{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T02:52:50Z","timestamp":1743043970844,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":76,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493928385"},{"type":"electronic","value":"9781493928392"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-1-4939-2839-2_1","type":"book-chapter","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T13:30:58Z","timestamp":1445693458000},"page":"3-14","source":"Crossref","is-referenced-by-count":1,"title":["Celiac Disease: Background and Historical Context"],"prefix":"10.1007","author":[{"given":"Graham D.","family":"Turner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R.","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","volume":"367","author":"A Fasano","year":"2012","unstructured":"Fasano A, Catassi C (2012) Clinical practice. Celiac disease. N Engl J Med 367:2419\u201326. doi:10.1056\/NEJMcp1113994","journal-title":"N Engl J Med"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S0738-081X(00)00184-X","volume":"19","author":"TL Reunala","year":"2001","unstructured":"Reunala TL (2001) Dermatitis herpetiformis. Clin Dermatol 19:728\u201336","journal-title":"Clin Dermatol"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nri885","volume":"2","author":"LM Sollid","year":"2002","unstructured":"Sollid LM (2002) Celiac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2:647\u201355. doi:10.1038\/nri885","journal-title":"Nat Rev Immunol"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"e1004137","DOI":"10.1371\/journal.pgen.1004137","volume":"10","author":"G Abraham","year":"2014","unstructured":"Abraham G, Tye-Din JA, Bhalala OG et al (2014) Accurate and robust genomic prediction of celiac disease using statistical learning. PLoS Genet 10:e1004137. doi:10.1371\/journal.pgen.1004137","journal-title":"PLoS Genet"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00431-012-1714-8","volume":"171","author":"CMF Kneepkens","year":"2012","unstructured":"Kneepkens CMF, von Blomberg BME (2012) Clinical practice : coeliac disease. Eur J Pediatr 171:1011\u201321. doi:10.1007\/s00431-012-1714-8","journal-title":"Eur J Pediatr"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","volume":"373","author":"A Di Sabatino","year":"2009","unstructured":"Di Sabatino A, Corazza GR (2009) Coeliac disease. Lancet 373:1480\u20131493. doi:10.1016\/S0140-6736(09)60254-3","journal-title":"Lancet"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/cei.12014","volume":"171","author":"SEJ Cooper","year":"2013","unstructured":"Cooper SEJ, Kennedy NP, Mohamed BM et al (2013) Immunological indicators of coeliac disease activity are not altered by long-term oats challenge. Clin Exp Immunol 171:313\u20138. doi:10.1111\/cei.12014","journal-title":"Clin Exp Immunol"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1136\/jcp.2008.058404","volume":"61","author":"U O\u2019Shea","year":"2008","unstructured":"O\u2019Shea U, Abuzakouk M, O\u2019Morain C et al (2008) Investigation of molecular markers in the diagnosis of refractory coeliac disease in a large patient cohort. J Clin Pathol 61:1200\u20132. doi:10.1136\/jcp.2008.058404","journal-title":"J Clin Pathol"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/ajg.2010.487","volume":"106","author":"JR Biesiekierski","year":"2011","unstructured":"Biesiekierski JR, Newnham ED, Irving PM et al (2011) Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 106:508\u201314. doi:10.1038\/ajg.2010.487, quiz 515","journal-title":"Am J Gastroenterol"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1053\/j.gastro.2013.08.061","volume":"146","author":"A Carroccio","year":"2014","unstructured":"Carroccio A, Rini G, Mansueto P (2014) Non-celiac wheat sensitivity is a more appropriate label than non-celiac gluten sensitivity. Gastroenterology 146:320\u20131. doi:10.1053\/j.gastro.2013.08.061","journal-title":"Gastroenterology"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nature02734","volume":"430","author":"DR Piperno","year":"2004","unstructured":"Piperno DR, Weiss E, Holst I, Nadel D (2004) Processing of wild cereal grains in the Upper Palaeolithic revealed by starch grain analysis. Nature 430:670\u20133. doi:10.1038\/nature02734","journal-title":"Nature"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"9551","DOI":"10.1073\/pnas.0402362101","volume":"101","author":"E Weiss","year":"2004","unstructured":"Weiss