{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:28:22Z","timestamp":1789568902361,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":31,"publisher":"Springer New York","isbn-type":[{"value":"9781493968381","type":"print"},{"value":"9781493968404","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-6840-4_18","type":"book-chapter","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T03:01:20Z","timestamp":1487991680000},"page":"261-278","source":"Crossref","is-referenced-by-count":41,"title":["Electrospun Nanofiber Scaffolds and Their Hydrogel Composites for the Engineering and Regeneration of Soft Tissues"],"prefix":"10.1007","author":[{"given":"Ohan S.","family":"Manoukian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Matta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustus D.","family":"Mazzocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangamesh G.","family":"Kumbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,26]]},"reference":[{"issue":"2","key":"18_CR1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1115\/1.2891223","volume":"113","author":"F Heineken","year":"1991","unstructured":"Heineken F, Skalak R (1991) Tissue engineering: a brief overview. J Biomech Eng 113(2):111\u2013112","journal-title":"J Biomech Eng"},{"key":"18_CR2","doi-asserted-by":"crossref","unstructured":"Yost MJ, Price RL, Simpson DG, Yan W, Terracio L (2008) Cardiac patch engineering. Encyclopedia of biomaterials and biomedical engineering, 2nd edn. p 542\u2013551","DOI":"10.1201\/b18990-52"},{"issue":"6","key":"18_CR3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/mus.21220","volume":"39","author":"EL Whitlock","year":"2009","unstructured":"Whitlock EL, Tuffaha SH, Luciano JP, Yan Y, Hunter DA, Magill CK, Moore AM, Tong AY, Mackinnon SE, Borschel GH (2009) Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve 39(6):787\u2013799","journal-title":"Muscle Nerve"},{"issue":"1","key":"18_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.expneurol.2009.03.031","volume":"223","author":"WZ Ray","year":"2010","unstructured":"Ray WZ, Mackinnon SE (2010) Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol 223(1):77\u201385. doi:\n10.1016\/j.expneurol.2009.03.031","journal-title":"Exp Neurol"},{"issue":"1","key":"18_CR5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhsa.2007.09.007","volume":"33","author":"R James","year":"2008","unstructured":"James R, Kesturu G, Balian G, Chhabra AB (2008) Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options. J Hand Surg Am 33(1):102\u2013112","journal-title":"J Hand Surg Am"},{"issue":"3","key":"18_CR6","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.msec.2006.05.019","volume":"27","author":"J Lannutti","year":"2007","unstructured":"Lannutti J, Reneker D, Ma T, Tomasko D, Farson D (2007) Electrospinning for tissue engineering scaffolds. Mater Sci Eng C 27(3):504\u2013509","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"18_CR7","doi-asserted-by":"crossref","first-page":"034002","DOI":"10.1088\/1748-6041\/3\/3\/034002","volume":"3","author":"S Kumbar","year":"2008","unstructured":"Kumbar S, James R, Nukavarapu S, Laurencin C (2008) Electrospun nanofiber scaffolds: engineering soft tissues. Biomed Mater 3(3):034002","journal-title":"Biomed Mater"},{"issue":"9\u201310","key":"18_CR8","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1166\/jnn.2006.462","volume":"6","author":"SG Kumbar","year":"2006","unstructured":"Kumbar SG, Nair LS, Bhattacharyya S, Laurencin CT (2006) Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules. J Nanosci Nanotechnol 6(9\u201310):2591\u20132607","journal-title":"J Nanosci Nanotechnol"},{"issue":"1","key":"18_CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jbm.b.30641","volume":"81","author":"SG Kumbar","year":"2007","unstructured":"Kumbar SG, Bhattacharyya S, Sethuraman S, Laurencin CT (2007) A preliminary report on a novel electrospray technique for nanoparticle based biomedical implants coating: precision electrospraying. J Biomed Mater Res B Appl Biomater 81(1):91\u2013103","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"30","key":"18_CR10","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1016\/j.biomaterials.2008.06.028","volume":"29","author":"SG