{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:07:09Z","timestamp":1794316029252,"version":"4.9.0"},"publisher-location":"New York, NY","reference-count":68,"publisher":"Springer New York","isbn-type":[{"value":"9781493967544","type":"print"},{"value":"9781493967568","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-6756-8_23","type":"book-chapter","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T03:51:53Z","timestamp":1487735513000},"page":"293-304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair"],"prefix":"10.1007","author":[{"given":"Honghai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"issue":"1","key":"23_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.athoracsur.2005.02.072","volume":"80","author":"YL Tang","year":"2005","unstructured":"Tang YL et al (2005) Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 80(1):229\u2013236 discussion 236-7","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"23_CR2","doi-asserted-by":"publisher","first-page":"H1772","DOI":"10.1152\/ajpheart.00242.2007","volume":"293","author":"J Feygin","year":"2007","unstructured":"Feygin J et al (2007) Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation. Am J Physiol Heart Circ Physiol 293(3):H1772\u2013H1780","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"23_CR3","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","volume":"109","author":"T Kinnaird","year":"2004","unstructured":"Kinnaird T et al (2004) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109(12):1543\u20131549","journal-title":"Circulation"},{"issue":"6","key":"23_CR4","doi-asserted-by":"publisher","first-page":"H2196","DOI":"10.1152\/ajpheart.01017.2005","volume":"290","author":"MF Berry","year":"2006","unstructured":"Berry MF et al (2006) Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 290(6):H2196\u2013H2203","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"23_CR5","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1056\/NEJMoa060186","volume":"355","author":"V Schachinger","year":"2006","unstructured":"Schachinger V et al (2006) Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355(12):1210\u20131221","journal-title":"N Engl J Med"},{"issue":"10","key":"23_CR6","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1161\/CIRCULATIONAHA.105.575118","volume":"113","author":"GP Meyer","year":"2006","unstructured":"Meyer GP et al (2006) Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months\u2019 follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113(10):1287\u20131294","journal-title":"Circulation"},{"issue":"9429","key":"23_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0140-6736(04)16626-9","volume":"364","author":"KC Wollert","year":"2004","unstructured":"Wollert KC et al (2004) Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364(9429):141\u2013148","journal-title":"Lancet"},{"issue":"9505","key":"23_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0140-6736(05)67861-0","volume":"367","author":"S Janssens","year":"2006","unstructured":"Janssens S et al (2006) Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367(9505):113\u2013121","journal-title":"Lancet"},{"issue":"5","key":"23_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/CIRCRESAHA.113.301202","volume":"113","author":"JM Duran","year":"2013","unstructured":"Duran JM et al (2013) Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res 113(5):539\u2013552","journal-title":"Circ Res"},{"issue":"2","key":"23_CR10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1161\/CIRCRESAHA.112.270462","volume":"111","author":"MA Thal","year":"2012","unstructured":"Thal MA et al (2012) Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair. Circ Res 111(2):180\u2013190","journal-title":"Circ Res"},{"issue":"7","key":"23_CR11","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1161\/CIRCRESAHA.110.222703","volume":"107","author":"KE Hatzistergos","year":"2010","unstructured":"Hatzistergos KE et al (2010) Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 107(7):913\u2013922","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"23_CR12","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1038\/ncpcardio0417","volume":"3","author":"J Bartunek","year":"2006","unstructured":"Bartunek J et al (2006) Timing of intracoronary bone-marrow-derived stem cell transplantation after ST-elevation myocardial infarction. Nat Clin Pract Cardiovasc Med 3(Suppl 1):S52\u2013S56","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"3","key":"23_CR13","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.ejcts.2006.11.057","volume":"31","author":"X Hu","year":"2007","unstructured":"Hu X et al (2007) Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg 31(3):438\u2013443","journal-title":"Eur J Cardiothorac Surg"},{"issue":"8","key":"23_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/clc.20575","volume":"32","author":"S Zhang","year":"2009","unstructured":"Zhang S et al (2009) Impact of timing on efficacy and safetyof intracoronary autologous bone marrow stem cells transplantation in acute myocardial infarction: a pooled subgroup analysis of randomized controlled trials. Clin Cardiol 32(8):458\u2013466","journal-title":"Clin Cardiol"},{"issue":"10","key":"23_CR15","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1111\/j.1582-4934.2010.01217.x","volume":"15","author":"S Zhang","year":"2011","unstructured":"Zhang S et al (2011) Infarcted myocardium-like stiffness contributes to endothelial progenitor lineage commitment of bone marrow mononuclear cells. J Cell Mol Med 15(10):2245\u20132261","journal-title":"J Cell Mol Med"},{"issue":"20","key":"23_CR16","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1016\/j.biomaterials.2014.03.044","volume":"35","author":"RK Das","year":"2014","unstructured":"Das RK, Zouani OF (2014) A review of the effects of the cell environment physicochemical nanoarchitecture on stem cell commitment. Biomaterials 35(20):5278\u20135293","journal-title":"Biomaterials"},{"issue":"1","key":"23_CR17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/jcp.20274","volume":"204","author":"SR Peyton","year":"2005","unstructured":"Peyton SR, Putnam AJ (2005) Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. J Cell Physiol 204(1):198\u2013209","journal-title":"J Cell Physiol"},{"issue":"5995","key":"23_CR18","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1191035","volume":"329","author":"PM Gilbert","year":"2010","unstructured":"Gilbert PM et al (2010) Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329(5995):1078\u20131081","journal-title":"Science"},{"issue":"1","key":"23_CR19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.stem.2009.06.016","volume":"5","author":"F Guilak","year":"2009","unstructured":"Guilak F et al (2009) Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 5(1):17\u201326","journal-title":"Cell Stem Cell"},{"issue":"8","key":"23_CR20","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1016\/j.bbagen.2014.01.010","volume":"1840","author":"F Gattazzo","year":"2014","unstructured":"Gattazzo F, Urciuolo A, Bonaldo P (2014) Extracellular matrix: a dynamic microenvironment for stem cell niche. Biochim Biophys Acta 1840(8):2506\u20132519","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"23_CR21","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nmat4051","volume":"13","author":"JH Wen","year":"2014","unstructured":"Wen JH et al (2014) Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater 13(10):979\u2013987","journal-title":"Nat Mater"},{"issue":"6","key":"23_CR22","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1161\/01.CIR.77.6.1424","volume":"77","author":"TE Raya","year":"1988","unstructured":"Raya TE et al (1988) Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats. Circulation 77(6):1424\u20131431","journal-title":"Circulation"},{"issue":"8","key":"23_CR23","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1161\/CIRCULATIONAHA.109.850677","volume":"121","author":"RR Chaturvedi","year":"2010","unstructured":"Chaturvedi RR et al (2010) Passive stiffness of myocardium from congenital heart disease and implications for diastole. Circulation 121(8):979\u2013988","journal-title":"Circulation"},{"issue":"1","key":"23_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1755-1536-6-11","volume":"6","author":"Y Ma","year":"2013","unstructured":"Ma Y, Yabluchanskiy A, Lindsey ML (2013) Neutrophil roles in left ventricular remodeling following myocardial infarction. Fibrogenesis Tissue Repair 6(1):11","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"6","key":"23_CR25","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1007\/s12265-012-9398-z","volume":"5","author":"Y Ma","year":"2012","unstructured":"Ma Y, Halade GV, Lindsey ML (2012) Extracellular matrix and fibroblast communication following myocardial infarction. J Cardiovasc Transl Res 5(6):848\u2013857","journal-title":"J Cardiovasc Transl Res"},{"issue":"4","key":"23_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1161\/CIRCRESAHA.111.300502","volume":"112","author":"Y Ma","year":"2013","unstructured":"Ma Y et al (2013) Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circ Res 112(4):675\u2013688","journal-title":"Circ Res"},{"issue":"4","key":"23_CR27","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1582-4934.2009.00710.x","volume":"13","author":"S