E, Wetterstrom W, Nadel D, Bar-Yosef O (2004) The broad spectrum revisited: evidence from plant remains. Proc Natl Acad Sci U S A 101:9551\u20135. doi:10.1073\/pnas.0402362101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.ajhg.2010.05.004","volume":"86","author":"A Zhernakova","year":"2010","unstructured":"Zhernakova A, Elbers CC, Ferwerda B et al (2010) Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. Am J Hum Genet 86:970\u20137. doi:10.1016\/j.ajhg.2010.05.004","journal-title":"Am J Hum Genet"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/ajpa.22517","volume":"154","author":"G Scorrano","year":"2014","unstructured":"Scorrano G, Brilli M, Mart\u00ednez-Labarga C et al (2014) Palaeodiet reconstruction in a woman with probable celiac disease: a stable isotope analysis of bone remains from the archaeological site of Cosa (Italy). Am J Phys Anthropol 154:349\u201356. doi:10.1002\/ajpa.22517","journal-title":"Am J Phys Anthropol"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1080\/00365520600699983","volume":"41","author":"D Pizzuti","year":"2006","unstructured":"Pizzuti D, Buda A, D\u2019Odorico A et al (2006) Lack of intestinal mucosal toxicity of Triticum monococcum in celiac disease patients. Scand J Gastroenterol 41:1305\u201311. doi:10.1080\/00365520600699983","journal-title":"Scand J Gastroenterol"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1136\/bmj.2.5909.45","volume":"2","author":"B Dowd","year":"1974","unstructured":"Dowd B, Walker-Smith J (1974) Samuel Gee, Aretaeus, and the coeliac affection. Br Med J 2:45\u20137","journal-title":"Br Med J"},{"key":"1_CR17","first-page":"17","volume":"24","author":"SJ Gee","year":"1888","unstructured":"Gee SJ (1888) On the coeliac affection. St Bartholomews Hosp Rep 24:17\u201320","journal-title":"St Bartholomews Hosp Rep"},{"key":"1_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/archpedi.1924.04120220017004","volume":"28","author":"SV Haas","year":"1924","unstructured":"Haas SV (1924) The value of the banana in the treatment of celiac disease. Am J Dis Child 28:421\u201337. doi:10.1001\/archpedi.1924.04120220017004","journal-title":"Am J Dis Child"},{"key":"1_CR19","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1136\/gut.34.11.1473","volume":"34","author":"GP Van Berge-Henegouwen","year":"1993","unstructured":"Van Berge-Henegouwen GP, Mulder CJ (1993) Pioneer in the gluten free diet: Willem-Karel Dicke 1905-1962, over 50 years of gluten free diet. Gut 34:1473\u20135","journal-title":"Gut"},{"key":"1_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1136\/gut.26.2.175","volume":"26","author":"MJ Langman","year":"1985","unstructured":"Langman MJ, McConnell TH, Spiegelhalter DJ, McConnell RB (1985) Changing patterns of coeliac disease frequency: an analysis of Coeliac Society membership records. Gut 26:175\u20138","journal-title":"Gut"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1136\/bmj.281.6250.1258","volume":"281","author":"CM Swinson","year":"1980","unstructured":"Swinson CM, Levi AJ (1980) Is coeliac disease underdiagnosed? Br Med J 281:1258\u201360","journal-title":"Br Med J"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1136\/gut.34.2.150","volume":"34","author":"A Ferguson","year":"1993","unstructured":"Ferguson A, Arranz E, O\u2019Mahony S (1993) Clinical and pathological spectrum of coeliac disease\u2013active, silent, latent, potential. Gut 34:150\u20131","journal-title":"Gut"},{"doi-asserted-by":"publisher","unstructured":"Catassi C, Fabiani E, R\u00e4tsch IM et al (1996) The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatrica, 85:29\u201335. doi: 10.1111\/j.1651-2227.1996.tb14244.x","key":"1_CR23","DOI":"10.1111\/j.1651-2227.1996.tb14244"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"e81151","DOI":"10.1371\/journal.pone.0081151","volume":"8","author":"J Yuan","year":"2013","unstructured":"Yuan J, Gao J, Li X et al (2013) The tip of the \u201cceliac iceberg\u201d in China: a systematic review and meta-analysis. PLoS One 8:e81151. doi:10.1371\/journal.pone.0081151","journal-title":"PLoS One"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1136\/gut.12.12.988","volume":"12","author":"A Ferguson","year":"1971","unstructured":"Ferguson A, Murray D (1971) Quantitation of intraepithelial lymphocytes in human jejunum. Gut 12:988\u201394","journal-title":"Gut"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/eji.1830230231","volume":"23","author":"TS