{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:36:26Z","timestamp":1784774186740,"version":"3.55.0"},"publisher-location":"New York, NY","reference-count":86,"publisher":"Springer New York","isbn-type":[{"value":"9781493922963","type":"print"},{"value":"9781493922970","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-2297-0_8","type":"book-chapter","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T08:50:59Z","timestamp":1422607859000},"page":"165-183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Mouse Models of Liver Cancer"],"prefix":"10.1007","author":[{"given":"Jorge Matias","family":"Caviglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"issue":"9822","key":"8_CR1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner A, Llovet JM, Bruix J (2012) Hepatocellular carcinoma. Lancet 379(9822):1245\u20131255. doi:10.1016\/s0140-6736(11)61347-0","journal-title":"Lancet"},{"issue":"12","key":"8_CR2","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMra1001683","volume":"365","author":"HB El-Serag","year":"2011","unstructured":"El-Serag HB (2011) Hepatocellular carcinoma. N Engl J Med 365(12):1118\u20131127. doi:10.1056\/NEJMra1001683","journal-title":"N Engl J Med"},{"issue":"1","key":"8_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1055\/s-0030-1247135","volume":"30","author":"N Fausto","year":"2010","unstructured":"Fausto N, Campbell JS (2010) Mouse models of hepatocellular carcinoma. Semin Liver Dis 30(1):87\u201398. doi:10.1055\/s-0030-1247135","journal-title":"Semin Liver Dis"},{"issue":"4","key":"8_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2613.2009.00656.x","volume":"90","author":"F Heindryckx","year":"2009","unstructured":"Heindryckx F, Colle I, Van Vlierberghe H (2009) Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 90(4):367\u2013386. doi:10.1111\/j.1365-2613.2009.00656.x","journal-title":"Int J Exp Pathol"},{"issue":"45","key":"8_CR5","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.3748\/wjg.14.6915","volume":"14","author":"MW Leenders","year":"2008","unstructured":"Leenders MW, Nijkamp MW, Borel Rinkes IH (2008) Mouse models in liver cancer research: a review of current literature. World J Gastroenterol 14(45):6915\u20136923","journal-title":"World J Gastroenterol"},{"issue":"5","key":"8_CR6","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.jhep.2008.01.008","volume":"48","author":"P Newell","year":"2008","unstructured":"Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM (2008) Experimental models of hepatocellular carcinoma. J Hepatol 48(5):858\u2013879. doi:10.1016\/j.jhep.2008.01.008","journal-title":"J Hepatol"},{"key":"8_CR7","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0378-4274(95)03505-2","volume":"82\u201383","author":"TA Dragani","year":"1995","unstructured":"Dragani TA, Manenti G, Gariboldi M, De Gregorio L, Pierotti MA (1995) Genetics of liver tumor susceptibility in mice. Toxicol Lett 82\u201383:613\u2013619","journal-title":"Toxicol Lett"},{"issue":"2","key":"8_CR8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bbcan.2005.08.007","volume":"1765","author":"F Feo","year":"2006","unstructured":"Feo F, De Miglio MR, Simile MM, Muroni MR, Calvisi DF, Frau M, Pascale RM (2006) Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition. Biochim Biophys Acta 1765(2):126\u2013147. doi:10.1016\/j.bbcan.2005.08.007","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"8_CR9","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/ng.2256","volume":"44","author":"C Guichard","year":"2012","unstructured":"Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J (2012) Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 44(6):694\u2013698. doi:10.1038\/ng.2256","journal-title":"Nat Genet"},{"issue":"7","key":"8_CR10","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/ng.2291","volume":"44","author":"A Fujimoto","year":"2012","unstructured":"Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H (2012) Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet 44(7):760\u2013764. doi:10.1038\/ng.2291","journal-title":"Nat Genet"},{"issue":"1","key":"8_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1055\/s-2006-960171","volume":"27","author":"A Villanueva","year":"2007","unstructured":"Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM (2007) Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 27(1):55\u201376. doi:10.1055\/s-2006-960171","journal-title":"Semin Liver Dis"},{"issue":"8779","key":"8_CR12","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/0140-6736(91)92236-U","volume":"338","author":"M Ozturk","year":"1991","unstructured":"Ozturk M (1991) p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet 