{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T18:23:25Z","timestamp":1750875805013,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":16,"publisher":"Springer New York","isbn-type":[{"type":"print","value":"9781493966233"},{"type":"electronic","value":"9781493966257"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-6625-7_28","type":"book-chapter","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T07:13:27Z","timestamp":1485155607000},"page":"355-367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Endothelial Dysfunction In Vivo"],"prefix":"10.1007","author":[{"given":"Mihail","family":"Todiras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Alenina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"28_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1113\/jphysiol.1983.sp014934","volume":"344","author":"JA Angus","year":"1983","unstructured":"Angus JA, Campbell GR, Cocks TM, Manderson JA (1983) Vasodilatation by acetylcholine is endothelium-dependent: a study by sonomicrometry in canine femoral artery in vivo. J Physiol 344:209\u2013222","journal-title":"J Physiol"},{"key":"28_CR2","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1253\/circj.67.572","volume":"67","author":"PM Vanhoutte","year":"2003","unstructured":"Vanhoutte PM (2003) Endothelial control of vasomotor function: from health to coronary disease. Circ J 67:572\u2013575","journal-title":"Circ J"},{"key":"28_CR3","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","volume":"87","author":"M Donoghue","year":"2000","unstructured":"Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S (2000) A novel angiotensin converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 87:E1\u20139","journal-title":"Circ Res"},{"issue":"2","key":"28_CR4","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JOE-12-0341","volume":"216","author":"RA Santos","year":"2013","unstructured":"Santos RA, Ferreira AJ, Verano-Braga T, Bader M (2013) Angiotensin-converting enzyme 2, Angiotensin-(1-7) and Mas: new players of the Renin Angiotensin System. J Endocrinol 216(2):R1\u2013R17","journal-title":"J Endocrinol"},{"key":"28_CR5","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1073\/pnas.1432869100","volume":"100","author":"RA Santos","year":"2003","unstructured":"Santos RA, Simoes-e-Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A 100:8258\u20138263","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28_CR6","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1161\/01.HYP.0000174594.17052.33","volume":"46","author":"R Faria-Silva","year":"2005","unstructured":"Faria-Silva R, Duarte FV, Santos RA (2005) Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension 46:948\u2013952","journal-title":"Hypertension"},{"key":"28_CR7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","volume":"49","author":"WO Sampaio","year":"2007","unstructured":"Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49:185\u2013192","journal-title":"Hypertension"},{"key":"28_CR8","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1161\/HYPERTENSIONAHA.107.102764","volume":"51","author":"P Xu","year":"2008","unstructured":"Xu P, Costa-Goncalves AC, Todiras M, Rabelo LA, Sampaio WO, Moura MM, Santos SS, Luft FC, Bader M, Gross V, Alenina N, Santos RA (2008) Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice. Hypertension 51:574\u2013580","journal-title":"Hypertension"},{"key":"28_CR9","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jash.2008.05.003","volume":"2","author":"LA Rabelo","year":"2008","unstructured":"Rabelo LA, Xu P, Todiras M, Sampaio WO, Buttgereit J, Bader M, Santos RA, Alenina N (2008) Ablation of angiotensin (1-7) receptor Mas in C57Bl\/6 mice causes endothelial dysfunction. J Am Soc Hypertens 2:418\u2013424","journal-title":"J Am Soc Hypertens"},{"key":"28_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/hr.2010.235","volume":"34","author":"LA Rabelo","year":"2011","unstructured":"Rabelo LA, Alenina N, Bader M (2011) ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease. Hypertens Res 34:154\u2013160","journal-title":"Hypertens Res"},{"key":"28_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/BF03086167","volume":"16","author":"BE Langeveld","year":"2008","unstructured":"Langeveld BE, Henning RH, de Smet BJ, Zijlstra F, Driessen A, Tijsma E, van Gilst WH, Roks A (2008) Rescue of arterial function by angiotensin-(1-7): towards improvement of endothelial function by drug-eluting stents. Neth Heart J 16:293\u2013298","journal-title":"Neth Heart J"},{"key":"28_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-1-59745-571-8_14","volume":"139","author":"R Scalia","year":"2007","unstructured":"Scalia R (2007) Evaluation of endothelial function by in vivo microscopy. Methods Mol Med 139:225\u2013235","journal-title":"Methods Mol Med"},{"key":"28_CR13","doi-asserted-by":"publisher","first-page":"H1072","DOI":"10.1152\/ajpheart.00072.2007","volume":"293","author":"SM Fitzgerald","year":"2007","unstructured":"Fitzgerald SM, Bashari H, Cox JA, Parkington HC, Evans RG (2007) Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo. Am J Physiol Heart Circ Physiol 293:H1072\u2013H1082","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"28_CR14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/MBC.0b013e328331fd18","volume":"20","author":"Y Tamura","year":"2009","unstructured":"Tamura Y, Naemura A, Inoue A, Ijiri Y, Seki J, Yada T, Goto M, Shinohara M, Kawashima S, Giddings JC, Yamamoto J (2009) Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic\/atherogenic mice. Blood Coagul Fibrinolysis 20:699\u2013705","journal-title":"Blood Coagul Fibrinolysis"},{"key":"28_CR15","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.jvs.2010.10.128","volume":"53","author":"CH Wang","year":"2011","unstructured":"Wang CH, Chen KT, Mei HF, Lee JF, Cherng WJ, Lin SJ (2011) Assessment of mouse hind limb endothelial function by measuring femoral artery blood flow responses. J Vasc Surg 53:1350\u20131358","journal-title":"J Vasc Surg"},{"key":"28_CR16","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1161\/HYPERTENSIONAHA.108.114322","volume":"52","author":"B Rentzsch","year":"2008","unstructured":"Rentzsch B, Todiras M, Iliescu R, Popova E, Campos LA, Oliveira ML, Baltatu OC, Santos RA, Bader M (2008) Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. Hypertension 52:967\u2013973","journal-title":"Hypertension"}],"container-title":["Methods in Molecular Biology","Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-6625-7_28","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T01:05:52Z","timestamp":1558055152000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-6625-7_28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493966233","9781493966257"],"references-count":16,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-6625-7_28","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"24 January 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}