Halstensen","year":"1993","unstructured":"Halstensen TS, Brandtzaeg P (1993) Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha\/beta cells in the lamina propria but proliferation (Ki-67) of alpha\/beta and gamma\/delta cells in the epithelium. Eur J Immunol 23:505\u201310. doi:10.1002\/eji.1830230231","journal-title":"Eur J Immunol"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/path.1773","volume":"206","author":"C Buri","year":"2005","unstructured":"Buri C, Burri P, B\u00e4hler P et al (2005) Cytotoxic T cells are preferentially activated in the duodenal epithelium from patients with florid coeliac disease. J Pathol 206:178\u201385. doi:10.1002\/path.1773","journal-title":"J Pathol"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1084\/jem.178.1.187","volume":"178","author":"KE Lundin","year":"1993","unstructured":"Lundin KE, Scott H, Hansen T et al (1993) Gliadin-specific, HLA-DQ(alpha 1*0501, beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178:187\u201396","journal-title":"J Exp Med"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.immuni.2012.06.006","volume":"36","author":"B Meresse","year":"2012","unstructured":"Meresse B, Malamut G, Cerf-Bensussan N (2012) Celiac disease: an immunological jigsaw. Immunity 36:907\u201319. doi:10.1016\/j.immuni.2012.06.006","journal-title":"Immunity"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nri3407","volume":"13","author":"LM Sollid","year":"2013","unstructured":"Sollid LM, Jabri B (2013) Triggers and drivers of autoimmunity: lessons from coeliac disease. Nat Rev Immunol 13:294\u2013302. doi:10.1038\/nri3407","journal-title":"Nat Rev Immunol"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1136\/gut.2007.129882","volume":"57","author":"D Fina","year":"2008","unstructured":"Fina D, Sarra M, Caruso R et al (2008) Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut 57:887\u201392. doi:10.1136\/gut.2007.129882","journal-title":"Gut"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1136\/gut.2005.068684","volume":"55","author":"A Di Sabatino","year":"2006","unstructured":"Di Sabatino A, Ciccocioppo R, Cupelli F et al (2006) Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 55:469\u201377. doi:10.1136\/gut.2005.068684","journal-title":"Gut"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nm0797-797","volume":"3","author":"W Dieterich","year":"1997","unstructured":"Dieterich W, Ehnis T, Bauer M et al (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797\u2013801","journal-title":"Nat Med"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1365-3083.1989.tb02474.x","volume":"30","author":"TS Halstensen","year":"1989","unstructured":"Halstensen TS, Scott H, Brandtzaeg P (1989) Intraepithelial T cells of the TcR gamma\/delta\u2009+\u2009CD8- and V delta 1\/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol 30:665\u201372","journal-title":"Scand J Immunol"},{"key":"1_CR35","doi-asserted-by":"publisher","first-page":"e76008","DOI":"10.1371\/journal.pone.0076008","volume":"8","author":"MR Dunne","year":"2013","unstructured":"Dunne MR, Elliott L, Hussey S et al (2013) Persistent changes in circulating and intestinal \u03b3\u03b4 T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease. PLoS One 8:e76008. doi:10.1371\/journal.pone.0076008","journal-title":"PLoS One"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1172\/JCI30989","volume":"118","author":"G Bhagat","year":"2008","unstructured":"Bhagat G, Naiyer AJ, Shah JG et al (2008) Small intestinal CD8\u2009+\u2009TCRgammadelta\u2009+\u2009NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 118:281\u201393. doi:10.1172\/JCI30989","journal-title":"J Clin Invest"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1084\/jem.20081787","volume":"206","author":"A Toulon","year":"2009","unstructured":"Toulon A, Breton L, Taylor KR et al (2009) A role for human skin-resident T cells in wound healing. J Exp Med 206:743\u201350. doi:10.1084\/jem.20081787","journal-title":"J Exp Med"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1136\/bmj.293.6552.908","volume":"293","author":"C O\u2019Farrelly","year":"1986","unstructured":"O\u2019Farrelly C, Feighery C, O\u2019Briain DS et al (1986) Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma. Br Med J (Clin Res Ed) 293:908\u201310","journal-title":"Br Med J (Clin Res