338(8779):1356\u20131359","journal-title":"Lancet"},{"issue":"7","key":"8_CR13","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1007\/BF01297149","volume":"36","author":"RG Simonetti","year":"1991","unstructured":"Simonetti RG, Camma C, Fiorello F, Politi F, D\u2019Amico G, Pagliaro L (1991) Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci 36(7):962\u2013972","journal-title":"Dig Dis Sci"},{"issue":"5 Suppl 1","key":"8_CR14","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","volume":"127","author":"G Fattovich","year":"2004","unstructured":"Fattovich G, Stroffolini T, Zagni I, Donato F (2004) Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127(5 Suppl 1):S35\u2013S50","journal-title":"Gastroenterology"},{"issue":"2","key":"8_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","volume":"8","author":"T Luedde","year":"2011","unstructured":"Luedde T, Schwabe RF (2011) NF-kappaB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 8(2):108\u2013118. doi:10.1038\/nrgastro.2010.213","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"8_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.med.45.1.297","volume":"45","author":"WS Robinson","year":"1994","unstructured":"Robinson WS (1994) Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Annu Rev Med 45:297\u2013323. doi:10.1146\/annurev.med.45.1.297","journal-title":"Annu Rev Med"},{"issue":"12","key":"8_CR17","doi-asserted-by":"publisher","first-page":"4850","DOI":"10.1172\/JCI59261","volume":"121","author":"Y Malato","year":"2011","unstructured":"Malato Y, Naqvi S, Schurmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H (2011) Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest 121(12):4850\u20134860. doi:10.1172\/JCI59261, 59261 [pii]","journal-title":"J Clin Invest"},{"issue":"12","key":"8_CR18","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/ng1481","volume":"36","author":"JS Lee","year":"2004","unstructured":"Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, Thorgeirsson SS (2004) Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 36(12):1306\u20131311. doi:10.1038\/ng1481","journal-title":"Nat Genet"},{"issue":"16","key":"8_CR19","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1093\/hmg\/ddp236","volume":"18","author":"AE Hill-Baskin","year":"2009","unstructured":"Hill-Baskin AE, Markiewski MM, Buchner DA, Shao H, DeSantis D, Hsiao G, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH (2009) Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet 18(16):2975\u20132988. doi:10.1093\/hmg\/ddp236","journal-title":"Hum Mol Genet"},{"issue":"5","key":"8_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.ccr.2010.03.021","volume":"17","author":"K Bettermann","year":"2010","unstructured":"Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Muller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T (2010) TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17(5):481\u2013496. doi:10.1016\/j.ccr.2010.03.021","journal-title":"Cancer Cell"},{"issue":"2","key":"8_CR21","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1073\/pnas.0909781107","volume":"107","author":"S Inokuchi","year":"2010","unstructured":"Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E (2010) Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 107(2):844\u2013849. doi:10.1073\/pnas.0909781107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"8_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0092-8674(93)90380-9","volume":"75","author":"JJ Smit","year":"1993","unstructured":"Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, Mol CA, Ottenhoff R, van der Lugt NM, van Roon MA et al (1993) Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75(3):451\u2013462","journal-title":"Cell"},{"issue":"2","key":"8_CR23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ccr.2006.12.016","volume":"11","author":"T Luedde","year":"2007","unstructured":"Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M (2007) Deletion of NEMO\/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 11(2):119\u2013132. doi:10.1016\/j.ccr.2006.12.016","journal-title":"Cancer Cell"},{"issue":"4","key":"8_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","volume":"21","author":"DH Dapito","year":"2012","unstructured":"Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH, Bower M, Friedman R, Sartor RB, Rabadan R, Schwabe RF (2012) Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21(4):504\u2013516. doi:10.1016\/j.ccr.2012.02.007","journal-title":"Cancer Cell"},{"issue":"5","key":"8_CR25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/labinvest.3700257","volume":"85","author":"M Matsuda","year":"2005","unstructured":"Matsuda