{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:57:57Z","timestamp":1768010277012,"version":"3.49.0"},"publisher-location":"New York, NY","reference-count":52,"publisher":"Springer New York","isbn-type":[{"value":"9781493917754","type":"print"},{"value":"9781493917761","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-1776-1_3","type":"book-chapter","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T04:27:24Z","timestamp":1413347244000},"page":"17-33","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Aspects of Sepsis: An Overview"],"prefix":"10.1007","author":[{"given":"Giacomo","family":"Monti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana","family":"Taddeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Isella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","volume":"31","author":"MM Levy","year":"2003","unstructured":"Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D et al (2003) 2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference. Crit Care Med 31:1250\u20131256","journal-title":"Crit Care Med"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","volume":"41","author":"RP Dellinger","year":"2013","unstructured":"Dellinger RP, Mitchell ML, Andrew R, Djillali A, HerwigGerlach SM, Opal JE et al (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock. Crit Care Med 41:580\u2013637","journal-title":"Crit Care Med"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00134-012-2549-5","volume":"38","author":"K Klein","year":"2012","unstructured":"Klein K, Peter MC, David SYO, Marc JMB, Olaf LC (2012) Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria. Intensive Care Med 38:811\u2013819","journal-title":"Intensive Care Med"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1378\/chest.11-0352","volume":"140","author":"G Kumar","year":"2011","unstructured":"Kumar G, Nilay K, Amit T, Thomas K, Sergey T, Emily M et al (2011) Nationwide trends of severe sepsis in the 21st century (2000\u20132007). Chest 140:1223\u20131231","journal-title":"Chest"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"R81","DOI":"10.1186\/cc12695","volume":"17","author":"JE Zimmerman","year":"2013","unstructured":"Zimmerman JE, Andrew AK, William AK (2013) Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care 17:R81","journal-title":"Crit Care"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1001\/jama.2013.2194","volume":"309","author":"S Opal","year":"2013","unstructured":"Opal S, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP et al (2013) Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 309:1154\u20131162","journal-title":"JAMA"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1097\/CCM.0b013e3182741551","volume":"41","author":"K Guntupalli","year":"2013","unstructured":"Guntupalli K, Nathan D, Peter EM, Venkata B, Benjamin M, Emanuel R et al (2013) A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. Crit Care Med 41:706\u2013716","journal-title":"Crit Care Med"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"e82775","DOI":"10.1371\/journal.pone.0082775","volume":"12","author":"L Pasin","year":"2013","unstructured":"Pasin L, Landoni G, Castro ML, Cabrini L, Belletti A, Feltracco P et al (2013) The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials. PLoS One 12:e82775","journal-title":"PLoS One"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","volume":"366","author":"VM Ranieri","year":"2012","unstructured":"Ranieri VM, Taylor T, Philip SB, Jean-Fran\u00e7ois D, Ivor SD, Simon F et al (2012) Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366:2055\u20132064","journal-title":"N Engl J Med"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1164\/rccm.201211-2020OC","volume":"187","author":"D Annane","year":"2013","unstructured":"Annane D, Timsit JF, Megarbane B, Martin C, Misset B, Mourvillier B et al (2013) Recombinant human activated protein C for adults with septic shock: a randomized controlled trial. Am J Respir Crit Care Med 187:1091\u20131097","journal-title":"Am J Respir Crit Care Med"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.medin.2013.04.005","volume":"38","author":"M Crivellari","year":"2013","unstructured":"Crivellari M, Silvetti S, Gerli C, Landoni G, Franco A, Bove T et al (2013) Protein C zymogen in adults with severe sepsis or septic shock. Med Intensiva 38:278\u2013282. doi:\n                  10.1016\/j.medin.2013.04.005","journal-title":"Med Intensiva"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s00134-009-1584-3","volume":"35","author":"M Crivellari","year":"2009","unstructured":"Crivellari M, Della Valle P, Landoni G, Pappalardo F, Gerli