Zhang","year":"2009","unstructured":"Zhang S et al (2009) A role of myocardial stiffness in cell-based cardiac repair: a hypothesis. J Cell Mol Med 13(4):660\u2013663","journal-title":"J Cell Mol Med"},{"key":"23_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/VHRM.S25665","volume":"8","author":"J Hoover-Plow","year":"2012","unstructured":"Hoover-Plow J, Gong Y (2012) Challenges for heart disease stem cell therapy. Vasc Health Risk Manag 8:99\u2013113","journal-title":"Vasc Health Risk Manag"},{"issue":"7","key":"23_CR29","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1161\/01.CIR.0000084828.50310.6A","volume":"108","author":"IM Barbash","year":"2003","unstructured":"Barbash IM et al (2003) Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108(7):863\u2013868","journal-title":"Circulation"},{"issue":"17","key":"23_CR30","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1161\/01.CIR.0000163546.27639.AA","volume":"111","author":"M Hofmann","year":"2005","unstructured":"Hofmann M et al (2005) Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 111(17):2198\u20132202","journal-title":"Circulation"},{"issue":"2","key":"23_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/01.RES.0000155333.69009.63","volume":"96","author":"KC Wollert","year":"2005","unstructured":"Wollert KC, Drexler H (2005) Clinical applications of stem cells for the heart. Circ Res 96(2):151\u2013163","journal-title":"Circ Res"},{"issue":"1","key":"23_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/jcb.21277","volume":"102","author":"H Qian","year":"2007","unstructured":"Qian H et al (2007) Intracoronary delivery of autologous bone marrow mononuclear cells radiolabeled by 18F-fluoro-deoxy-glucose: tissue distribution and impact on post-infarct swine hearts. J Cell Biochem 102(1):64\u201374","journal-title":"J Cell Biochem"},{"issue":"3","key":"23_CR33","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3727\/096368909788534915","volume":"18","author":"TP Martens","year":"2009","unstructured":"Martens TP et al (2009) Percutaneous cell delivery into the heart using hydrogels polymerizing in situ. Cell Transplant 18(3):297\u2013304","journal-title":"Cell Transplant"},{"issue":"5","key":"23_CR34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1006\/jmcc.2001.1367","volume":"33","author":"M Zhang","year":"2001","unstructured":"Zhang M et al (2001) Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J Mol Cell Cardiol 33(5):907\u2013921","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"23_CR35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/hc0102.101442","volume":"105","author":"C Toma","year":"2002","unstructured":"Toma C et al (2002) Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105(1):93\u201398","journal-title":"Circulation"},{"issue":"9 Suppl","key":"23_CR36","first-page":"I150","volume":"112","author":"D Hou","year":"2005","unstructured":"Hou D et al (2005) Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation 112(9 Suppl):I150\u2013I156","journal-title":"Circulation"},{"issue":"49","key":"23_CR37","doi-asserted-by":"publisher","first-page":"18534","DOI":"10.1073\/pnas.0605960103","volume":"103","author":"HJ Kong","year":"2006","unstructured":"Kong HJ, Boontheekul T, Mooney DJ (2006) Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype. Proc Natl Acad Sci U S A 103(49):18534\u201318539","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5751","key":"23_CR38","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1126\/science.1116995","volume":"310","author":"DE Discher","year":"2005","unstructured":"Discher DE, Janmey P, Wang YL (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310(5751):1139\u20131143","journal-title":"Science"},{"issue":"26","key":"23_CR39","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.1016\/j.biomaterials.2011.04.003","volume":"32","author":"AR Cameron","year":"2011","unstructured":"Cameron AR, Frith JE, Cooper-White JJ (2011) The influence of substrate creep on mesenchymal stem cell behaviour and phenotype. Biomaterials 32(26):5979\u20135993","journal-title":"Biomaterials"},{"key":"23_CR40","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.biomaterials.2015.01.021","volume":"49","author":"Y Navaro","year":"2015","unstructured":"Navaro Y et al (2015) Matrix stiffness determines the fate of nucleus pulposus-derived stem cells. Biomaterials 49:68\u201376","journal-title":"Biomaterials"},{"issue":"5935","key":"23_CR41","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1126\/science.1171643","volume":"324","author":"DE Discher","year":"2009","unstructured":"Discher DE, Mooney DJ, Zandstra PW (2009) Growth factors, matrices, and forces combine and control