Ed)"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(00)02481-8","volume":"356","author":"C Cellier","year":"2000","unstructured":"Cellier C, Delabesse E, Helmer C et al (2000) Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 356:203\u20138","journal-title":"Lancet"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1084\/jem.169.1.345","volume":"169","author":"LM Sollid","year":"1989","unstructured":"Sollid LM, Markussen G, Ek J et al (1989) Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer. J Exp Med 169:345\u201350","journal-title":"J Exp Med"},{"key":"1_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1651-2227.1996.tb14239.x","volume":"412","author":"H Wieser","year":"1996","unstructured":"Wieser H (1996) Relation between gliadin structure and coeliac toxicity. Acta Paediatr Suppl 412:3\u20139","journal-title":"Acta Paediatr Suppl"},{"key":"1_CR42","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1172\/JCI30253","volume":"117","author":"MF Kagnoff","year":"2007","unstructured":"Kagnoff MF (2007) Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest 117:41\u20139. doi:10.1172\/JCI30253","journal-title":"J Clin Invest"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0950-3528(95)90027-6","volume":"9","author":"H Wieser","year":"1995","unstructured":"Wieser H (1995) The precipitating factor in coeliac disease. Baillieres Clin Gastroenterol 9:191\u2013207","journal-title":"Baillieres Clin Gastroenterol"},{"key":"1_CR44","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1126\/science.1074129","volume":"297","author":"L Shan","year":"2002","unstructured":"Shan L, Molberg \u00d8, Parrot I et al (2002) Structural basis for gluten intolerance in celiac sprue. Science 297:2275\u20139. doi:10.1126\/science.1074129","journal-title":"Science"},{"key":"1_CR45","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1172\/JCI27620","volume":"116","author":"S Tollefsen","year":"2006","unstructured":"Tollefsen S, Arentz-Hansen H, Fleckenstein B et al (2006) HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest 116:2226\u201336. doi:10.1172\/JCI27620","journal-title":"J Clin Invest"},{"key":"1_CR46","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1002\/eji.1830261132","volume":"26","author":"F Vartdal","year":"1996","unstructured":"Vartdal F, Johansen BH, Friede T et al (1996) The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule. Eur J Immunol 26:2764\u201372. doi:10.1002\/eji.1830261132","journal-title":"Eur J Immunol"},{"key":"1_CR47","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4049\/jimmunol.175.1.254","volume":"175","author":"S-W Qiao","year":"2005","unstructured":"Qiao S-W, Bergseng E, Molberg O et al (2005) Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J Immunol 175:254\u201361","journal-title":"J Immunol"},{"key":"1_CR48","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","volume":"161","author":"Y Van de Wal","year":"1998","unstructured":"Van de Wal Y, Kooy Y, van Veelen P et al (1998) Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 161:1585\u20138","journal-title":"J Immunol"},{"key":"1_CR49","doi-asserted-by":"publisher","first-page":"34109","DOI":"10.1074\/jbc.M204521200","volume":"277","author":"B Fleckenstein","year":"2002","unstructured":"Fleckenstein B, Molberg \u00d8, Qiao S-W et al (2002) Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process. J Biol Chem 277:34109\u201316. doi:10.1074\/jbc.M204521200","journal-title":"J Biol Chem"},{"key":"1_CR50","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1136\/gut.2005.069385","volume":"55","author":"W Dieterich","year":"2006","unstructured":"Dieterich W, Esslinger B, Trapp D et al (2006) Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease. Gut 55:478\u201384. doi:10.1136\/gut.2005.069385","journal-title":"Gut"},{"key":"1_CR51","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1042\/bj20021234","volume":"368","author":"M Griffin","year":"2002","unstructured":"Griffin M, Casadio R, Bergamini CM (2002) Transglutaminases: nature\u2019s biological glues. Biochem J 368:377\u201396. doi:10.1042\/BJ20021234","journal-title":"Biochem J"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0198-8859(95)00144-1","volume":"45","author":"R McManus","year":"1996","unstructured":"McManus R, Moloney M, Borton M et al (1996) Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes. Hum Immunol 45:24\u201331","journal-title":"Hum