C, Bignami E et al (2009) Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery. Intensive Care Med 35:1959\u20131963","journal-title":"Intensive Care Med"},{"key":"3_CR13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/003335490712200205","volume":"122","author":"RM Klevens","year":"2007","unstructured":"Klevens RM, Edwards JR, Richards LR Jr, Horan TC, Gaynes RP, Pollock DA et al (2007) Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 122:160\u2013166","journal-title":"Public Health Rep"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.mib.2009.08.001","volume":"12","author":"LB Rice","year":"2009","unstructured":"Rice LB (2009) The clinical consequences of antimicrobial resistance. Curr Opin Microbiol 12:476\u2013481","journal-title":"Curr Opin Microbiol"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1001\/jama.2012.5833","volume":"307","author":"FM Brunkhorst","year":"2012","unstructured":"Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C et al (2012) Effect of empirical treatment with moxifloxacin and meropenem vs. meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA 307:2390\u20132399","journal-title":"JAMA"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1164\/rccm.201110-1820OC","volume":"185","author":"F Schortgen","year":"2012","unstructured":"Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N et al (2012) Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med 185:1088\u20131095","journal-title":"Am J Respir Crit Care Med"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1001\/jama.2013.278477","volume":"310","author":"A Morelli","year":"2013","unstructured":"Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S et al (2013) Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 310:1683\u20131691","journal-title":"JAMA"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1001\/jama.2009.1754","volume":"302","author":"J Vincent","year":"2009","unstructured":"Vincent J, Rello J, Marshall J (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323\u20132329","journal-title":"JAMA"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000086574","volume":"51","author":"R Ramphal","year":"2005","unstructured":"Ramphal R (2005) Importance of adequate initial antimicrobial therapy. Chemotherapy 51:171\u2013176","journal-title":"Chemotherapy"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1097\/01.CCM.0000129973.13104.2D","volume":"32","author":"J Cohen","year":"2004","unstructured":"Cohen J, Cristofaro P, Carlet J, Opal S (2004) New method of classifying infections in critically Ill patients. Crit Care Med 32:1510\u20131526","journal-title":"Crit Care Med"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1001\/jama.1995.03520260039030","volume":"273","author":"MS Rangel-Frausto","year":"1995","unstructured":"Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP (1995) The Natural History of the Systemic Inflammatory Response Syndrome (SIRS). A prospective study. JAMA 273:117\u2013123","journal-title":"JAMA"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/01.CCM.0000150027.98160.80","volume":"33","author":"V Sundararajan","year":"2005","unstructured":"Sundararajan V, Macisaac C, Presneill JJ, Cade JF, Visvanathan K (2005) Epidemiology of sepsis in Victoria, Australia. Crit Care Med 33:71\u201380","journal-title":"Crit Care Med"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1001\/jama.1996.03530300054040","volume":"275","author":"LA Eidelman","year":"1966","unstructured":"Eidelman LA, Putterman D, Putterman C, Sprung CL (1966) The spectrum of septic encephalopathy. definitions, etiologies, and mortalities. JAMA 275:470\u2013473","journal-title":"JAMA"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1097\/00003246-199812000-00045","volume":"26","author":"G Friedman","year":"1998","unstructured":"Friedman G, Silva E, Vincent JL (1998) Has the mortality of septic shock changed with time. Crit Care Med 26:2078\u20132086","journal-title":"Crit Care Med"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1208623","volume":"369","author":"DC Angus","year":"2013","unstructured":"Angus DC, van der Poll T (2013) Severe sepsis and septic shock. NEJM 369:840\u2013851","journal-title":"NEJM"},{"key":"3_CR26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00134-002-1624-8","volume":"29","author":"DC Angus","year":"2003","unstructured":"Angus DC, Carlet J, 2002 Brussels Roundtable Participants (2003) Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med 29:368\u2013377","journal-title":"Intensive Care Med"},{"key":"3_CR27","unstructured":"American Thoracic Society (2001) Guidelines for the management of adults