{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:13:00Z","timestamp":1791825180535,"version":"4.3.4"},"publisher-location":"New York, NY","reference-count":86,"publisher":"Springer New York","isbn-type":[{"value":"9781493915675","type":"print"},{"value":"9781493915682","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-1568-2_9","type":"book-chapter","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T15:53:08Z","timestamp":1415980388000},"page":"141-154","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Parasympathetic Nervous System as a Regulator of Mast Cell Function"],"prefix":"10.1007","author":[{"given":"Paul","family":"Forsythe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/nri1810","volume":"6","author":"EM Sternberg","year":"2006","unstructured":"Sternberg EM (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6:318\u2013328","journal-title":"Nat Rev Immunol"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1189\/jlb.1105625","volume":"79","author":"NW Kin","year":"2006","unstructured":"Kin NW, Sanders VM (2006) It takes nerve to tell T and B cells what to do. J Leukoc Biol 79:1093\u20131104","journal-title":"J Leukoc Biol"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jneuroim.2005.10.017","volume":"172","author":"D Wrona","year":"2006","unstructured":"Wrona D (2006) Neural-immune interactions: an integrative view of the bidirectional relationship between the brain and immune systems. J Neuroimmunol 172:38\u201358","journal-title":"J Neuroimmunol"},{"key":"9_CR4","first-page":"1","volume":"18","author":"TC Theoharides","year":"1996","unstructured":"Theoharides TC (1996) The mast cell: a neuroimmunoendocrine master player. Int J Tissue React 18:1\u201321","journal-title":"Int J Tissue React"},{"key":"9_CR5","first-page":"G1017","volume":"261","author":"T Frieling","year":"1991","unstructured":"Frieling T, Cooke HJ, Wood JD (1991) Serotonin receptors on submucous neurons in guinea pig colon. Am J Physiol 261:G1017\u2013G1023","journal-title":"Am J Physiol"},{"key":"9_CR6","first-page":"G74","volume":"264","author":"T Frieling","year":"1993","unstructured":"Frieling T, Cooke HJ, Wood JD (1993) Histamine receptors on submucous neurons in guinea pig colon. Am J Physiol 264:G74\u2013G80","journal-title":"Am J Physiol"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"5297","DOI":"10.4049\/jimmunol.168.10.5297","volume":"168","author":"AH van Houwelingen","year":"2002","unstructured":"van Houwelingen AH, Kool M, de Jager SCA et al (2002) Mast cell-derived TNF-{alpha} primes sensory nerve endings in a pulmonary hypersensitivity reaction. J Immunol 168:5297\u20135302","journal-title":"J Immunol"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1073\/pnas.91.9.3739","volume":"91","author":"A Leon","year":"1994","unstructured":"Leon A, Buriani A, Dal Toso R et al (1994) Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci U S A 91:3739\u20133743","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2353\/ajpath.2006.060602","volume":"169","author":"M Kakurai","year":"2006","unstructured":"Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S, Galli SJ (2006) Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol 169:1713\u20131721","journal-title":"Am J Pathol"},{"key":"9_CR10","doi-asserted-by":"crossref","first-page":"9824","DOI":"10.1523\/JNEUROSCI.23-30-09824.2003","volume":"23","author":"HA Arnett","year":"2003","unstructured":"Arnett HA, Wang Y, Matsushima GK, Suzuki K, Ting JP (2003) Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23:9824\u20139832","journal-title":"J Neurosci"},{"key":"9_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0079-6123(08)62388-2","volume":"98","author":"MR Brann","year":"1993","unstructured":"Brann MR, Ellis J, Jorgensen H, Hill-Eubanks D, Jones SV (1993) Muscarinic acetylcholine receptor subtypes: localization and structure\/function. Prog Brain Res 98:121\u2013127","journal-title":"Prog Brain Res"},{"key":"9_CR12","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.bcp.2011.07.067","volume":"82","author":"J Wu","year":"2011","unstructured":"Wu J, Lukas RJ (2011) Naturally-expressed nicotinic acetylcholine receptor subtypes. Biochem Pharmacol 82:800\u2013807","journal-title":"Biochem