M, Nakamoto Y, Suzuki S, Kurata T, Kaneko S (2005) Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine. Lab Invest 85(5):655\u2013663. doi:10.1038\/labinvest.3700257, 3700257 [pii]","journal-title":"Lab Invest"},{"issue":"9","key":"8_CR26","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1073\/pnas.0409722102","volume":"102","author":"JS Campbell","year":"2005","unstructured":"Campbell JS, Hughes SD, Gilbertson DG, Palmer TE, Holdren MS, Haran AC, Odell MM, Bauer RL, Ren HP, Haugen HS, Yeh MM, Fausto N (2005) Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A 102(9):3389\u20133394. doi:10.1073\/pnas.0409722102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"8_CR27","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1016\/S0959-8049(99)00224-5","volume":"35","author":"J Schnur","year":"1999","unstructured":"Schnur J, Nagy P, Sebestyen A, Schaff Z, Thorgeirsson SS (1999) Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver. Eur J Cancer 35(13):1842\u20131845","journal-title":"Eur J Cancer"},{"issue":"1","key":"8_CR28","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrgastro.2011.196","volume":"9","author":"Y Li","year":"2012","unstructured":"Li Y, Tang Z-Y, Hou J-X (2012) Hepatocellular carcinoma: insight from animal models. Nat Rev Gastroenterol Hepatol 9(1):32\u201343","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"8_CR29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","volume":"140","author":"EJ Park","year":"2010","unstructured":"Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197\u2013208. doi:10.1016\/j.cell.2009.12.052","journal-title":"Cell"},{"key":"8_CR30","doi-asserted-by":"publisher","unstructured":"Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N (2013) Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499: 97\u2013101. doi:10.1038\/nature12347","DOI":"10.1038\/nature12347"},{"issue":"5","key":"8_CR31","doi-asserted-by":"publisher","first-page":"G825","DOI":"10.1152\/ajpgi.00145.2011","volume":"301","author":"M Charlton","year":"2011","unstructured":"Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A, Masuoko H, Gores G (2011) Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 301(5):G825\u2013G834. doi:10.1152\/ajpgi.00145.2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"8_CR32","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/hep.23797","volume":"52","author":"R Kohli","year":"2010","unstructured":"Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ (2010) High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 52(3):934\u2013944. doi:10.1002\/hep.23797","journal-title":"Hepatology"},{"issue":"3","key":"8_CR33","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3390\/cancers2031441","volume":"2","author":"CM Bagi","year":"2010","unstructured":"Bagi CM, Andresen CJ (2010) Models of hepatocellular carcinoma and biomarker strategy. Cancers 2(3):1441\u20131452. doi:10.3390\/cancers2031441","journal-title":"Cancers"},{"issue":"9","key":"8_CR34","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1073\/pnas.1222878110","volume":"110","author":"J Seok","year":"2013","unstructured":"Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, Lopez CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG, Inflammation, Host Response to Injury LSCRP (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 110(9):3507\u20133512. doi:10.1073\/pnas.1222878110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"8_CR35","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1053\/j.gastro.2013.09.009","volume":"145","author":"M Grompe","year":"2013","unstructured":"Grompe M, Strom S (2013) Mice with human livers. Gastroenterology 145(6):1209\u20131214. doi:10.1053\/j.gastro.2013.09.009, S0016-5085(13)01308-5 [pii]","journal-title":"Gastroenterology"},{"issue":"9","key":"8_CR36","first-page":"4253","volume":"43","author":"SD Vesselinovitch","year":"1983","unstructured":"Vesselinovitch SD, Mihailovich N (1983) Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse. Cancer Res 43(9):4253\u20134259","journal-title":"Cancer Res"},{"issue":"1","key":"8_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/BF00390974","volume":"108","author":"SD Vesselinovitch","year":"1984","unstructured":"Vesselinovitch SD, Koka M, Mihailovich N, Rao KV (1984) Carcinogenicity of diethylnitrosamine in newborn, infant, and adult mice. J Cancer Res Clin Oncol 108(1):60\u201365","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1\u20132","key":"8_CR38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","volume":"71","author":"L Verna","year":"1996","unstructured":"Verna L, Whysner J, Williams GM (1996) N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther 71(1\u20132):57\u201381","journal-title":"Pharmacol Ther"},{"key":"8_CR39","first-page":"69","volume":"331","author":"BA Diwan","year":"1990","unstructured":"Diwan BA, Rice JM, Ward JM (1990) Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice. Prog Clin Biol Res 331:69\u201383","journal-title":"Prog Clin Biol Res"},{"issue":"3","key":"8_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0304-3835(91)90141-4","volume":"59","author":"K Tokumo","year":"1991","unstructured":"Tokumo K, Iatropoulos MJ, Williams GM (1991) Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. Cancer Lett 59(3):193\u2013199","journal-title":"Cancer Lett"},{"issue":"1","key":"8_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/toxsci\/kfs342","volume":"132","author":"T Uehara","year":"2013","unstructured":"Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I (2013) Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 132(1):53\u201363. doi:10.1093\/toxsci\/kfs342, kfs342 [pii]","journal-title":"Toxicol Sci"},{"issue":"7","key":"8_CR42","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/0092-8674(94)90446-4","volume":"77","author":"S Ruetz","year":"1994","unstructured":"Ruetz S, Gros P (1994) Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77(7):1071\u20131081","journal-title":"Cell"},{"issue":"5","key":"8_CR43","first-page":"1237","volume":"145","author":"TH Mauad","year":"1994","unstructured":"Mauad TH, van Nieuwkerk CM, Dingemans KP, Smit JJ, Schinkel AH, Notenboom RG, van den Bergh Weerman MA, Verkruisen RP, Groen AK, Oude Elferink RP et al (1994) Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. Am J Pathol 145(5):1237\u20131245","journal-title":"Am J Pathol"},{"issue":"11","key":"8_CR44","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1541-7786.MCR-07-0172","volume":"5","author":"M Katzenellenbogen","year":"2007","unstructured":"Katzenellenbogen M, Mizrahi L, Pappo O, Klopstock N, Olam D, Jacob-Hirsch J, Amariglio N, Rechavi G, Domany E, Galun E, Goldenberg D (2007) Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice. Mol Cancer Res 5(11):1159\u20131170. doi:10.1158\/1541-7786.mcr-07-0172","journal-title":"Mol Cancer Res"},{"issue":"7007","key":"8_CR45","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature02924","volume":"431","author":"E Pikarsky","year":"2004","unstructured":"Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431(7007):461\u2013466. doi:10.1038\/nature02924","journal-title":"Nature"},{"issue":"4","key":"8_CR46","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.celrep.2013.07.035","volume":"4","author":"M Vucur","year":"2013","unstructured":"Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T (2013) RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep 4(4):776\u2013790. doi:10.1016\/j.celrep.2013.07.035, S2211-1247(13)00397-5 [pii]","journal-title":"Cell Rep"},{"issue":"5","key":"8_CR47","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3330","volume":"13","author":"MS Song","year":"2012","unstructured":"Song MS, Salmena L, Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13(5):283\u2013296. doi:10.1038\/nrm3330","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"8_CR48","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nrc3037","volume":"11","author":"MC Hollander","year":"2011","unstructured":"Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11(4):289\u2013301. doi:10.1038\/nrc3037","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"8_CR49","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1582-4934.2003.tb00204.x","volume":"7","author":"L Dong-Dong","year":"2003","unstructured":"Dong-Dong L, Xi-Ran Z, Xiang-Rong C (2003) Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. J Cell Mol Med 7(1):67\u201371","journal-title":"J Cell Mol Med"},{"issue":"8","key":"8_CR50","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/cncr.11266","volume":"97","author":"TH Hu","year":"2003","unstructured":"Hu TH, Huang CC, Lin PR, Chang HW, Ger LP, Lin YW, Changchien CS, Lee CM, Tai MH (2003) Expression and prognostic role of tumor suppressor gene PTEN\/MMAC1\/TEP1 in hepatocellular carcinoma. Cancer 97(8):1929\u20131940. doi:10.1002\/cncr.11266","journal-title":"Cancer"},{"issue":"20","key":"8_CR51","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1038\/sj.onc.1202659","volume":"18","author":"YJ Yao","year":"1999","unstructured":"Yao YJ, Ping XL, Zhang H, Chen FF, Lee PK, Ahsan H, Chen CJ, Lee PH, Peacocke M, Santella RM, Tsou HC (1999) PTEN\/MMAC1 mutations in hepatocellular carcinomas. Oncogene 18(20):3181\u20133185. doi:10.1038\/sj.onc.1202659","journal-title":"Oncogene"},{"issue":"4","key":"8_CR52","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/1235","volume":"19","author":"A