with community-acquired pneumonia. \n                  http:\/\/www.thoracic.org\/statements\/resources\/archive\/commacq1-25.pdf\n                  \n                . Accessed 19 Feb 2014"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000357449","volume":"87","author":"A Reissig","year":"2014","unstructured":"Reissig A, Copetti R (2014) Lung ultrasound in community-acquired pneumonia and in interstitial lung diseases. Respiration 87:179\u2013189. doi:\n                  10.1159\/000357449","journal-title":"Respiration"},{"key":"3_CR29","first-page":"114","volume":"6","author":"CM Reynaldos","year":"2014","unstructured":"Reynaldos CM, Gy\u00f6rik T, Lora S, Gaia V, Pagnamenta A (2014) ARDS with septic shock due to Legionella longbeachae pneumonia in a patient with polymyalgia rheumatic. Heart Lung Vessel 6:114\u2013118","journal-title":"Heart Lung Vessel"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","volume":"171","author":"American Thoracic Society, Infectious Diseases Society of America","year":"2005","unstructured":"American Thoracic Society, Infectious Diseases Society of America (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388\u2013416","journal-title":"Am J Respir Crit Care Med"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1097\/CCM.0b013e3182a262db","volume":"41","author":"SS Magill","year":"2013","unstructured":"Magill SS, Klompas M, Balk R, Burns SM, Deutschman CS, Diekema D et al (2013) Developing a new, national approach to surveillance for ventilator-associated events. Crit Care Med 41:2467\u20132475","journal-title":"Crit Care Med"},{"key":"3_CR32","first-page":"103","volume":"3","author":"M Cruciani","year":"2011","unstructured":"Cruciani M (2011) Meta-analyses of diagnostic tests in infectious diseases: how helpful are they in the intensive care setting? HSR Proc Intensive Care Cardiovasc Anesth 3:103\u2013108","journal-title":"HSR Proc Intensive Care Cardiovasc Anesth"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/MCC.0b013e3283577d37","volume":"18","author":"M Lung","year":"2012","unstructured":"Lung M, Codina G (2012) Molecular diagnosis in HAP\/VAP. Curr Opin Crit Care 18:487\u2013494","journal-title":"Curr Opin Crit Care"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"S539","DOI":"10.1097\/CCM.0b013e3181f1fcf7","volume":"38","author":"L Gattinoni","year":"2010","unstructured":"Gattinoni L, Protti A, Caironi P, Carlesso E (2010) Ventilator-induced lung injury: the anatomical and physiological framework. Crit Care Med 38:S539\u2013S548","journal-title":"Crit Care Med"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"2s","DOI":"10.1183\/09031936.03.00420103","volume":"42","author":"JD Ricard","year":"2003","unstructured":"Ricard JD, Dreyfuss D, Saumon G (2003) Ventilator-induced lung injury. Eur Respir J 42:2s\u20139s","journal-title":"Eur Respir J"},{"key":"3_CR36","doi-asserted-by":"publisher","first-page":"R30","DOI":"10.1186\/cc12512","volume":"17","author":"A Zangrillo","year":"2013","unstructured":"Zangrillo A, Biondi-Zoccai G, Landoni G, Frati G, Patroniti N, Pesenti A et al (2013) Extracorporeal membrane oxygenation (ECMO) in patients with H1N1 influenza infection: a systematicreview and meta-analysis including 8 studies and 266 patients receiving ECMO. Crit Care 17:R30","journal-title":"Crit Care"},{"key":"3_CR37","first-page":"172","volume":"15","author":"A Zangrillo","year":"2013","unstructured":"Zangrillo A, Landoni G, Biondi-Zoccai G, Greco M, Greco T, Frati G et al (2013) A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc 15:172\u2013178","journal-title":"Crit Care Resusc"},{"key":"3_CR38","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/MCP.0b013e32835f27be","volume":"19","author":"F Barbier","year":"2013","unstructured":"Barbier F, Andremont F, Wolff M, Bouadma L (2013) Hospital-acquired pneumonia and ventilator-associated pneumonia: recent advances in epidemiology and management. Curr Opin Pulm Med 19:216\u2013228","journal-title":"Curr Opin Pulm Med"},{"key":"3_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1179\/joc.2009.21.Supplement-1.3","volume":"21","author":"F Menichetti","year":"2009","unstructured":"Menichetti F, Sganga G (2009) Definition and classification of intra-abdominal infections. J Chemother 21:3\u20134","journal-title":"J Chemother"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1749-7922-8-3","volume":"8","author":"M Sartelli","year":"2013","unstructured":"Sartelli M, Viale P, Catena F, Ansaloni L, Moore E, Malangoni M et al (2013) 2013 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg 8:3","journal-title":"World J Emerg