Pharmacol"},{"key":"9_CR13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.bbrc.2008.10.004","volume":"377","author":"N Kageyama-Yahara","year":"2008","unstructured":"Kageyama-Yahara N, Suehiro Y, Yamamoto T, Kadowaki M (2008) IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem Biophys Res Commun 377:321\u2013325","journal-title":"Biochem Biophys Res Commun"},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000233780","volume":"77","author":"E Masini","year":"1985","unstructured":"Masini E, Fantozzi R, Conti A, Blandina P, Brunelleschi S, Mannaioni PF (1985) Mast cell heterogeneity in response to cholinergic stimulation. Int Arch Allergy Appl Immunol 77:184\u2013185","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.4049\/jimmunol.0902227","volume":"185","author":"NC Mishra","year":"2010","unstructured":"Mishra NC, Rir-sima-ah J, Boyd RT et al (2010) Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7\/alpha 9\/alpha 10-nicotinic receptors. J Immunol 185:588\u2013596","journal-title":"J Immunol"},{"key":"9_CR16","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1113\/jphysiol.2009.173054","volume":"587","author":"LA Weigand","year":"2009","unstructured":"Weigand LA, Myers AC, Meeker S, Undem BJ (2009) Mast cell-cholinergic nerve interaction in mouse airways. J Physiol 587:3355\u20133362","journal-title":"J Physiol"},{"key":"9_CR17","first-page":"208","volume":"280","author":"PJ Barnes","year":"1986","unstructured":"Barnes PJ (1986) Non-adrenergic non-cholinergic neural control of human airways. Arch Int Pharmacodyn Ther 280:208\u2013228","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1749-6632.1998.tb09569.x","volume":"840","author":"SF Maier","year":"1998","unstructured":"Maier SF, Goehler LE, Fleshner M, Watkins LR (1998) The role of the vagus nerve in cytokine-to-brain communication. Ann N Y Acad Sci 840:289\u2013300","journal-title":"Ann N Y Acad Sci"},{"key":"9_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0304-3940(94)11105-R","volume":"183","author":"LR Watkins","year":"1995","unstructured":"Watkins LR, Goehler LE, Relton JK et al (1995) Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 183:27\u201331","journal-title":"Neurosci Lett"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nature01321","volume":"420","author":"KJ Tracey","year":"2002","unstructured":"Tracey KJ (2002) The inflammatory reflex. Nature 420:853\u2013859","journal-title":"Nature"},{"key":"9_CR21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000097346","volume":"4","author":"RM Williams","year":"1997","unstructured":"Williams RM, Berthoud HR, Stead RH (1997) Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation 4:266\u2013270","journal-title":"Neuroimmunomodulation"},{"key":"9_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1046\/j.1365-2982.1997.d01-4.x","volume":"9","author":"T Gottwald","year":"1997","unstructured":"Gottwald T, Lhotak S, Stead RH (1997) Effect of truncal vagotomy and capsaicin on mast cells and IgA-positive plasma cells in rat jejunal mucosa. Neurogastroenterol Motil 9:25\u201332","journal-title":"Neurogastroenterol Motil"},{"key":"9_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/00001756-199512290-00075","volume":"7","author":"TP Gottwald","year":"1995","unstructured":"Gottwald TP, Hewlett BR, Lhotak S, Stead RH (1995) Electrical stimulation of the vagus nerve modulates the histamine content of mast cells in the rat jejunal mucosa. Neuroreport 7:313\u2013317","journal-title":"Neuroreport"},{"key":"9_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.autneu.2006.01.002","volume":"125","author":"RH Stead","year":"2006","unstructured":"Stead RH, Colley EC, Wang B et al (2006) Vagal influences over mast cells. Auton Neurosci 125:53\u201361","journal-title":"Auton Neurosci"},{"key":"9_CR25","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/35013070","volume":"405","author":"LV Borovikova","year":"2000","unstructured":"Borovikova LV, Ivanova S, Zhang M et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405:458\u2013462","journal-title":"Nature"},{"key":"9_CR26","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1053\/j.gastro.2006.08.016","volume":"131","author":"JE Ghia","year":"2006","unstructured":"Ghia