Immunol"},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00251-002-0461-9","volume":"54","author":"N Otting","year":"2002","unstructured":"Otting N, de Groot NG, Doxiadis GGM, Bontrop RE (2002) Extensive Mhc-DQB variation in humans and non-human primate species. Immunogenetics 54:230\u20139. doi:10.1007\/s00251-002-0461-9","journal-title":"Immunogenetics"},{"key":"1_CR54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4049\/jimmunol.149.2.461","volume":"149","author":"N Otting","year":"1992","unstructured":"Otting N, Kenter M, van Weeren P et al (1992) Mhc-DQB repertoire variation in hominoid and Old World primate species. J Immunol 149:461\u201370","journal-title":"J Immunol"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1209202","volume":"334","author":"L Abi-Rached","year":"2011","unstructured":"Abi-Rached L, Jobin MJ, Kulkarni S et al (2011) The shaping of modern human immune systems by multiregional admixture with archaic humans. Science 334:89\u201394. doi:10.1126\/science.1209202","journal-title":"Science"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1469-1809.2001.6510035.x","volume":"65","author":"L Greco","year":"2001","unstructured":"Greco L, Babron MC, Corazza GR et al (2001) Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease families. Ann Hum Genet 65:35\u201341","journal-title":"Ann Hum Genet"},{"key":"1_CR57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1399-0039.2007.00955.x","volume":"71","author":"S Adamovic","year":"2008","unstructured":"Adamovic S, Amundsen SS, Lie BA et al (2008) Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32. Tissue Antigens 71:27\u201334. doi:10.1111\/j.1399-0039.2007.00955.x","journal-title":"Tissue Antigens"},{"key":"1_CR58","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1399-0039.2004.00251.x","volume":"64","author":"AW Ryan","year":"2004","unstructured":"Ryan AW, Thornton JM, Brophy K et al (2004) Haplotype variation at the IBD5\/SLC22A4 locus (5q31) in coeliac disease in the Irish population. Tissue Antigens 64:195\u20138. doi:10.1111\/j.1399-0039.2004.00251.x","journal-title":"Tissue Antigens"},{"key":"1_CR59","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1399-0039.2005.00354.x","volume":"65","author":"AW Ryan","year":"2005","unstructured":"Ryan AW, Thornton JM, Brophy K et al (2005) Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. Tissue Antigens 65:150\u20135. doi:10.1111\/j.1399-0039.2005.00354.x","journal-title":"Tissue Antigens"},{"key":"1_CR60","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1034\/j.1399-0039.1999.530503.x","volume":"53","author":"P Holopainen","year":"1999","unstructured":"Holopainen P, Arvas M, Sistonen P et al (1999) CD28\/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study. Tissue Antigens 53:470\u20135","journal-title":"Tissue Antigens"},{"key":"1_CR61","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1073\/pnas.0610124104","volume":"104","author":"V Butty","year":"2007","unstructured":"Butty V, Roy M, Sabeti P et al (2007) Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A 104:570\u20135. doi:10.1073\/pnas.0610124104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1_CR62","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng2058","volume":"39","author":"DA Van Heel","year":"2007","unstructured":"Van Heel DA, Franke L, Hunt KA et al (2007) A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 39:827\u20139. doi:10.1038\/ng2058","journal-title":"Nat Genet"},{"key":"1_CR63","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ng.102","volume":"40","author":"KA Hunt","year":"2008","unstructured":"Hunt KA, Zhernakova A, Turner G et al (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40:395\u2013402. doi:10.1038\/ng.102","journal-title":"Nat Genet"},{"key":"1_CR64","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng.543","volume":"42","author":"PCA Dubois","year":"2010","unstructured":"Dubois PCA, Trynka G, Franke L et al (2010) Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 42:295\u2013302. doi:10.1038\/ng.543","journal-title":"Nat Genet"},{"key":"1_CR65","doi-asserted-by":"publisher","first-page":"e101428","DOI":"10.1371\/journal.pone.0101428","volume":"9","author":"C Garner","year":"2014","unstructured":"Garner C, Ahn R, Ding YC et al (2014) Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. PLoS One 9:e101428. doi:10.1371\/journal.pone.0101428","journal-title":"PLoS