Kumbar","year":"2008","unstructured":"Kumbar SG, Nukavarapu SP, James R, Nair LS, Laurencin CT (2008) Electrospun poly (lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials 29(30):4100\u20134107","journal-title":"Biomaterials"},{"issue":"7","key":"18_CR11","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1089\/ten.2006.12.1775","volume":"12","author":"W-J Li","year":"2006","unstructured":"Li W-J, Jiang YJ, Tuan RS (2006) Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng 12(7):1775\u20131785","journal-title":"Tissue Eng"},{"issue":"2","key":"18_CR12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jbm.b.30041","volume":"70","author":"DS Katti","year":"2004","unstructured":"Katti DS, Robinson KW, Ko FK, Laurencin CT (2004) Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res B Appl Biomater 70(2):286\u2013296","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"18_CR13","doi-asserted-by":"crossref","first-page":"013002","DOI":"10.1088\/1468-6996\/12\/1\/013002","volume":"12","author":"WE Teo","year":"2016","unstructured":"Teo WE, Inai R, Ramakrishna S (2016) Technological advances in electrospinning of nanofibers. Sci Technol Adv Mater 12:013002","journal-title":"Sci Technol Adv Mater"},{"key":"18_CR14","doi-asserted-by":"publisher","unstructured":"Guadalupe E, Ramos D, Shelke NB, James R, Gibney C, Kumbar SG (2015) Bioactive polymeric nanofiber matrices for skin regeneration. J Appl Polym Sci 132. doi:\n10.1002\/app.41879","DOI":"10.1002\/app.41879"},{"issue":"2","key":"18_CR15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1166\/jbn.2014.1753","volume":"10","author":"Y Cheng","year":"2014","unstructured":"Cheng Y, Ramos D, Lee P, Liang D, Yu X, Kumbar SG (2014) Collagen functionalized bioactive nanofiber matrices for osteogenic differentiation of mesenchymal stem cells: bone tissue engineering. J Biomed Nanotechnol 10(2):287\u2013298","journal-title":"J Biomed Nanotechnol"},{"issue":"19","key":"18_CR16","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/j.biomaterials.2008.03.031","volume":"29","author":"JS Choi","year":"2008","unstructured":"Choi JS, Lee SJ, Christ GJ, Atala A, Yoo JJ (2008) The influence of electrospun aligned poly(\u025b-Caprolactone)\/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 29(19):2899\u20132906","journal-title":"Biomaterials"},{"issue":"76","key":"18_CR17","doi-asserted-by":"crossref","first-page":"72246","DOI":"10.1039\/C6RA08449D","volume":"6","author":"P Lee","year":"2016","unstructured":"Lee P, Manoukian OS, Zhou G, Wang Y, Chang W, Yu X, Kumbar SG (2016) Osteochondral scaffold combined with aligned nanofibrous scaffolds for cartilage regeneration. RSC Adv 6(76):72246\u201372255","journal-title":"RSC Adv"},{"issue":"1","key":"18_CR18","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/pat.3594","volume":"27","author":"NB Shelke","year":"2016","unstructured":"Shelke NB, Lee P, Anderson M, Mistry N, Nagarale RK, Ma X, Yi X, Kumbar SG (2016) Neural tissue engineering: nanofiber-hydrogel based composite scaffolds. Polym Adv Technol 27(1):42\u201351. doi:\n10.1002\/pat.3594","journal-title":"Polym Adv Technol"},{"issue":"5","key":"18_CR19","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/pat.3266","volume":"25","author":"NB Shelke","year":"2014","unstructured":"Shelke NB, James R, Laurencin CT, Kumbar SG (2014) Polysaccharide biomaterials for drug delivery and regenerative engineering. Polym Adv Technol 25(5):448\u2013460","journal-title":"Polym Adv Technol"},{"issue":"4","key":"18_CR20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/(SICI)1097-0290(19960520)50:4<357::AID-BIT2>3.3.CO;2-F","volume":"50","author":"AC Jen","year":"1996","unstructured":"Jen AC, Wake MC, Mikos AG (1996) Review: hydrogels for cell immobilization. Biotechnol Bioeng 50(4):357\u2013364","journal-title":"Biotechnol Bioeng"},{"issue":"2","key":"18_CR21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/app.12675","volume":"90","author":"SG Kumbar","year":"2003","unstructured":"Kumbar SG, Dave AM, Aminabhavi TM (2003) Release kinetics and diffusion coefficients of solid and liquid pesticides through interpenetrating polymer network beads of polyacrylamide-g-guar gum with sodium