{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:50:22Z","timestamp":1743144622507,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":29,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493932702"},{"type":"electronic","value":"9781493932719"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-1-4939-3271-9_31","type":"book-chapter","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T06:47:47Z","timestamp":1448520467000},"page":"467-482","source":"Crossref","is-referenced-by-count":7,"title":["Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms"],"prefix":"10.1007","author":[{"given":"Neha","family":"Kamran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianela","family":"Candolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela Moreno","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Dzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro R.","family":"Lowenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"2","key":"31_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11060-007-9400-9","volume":"85","author":"M Candolfi","year":"2007","unstructured":"Candolfi M et al (2007) Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. J Neurooncol 85(2):133\u2013148","journal-title":"J Neurooncol"},{"issue":"3","key":"31_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2174\/156652311795684722","volume":"11","author":"MG Castro","year":"2011","unstructured":"Castro MG et al (2011) Gene therapy and targeted toxins for glioma. Curr Gene Ther 11(3):155\u2013180","journal-title":"Curr Gene Ther"},{"issue":"6","key":"31_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2174\/156652305774964631","volume":"5","author":"GD King","year":"2005","unstructured":"King GD et al (2005) Gene therapy and targeted toxins for glioma. Curr Gene Ther 5(6):535\u2013557","journal-title":"Curr Gene Ther"},{"issue":"7","key":"31_CR4","first-page":"879","volume":"24","author":"E Radaelli","year":"2009","unstructured":"Radaelli E et al (2009) Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease. Histol Histopathol 24(7):879\u2013891","journal-title":"Histol Histopathol"},{"issue":"7","key":"31_CR5","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.neo.2014.06.003","volume":"16","author":"GJ Baker","year":"2014","unstructured":"Baker GJ et al (2014) Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy. Neoplasia 16(7):543\u2013561","journal-title":"Neoplasia"},{"issue":"2","key":"31_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neulet.2012.08.003","volume":"527","author":"H Assi","year":"2012","unstructured":"Assi H et al (2012) Gene therapy for brain tumors: basic developments and clinical implementation. Neurosci Lett 527(2):71\u201377","journal-title":"Neurosci Lett"},{"issue":"23","key":"31_CR7","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1016\/j.febslet.2011.05.030","volume":"585","author":"B Finsen","year":"2011","unstructured":"Finsen B, Owens T (2011) Innate immune responses in central nervous system inflammation. FEBS Lett 585(23):3806\u20133812","journal-title":"FEBS Lett"},{"issue":"4","key":"31_CR8","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.coph.2008.07.009","volume":"8","author":"Z Fabry","year":"2008","unstructured":"Fabry Z et al (2008) Sensing the microenvironment of the central nervous system: immune cells in the central nervous system and their pharmacological manipulation. Curr Opin Pharmacol 8(4):496\u2013507","journal-title":"Curr Opin Pharmacol"},{"issue":"4","key":"31_CR9","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1172\/JCI58644","volume":"122","author":"RM Ransohoff","year":"2012","unstructured":"Ransohoff RM, Brown MA (2012) Innate immunity in the central nervous system. J Clin Invest 122(4):1164\u20131171","journal-title":"J Clin Invest"},{"issue":"16","key":"31_CR10","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1158\/0008-5472.CAN-04-3434","volume":"65","author":"S Ali","year":"2005","unstructured":"Ali S et al (2005) Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. Cancer Res 65(16):7194\u20137204","journal-title":"Cancer Res"},{"issue":"12","key":"31_CR11","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.2174\/156802605774370856","volume":"5","author":"JF Curtin","year":"2005","unstructured":"Curtin JF et al (2005) Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Curr Top Med Chem 5(12):1151\u20131170","journal-title":"Curr Top Med Chem"},{"issue":"19","key":"31_CR12","doi-asserted-by":"publisher","first-page":"6113","DOI":"10.1158\/1078-0432.CCR-09-1087","volume":"15","author":"AK Ghulam Muhammad","year":"2009","unstructured":"Ghulam Muhammad AK et al (2009) Antiglioma immunological memory in response to conditional cytotoxic\/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. Clin Cancer Res 15(19):6113\u20136127","journal-title":"Clin Cancer Res"},{"issue":"1","key":"31_CR13","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1371\/journal.pmed.1000010","volume":"6","author":"JF Curtin","year":"2009","unstructured":"Curtin JF et al (2009) HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Med 6(1):e10","journal-title":"PLoS