stem cells. Science 324(5935):1673\u20131677","journal-title":"Science"},{"issue":"4","key":"23_CR42","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","volume":"126","author":"AJ Engler","year":"2006","unstructured":"Engler AJ et al (2006) Matrix elasticity directs stem cell lineage specification. Cell 126(4):677\u2013689","journal-title":"Cell"},{"issue":"3","key":"23_CR43","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/cvr\/cvq005","volume":"86","author":"S Walsh","year":"2010","unstructured":"Walsh S et al (2010) Cardiomyocyte cell cycle control and growth estimation in vivo\u2014an analysis based on cardiomyocyte nuclei. Cardiovasc Res 86(3):365\u2013373","journal-title":"Cardiovasc Res"},{"issue":"1","key":"23_CR44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jbiomech.2009.09.014","volume":"43","author":"JG Jacot","year":"2010","unstructured":"Jacot JG, Martin JC, Hunt DL (2010) Mechanobiology of cardiomyocyte development. J Biomech 43(1):93\u201398","journal-title":"J Biomech"},{"issue":"4","key":"23_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094764","volume":"9","author":"A Shkumatov","year":"2014","unstructured":"Shkumatov A, Baek K, Kong H (2014) Matrix rigidity-modulated cardiovascular organoid formation from embryoid bodies. PLoS One 9(4):e94764","journal-title":"PLoS One"},{"issue":"Pt 22","key":"23_CR46","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1242\/jcs.029678","volume":"121","author":"AJ Engler","year":"2008","unstructured":"Engler AJ et al (2008) Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci 121(Pt 22):3794\u20133802","journal-title":"J Cell Sci"},{"issue":"41","key":"23_CR47","doi-asserted-by":"publisher","first-page":"12705","DOI":"10.1073\/pnas.1508073112","volume":"112","author":"AJ Ribeiro","year":"2015","unstructured":"Ribeiro AJ et al (2015) Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A 112(41):12705\u201312710","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7347","key":"23_CR48","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature10147","volume":"473","author":"MA Laflamme","year":"2011","unstructured":"Laflamme MA, Murry CE (2011) Heart regeneration. Nature 473(7347):326\u2013335","journal-title":"Nature"},{"issue":"4\u20135","key":"23_CR49","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.addr.2011.01.007","volume":"63","author":"CV Bouten","year":"2011","unstructured":"Bouten CV et al (2011) Substrates for cardiovascular tissue engineering. Adv Drug Deliv Rev 63(4\u20135):221\u2013241","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"23_CR50","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.transproceed.2014.12.030","volume":"47","author":"KM Lee","year":"2015","unstructured":"Lee KM et al (2015) Natural cardiac extracellular matrix sheet as a biomaterial for cardiomyocyte transplantation. Transplant Proc 47(3):751\u2013756","journal-title":"Transplant Proc"},{"issue":"2","key":"23_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090406","volume":"9","author":"MJ Robertson","year":"2014","unstructured":"Robertson MJ et al (2014) Optimizing recellularization of whole decellularized heart extracellular matrix. PLoS One 9(2):e90406","journal-title":"PLoS One"},{"issue":"8","key":"23_CR52","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jacc.2011.10.888","volume":"59","author":"JM Singelyn","year":"2012","unstructured":"Singelyn JM et al (2012) Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol 59(8):751\u2013763","journal-title":"J Am Coll Cardiol"},{"key":"23_CR53","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1038\/ncomms4935","volume":"5","author":"F Pati","year":"2014","unstructured":"Pati F et al (2014) Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink. Nat Commun 5:3935","journal-title":"Nat Commun"},{"issue":"10","key":"23_CR54","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/01.RES.0000039537.73816.E5","volume":"91","author":"DE Ingber","year":"2002","unstructured":"Ingber DE (2002) Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circ Res 91(10):877\u2013887","journal-title":"Circ Res"},{"issue":"5","key":"23_CR55","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nmat3586","volume":"12","author":"S Khetan","year":"2013","unstructured":"Khetan S et al (2013) Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater 12(5):458\u2013465","journal-title":"Nat Mater"},{"issue":"6","key":"23_CR56","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nmat2732","volume":"9","author":"N Huebsch","year":"2010","unstructured":"Huebsch N et al (2010) Harnessing traction-mediated manipulation of the cell\/matrix interface to control stem-cell fate. Nat