{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:47:59Z","timestamp":1791341279619,"version":"4.3.1"},"publisher-location":"New York, NY","reference-count":105,"publisher":"Springer New York","isbn-type":[{"value":"9781493968701","type":"print"},{"value":"9781493968725","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-6872-5_15","type":"book-chapter","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:09:21Z","timestamp":1490782161000},"page":"197-216","source":"Crossref","is-referenced-by-count":28,"title":["Overview of Targeted Therapies for Adult T-Cell Leukemia\/Lymphoma"],"prefix":"10.1007","author":[{"given":"Rihab","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambroise","family":"Mar\u00e7ais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"15_CR1","first-page":"73","volume-title":"Topics in haematology","author":"K Takatsuki","year":"1977","unstructured":"Takatsuki K, Uchiyama T, Sagawa K, Yodoi J (1977) Adult T cell leukaemia in Japan. In: Seno S, Takaku F, Irino S (eds) Topics in haematology. Excerpta Medica, Amsterdam, pp 73\u201377"},{"key":"15_CR2","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","volume":"77","author":"BJ Poiesz","year":"1980","unstructured":"Poiesz BJ, Ruscetti F, Gazdar A, Bunn P, Minna J, Gallo R (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A 77:7415\u20137419","journal-title":"Proc Natl Acad Sci U S A"},{"key":"15_CR3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/ijc.2910290606","volume":"29","author":"Y Hinuma","year":"1982","unstructured":"Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hanaoka M (1982) Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study. Int J Cancer 29:631\u2013635","journal-title":"Int J Cancer"},{"issue":"5","key":"15_CR4","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/JVI.69.5.2863-2868.1995","volume":"69","author":"E Wattel","year":"1995","unstructured":"Wattel E, Vartanian JP, Pannetier C, Wain-Hobson S (1995) Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy. J Virol 69(5):2863\u20132868","journal-title":"J Virol"},{"issue":"2","key":"15_CR5","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1128\/JVI.75.2.1083-1089.2001","volume":"75","author":"F Mortreux","year":"2001","unstructured":"Mortreux F, Kazanji M, Gabet AS, de Thoisy B, Wattel E (2001) Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus). J Virol 75(2):1083\u20131089","journal-title":"J Virol"},{"key":"15_CR6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","volume":"2","author":"A Gessain","year":"1985","unstructured":"Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, De-Th\u00e9 G (1985) Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2:407\u2013410","journal-title":"Lancet"},{"key":"15_CR7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0140-6736(87)92431-7","volume":"2","author":"JC Vernant","year":"1987","unstructured":"Vernant JC, Buisson G, Sobesky G, Arfi S, Gervaise G, Roman G (1987) Can HTLV-I lead to immunological disease. Lancet 2:404","journal-title":"Lancet"},{"key":"15_CR8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/rmv.1980030304","volume":"3","author":"JE Kaplan","year":"1993","unstructured":"Kaplan JE, Khabbaz RF (1993) The epidemiology of human T-lymphotropic virus types I and II. Med Virol 3:137\u2013148","journal-title":"Med Virol"},{"issue":"2","key":"15_CR9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0609.1994.tb01297.x","volume":"52","author":"L Paun","year":"1994","unstructured":"Paun L, Ispas O, Del Mistro A, Chieco-Bianchi L (1994) HTLV-I in Romania. Eur J Haematol 52(2):117\u2013118","journal-title":"Eur J Haematol"},{"key":"15_CR10","first-page":"33","volume-title":"Human T-cell lymphotropic virus type 1","author":"A Gessain","year":"1996","unstructured":"Gessain A (1996) Epidemiology of HTLV-1 and associated disease. In: Hollsberg P, Hafler DA (eds) Human T-cell lymphotropic virus type 1. Wiley, Chichester, pp 33\u201364"},{"issue":"6","key":"15_CR11","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/JCM.41.6.2593-2595.2003","volume":"41","author":"MR Abbaszadegan","year":"2003","unstructured":"Abbaszadegan MR, Gholamin M, Tabatabaee A, Farid R, Houshmand M, Abbaszadegan M (2003) Prevalence of human T-lymphotropic virus type 1among blood donors from Mashhad, Iran. J Clin Microbiol 41(6):2593\u20132595","journal-title":"J Clin Microbiol"},{"key":"15_CR12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1423-0410.1984.tb00083.x","volume":"46","author":"K Okochi","year":"1984","unstructured":"Okochi K, Sato H, Hinuma Y (1984) A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion : seroconversion in recipients. Vox Sang 46:245\u2013253","journal-title":"Vox Sang"},{"key":"15_CR13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(87)92358-0","volume":"2","author":"S Hino","year":"1987","unstructured":"Hino S, Sugiyama H, Doi H, Ishimaru T, Yamabe T, Tsuji Y, Miyamoto T (1987) Breaking the cycle of HTLV-I transmission via carrier mother\u2019s milk. Lancet 2:158\u2013159","journal-title":"Lancet"},{"key":"15_CR14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ijc.2910430214","volume":"43","author":"E Murphy","year":"1989","unstructured":"Murphy E, Hanchard B, Figueroa J, Gibbs W, Lofters W, Campbell M, Goedert J, Blattner W (1989) Modelling the risk of adult T-cell leukemia\/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer 43:250\u2013253","journal-title":"Int J Cancer"},{"issue":"10","key":"15_CR15","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1182\/blood.V86.10.3619.bloodjournal86103619","volume":"86","author":"G Franchini","year":"1995","unstructured":"Franchini G (1995) Molecular mechanisms of human T-cell leukemia\/lymphotropic virus type I infection. Blood 86(10):3619\u20133639","journal-title":"Blood"},{"key":"15_CR16","first-page":"4559s","volume":"45","author":"TA Waldmann","year":"1985","unstructured":"Waldmann TA, Longo DL, Leonard WJ et al (1985) Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia. Cancer Res 45:4559s\u20134562s","journal-title":"Cancer Res"},{"issue":"7","key":"15_CR17","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.4049\/jimmunol.163.7.4064","volume":"163","author":"N Azimi","year":"1999","unstructured":"Azimi N, Jacobson S, Leist T, Waldmann TA (1999) Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy\/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2\/15R beta receptor. J Immunol 163(7):4064\u20134072","journal-title":"J Immunol"},{"key":"15_CR18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.immunol.19.1.475","volume":"19","author":"M Yoshida","year":"2001","unstructured":"Yoshida M (2001) Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol 19:475\u2013496","journal-title":"Annu Rev Immunol"},{"key":"15_CR19","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/sj.cdd.4401624","volume":"12","author":"Y Kfoury","year":"2005","unstructured":"Kfoury Y, Nasr R, Hermine O, de The H, Bazarbachi A (2005) Proapoptotic regimes for HTLV-I\u2013transformed cells: targeting Tax and the NF-kappaB pathway. Cell Death Differ 12:871\u2013877","journal-title":"Cell Death Differ"},{"issue":"39","key":"15_CR20","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","volume":"24","author":"R Grassmann","year":"2005","unstructured":"Grassmann R, Aboud M, Jeang KT (2005) Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 24(39):5976\u20135985","journal-title":"Oncogene"},{"issue":"4","key":"15_CR21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/carcin\/bgi274","volume":"27","author":"Y Tabakin-Fix","year":"2006","unstructured":"Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M (2006) Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications. Carcinogenesis 27(4):673\u2013681","journal-title":"Carcinogenesis"},{"issue":"6","key":"15_CR22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10495-008-0208-7","volume":"13","author":"JM Taylor","year":"2008","unstructured":"Taylor JM, Nicot C (2008) HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. Apoptosis 13(6):733\u2013747","journal-title":"Apoptosis"},{"issue":"1","key":"15_CR23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(00)81148-4","volume":"93","author":"DY Jin","year":"1998","unstructured":"Jin DY, Spencer F, Jeang KT (1998) Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93(1):81\u201391","journal-title":"Cell"},{"key":"15_CR24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-4690-5-76","volume":"5","author":"M Boxus","year":"2008","unstructured":"Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L (2008) The HTLV-1 Tax interactome. Retrovirology 5:76","journal-title":"Retrovirology"},{"key":"15_CR25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1742-4690-2-54","volume":"2","author":"K Fraedrich","year":"2005","unstructured":"Fraedrich K, Muller B, Grassmann R (2005) The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix. Retrovirology 2:54","journal-title":"Retrovirology"},{"issue":"4","key":"15_CR26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","volume":"7","author":"M Matsuoka","year":"2007","unstructured":"Matsuoka M, Jeang KT (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7(4):270\u2013280","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"15_CR27","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1182\/blood-2005-09-3572","volume":"107","author":"R Nasr","year":"2006","unstructured":"Nasr R, Chiari E, El-Sabban M et al (2006) Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation. Blood 107(10):4021\u20134029","journal-title":"Blood"},{"issue":"23","key":"15_CR28","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1128\/MCB.25.23.10391-10406.2005","volume":"25","author":"I Lamsoul","year":"2005","unstructured":"Lamsoul I, Lodewick J, Lebrun S et al (2005) Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol Cell Biol 25(23):10391\u201310406","journal-title":"Mol Cell Biol"},{"issue":"12","key":"15_CR29","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/sj.onc.1210804","volume":"27","author":"Y Kfoury","year":"2008","unstructured":"Kfoury Y, Nasr R, Favre-Bonvin A et al (2008) Ubiquitylated tax targets and binds the IKK signalosome at the centrosome. Oncogene 27(12):1665\u20131676","journal-title":"Oncogene"},{"issue":"1","key":"15_CR30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1182\/blood-2010-05-285742","volume":"117","author":"Y Kfoury","year":"2011","unstructured":"Kfoury Y, Setterblad N, El-Sabban M et al (2011) Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome. Blood 117(1):190\u2013199","journal-title":"Blood"},{"issue":"15","key":"15_CR31","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.1128\/JVI.00918-15","volume":"89","author":"M Shirinian","year":"2015","unstructured":"Shirinian M, Kambris Z, Hamadeh L, Grabbe C, Journo C, Mahieux R, Bazarbachi A (2015) A transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein tax-1-driven transformation in vivo. J Virol 89(15):8092\u20138095","journal-title":"J Virol"},{"issue":"9","key":"15_CR32","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1182\/blood.V99.9.3383","volume":"99","author":"ME El-Sabban","year":"2002","unstructured":"El-Sabban ME, Merhi RA, Haidar HA et al (2002) Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells. Blood 99(9):3383\u20133389","journal-title":"Blood"},{"issue":"6","key":"15_CR33","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1158\/0008-5472.CAN-03-2390","volume":"64","author":"A Bazarbachi","year":"2004","unstructured":"Bazarbachi A, Abou Merhi R, Gessain A et al (2004) Human T-cell lymphotropic virus type I-infected cells extravasate through the endothelial barrier by a local angiogenesis-like mechanism. Cancer Res 64(6):2039\u20132046","journal-title":"Cancer Res"},{"issue":"12","key":"15_CR34","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1182\/blood-2001-12-0372","volume":"100","author":"B Arnulf","year":"2002","unstructured":"Arnulf B, Villemain A, Nicot C et al (2002) Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100(12):4129\u20134138","journal-title":"Blood"},{"issue":"1400","key":"15_CR35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1098\/rstb.2000.0638","volume":"355","author":"B Asquith","year":"2000","unstructured":"Asquith B, Hanon E, Taylor GP, Bangham CR (2000) Is human T-cell lymphotropic virus type I really silent? Philos Trans R Soc Lond B Biol Sci 355(1400):1013\u20131019","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"19","key":"15_CR36","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.81.19.6207","volume":"81","author":"G Franchini","year":"1984","unstructured":"Franchini G, Wong-Staal F, Gallo RC (1984) Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. Proc Natl Acad Sci U S A 81(19):6207\u20136211","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"15_CR37","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1073\/pnas.87.13.5218","volume":"87","author":"CL Tendler","year":"1990","unstructured":"Tendler CL, Greenberg SJ, Blattner WA et al (1990) Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci U S A 87(13):5218\u20135222","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"15_CR38","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1128\/JVI.65.3.1628-1633.1991","volume":"65","author":"A Gessain","year":"1991","unstructured":"Gessain A, Louie A, Gout O, Gallo RC, Franchini G (1991) Human T-cell leukemia-lymphoma virus type I(HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis\/HTLV-I-associated myelopathy. J Virol 65(3):1628\u20131633","journal-title":"J Virol"},{"key":"15_CR39","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1099\/vir.0.19334-0","volume":"84","author":"CR Bangham","year":"2003","unstructured":"Bangham