol Brain Res"},{"key":"23_CR2","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1523\/JNEUROSCI.3718-04.2005","volume":"25","author":"DY Hwang","year":"2005","unstructured":"Hwang DY, Fleming SM, Ardayfio P, Moran-Gates T, Kim H, Tarazi FI, Chesselet MF, Kim KS (2005) 3,4-Dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson\u2019s disease. J Neurosci 25:2132\u20132137","journal-title":"J Neurosci"},{"key":"23_CR3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0896-6273(02)00780-8","volume":"35","author":"T Dawson","year":"2002","unstructured":"Dawson T, Mandir A, Lee M (2002) Animal models of PD: pieces of the same puzzle? Neuron 35:219\u2013222","journal-title":"Neuron"},{"key":"23_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/35072550","volume":"2","author":"MF Beal","year":"2001","unstructured":"Beal MF (2001) Experimental models of Parkinson\u2019s disease. Nat Rev Neurosci 2:325\u2013334","journal-title":"Nat Rev Neurosci"},{"key":"23_CR5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1242\/dev.01022","volume":"131","author":"MP Smidt","year":"2004","unstructured":"Smidt MP, Smits SM, Bouwmeester H, Hamers FPT, van der Linden AJA, Hellemons AJCGM, Graw J, Burbach JP (2004) Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131:1145\u20131155","journal-title":"Development"},{"key":"23_CR6","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1242\/dev.00464","volume":"130","author":"P van den Munckhof","year":"2003","unstructured":"van den Munckhof P, Luk KC, Ste-Marie L, Montgomery J, Blanchet PJ, Sadikot AF, Drouin J (2003) Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 130:2535\u20132542","journal-title":"Development"},{"key":"23_CR7","doi-asserted-by":"publisher","first-page":"4245","DOI":"10.1073\/pnas.0230529100","volume":"100","author":"I Nunes","year":"2003","unstructured":"Nunes I, Tovmasian LT, Silva RM, Burke RE, Goff SP (2003) Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc Natl Acad Sci U S A 100:4245\u20134250","journal-title":"Proc Natl Acad Sci U S A"},{"key":"23_CR8","doi-asserted-by":"publisher","first-page":"9703","DOI":"10.1073\/pnas.1016443108","volume":"108","author":"S Chung","year":"2011","unstructured":"Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS (2011) ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci U S A 108:9703\u20139708","journal-title":"Proc Natl Acad Sci U S A"},{"key":"23_CR9","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3727\/096368912X657242","volume":"22","author":"J Moon","year":"2013","unstructured":"Moon J, Lee HS, Kang JM, Park J, Leung A, Hong S, Chung S, Kim KS (2013) Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson\u2019s disease, the aphakia (ak) mouse. Cell Transplant 22:1263\u20131279","journal-title":"Cell Transplant"},{"key":"23_CR10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1242\/dev.011031","volume":"135","author":"D Enshell-Seijffers","year":"2008","unstructured":"Enshell-Seijffers D, Lindon C, Morgan BA (2008) The serine protease Corin is a novel modifier of the Agouti pathway. Development 135:217\u2013225","journal-title":"Development"},{"key":"23_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1471-213X-7-122","volume":"7","author":"N Fossat","year":"2007","unstructured":"Fossat N, Le Greneur C, Beby F, Vincent S, Godement P, Chatelain G, Lamonerie T (2007) A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. BMC Dev Biol 7:122","journal-title":"BMC Dev Biol"},{"key":"23_CR12","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1634\/stemcells.2007-0996","volume":"26","author":"E Hedlund","year":"2008","unstructured":"Hedlund E, Pruszak J, Lardaro T, Ludwig W, Vinuela A, Kim KS, Isacson O (2008) Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson\u2019s disease. Stem Cells 26:1526\u20131536","journal-title":"Stem Cells"}],"container-title":["Methods in Molecular Biology","Animal Models for Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1453-1_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:36:00Z","timestamp":1676864160000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1453-1_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9781493914524","9781493914531"],"references-count":12,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1453-1_23","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4939-1453-1","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"4 August 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}