Mater 9(6):518\u2013526","journal-title":"Nat Mater"},{"issue":"5","key":"23_CR57","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/10937400600681430","volume":"9","author":"JH Exon","year":"2006","unstructured":"Exon JH (2006) A review of the toxicology of acrylamide. J Toxicol Environ Health B Crit Rev 9(5):397\u2013412","journal-title":"J Toxicol Environ Health B Crit Rev"},{"issue":"33","key":"23_CR58","doi-asserted-by":"publisher","first-page":"8042","DOI":"10.1016\/j.biomaterials.2013.06.061","volume":"34","author":"MC Darnell","year":"2013","unstructured":"Darnell MC et al (2013) Performance and biocompatibility of extremely tough alginate\/polyacrylamide hydrogels. Biomaterials 34(33):8042\u20138048","journal-title":"Biomaterials"},{"issue":"3","key":"23_CR59","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.jacc.2004.04.040","volume":"44","author":"KL Christman","year":"2004","unstructured":"Christman KL et al (2004) Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol 44(3):654\u2013660","journal-title":"J Am Coll Cardiol"},{"key":"23_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.12","volume":"5","author":"C Bearzi","year":"2014","unstructured":"Bearzi C et al (2014) PlGF-MMP9-engineered iPS cells supported on a PEG-fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium. Cell Death Dis 5:e1053","journal-title":"Cell Death Dis"},{"issue":"3","key":"23_CR61","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jtcvs.2014.06.038","volume":"148","author":"P Atluri","year":"2014","unstructured":"Atluri P et al (2014) Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function. J Thorac Cardiovasc Surg 148(3):1090\u20131097 discussion 1097-8","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"23_CR62","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2005.05.010","volume":"122","author":"CA Collins","year":"2005","unstructured":"Collins CA et al (2005) Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell 122(2):289\u2013301","journal-title":"Cell"},{"issue":"8","key":"23_CR63","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1016\/j.actbio.2009.04.040","volume":"5","author":"T Wang","year":"2009","unstructured":"Wang T et al (2009) Bone marrow stem cells implantation with alpha-cyclodextrin\/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction. Acta Biomater 5(8):2939\u20132944","journal-title":"Acta Biomater"},{"key":"23_CR64","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.biomaterials.2015.06.009","volume":"63","author":"S Lee","year":"2015","unstructured":"Lee S et al (2015) Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes. Biomaterials 63:158\u2013167","journal-title":"Biomaterials"},{"issue":"6368","key":"23_CR65","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/356435a0","volume":"356","author":"E Gussoni","year":"1992","unstructured":"Gussoni E et al (1992) Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Nature 356(6368):435\u2013438","journal-title":"Nature"},{"issue":"4","key":"23_CR66","doi-asserted-by":"publisher","first-page":"C1037","DOI":"10.1152\/ajpcell.67.2008","volume":"295","author":"AS Rowlands","year":"2008","unstructured":"Rowlands AS, George PA, Cooper-White JJ (2008) Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation. Am J Physiol Cell Physiol 295(4):C1037\u2013C1044","journal-title":"Am J Physiol Cell Physiol"},{"issue":"25","key":"23_CR67","doi-asserted-by":"publisher","first-page":"13661","DOI":"10.1073\/pnas.94.25.13661","volume":"94","author":"RJ Pelham Jr","year":"1997","unstructured":"Pelham RJ Jr (1997) and Y. Wang, Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A 94(25):13661\u201313665","journal-title":"Proc Natl Acad Sci U S A"},{"key":"23_CR68","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0091-679X(02)69021-1","volume":"69","author":"KA Beningo","year":"2002","unstructured":"Beningo KA, Lo CM, Wang YL (2002) Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions. Methods Cell Biol 69:325\u2013339","journal-title":"Methods Cell Biol"}],"container-title":["Methods in Molecular Biology","Adult Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-6756-8_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T15:43:25Z","timestamp":1558107805000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-6756-8_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493967544","9781493967568"],"references-count":68,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-6756-8_23","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-1-4939-6756-8","asserted-by":"object"}]},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"23 February 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}