{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T14:48:09Z","timestamp":1742914089718,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":19,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493918744"},{"type":"electronic","value":"9781493918751"}],"license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-1875-1_5","type":"book-chapter","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T05:20:24Z","timestamp":1413177624000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Measuring PGC-1\u03b1 and Its Acetylation Status in Mouse Primary Myotubes"],"prefix":"10.1007","author":[{"given":"Ana P.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"issue":"2","key":"5_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1079\/PNS2004349","volume":"63","author":"L Storlien","year":"2004","unstructured":"Storlien L, Oakes DE, Kelley DE (2004) Metabolic flexibility. Proc Nutr Soc 63(2):363\u2013368. doi:10.1079\/PNS2004349","journal-title":"Proc Nutr Soc"},{"issue":"5","key":"5_CR2","doi-asserted-by":"publisher","first-page":"E1009","DOI":"10.1152\/ajpendo.90558.2008","volume":"295","author":"JE Galgani","year":"2008","unstructured":"Galgani JE, Moro C, Ravussin E (2008) Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab 295(5):E1009\u2013E1017. doi:10.1152\/ajpendo.90558.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"5_CR3","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1210\/en.2007-1444","volume":"149","author":"AE Civitarese","year":"2008","unstructured":"Civitarese AE, Ravussin E (2008) Mitochondrial energetics and insulin resistance. Endocrinology 149(3):950\u2013954. doi:10.1210\/en.2007-1444","journal-title":"Endocrinology"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1475-2840-8-39","volume":"8","author":"CE van den Brom","year":"2009","unstructured":"van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CF, Lammertsma AA, van der Velden J, Boer C, Ouwens DM, Diamant M (2009) Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovasc Diabetol 8:39. doi:10.1186\/1475-2840-8-39","journal-title":"Cardiovasc Diabetol"},{"issue":"1\u20132","key":"5_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-4781(02)00343-3","volume":"1576","author":"RC Scarpulla","year":"2002","unstructured":"Scarpulla RC (2002) Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta 1576(1\u20132):1\u201314. doi:10.1152\/physrev.00025.2007","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"5_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0378-1119(01)00809-5","volume":"286","author":"RC Scarpulla","year":"2002","unstructured":"Scarpulla RC (2002) Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells. Gene 286(1):81\u201389. doi:10.1016\/S0378-1119(01)00809-5","journal-title":"Gene"},{"issue":"6","key":"5_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"P Puigserver","year":"1998","unstructured":"Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92(6):829\u2013839. doi:10.1016\/S0092-8674(00)81410-5","journal-title":"Cell"},{"issue":"1","key":"5_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","volume":"98","author":"Z Wu","year":"1999","unstructured":"Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98(1):115\u2013124. doi:10.1016\/S0092-8674(00)80611-X","journal-title":"Cell"},{"issue":"4","key":"5_CR9","doi-asserted-by":"publisher","first-page":"884S","DOI":"10.3945\/ajcn.110.001917","volume":"93","author":"PJ Fernandez-Marcos","year":"2011","unstructured":"Fernandez-Marcos PJ, Auwerx J (2011) Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 93(4):884S\u2013890S. doi:10.3945\/ajcn.110.001917","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"5_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.cmet.2006.04.013","volume":"3","author":"C Lerin","year":"2006","unstructured":"Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P (2006) GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab 3(6):429\u2013438. doi:10.1016\/j.cmet.2006.04.013","journal-title":"Cell Metab"},{"issue":"30","key":"5_CR11","doi-asserted-by":"publisher","first-page":"19945","DOI":"10.1074\/jbc.M109.015164","volume":"284","author":"TJ Kelly","year":"2009","unstructured":"Kelly TJ, Lerin C, Haas W, Sp G, Puigserver P (2009) GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem 284(30):19945\u201319952. doi:10.1074\/jbc.M109.015164","journal-title":"J Biol Chem"},{"issue":"7029","key":"5_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature03354","volume":"434","author":"JT Rodgers","year":"2005","unstructured":"Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434(7029):113\u2013118. doi:10.1038\/nature03354","journal-title":"Nature"},{"issue":"7","key":"5_CR13","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","volume":"26","author":"Z Gerhart-Hines","year":"2007","unstructured":"Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1alpha. EMBO J 26(7):1913\u20131923","journal-title":"EMBO J"},{"issue":"33","key":"5_CR14","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1038\/onc.2010.206","volume":"29","author":"EH Jeninga","year":"2010","unstructured":"Jeninga EH, Schoojans K, Auwerx J (2010) Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene 29(33):4617\u20134624. doi:10.1038\/onc.2010.206","journal-title":"Oncogene"},{"issue":"6","key":"5_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"M Lagouge","year":"2006","unstructured":"Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127(6):1109\u20131122. doi:10.1016\/j.cell.2006.11.013","journal-title":"Cell"},{"issue":"5","key":"5_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.cmet.2008.08.017","volume":"8","author":"JN Feige","year":"2008","unstructured":"Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliot PJ, Auwerx J (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8(5):347\u2013358. doi:10.1016\/j.cmet.2008.08.017","journal-title":"Cell Metab"},{"issue":"7117","key":"5_CR17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopex-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Psencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117):337\u2013342. doi:10.3410\/f.1052795.504713","journal-title":"Nature"},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/srep00070","volume":"1","author":"RJ Minor","year":"2011","unstructured":"Minor RJ, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martin-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R (2011) SRT1720 improves survival and healthspan of obese mice. Sci Rep 1:70. doi:10.1038\/srep00070","journal-title":"Sci Rep"},{"key":"5_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. doi:10.1016\/0003-2697(76)905273","journal-title":"Anal Biochem"}],"container-title":["Methods in Molecular Biology","Mitochondrial Regulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-1875-1_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T08:59:22Z","timestamp":1674550762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-1875-1_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"ISBN":["9781493918744","9781493918751"],"references-count":19,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-1875-1_5","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2014,9,22]]},"assertion":[{"value":"22 September 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}