Di Cristofano","year":"1998","unstructured":"Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19(4):348\u2013355. doi:10.1038\/1235","journal-title":"Nat Genet"},{"issue":"4","key":"8_CR53","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1073\/pnas.96.4.1563","volume":"96","author":"K Podsypanina","year":"1999","unstructured":"Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R (1999) Mutation of Pten\/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A 96(4):1563\u20131568","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"8_CR54","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI20513","volume":"113","author":"Y Horie","year":"2004","unstructured":"Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, Mizuno K, Hasegawa G, Kishimoto H, Iizuka M, Naito M, Enomoto K, Watanabe S, Mak TW, Nakano T (2004) Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 113(12):1774\u20131783. doi:10.1172\/jci20513","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"8_CR55","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1111\/j.1440-1746.2006.04665.x","volume":"22","author":"S Watanabe","year":"2007","unstructured":"Watanabe S, Horie Y, Kataoka E, Sato W, Dohmen T, Ohshima S, Goto T, Suzuki A (2007) Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. J Gastroenterol Hepatol 22(Suppl 1):S96\u2013S100. doi:10.1111\/j.1440-1746.2006.04665.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"8_CR56","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cell.2013.09.031","volume":"155","author":"G He","year":"2013","unstructured":"He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M (2013) Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384\u2013396. doi:10.1016\/j.cell.2013.09.031","journal-title":"Cell"},{"issue":"5","key":"8_CR57","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.jhep.2004.01.010","volume":"40","author":"V Schmitz","year":"2004","unstructured":"Schmitz V, Tirado-Ledo L, Tiemann K, Raskopf E, Heinicke T, Ziske C, Gonzalez-Carmona MA, Rabe C, Wernert N, Prieto J, Qian C, Sauerbruch T, Caselmann WH (2004) Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice. J Hepatol 40(5):787\u2013791. doi:10.1016\/j.jhep.2004.01.010","journal-title":"J Hepatol"},{"issue":"7","key":"8_CR58","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00262-010-0831-3","volume":"59","author":"W Abushahba","year":"2010","unstructured":"Abushahba W, Balan M, Castaneda I, Yuan Y, Reuhl K, Raveche E, de la Torre A, Lasfar A, Kotenko SV (2010) Antitumor activity of type I and type III interferons in BNL hepatoma model. Cancer Immunol Immunother 59(7):1059\u20131071. doi:10.1007\/s00262-010-0831-3","journal-title":"Cancer Immunol Immunother"},{"issue":"4","key":"8_CR59","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1478-3231.2008.01670.x","volume":"28","author":"M Kornek","year":"2008","unstructured":"Kornek M, Raskopf E, Tolba R, Becker U, Klockner M, Sauerbruch T, Schmitz V (2008) Accelerated orthotopic hepatocellular carcinomas growth is linked to increased expression of pro-angiogenic and prometastatic factors in murine liver fibrosis. Liver Int 28(4):509\u2013518. doi:10.1111\/j.1478-3231.2008.01670.x","journal-title":"Liver Int"},{"issue":"11","key":"8_CR60","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/ni1255","volume":"6","author":"S Sato","year":"2005","unstructured":"Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S (2005) Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6(11):1087\u20131095. doi:10.1038\/ni1255","journal-title":"Nat Immunol"},{"issue":"46","key":"8_CR61","doi-asserted-by":"publisher","first-page":"17378","DOI":"10.1073\/pnas.0604708103","volume":"103","author":"M Xie","year":"2006","unstructured":"Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS, Schneider MD (2006) A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1\/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A 103(46):17378\u201317383. doi:10.1073\/pnas.0604708103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 2","key":"8_CR62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1440-1746.2011.07010.x","volume":"27","author":"K Machida","year":"2012","unstructured":"Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H (2012) Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol 27(Suppl 2):19\u201322. doi:10.1111\/j.1440-1746.2011.07010.