Surg"},{"key":"3_CR41","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1097\/01.CCM.0000087326.59341.51","volume":"31","author":"JC Marshall","year":"2008","unstructured":"Marshall JC, Innes M (2008) Intensive care unit management of intra-abdominal infection. Crit Care Med 31:2228\u20132237","journal-title":"Crit Care Med"},{"key":"3_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1046\/j.1463-1318.2001.00210.x","volume":"3","author":"BJ Moran","year":"2001","unstructured":"Moran BJ, Heald RJ (2001) Risk factors for, and management of anastomotic leakage in rectal surgery. Colorectal Dis 3:135\u2013137","journal-title":"Colorectal Dis"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s15010-009-8249-6","volume":"37","author":"J Ruiter De","year":"2009","unstructured":"De Ruiter J, Weel J, Manusama E, Kingma WP, van der Voort PHJ (2009) The epidemiology of intra-abdominal flora in critically ill patients with secondary and tertiary abdominal sepsis. Infection 37:522\u2013527","journal-title":"Infection"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.resuscitation.2009.03.008","volume":"80","author":"SL Peake","year":"2009","unstructured":"Peake SL, Bailey M, Bellomo R, Cameron PA, Cross A, Delaney A et al (2009) Australasian resuscitation of sepsis evaluation (ARISE): a multi-centre, prospective, inception cohort study. Resuscitation 80:811\u2013818","journal-title":"Resuscitation"},{"key":"3_CR45","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jinf.2005.12.005","volume":"53","author":"Y Chen","year":"2006","unstructured":"Chen Y, Nitzan O, Saliba W, Chazan B, Colodner R, Raz R (2006) Are blood cultures necessary in the management of women with complicated pyelonephritis? J Infect 53:235\u2013240","journal-title":"J Infect"},{"key":"3_CR46","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1097\/01.CCM.0000168253.91200.83","volume":"33","author":"T Calandra","year":"2005","unstructured":"Calandra T, Cohen J, International Sepsis Forum Definition of Infection in the ICU Consensus Conference (2005) The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 33:1538\u20131548","journal-title":"Crit Care Med"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/S0022-5347(05)67150-9","volume":"164","author":"R Raz","year":"2000","unstructured":"Raz R, Schiller D, Nicolle LE (2000) Chronic indwelling catheter replacement before antimicrobial therapy for symptomatic urinary tract infection. J Urol 164:1254\u20131258","journal-title":"J Urol"},{"key":"3_CR48","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ccc.2013.03.014","volume":"29","author":"LE Nicolle","year":"2013","unstructured":"Nicolle LE (2013) Urinary tract infection. Crit Care Clin 29:699\u2013715","journal-title":"Crit Care Clin"},{"key":"3_CR49","unstructured":"Grabe M, Bjerklund-Johansen TE, Botto H (2011) Guidelines on urological infections. Eur Assoc of Urology. Available at: \n                  http:\/\/www.uroweb.org\/gls\/pdf\/18_Urological%20infections_LR.pdf\n                  \n                . Accessed 13 Feb 2014"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s00134-010-1851-3","volume":"36","author":"CC Sheu","year":"2010","unstructured":"Sheu CC, Gong MN, Zhai R, Bajwa EK, Chen F, Thompson TB et al (2010) The influence of infection sites on development and mortality of ARDS. Intensive Care Med 36:963\u2013970","journal-title":"Intensive Care Med"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4161\/viru.27409","volume":"5","author":"CA Schorr","year":"2014","unstructured":"Schorr CA, Zanotti S, Dellinger RP (2014) Severe sepsis and septic shock: management and performance improvement. Virulence 5:190\u2013199","journal-title":"Virulence"},{"key":"3_CR53","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.ccm.2008.06.011","volume":"29","author":"SR Townsend","year":"2008","unstructured":"Townsend SR, Schorr C, Levy MM, Dellinger RP (2008) Reducing mortality in severe sepsis: the surviving sepsis campaign. Clin Chest Med 29:721\u2013733","journal-title":"Clin Chest Med"}],"container-title":["Methods in Molecular Biology","Sepsis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1776-1_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T11:11:48Z","timestamp":1585048308000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-1776-1_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,24]]},"ISBN":["9781493917754","9781493917761"],"references-count":52,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1776-1_3","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,24]]},"assertion":[{"value":"24 September 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}