{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:20:30Z","timestamp":1783570830350,"version":"3.55.0"},"publisher-location":"New York, NY","reference-count":11,"publisher":"Springer New York","isbn-type":[{"value":"9781493933334","type":"print"},{"value":"9781493933358","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-1-4939-3335-8_18","type":"book-chapter","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T10:02:31Z","timestamp":1453543351000},"page":"287-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Toll-Like Receptor Signalling and the Control of Intestinal Barrier Function"],"prefix":"10.1007","author":[{"given":"Daniel G. W.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9ad C.","family":"Corr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,24]]},"reference":[{"key":"18_CR1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9:799\u2013809","journal-title":"Nat Rev Immunol"},{"key":"18_CR2","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.biocel.2003.08.007","volume":"36","author":"NS Harhaj","year":"2004","unstructured":"Harhaj NS, Antonetti DA (2004) Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 36:1206\u20131237","journal-title":"Int J Biochem Cell Biol"},{"key":"18_CR3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/ncpgasthep0259","volume":"2","author":"A Fasano","year":"2005","unstructured":"Fasano A, Shea-Donohue T (2005) Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2:416\u2013422","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"18_CR4","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S1286-4579(03)00089-3","volume":"5","author":"DF Balkovetz","year":"2003","unstructured":"Balkovetz DF, Katz J (2003) Bacterial invasion by a paracellular route: divide and conquer. Microbes Infect 5:613\u2013619","journal-title":"Microbes Infect"},{"issue":"1","key":"18_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/mi.2013.24","volume":"7","author":"SC Corr","year":"2014","unstructured":"Corr SC, Palsson-McDermott EM, Grishina I et al (2014) MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C. Mucosal Immunol 7(1):57\u201367","journal-title":"Mucosal Immunol"},{"key":"18_CR6","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.bbamem.2007.08.018","volume":"1778","author":"L Gonzalez-Mariscal","year":"2008","unstructured":"Gonzalez-Mariscal L, Tapia R, Chamorro D (2008) Crosstalk of tight junction components with signaling pathways. Biochim Biophys Acta 1778:729\u2013756","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"18_CR7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","volume":"182","author":"S Guo","year":"2013","unstructured":"Guo S, Al-Sadi R, Said HM et al (2013) Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. Am J Pathol 182(2):375\u2013387","journal-title":"Am J Pathol"},{"key":"18_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature12687","volume":"504","author":"T Alenghat","year":"2013","unstructured":"Alenghat T, Osborne LC, Saenz SA et al (2013) Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature 504:153\u2013157","journal-title":"Nature"},{"issue":"1","key":"18_CR9","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1053\/j.gastro.2004.04.015","volume":"127","author":"E Cario","year":"2004","unstructured":"Cario E, Gerken G, Podolsky DK (2004) Toll-like receptor 2 enhances ZO-1 associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127(1):224\u2013238","journal-title":"Gastroenterology"},{"issue":"9","key":"18_CR10","first-page":"G769","volume":"306","author":"G Aviello","year":"2014","unstructured":"Aviello G, Corr SC, Johnston DGW et al (2014) MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. Am J Physiol 306(9):G769\u2013G778","journal-title":"Am J Physiol"},{"issue":"46","key":"18_CR11","doi-asserted-by":"publisher","first-page":"19967","DOI":"10.1073\/pnas.1014669107","volume":"107","author":"K Brandl","year":"2010","unstructured":"Brandl K, Sun L, Neppl C (2010) MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci 107(46):19967\u201319972","journal-title":"Proc Natl Acad Sci"}],"container-title":["Methods in Molecular Biology","Toll-Like Receptors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-3335-8_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T07:26:40Z","timestamp":1559374000000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-3335-8_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9781493933334","9781493933358"],"references-count":11,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-3335-8_18","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"24 January 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}