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"8_CR63","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1046\/j.1365-2125.1996.03748.x","volume":"42","author":"SS Thorgeirsson","year":"1996","unstructured":"Thorgeirsson SS, Santoni-Rugiu E (1996) Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. Br J Clin Pharmacol 42(1):43\u201352","journal-title":"Br J Clin Pharmacol"},{"issue":"49","key":"8_CR64","doi-asserted-by":"publisher","first-page":"17216","DOI":"10.1073\/pnas.0404761101","volume":"101","author":"S Colnot","year":"2004","unstructured":"Colnot S, Decaens T, Niwa-Kawakita M, Godard C, Hamard G, Kahn A, Giovannini M, Perret C (2004) Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A 101(49):17216\u201317221. doi:10.1073\/pnas.0404761101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"8_CR65","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1158\/0008-5472.CAN-03-2123","volume":"64","author":"N Harada","year":"2004","unstructured":"Harada N, Oshima H, Katoh M, Tamai Y, Oshima M, Taketo MM (2004) Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 64(1):48\u201354","journal-title":"Cancer Res"},{"issue":"1","key":"8_CR66","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.semcancer.2010.12.010","volume":"21","author":"KN Nejak-Bowen","year":"2011","unstructured":"Nejak-Bowen KN, Monga SP (2011) Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol 21(1):44\u201358. doi:10.1016\/j.semcancer.2010.12.010","journal-title":"Semin Cancer Biol"},{"issue":"5","key":"8_CR67","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1053\/j.gastro.2012.02.009","volume":"142","author":"SF Katz","year":"2012","unstructured":"Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus JM, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL (2012) Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. Gastroenterology 142(5):1229\u20131239.e1223. doi:10.1053\/j.gastro.2012.02.009","journal-title":"Gastroenterology"},{"issue":"6","key":"8_CR68","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/0092-8674(90)90076-Q","volume":"61","author":"C Jhappan","year":"1990","unstructured":"Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT (1990) TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61(6):1137\u20131146","journal-title":"Cell"},{"issue":"5","key":"8_CR69","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/jcb.153.5.1023","volume":"153","author":"R Wang","year":"2001","unstructured":"Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM (2001) Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 153(5):1023\u20131034","journal-title":"J Cell Biol"},{"issue":"11","key":"8_CR70","first-page":"2289","volume":"32","author":"SD Vesselinovitch","year":"1972","unstructured":"Vesselinovitch SD, Mihailovich N, Wogan GN, Lombard LS, Rao KV (1972) Aflatoxin B 1, a hepatocarcinogen in the infant mouse. Cancer Res 32(11):2289\u20132291","journal-title":"Cancer Res"},{"issue":"1","key":"8_CR71","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/carcin\/20.1.59","volume":"20","author":"G Shiota","year":"1999","unstructured":"Shiota G, Harada K, Ishida M, Tomie Y, Okubo M, Katayama S, Ito H, Kawasaki H (1999) Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice. Carcinogenesis 20(1):59\u201363","journal-title":"Carcinogenesis"},{"issue":"6","key":"8_CR72","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.ccr.2012.04.026","volume":"21","author":"K Nikolaou","year":"2012","unstructured":"Nikolaou K, Tsagaratou A, Eftychi C, Kollias G, Mosialos G, Talianidis I (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer Cell 21(6):738\u2013750. doi:10.1016\/j.ccr.2012.04.026","journal-title":"Cancer Cell"},{"issue":"4","key":"8_CR73","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1002\/hep.23479","volume":"51","author":"A Weber","year":"2010","unstructured":"Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer PH, Opferman JT, Galle PR, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H (2010) Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology 51(4):1226\u20131236. doi:10.1002\/hep.23479","journal-title":"Hepatology"},{"issue":"1","key":"8_CR74","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jhep.2012.01.027","volume":"57","author":"H Hikita","year":"2012","unstructured":"Hikita H, Kodama T, Shimizu S, Li W, Shigekawa M, Tanaka S, Hosui A, Miyagi T, Tatsumi T, Kanto T, Hiramatsu N, Morii E, Hayashi N, Takehara T (2012) Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis. J Hepatol 57(1):92\u2013100. doi:10.1016\/j.jhep.2012.01.027","journal-title":"J Hepatol"},{"issue":"6","key":"8_CR75","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/0092-8674(89)90770-8","volume":"59","author":"FV Chisari","year":"1989","unstructured":"Chisari FV, Klopchin K, Moriyama T, Pasquinelli C, Dunsford HA, Sell S, Pinkert CA, Brinster RL, Palmiter RD (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59(6):1145\u20131156","journal-title":"Cell"},{"issue":"6324","key":"8_CR76","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/351317a0","volume":"351","author":"CM Kim","year":"1991","unstructured":"Kim CM, Koike K, Saito I, Miyamura T, Jay G (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351(6324):317\u2013320. doi:10.1038\/351317a0","journal-title":"Nature"},{"issue":"9","key":"8_CR77","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/2053","volume":"4","author":"K Moriya","year":"1998","unstructured":"Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, Matsuura Y, Kimura S, Miyamura T, Koike K (1998) The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4(9):1065\u20131067. doi:10.1038\/2053","journal-title":"Nat Med"},{"issue":"10","key":"8_CR78","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/carcin\/5.10.1367","volume":"5","author":"AK Ghoshal","year":"1984","unstructured":"Ghoshal AK, Farber E (1984) The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis 5(10):1367\u20131370","journal-title":"Carcinogenesis"},{"issue":"25","key":"8_CR79","doi-asserted-by":"publisher","first-page":"15639","DOI":"10.1074\/jbc.273.25.15639","volume":"273","author":"CY Fan","year":"1998","unstructured":"Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK (1998) Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 273(25):15639\u201315645","journal-title":"J Biol Chem"},{"issue":"8","key":"8_CR80","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1101\/gad.2016211","volume":"25","author":"A Takamura","year":"2011","unstructured":"Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25(8):795\u2013800. doi:10.1101\/gad.2016211","journal-title":"Genes Dev"},{"issue":"2","key":"8_CR81","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1083\/jcb.201102031","volume":"193","author":"Y Inami","year":"2011","unstructured":"Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M (2011) Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 193(2):275\u2013284. doi:10.1083\/jcb.201102031","journal-title":"J Cell Biol"},{"issue":"217","key":"8_CR82","doi-asserted-by":"publisher","first-page":"ra24","DOI":"10.1126\/scisignal.2002739","volume":"5","author":"S Menon","year":"2012","unstructured":"Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD (2012) Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal 5(217):ra24. doi:10.1126\/scisignal.2002739","journal-title":"Sci Signal"},{"issue":"11","key":"8_CR83","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1593\/neo.10804","volume":"12","author":"TC Tang","year":"2010","unstructured":"Tang TC, Man S, Xu P, Francia G, Hashimoto K, Emmenegger U, Kerbel RS (2010) Development of a resistance-like phenotype to sorafenib by human hepatocellular carcinoma cells is reversible and can be delayed by metronomic UFT chemotherapy. Neoplasia 12(11):928\u2013940","journal-title":"Neoplasia"},{"issue":"3","key":"8_CR84","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1073\/pnas.1114438109","volume":"109","author":"DE Feldman","year":"2012","unstructured":"Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K (2012) Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A 109(3):829\u2013834. doi:10.1073\/pnas.1114438109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14 Pt 1","key":"8_CR85","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1158\/1078-0432.CCR-05-2568","volume":"12","author":"H Huynh","year":"2006","unstructured":"Huynh H, Soo KC, Chow PK, Panasci L, Tran E (2006) Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. Clin Cancer Res 12(14 Pt 1):4306\u20134314. doi:10.1158\/1078-0432.ccr-05-2568","journal-title":"Clin Cancer Res"},{"issue":"1","key":"8_CR86","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.canlet.2008.11.011","volume":"286","author":"K Kashofer","year":"2009","unstructured":"Kashofer K, Tschernatsch MM, Mischinger HJ, Iberer F, Zatloukal K (2009) The disease relevance of human hepatocellular xenograft models: molecular characterization and review of the literature. Cancer Lett 286(1):121\u2013128. doi:10.1016\/j.canlet.2008.11.011","journal-title":"Cancer Lett"}],"container-title":["Methods in Molecular Biology","Mouse Models of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-2297-0_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T23:12:41Z","timestamp":1676675561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-2297-0_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9781493922963","9781493922970"],"references-count":86,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-2297-0_8","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"6 January 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}