Med"},{"issue":"3","key":"31_CR14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ng0393-224","volume":"3","author":"S Akli","year":"1993","unstructured":"Akli S et al (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 3(3):224\u2013228","journal-title":"Nat Genet"},{"issue":"5097","key":"31_CR15","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.8382374","volume":"259","author":"G Le Gal La Salle","year":"1993","unstructured":"Le Gal La Salle G et al (1993) An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259(5097):988\u2013990","journal-title":"Science"},{"key":"31_CR16","unstructured":"Southgate T et al (2008) Gene transfer into neural cells in vitro using adenoviral vectors. Curr Protoc Neurosci. Chapter 4: p. Unit 4 23"},{"issue":"4","key":"31_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1017\/S1740925X07000579","volume":"2","author":"C Barcia","year":"2006","unstructured":"Barcia C et al (2006) Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells. Neuron Glia Biol 2(4):309\u2013322","journal-title":"Neuron Glia Biol"},{"key":"31_CR18","first-page":"389","volume":"69","author":"P Ng","year":"2002","unstructured":"Ng P, Graham FL (2002) Construction of first-generation adenoviral vectors. Methods Mol Med 69:389\u2013414","journal-title":"Methods Mol Med"},{"issue":"19","key":"31_CR19","doi-asserted-by":"publisher","first-page":"8802","DOI":"10.1073\/pnas.91.19.8802","volume":"91","author":"AJ Bett","year":"1994","unstructured":"Bett AJ et al (1994) An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A 91(19):8802\u20138806","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"31_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1006\/mthe.2000.0224","volume":"3","author":"CE Thomas","year":"2001","unstructured":"Thomas CE et al (2001) Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. Mol Ther 3(1):36\u201346","journal-title":"Mol Ther"},{"issue":"6","key":"31_CR21","first-page":"1965","volume":"43","author":"F Kreppel","year":"2002","unstructured":"Kreppel F et al (2002) Long-term transgene expression in the RPE after gene transfer with a high-capacity adenoviral vector. Invest Ophthalmol Vis Sci 43(6):1965\u20131970","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"31_CR22","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1128\/JVI.00232-08","volume":"82","author":"GD King","year":"2008","unstructured":"King GD et al (2008) High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity. J Virol 82(9):4680\u20134684","journal-title":"J Virol"},{"key":"31_CR23","unstructured":"Puntel M et al (2010) Gene transfer into rat brain using adenoviral vectors. Curr Protoc Neurosci. Chapter 4: p. Unit 4 24"},{"issue":"7","key":"31_CR24","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/jgm.381","volume":"5","author":"CP Glover","year":"2003","unstructured":"Glover CP et al (2003) Long-term transgene expression can be mediated in the brain by adenoviral vectors when powerful neuron-specific promoters are used. J Gene Med 5(7):554\u2013559","journal-title":"J Gene Med"},{"issue":"10","key":"31_CR25","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1593\/neo.11024","volume":"13","author":"M Candolfi","year":"2011","unstructured":"Candolfi M et al (2011) B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory\/conditionally cytotoxic therapy for glioblastoma. Neoplasia 13(10):947\u2013960","journal-title":"Neoplasia"},{"issue":"6","key":"31_CR26","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1158\/1078-0432.CCR-13-2140","volume":"20","author":"M Candolfi","year":"2014","unstructured":"Candolfi M et al (2014) Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models. Clin Cancer Res 20(6):1555\u20131565","journal-title":"Clin Cancer Res"},{"issue":"10","key":"31_CR27","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1038\/mt.2011.77","volume":"19","author":"GD King","year":"2011","unstructured":"King GD et al (2011) Combined Flt3L\/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen. Mol Ther 19(10):1793\u20131801","journal-title":"Mol Ther"},{"issue":"12","key":"31_CR28","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1158\/1535-7163.MCT-14-0400","volume":"13","author":"Y Mineharu","year":"2014","unstructured":"Mineharu Y et al (2014) Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions. Mol Cancer Ther 13(12):3024\u20133036","journal-title":"Mol Cancer Ther"},{"issue":"14","key":"31_CR29","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1158\/1078-0432.CCR-11-0915","volume":"17","author":"Y Mineharu","year":"2011","unstructured":"Mineharu Y et al (2011) Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design. Clin Cancer Res 17(14):4705\u20134718","journal-title":"Clin Cancer Res"}],"container-title":["Methods in Molecular Biology","Gene Therapy for Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-3271-9_31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T13:42:11Z","timestamp":1676986931000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-4939-3271-9_31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9781493932702","9781493932719"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-3271-9_31","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2016]]}}}