JE, Blennerhassett P, Kumar-Ondiveeran H, Verdu EF, Collins SM (2006) The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 131:1122\u20131130","journal-title":"Gastroenterology"},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature01339","volume":"421","author":"H Wang","year":"2003","unstructured":"Wang H, Yu M, Ochani M et al (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384\u2013388","journal-title":"Nature"},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1053\/j.gastro.2006.02.022","volume":"130","author":"DJ van Westerloo","year":"2006","unstructured":"van Westerloo DJ, Giebelen IA, Florquin S et al (2006) The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 130:1822\u20131830","journal-title":"Gastroenterology"},{"key":"9_CR29","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1097\/01.CCM.0000259381.56526.96","volume":"35","author":"VA Pavlov","year":"2007","unstructured":"Pavlov VA, Ochani M, Yang LH et al (2007) Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med 35:1139\u20131144","journal-title":"Crit Care Med"},{"key":"9_CR30","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bbi.2009.10.016","volume":"24","author":"K Karimi","year":"2010","unstructured":"Karimi K, Bienenstock J, Wang L, Forsythe P (2010) The vagus nerve modulates CD4+ T cell activity. Brain Behav Immun 24:316\u2013323","journal-title":"Brain Behav Immun"},{"key":"9_CR31","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1084\/jem.20042397","volume":"202","author":"MD Luyer","year":"2005","unstructured":"Luyer MD, Greve JW, Hadfoune M, Jacobs JA, Dejong CH, Buurman WA (2005) Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med 202:1023\u20131029","journal-title":"J Exp Med"},{"key":"9_CR32","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1084\/jem.20051760","volume":"202","author":"KJ Tracey","year":"2005","unstructured":"Tracey KJ (2005) Fat meets the cholinergic antiinflammatory pathway. J Exp Med 202:1017\u20131021","journal-title":"J Exp Med"},{"key":"9_CR33","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1365-2133.2008.08774.x","volume":"159","author":"F Kindt","year":"2008","unstructured":"Kindt F, Wiegand S, Niemeier V et al (2008) Reduced expression of nicotinic alpha subunits 3, 7, 9 and 10 in lesional and nonlesional atopic dermatitis skin but enhanced expression of alpha subunits 3 and 5 in mast cells. Br J Dermatol 159:847\u2013857","journal-title":"Br J Dermatol"},{"key":"9_CR34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1113\/jphysiol.1980.sp013205","volume":"301","author":"P Blandina","year":"1980","unstructured":"Blandina P, Fantozzi R, Mannaioni PF, Masini E (1980) Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells. J Physiol 301:281\u2013293","journal-title":"J Physiol"},{"key":"9_CR35","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/273473a0","volume":"273","author":"R Fantozzi","year":"1978","unstructured":"Fantozzi R, Masini E, Blandina P, Mannaioni PF, Bani-Sacchi T (1978) Release of histamine from rat mast cells by acetylcholine. Nature 273:473\u2013474","journal-title":"Nature"},{"key":"9_CR36","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1476-5381.1984.tb16136.x","volume":"81","author":"KB Leung","year":"1984","unstructured":"Leung KB, Pearce FL (1984) A comparison of histamine secretion from peritoneal mast cells of the rat and hamster. Br J Pharmacol 81:693\u2013701","journal-title":"Br J Pharmacol"},{"key":"9_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02024170","volume":"10","author":"W Kazimierczak","year":"1980","unstructured":"Kazimierczak W, Adamas B, Maslinski C (1980) Failure of acetylcholine to release histamine from rat mast cells. Agents Actions 10:1\u20133","journal-title":"Agents Actions"},{"key":"9_CR38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1113\/jphysiol.1986.sp015960","volume":"371","author":"T Bani-Sacchi","year":"1986","unstructured":"Bani-Sacchi T, Barattini M, Bianchi S et al (1986) The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum. J Physiol 371:29\u201343","journal-title":"J Physiol"},{"key":"9_CR39","doi-asserted-by":"crossref","first-page":"8105","DOI":"10.1523\/JNEUROSCI.16-24-08105.1996","volume":"16","author":"FS