One"},{"key":"1_CR66","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/ng.998","volume":"43","author":"G Trynka","year":"2011","unstructured":"Trynka G, Hunt KA, Bockett NA et al (2011) Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 43:1193\u2013201. doi:10.1038\/ng.998","journal-title":"Nat Genet"},{"doi-asserted-by":"crossref","unstructured":"Coleman C, Quinn EM, Ryan AW, et al. (2015) Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci. Eur J Hum Genet (in press)","key":"1_CR67","DOI":"10.1038\/ejhg.2015.87"},{"key":"1_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1755-8794-2-1","volume":"2","author":"GA Heap","year":"2009","unstructured":"Heap GA, Trynka G, Jansen RC et al (2009) Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Med Genomics 2:1. doi:10.1186\/1755-8794-2-1","journal-title":"BMC Med Genomics"},{"key":"1_CR69","doi-asserted-by":"publisher","first-page":"e74747","DOI":"10.1371\/journal.pone.0074747","volume":"8","author":"M Galatola","year":"2013","unstructured":"Galatola M, Izzo V, Cielo D et al (2013) Gene expression profile of peripheral blood monocytes: A step towards the molecular diagnosis of celiac disease? PLoS One 8:e74747. doi:10.1371\/journal.pone.0074747","journal-title":"PLoS One"},{"key":"1_CR70","doi-asserted-by":"publisher","first-page":"e66307","DOI":"10.1371\/journal.pone.0066307","volume":"8","author":"A Parmar","year":"2013","unstructured":"Parmar A, Greco D, Ven\u00e4l\u00e4inen J et al (2013) Gene expression profiling of gliadin effects on intestinal epithelial cells suggests novel non-enzymatic functions of pepsin and trypsin. PLoS One 8:e66307. doi:10.1371\/journal.pone.0066307","journal-title":"PLoS One"},{"key":"1_CR71","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1038\/ncomms6257","volume":"5","author":"C Gamba","year":"2014","unstructured":"Gamba C, Jones ER, Teasdale MD et al (2014) Genome flux and stasis in a five millennium transect of European prehistory. Nat Commun 5:5257. doi:10.1038\/ncomms6257","journal-title":"Nat Commun"},{"key":"1_CR72","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature13673","volume":"513","author":"I Lazaridis","year":"2014","unstructured":"Lazaridis I, Patterson N, Mittnik A et al (2014) Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513:409\u201313. doi:10.1038\/nature13673","journal-title":"Nature"},{"key":"1_CR73","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/jid.2010.350","volume":"131","author":"E Riveira-Munoz","year":"2011","unstructured":"Riveira-Munoz E, He S-M, Escaram\u00eds G et al (2011) Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol 131:1105\u20139. doi:10.1038\/jid.2010.350","journal-title":"J Invest Dermatol"},{"key":"1_CR74","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.biopsych.2011.07.011","volume":"70","author":"E Rees","year":"2011","unstructured":"Rees E, Moskvina V, Owen MJ et al (2011) De novo rates and selection of schizophrenia-associated copy number variants. Biol Psychiatry 70:1109\u201314. doi:10.1016\/j.biopsych.2011.07.011","journal-title":"Biol Psychiatry"},{"key":"1_CR75","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1093\/hmg\/ddt520","volume":"23","author":"N Fernandez-Jimenez","year":"2014","unstructured":"Fernandez-Jimenez N, Castellanos-Rubio A, Plaza-Izurieta L et al (2014) Coregulation and modulation of NF\u03baB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation. Hum Mol Genet 23:1298\u2013310. doi:10.1093\/hmg\/ddt520","journal-title":"Hum Mol Genet"},{"key":"1_CR76","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.1572-0241.2007.01716.x","volume":"103","author":"F Megiorni","year":"2008","unstructured":"Megiorni F, Mora B, Bonamico M et al (2008) HLA-DQ and susceptibility to celiac disease: evidence for gender differences and parent-of-origin effects. Am J Gastroenterol 103:997\u20131003. doi:10.1111\/j.1572-0241.2007.01716.x","journal-title":"Am J Gastroenterol"}],"container-title":["Methods in Molecular Biology","Celiac Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-2839-2_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T17:32:27Z","timestamp":1676482347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-2839-2_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9781493928385","9781493928392"],"references-count":76,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-2839-2_1","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2015]]}}}