alginate. J Appl Polym Sci 90(2):451\u2013457","journal-title":"J Appl Polym Sci"},{"issue":"6","key":"18_CR22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3109\/10837450.2011.583927","volume":"17","author":"S Mao","year":"2012","unstructured":"Mao S, Zhang T, Sun W, Ren X (2012) The depolymerization of sodium alginate by oxidative degradation. Pharm Dev Technol 17(6):763\u2013769","journal-title":"Pharm Dev Technol"},{"key":"18_CR23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/jbm.a.31408","volume":"83","author":"B Duan","year":"2007","unstructured":"Duan B, Wu L, Yuan X, Hu Z, Li X, Zhang Y, Yao K, Wang M (2007) Hybrid nanofibrous membranes of PLGA\/Chitosan fabricated via an electrospinning array. J Biomed Mater Res A 83:868\u2013878","journal-title":"J Biomed Mater Res A"},{"issue":"11","key":"18_CR24","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1166\/jbn.2015.2100","volume":"11","author":"D Jaiswal","year":"2015","unstructured":"Jaiswal D, Roshan J, Shelke NB, Harmon MD, Brown JL, Hussain F, Kumbar SG (2015) Gelatin nanofiber matrices derived from Schiff base derivative for tissue engineering applications. J Biomed Nanotechnol 11(11):2067\u20132080. doi:\n10.1166\/jbn.2015.2100","journal-title":"J Biomed Nanotechnol"},{"key":"18_CR25","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.jbiomech.2006.09.004","volume":"40","author":"WJ Li","year":"2007","unstructured":"Li WJ, Mauck RL, Cooper JA, Yuan X, Tuan RS (2007) Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 40:1686\u20131693","journal-title":"J Biomech"},{"key":"18_CR26","doi-asserted-by":"crossref","unstructured":"Anderson M, Shelke NB, Manoukian OS, Yu X, McCullough LD, Kumbar SG (2015) Peripheral nerve regeneration strategies: electrically stimulating polymer based nerve growth conduits. Crit Rev Biomed Eng 43(2\u20133)","DOI":"10.1615\/CritRevBiomedEng.2015014015"},{"key":"18_CR27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11010-007-9417-6","volume":"301","author":"I Ahmed","year":"2007","unstructured":"Ahmed I, Ponery AS, Nur-E-Kamal A, Kamal J, Meshel AS, Sheetz MP, Schindler M, Meiners S (2007) Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfaces. Mol Cell Biochem 301:241\u2013249","journal-title":"Mol Cell Biochem"},{"key":"18_CR28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/ten.2006.12.91","volume":"12","author":"S Sahoo","year":"2006","unstructured":"Sahoo S, Ouyang H, Goh JC, Tay TE, Toh SL (2006) Characterization of a novel polymeric scaffold for potential application in tendon\/ligament tissue engineering. Tissue Eng 12:91\u201399","journal-title":"Tissue Eng"},{"issue":"3","key":"18_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/jid.2014.541","volume":"135","author":"V Schacht","year":"2015","unstructured":"Schacht V, Kern JS (2015) Basics of Immunohistochemistry. J Invest Dermatol 135(3):1\u20134. doi:\n10.1038\/jid.2014.541","journal-title":"J Invest Dermatol"},{"key":"18_CR30","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1063\/1.1408260","volume":"90","author":"AL Yarin","year":"2001","unstructured":"Yarin AL, Koombhongse S, Reneker DH (2001a) Taylor cone and jetting from liquid droplets in electrospinning of nanofibers. J Appl Phys 90:4836\u20134846","journal-title":"J Appl Phys"},{"issue":"2","key":"18_CR31","doi-asserted-by":"publisher","first-page":"025011","DOI":"10.1088\/1748-6041\/6\/2\/025011","volume":"6","author":"R James","year":"2011","unstructured":"James R, Kumbar SG, Laurencin CT, Balian G, Chhabra AB (2011) Tendon tissue-engineering: adipose 1 derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems. Biomed Mater 6(2):025011. doi:\n10.1088\/1748-6041\/6\/2\/025011","journal-title":"Biomed Mater"}],"container-title":["Methods in Molecular Biology","Biomedical Nanotechnology"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-6840-4_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T07:07:02Z","timestamp":1494918422000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-6840-4_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493968381","9781493968404"],"references-count":31,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-6840-4_18","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}