Vilim","year":"1996","unstructured":"Vilim FS, Cropper EC, Price DA, Kupfermann I, Weiss KR (1996) Release of peptide cotransmitters in Aplysia: regulation and functional implications. J Neurosci 16:8105\u20138114","journal-title":"J Neurosci"},{"key":"9_CR40","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/sj.bjp.0702786","volume":"128","author":"JD Moffatt","year":"1999","unstructured":"Moffatt JD, Dumsday B, McLean JR (1999) Characterization of non-adrenergic, non-cholinergic inhibitory responses of the isolated guinea-pig trachea: differences between pre- and post-ganglionic nerve stimulation. Br J Pharmacol 128:458\u2013464","journal-title":"Br J Pharmacol"},{"key":"9_CR41","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2174\/156802606775270288","volume":"6","author":"C Abad","year":"2006","unstructured":"Abad C, Gomariz RP, Waschek JA (2006) Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP. Curr Top Med Chem 6:151\u2013163","journal-title":"Curr Top Med Chem"},{"key":"9_CR42","first-page":"619","volume":"21","author":"NM Sherwood","year":"2000","unstructured":"Sherwood NM, Krueckl SL, McRory JE (2000) The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)\/glucagon superfamily. Endocr Rev 21:619\u2013670","journal-title":"Endocr Rev"},{"key":"9_CR43","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.1016\/S0021-9258(19)76511-9","volume":"263","author":"EJ Goetzl","year":"1988","unstructured":"Goetzl EJ, Sreedharan SP, Turck CW (1988) Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. J Biol Chem 263:9083\u20139086","journal-title":"J Biol Chem"},{"key":"9_CR44","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1006\/cimm.1993.1246","volume":"151","author":"BK Wershil","year":"1993","unstructured":"Wershil BK, Turck CW, Sreedharan SP et al (1993) Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells. Cell Immunol 151:369\u2013378","journal-title":"Cell Immunol"},{"key":"9_CR45","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1749-6632.1998.tb09593.x","volume":"840","author":"EJ Goetzl","year":"1998","unstructured":"Goetzl EJ, Pankhaniya RR, Gaufo GO, Mu Y, Xia M, Sreedharan SP (1998) Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses. Ann N Y Acad Sci 840:540\u2013550","journal-title":"Ann N Y Acad Sci"},{"key":"9_CR46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0167-0115(95)00124-7","volume":"60","author":"JA Waschek","year":"1995","unstructured":"Waschek JA, Bravo DT, Richards ML (1995) High levels of vasoactive intestinal peptide\/pituitary adenylate cyclase-activating peptide receptor mRNA expression in primary and tumor lymphoid cells. Regul Pept 60:149\u2013157","journal-title":"Regul Pept"},{"key":"9_CR47","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1365-2567.2007.02705.x","volume":"123","author":"M Kulka","year":"2008","unstructured":"Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP (2008) Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 123:398\u2013410","journal-title":"Immunology"},{"key":"9_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1476-5381.1988.tb16555.x","volume":"95","author":"MA Lowman","year":"1988","unstructured":"Lowman MA, Benyon RC, Church MK (1988) Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells. Br J Pharmacol 95:121\u2013130","journal-title":"Br J Pharmacol"},{"key":"9_CR49","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0014-2999(83)90012-2","volume":"88","author":"BJ Undem","year":"1983","unstructured":"Undem BJ, Dick EC, Buckner CK (1983) Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung. Eur J Pharmacol 88:247\u2013250","journal-title":"Eur J Pharmacol"},{"key":"9_CR50","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0196-9781(99)00177-1","volume":"21","author":"N Tuncel","year":"2000","unstructured":"Tuncel N, Tore F, Sahinturk V, Ak D, Tuncel M (2000) Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: a potential therapeutic strategy in controlling septic shock. Peptides 21:81\u201389","journal-title":"Peptides"},{"key":"9_CR51","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1172\/JCI46139","volume":"121","author":"M Akahoshi","year":"2011","unstructured":"Akahoshi M, Song CH, Piliponsky AM et al (2011) Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121:4180\u20134191","journal-title":"J Clin Invest"},{"key":"9_CR52","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3565(25)24227-6","volume":"244","author":"GH Caughey","year":"1988","unstructured":"Caughey GH, Leidig F, Viro NF, Nadel JA (1988) Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J Pharmacol Exp Ther 244:133\u2013137","journal-title":"J Pharmacol Exp Ther"},{"key":"9_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1165\/ajrcmb\/3.1.27","volume":"3","author":"EK Tam","year":"1990","unstructured":"Tam EK, Caughey GH (1990) Degradation of airway neuropeptides by human lung tryptase. Am J Respir Cell Mol Biol 3:27\u201332","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9_CR54","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.peptides.2004.12.019","volume":"26","author":"N Tuncel","year":"2005","unstructured":"Tuncel N, Sener E, Cerit C et al (2005) Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson\u2019s disease model in rats: brain microdialysis, behavior, and microscopy. Peptides 26:827\u2013836","journal-title":"Peptides"},{"key":"9_CR55","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.4049\/jimmunol.176.3.1860","volume":"176","author":"A El-Shazly","year":"2006","unstructured":"El-Shazly A, Berger P, Girodet PO et al (2006) Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol 176:1860\u20131868","journal-title":"J Immunol"},{"key":"9_CR56","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jaci.2003.09.041","volume":"112","author":"AC Rimaniol","year":"2003","unstructured":"Rimaniol AC, Till SJ, Garcia G et al (2003) The CX3C chemokine fractalkine in allergic asthma and rhinitis. J Allergy Clin Immunol 112:1139\u20131146","journal-title":"J Allergy Clin Immunol"},{"key":"9_CR57","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1006\/pupt.2001.0306","volume":"14","author":"DA Groneberg","year":"2001","unstructured":"Groneberg DA, Springer J, Fischer A (2001) Vasoactive intestinal polypeptide as mediator of asthma. Pulm Pharmacol Ther 14:391\u2013401","journal-title":"Pulm Pharmacol Ther"},{"key":"9_CR58","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/S1567-5769(01)00096-0","volume":"1","author":"P Forsythe","year":"2001","unstructured":"Forsythe P, Gilchrist M, Kulka M, Befus AD (2001) Mast cells and nitric oxide: control of production, mechanisms of response. Int Immunopharmacol 1:1525\u20131541","journal-title":"Int Immunopharmacol"},{"key":"9_CR59","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000023892","volume":"115","author":"M Iikura","year":"1998","unstructured":"Iikura M, Takaishi T, Hirai K et al (1998) Exogenous nitric oxide regulates the degranulation of human basophils and rat peritoneal mast cells. Int Arch Allergy Immunol 115:129\u2013136","journal-title":"Int Arch Allergy Immunol"},{"key":"9_CR60","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0014-2999(01)01205-5","volume":"425","author":"KH Peh","year":"2001","unstructured":"Peh KH, Moulson A, Wan BY, Assem EK, Pearce FL (2001) Role of nitric oxide in histamine release from human basophils and rat peritoneal mast cells. Eur J Pharmacol 425:229\u2013238","journal-title":"Eur J Pharmacol"},{"key":"9_CR61","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4049\/jimmunol.159.3.1444","volume":"159","author":"NC Eastmond","year":"1997","unstructured":"Eastmond NC, Banks EM, Coleman JW (1997) Nitric oxide inhibits IgE-mediated degranulation of mast cells and is the principal intermediate in IFN-gamma-induced suppression of exocytosis. J Immunol 159:1444\u20131450","journal-title":"J Immunol"},{"key":"9_CR62","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1006\/bbrc.1995.1689","volume":"210","author":"M Bidri","year":"1995","unstructured":"Bidri M, Becherel PA, Le Goff L et al (1995) Involvement of cyclic nucleotides in the immunomodulatory effects of nitric oxide on murine mast cells. Biochem Biophys Res Commun 210:507\u2013517","journal-title":"Biochem Biophys Res Commun"},{"key":"9_CR63","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.4049\/jimmunol.173.11.6914","volume":"173","author":"BJ Davis","year":"2004","unstructured":"Davis BJ, Flanagan