{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:31:13Z","timestamp":1794486673472,"version":"4.9.1"},"publisher-location":"New York, NY","reference-count":9,"publisher":"Springer New York","isbn-type":[{"value":"9781493915378","type":"print"},{"value":"9781493915385","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-1538-5_16","type":"book-chapter","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T02:14:49Z","timestamp":1413339289000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunosuppressive Factor Blockade in Dendritic Cells via siRNAs Results in Objective Clinical Responses"],"prefix":"10.1007","author":[{"given":"Mouldy","family":"Sioud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mobergslien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"S\u00e6b\u00f8e-Larssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nature06175","volume":"449","author":"RM Steinman","year":"2007","unstructured":"Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:245\u2013252","journal-title":"Nature"},{"key":"16_CR2","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nbt.2000","volume":"29","author":"A Hoos","year":"2011","unstructured":"Hoos A, Britten CM, Huber C, O\u2019Donnell-Tormey J (2011) A methodological framework to enhance the clinical success of cancer immunotherapy. Nat Biotechnol 29:867\u2013870","journal-title":"Nat Biotechnol"},{"key":"16_CR3","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1126\/science.1073514","volume":"297","author":"DH Munn","year":"2002","unstructured":"Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS et al (2002) Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297:1867\u20131870","journal-title":"Science"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.4049\/jimmunol.164.7.3596","volume":"164","author":"P Hwu","year":"2000","unstructured":"Hwu P, Du MX, Lapointe R, Do M, Taylor M-W, Young HA (2000) Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 164:3596\u20133599","journal-title":"J Immunol"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2005-03-0979","volume":"106","author":"D Braun","year":"2005","unstructured":"Braun D, Longman RS, Albert ML (2005) A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic cell maturation. Blood 106:2375\u20132381","journal-title":"Blood"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1172\/JCI200421583","volume":"114","author":"DH Munn","year":"2004","unstructured":"Munn DH, Sharma MD, Hou D (2004) Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in draining-draining lymph nodes. J Clin Invest 114:280\u2013290","journal-title":"J Clin Invest"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S1471-4906(01)01952-4","volume":"22","author":"H Jonuleit","year":"2001","unstructured":"Jonuleit H, Schmitt E, Stenbrink K, Enk AH (2001) Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol 22:394\u2013400","journal-title":"Trends Immunol"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"e837","DOI":"10.1111\/j.1365-2567.2009.03093.x","volume":"128","author":"GF Flatekval","year":"2009","unstructured":"Flatekval GF, Sioud M (2009) Modulation of dendritic cell function and maturation with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase. Immunology 128:e837\u2013e848","journal-title":"Immunology"},{"key":"16_CR9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3892\/ijo.2013.1922","volume":"43","author":"M Sioud","year":"2013","unstructured":"Sioud M, Saeb\u00f8e-Larssen S, Hetland TE, Kaern J, Mobergslien A, Kvalheim G (2013) Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients. Int J Oncol 43:280\u2013288","journal-title":"Int J Oncol"}],"container-title":["Methods in Molecular Biology","RNA Interference"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1538-5_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T22:16:05Z","timestamp":1675980965000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1538-5_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,23]]},"ISBN":["9781493915378","9781493915385"],"references-count":9,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1538-5_16","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4939-1538-5","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,23]]},"assertion":[{"value":"23 September 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}