{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:44:33Z","timestamp":1762004673604,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":17,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493920730"},{"type":"electronic","value":"9781493920747"}],"license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-2074-7_30","type":"book-chapter","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T11:54:19Z","timestamp":1416570859000},"page":"391-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of Liver Fibrotic Insults In Vitro"],"prefix":"10.1007","author":[{"given":"Luis","family":"Perea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Coll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Sancho-Bru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"30_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tox.2013.08.011","volume":"4","author":"M Vinken","year":"2013","unstructured":"Vinken M (2013) The adverse outcome pathway concept: a pragmatic tool in toxicology. Toxicology 4:158\u2013165","journal-title":"Toxicology"},{"key":"30_CR2","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1002\/hep.26521","volume":"58","author":"O Morales-Ibanez","year":"2013","unstructured":"Morales-Ibanez O, Dominguez M, Ki SH et al (2013) Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology 58:1742\u20131756","journal-title":"Hepatology"},{"key":"30_CR3","doi-asserted-by":"publisher","first-page":"e55786","DOI":"10.1371\/journal.pone.0055786","volume":"8","author":"I Mannaerts","year":"2013","unstructured":"Mannaerts I, Eysackers N, Onyema OO et al (2013) Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29. PloS One 8:e55786","journal-title":"PloS One"},{"key":"30_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"SL Friedman","year":"2008","unstructured":"Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88:125\u2013172","journal-title":"Physiol Rev"},{"key":"30_CR5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209\u2013218","journal-title":"J Clin Invest"},{"key":"30_CR6","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","volume":"4","author":"I Mederacke","year":"2013","unstructured":"Mederacke I, Hsu CC, Troeger JS et al (2013) Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 4:2823","journal-title":"Nat Commun"},{"key":"30_CR7","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","volume":"143","author":"JS Troeger","year":"2012","unstructured":"Troeger JS, Mederacke I, Gwak GY et al (2012) Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology 143:1073\u20131083","journal-title":"Gastroenterology"},{"key":"30_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","volume":"7","author":"SL Friedman","year":"2010","unstructured":"Friedman SL (2010) Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 7:425\u2013436","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"30_CR9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/ncpgasthep0055","volume":"1","author":"SL Friedman","year":"2004","unstructured":"Friedman SL (2004) Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 1:98\u2013105","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"30_CR10","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","volume":"383","author":"EA Tsochatzis","year":"2014","unstructured":"Tsochatzis EA, Bosch J, Burroughs AK (2014) Liver cirrhosis. Lancet 383:1749\u20131761","journal-title":"Lancet"},{"key":"30_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/MOG.0b013e328329e154","volume":"25","author":"A Cardenas","year":"2009","unstructured":"Cardenas A, Gines P (2009) Portal hypertension. Curr Opin Gastroenterol 25:195\u2013201","journal-title":"Curr Opin Gastroenterol"},{"key":"30_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jhep.2005.02.035","volume":"43","author":"P Sancho-Bru","year":"2005","unstructured":"Sancho-Bru P, Bataller R, Gasull X et al (2005) Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 43:272\u2013282","journal-title":"J Hepatol"},{"key":"30_CR13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1136\/gut.2004.042127","volume":"54","author":"L Xu","year":"2005","unstructured":"Xu L, Hui AY, Albanis E et al (2005) Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 54:142\u2013151","journal-title":"Gut"},{"key":"30_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000091096","volume":"181","author":"RJ Thomas","year":"2005","unstructured":"Thomas RJ, Bhandari R, Barrett DA et al (2005) The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro. Cells Tissues Organs 181:67\u201379","journal-title":"Cells Tissues Organs"},{"key":"30_CR15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11626-008-9166-1","volume":"45","author":"P Krause","year":"2009","unstructured":"Krause P, Saghatolislam F, Koenig S et al (2009) Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells. In Vitro Cell Dev Biol Anim 45:205\u2013212","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"30_CR16","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","volume":"87","author":"P Godoy","year":"2013","unstructured":"Godoy P, Hewitt NJ, Albrecht U et al (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87:1315\u20131530","journal-title":"Arch Toxicol"},{"key":"30_CR17","doi-asserted-by":"crossref","unstructured":"Affo S, Morales-Ibanez O, Rodrigo-Torres D et al (2014) CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut doi: 10.1136\/gutjnl-2013-306098","DOI":"10.1136\/gutjnl-2013-306098"}],"container-title":["Methods in Molecular Biology","Protocols in In Vitro Hepatocyte Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-2074-7_30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T01:00:47Z","timestamp":1676422847000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-2074-7_30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"ISBN":["9781493920730","9781493920747"],"references-count":17,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-2074-7_30","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2014,11,3]]},"assertion":[{"value":"3 November 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}