{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T23:41:03Z","timestamp":1794526863704,"version":"4.9.1"},"publisher-location":"New York, NY","reference-count":8,"publisher":"Springer New York","isbn-type":[{"value":"9781493936854","type":"print"},{"value":"9781493936878","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-1-4939-3687-8_9","type":"book-chapter","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:11:41Z","timestamp":1469578301000},"page":"119-139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["In Vitro Modeling of RSV Infection and Cytopathogenesis in Well-Differentiated Human Primary Airway Epithelial Cells (WD-PAECs)"],"prefix":"10.1007","author":[{"given":"Lindsay","family":"Broadbent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Villenave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo-Parke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ultan F.","family":"Power","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1128\/JVI.76.11.5654-5666.2002","volume":"76","author":"L Zhang","year":"2002","unstructured":"Zhang L, Peeples ME, Boucher RC et al (2002) Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology. J Virol 76:5654\u20135666. doi:\n                  10.1128\/JVI.76.11.5654-5666.2002","journal-title":"J Virol"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.tim.2013.02.004","volume":"21","author":"R Villenave","year":"2013","unstructured":"Villenave R, Shields MD, Power UF (2013) Respiratory syncytial virus interaction with human airway epithelium. Trends Microbiol 21:238\u2013244. doi:\n                  10.1016\/j.tim.2013.02.004","journal-title":"Trends Microbiol"},{"key":"9_CR3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1165\/ajrcmb.14.1.8534481","volume":"14","author":"TE Gray","year":"1996","unstructured":"Gray TE, Guzman K, Davis CW et al (1996) Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 14:104\u2013112. doi:\n                  10.1165\/ajrcmb.14.1.8534481","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9_CR4","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.1073\/pnas.1110203109","volume":"109","author":"R Villenave","year":"2012","unstructured":"Villenave R, Thavagnanam S, Sarlang S et al (2012) In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo. Proc Natl Acad Sci 109:5040\u20135045. doi:\n                  10.1073\/pnas.1110203109","journal-title":"Proc Natl Acad Sci"},{"key":"9_CR5","doi-asserted-by":"publisher","first-page":"L25","DOI":"10.1152\/ajplung.00256.2010","volume":"300","author":"AA Pezzulo","year":"2011","unstructured":"Pezzulo AA, Starner TD, Scheetz TE et al (2011) The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol 300:L25\u2013L31. doi:\n                  10.1152\/ajplung.00256.2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9_CR6","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1164\/rccm.201304-0750OC","volume":"188","author":"H Guo-Parke","year":"2013","unstructured":"Guo-Parke H, Canning P, Douglas I et al (2013) Relative respiratory syncytial virus cytopathogenesis in upper and lower respiratory tract epithelium. Am J Respir Crit Care Med 188:842\u2013851. doi:\n                  10.1164\/rccm.201304-0750OC","journal-title":"Am J Respir Crit Care Med"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1164\/rccm.201308-1491ED","volume":"188","author":"RA Tripp","year":"2013","unstructured":"Tripp RA (2013) Modeling respiratory syncytial virus cytopathogenesis in the human airway. Am J Respir Crit Care Med 188:766\u2013767. doi:\n                  10.1164\/rccm.201308-1491ED","journal-title":"Am J Respir Crit Care Med"},{"key":"9_CR8","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1046\/j.1365-2222.2003.01752.x","volume":"33","author":"GM Doherty","year":"2003","unstructured":"Doherty GM, Christie SN, Skibinski G et al (2003) Non-bronchoscopic sampling and culture of bronchial epithelial cells in children. Clin Exp Allergy 33:1221\u20131225. doi:\n                  10.1046\/j.1365-2222.2003.01752.x","journal-title":"Clin Exp Allergy"}],"container-title":["Methods in Molecular Biology","Human Respiratory Syncytial Virus"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-3687-8_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T23:38:08Z","timestamp":1558049888000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-3687-8_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9781493936854","9781493936878"],"references-count":8,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-3687-8_9","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4939-3687-8","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"28 July 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}