{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T21:09:17Z","timestamp":1794517757081,"version":"4.9.1"},"publisher-location":"New York, NY","reference-count":19,"publisher":"Springer New York","isbn-type":[{"value":"9781493936595","type":"print"},{"value":"9781493936618","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-1-4939-3661-8_13","type":"book-chapter","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T06:04:12Z","timestamp":1462428252000},"page":"225-243","source":"Crossref","is-referenced-by-count":19,"title":["Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research"],"prefix":"10.1007","author":[{"given":"Cong","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"13_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nrc1567","volume":"5","author":"R Ren","year":"2005","unstructured":"Ren R (2005) Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 5:172\u2013183","journal-title":"Nat Rev Cancer"},{"key":"13_CR2","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood.V91.7.2406","volume":"91","author":"JC Wang","year":"1998","unstructured":"Wang JC et al (1998) High level engraftment of NOD\/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood 91:2406\u20132414","journal-title":"Blood"},{"key":"13_CR3","first-page":"85","volume":"25","author":"PC Nowell","year":"1960","unstructured":"Nowell PC, Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85\u2013109","journal-title":"J Natl Cancer Inst"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"JD Rowley","year":"1973","unstructured":"Rowley JD (1973) Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243:290\u2013293","journal-title":"Nature"},{"key":"13_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","volume":"36","author":"J Groffen","year":"1984","unstructured":"Groffen J et al (1984) Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93\u201399","journal-title":"Cell"},{"key":"13_CR6","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1038\/leu.2010.143","volume":"24","author":"Y Chen","year":"2010","unstructured":"Chen Y, Peng C, Sullivan C, Li D, Li S (2010) Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia 24:1545\u20131554","journal-title":"Leukemia"},{"key":"13_CR7","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1128\/MCB.9.7.2798","volume":"9","author":"IK Hariharan","year":"1989","unstructured":"Hariharan IK et al (1989) A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol Cell Biol 9:2798\u20132805","journal-title":"Mol Cell Biol"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF02512996","volume":"1","author":"N Heisterkamp","year":"1991","unstructured":"Heisterkamp N, Jenster G, Kioussis D, Pattengale PK, Groffen J (1991) Human bcr-abl gene has a lethal effect on embryogenesis. Transgenic Res 1:45\u201353","journal-title":"Transgenic Res"},{"key":"13_CR9","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1182\/blood.V90.6.2168","volume":"90","author":"A Castellanos","year":"1997","unstructured":"Castellanos A et al (1997) A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Blood 90:2168\u20132174","journal-title":"Blood"},{"key":"13_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1182\/blood-2002-10-3182","volume":"102","author":"K Inokuchi","year":"2003","unstructured":"Inokuchi K et al (2003) Myeloproliferative disease in transgenic mice expressing P230 Bcr\/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. Blood 102:320\u2013323","journal-title":"Blood"},{"key":"13_CR11","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1126\/science.2406902","volume":"247","author":"GQ Daley","year":"1990","unstructured":"Daley GQ, Van Etten RA, Baltimore D (1990) Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome. Science 247:824\u2013830","journal-title":"Science"},{"key":"13_CR12","doi-asserted-by":"publisher","first-page":"6649","DOI":"10.1073\/pnas.87.17.6649","volume":"87","author":"MA Kelliher","year":"1990","unstructured":"Kelliher MA, McLaughlin J, Witte ON, Rosenberg N (1990) Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR\/ABL. Proc Natl Acad Sci U S A 87:6649\u20136653","journal-title":"Proc Natl Acad Sci U S A"},{"key":"13_CR13","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1084\/jem.189.9.1399","volume":"189","author":"S Li","year":"1999","unstructured":"Li S, Ilaria RL Jr, Million RP, Daley GQ, Van Etten RA (1999) The P190, P210, and P230 forms of the BCR\/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 189:1399\u20131412","journal-title":"J Exp Med"},{"key":"13_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/ng1343","volume":"36","author":"Y Hu","year":"2004","unstructured":"Hu Y et al (2004) Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 36:453\u2013461","journal-title":"Nat Genet"},{"key":"13_CR15","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1182\/blood-2006-10-054098","volume":"110","author":"C Peng","year":"2007","unstructured":"Peng C et al (2007) Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells. Blood 110:678\u2013685","journal-title":"Blood"},{"key":"13_CR16","doi-asserted-by":"publisher","first-page":"16870","DOI":"10.1073\/pnas.0606509103","volume":"103","author":"Y Hu","year":"2006","unstructured":"Hu Y et al (2006) Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A 103:16870\u201316875","journal-title":"Proc Natl Acad Sci U S A"},{"key":"13_CR17","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature04703","volume":"441","author":"OH Yilmaz","year":"2006","unstructured":"Yilmaz OH et al (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441:475\u2013482","journal-title":"Nature"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nature04747","volume":"441","author":"J Zhang","year":"2006","unstructured":"Zhang J et al (2006) PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441:518\u2013522","journal-title":"Nature"},{"key":"13_CR19","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1182\/blood-2009-06-228130","volume":"115","author":"C Peng","year":"2010","unstructured":"Peng C et al (2010) PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood 115:626\u2013635","journal-title":"Blood"}],"container-title":["Methods in Molecular Biology","Mouse Models for Drug Discovery"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-3661-8_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T08:41:43Z","timestamp":1600504903000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-3661-8_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9781493936595","9781493936618"],"references-count":19,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-3661-8_13","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4939-3661-8","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}