BF, Gilfillan AM, Metcalfe DD, Coleman JW (2004) Nitric oxide inhibits IgE-dependent cytokine production and Fos and Jun activation in mast cells. J Immunol 173:6914\u20136920","journal-title":"J Immunol"},{"key":"9_CR64","doi-asserted-by":"publisher","first-page":"287","DOI":"10.4049\/jimmunol.170.1.287","volume":"170","author":"P Forsythe","year":"2003","unstructured":"Forsythe P, Befus AD (2003) Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion. J Immunol 170:287\u2013293","journal-title":"J Immunol"},{"key":"9_CR65","doi-asserted-by":"crossref","first-page":"G222","DOI":"10.1152\/ajpcell.1994.266.1.C222","volume":"266","author":"S Kanwar","year":"1994","unstructured":"Kanwar S, Wallace JL, Befus D, Kubes P (1994) Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. Am J Physiol 266:G222\u2013G229","journal-title":"Am J Physiol"},{"key":"9_CR66","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1053\/gast.1996.v111.pm8690206","volume":"111","author":"B Qiu","year":"1996","unstructured":"Qiu B, Pothoulakis C, Castagliuolo I, Nikulasson Z, LaMont JT (1996) Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin. Gastroenterology 111:409\u2013418","journal-title":"Gastroenterology"},{"key":"9_CR67","doi-asserted-by":"publisher","first-page":"G1308","DOI":"10.1152\/ajpgi.00156.2010","volume":"299","author":"TW Costantini","year":"2010","unstructured":"Costantini TW, Bansal V, Krzyzaniak M et al (2010) Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells. Am J Physiol Gastrointest Liver Physiol 299:G1308\u2013G1318","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9_CR68","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1097\/TA.0b013e318216f754","volume":"70","author":"M Krzyzaniak","year":"2011","unstructured":"Krzyzaniak M, Peterson C, Loomis W et al (2011) Postinjury vagal nerve stimulation protects against intestinal epithelial barrier breakdown. J Trauma 70:1168\u20131175, discussion 1175\u20136","journal-title":"J Trauma"},{"key":"9_CR69","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1046\/j.1440-1843.2003.00473.x","volume":"8","author":"MJ Carr","year":"2003","unstructured":"Carr MJ, Undem BJ (2003) Bronchopulmonary afferent nerves. Respirology 8:291\u2013301","journal-title":"Respirology"},{"key":"9_CR70","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0163-7258(87)90055-6","volume":"32","author":"RG Andersson","year":"1987","unstructured":"Andersson RG, Grundstrom N (1987) Innervation of airway smooth muscle. Efferent mechanisms. Pharmacol Ther 32:107\u2013130","journal-title":"Pharmacol Ther"},{"key":"9_CR71","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1440-1843.1997.tb00088.x","volume":"2","author":"ML Kowalski","year":"1997","unstructured":"Kowalski ML, Didier A, Lundgren JD, Igarashi Y, Kaliner MA (1997) Role of sensory innervation and mast cells in neurogenic plasma protein exudation into the airway lumen. Respirology 2:267\u2013274","journal-title":"Respirology"},{"key":"9_CR72","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1159\/000236976","volume":"107","author":"BJ Undem","year":"1995","unstructured":"Undem BJ, Riccio MM, Weinreich D, Ellis JL, Myers AC (1995) Neurophysiology of mast cell-nerve interactions in the airways. Int Arch Allergy Immunol 107:199\u2013201","journal-title":"Int Arch Allergy Immunol"},{"key":"9_CR73","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jaci.2005.03.040","volume":"116","author":"H Akiyama","year":"2005","unstructured":"Akiyama H, Amano H, Bienenstock J (2005) Rat tracheal epithelial responses to water avoidance stress. J Allergy Clin Immunol 116:318\u2013324","journal-title":"J Allergy Clin Immunol"},{"key":"9_CR74","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1164\/ajrccm\/141.2.393","volume":"141","author":"P Sestini","year":"1990","unstructured":"Sestini P, Bienenstock J, Crowe SE et al (1990) Ion transport in rat tracheal epithelium in vitro. Role of capsaicin-sensitive nerves in allergic reactions. Am Rev Respir Dis 141:393\u2013397","journal-title":"Am Rev Respir Dis"},{"key":"9_CR75","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1365-2222.2000.00770.x","volume":"30","author":"P Forsythe","year":"2000","unstructured":"Forsythe P, McGarvey LP, Heaney LG, MacMahon J, Ennis M (2000) Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics. Clin Exp Allergy 30:225\u2013232","journal-title":"Clin Exp Allergy"},{"key":"9_CR76","doi-asserted-by":"publisher","first-page":"7430","DOI":"10.4049\/jimmunol.0900039","volume":"182","author":"JM Cyphert","year":"2009","unstructured":"Cyphert JM, Kovarova M, Allen IC et al (2009) Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol 182:7430\u20137439","journal-title":"J Immunol"},{"key":"9_CR77","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1152\/jappl.1991.71.3.970","volume":"71","author":"AC Myers","year":"1991","unstructured":"Myers AC, Undem BJ, Weinreich D (1991) Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. J Appl Physiol 71:970\u2013976","journal-title":"J Appl Physiol"},{"key":"9_CR78","doi-asserted-by":"crossref","first-page":"L581","DOI":"10.1152\/ajplung.00332.2002","volume":"284","author":"R Kajekar","year":"2003","unstructured":"Kajekar R, Undem BJ, Myers AC (2003) Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. Am J Physiol Lung Cell Mol Physiol 284:L581\u2013L587","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9_CR79","first-page":"L13","volume":"265","author":"RW Mitchell","year":"1993","unstructured":"Mitchell RW, Ndukuw IM, Ikeda K, Arbetter K, Leff AR (1993) Effect of immune sensitization on stimulated ACh release from trachealis muscle in vitro. Am J Physiol 265:L13\u2013L18","journal-title":"Am J Physiol"},{"key":"9_CR80","first-page":"L263","volume":"266","author":"GL Larsen","year":"1994","unstructured":"Larsen GL, Fame TM, Renz H et al (1994) Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice. Am J Physiol 266:L263\u2013L270","journal-title":"Am J Physiol"},{"key":"9_CR81","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","volume":"127","author":"R Razavi","year":"2006","unstructured":"Razavi R, Chan Y, Afifiyan FN et al (2006) TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell 127:1123\u20131135","journal-title":"Cell"},{"key":"9_CR82","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s000110050574","volume":"49","author":"P Forsythe","year":"2000","unstructured":"Forsythe P, Ennis M (2000) Clinical consequences of mast cell heterogeneity. Inflamm Res 49:147\u2013154","journal-title":"Inflamm Res"},{"key":"9_CR83","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/mi.2009.136","volume":"3","author":"TC Moon","year":"2010","unstructured":"Moon TC, St Laurent CD, Morris KE et al (2010) Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol 3:111\u2013128","journal-title":"Mucosal Immunol"},{"key":"9_CR84","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4049\/jimmunol.135.2.1331","volume":"135","author":"F Shanahan","year":"1985","unstructured":"Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D (1985) Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J Immunol 135:1331\u20131337","journal-title":"J Immunol"},{"key":"9_CR85","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1159\/000234198","volume":"82","author":"Y Kitamura","year":"1987","unstructured":"Kitamura Y, Kanakura Y, Sonoda S, Asai H, Nakano T (1987) Mutual phenotypic changes between connective tissue type and mucosal mast cells. Int Arch Allergy Appl Immunol 82:244\u2013248","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"9_CR86","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1073\/pnas.1000803107","volume":"107","author":"TC Theoharides","year":"2010","unstructured":"Theoharides TC, Zhang B, Kempuraj D et al (2010) IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A 107:4448\u20134453","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Methods in Molecular Biology","Mast Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1568-2_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:09:31Z","timestamp":1747159771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1568-2_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"ISBN":["9781493915675","9781493915682"],"references-count":86,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1568-2_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]},"assertion":[{"value":"12 September 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}