CR (2003) The immune control and cell-to-cell spread of human T-lymphotropic virus type 1. J Gen Virol 84:3177\u20133189","journal-title":"J Gen Virol"},{"key":"15_CR40","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3390\/v3060750","volume":"3","author":"R Nasr","year":"2011","unstructured":"Nasr R, El Hajj H, Kfoury Y, de Th\u00e9 H, Hermine O, Bazarbachi A (2011) Controversies in targeted therapy of adult T cell leukemia\/lymphoma: ON target or OFF target effects? Viruses 3:750\u2013769","journal-title":"Viruses"},{"issue":"2","key":"15_CR41","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1182\/blood.V79.2.477.477","volume":"79","author":"A Sakashita","year":"1992","unstructured":"Sakashita A, Hattori T, Miller CW et al (1992) Mutations of the p53 gene in adult T-cell leukemia. Blood 79(2):477\u2013480","journal-title":"Blood"},{"issue":"24","key":"15_CR42","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1038\/sj.onc.1206468","volume":"22","author":"AS Gabet","year":"2003","unstructured":"Gabet AS, Mortreux F, Charneau P et al (2003) Inactivation of hTERT transcription by Tax. Oncogene 22(24):3734\u20133741","journal-title":"Oncogene"},{"issue":"11","key":"15_CR43","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","volume":"47","author":"K Kataoka","year":"2015","unstructured":"Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J et al (2015) Integrated molecular analysis of adult T cell leukemia\/lymphoma. Nat Genet 47(11):1304\u20131315","journal-title":"Nat Genet"},{"issue":"4","key":"15_CR44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nm1389","volume":"12","author":"H Hasegawa","year":"2006","unstructured":"Hasegawa H, Sawa H, Lewis MJ et al (2006) Thymus derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12(4):466\u2013472","journal-title":"Nat Med"},{"issue":"4","key":"15_CR45","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V98.4.1200","volume":"98","author":"T Portis","year":"2001","unstructured":"Portis T, Harding JC, Ratner L (2001) The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. Blood 98(4):1200\u20131208","journal-title":"Blood"},{"issue":"4","key":"15_CR46","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/JVI.01513-06","volume":"81","author":"P Banerjee","year":"2007","unstructured":"Banerjee P, Rochford R, Antel J et al (2007) Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells. J Virol 81(4):1690\u20131700","journal-title":"J Virol"},{"issue":"1","key":"15_CR47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.leu.2403176","volume":"18","author":"B Arnulf","year":"2004","unstructured":"Arnulf B, Thorel M, Poirot Y et al (2004) Loss of the ex vivo but not the reinducible CD8-T-cell response to Tax in human T-cell leukemia virus type 1\u2013infected patients with adult T-cell leukemia\/lymphoma. Leukemia 18(1):126\u2013132","journal-title":"Leukemia"},{"issue":"3","key":"15_CR48","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1182\/blood-2014-04-572750","volume":"125","author":"Z Dassouki","year":"2015","unstructured":"Dassouki Z, Sahin U, El Hajj H, Jollivet F, Kfoury Y, Lallemand-Breitenbach V, Hermine O, de Th\u00e9 H, Bazarbachi A (2015) ATL response to arsenic\/interferon therapy is triggered by SUMO\/PML\/RNF4-dependent Tax degradation. Blood 125(3):474\u2013482","journal-title":"Blood"},{"issue":"3","key":"15_CR49","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/bjh.13302","volume":"169","author":"Y Suehiro","year":"2015","unstructured":"Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Matsuoka M, Takamori A, Tanosaki R, Utsunomiya A, Choi I, Fukuda T, Miura O, Takaishi S, Teshima T, Akashi K, Kannagi M, Uike N, Okamura J (2015) Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia\/lymphoma in a pilot study. Br J Haematol 169(3):356\u2013367","journal-title":"Br J Haematol"},{"issue":"13","key":"15_CR50","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1182\/blood-2006-03-007732","volume":"108","author":"JM Mesnard","year":"2006","unstructured":"Mesnard JM, Barbeau B, Devaux C (2006) HBZ, a new important player in the mystery of adult T-cell leukemia. Blood 108(13):3979\u20133982","journal-title":"Blood"},{"key":"15_CR51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1742-4690-6-71","volume":"6","author":"M Matsuoka","year":"2009","unstructured":"Matsuoka M, Green PL (2009) The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 6:71","journal-title":"Retrovirology"},{"issue":"1","key":"15_CR52","doi-asserted-by":"crossref","first-page":"e1005372","DOI":"10.1371\/journal.ppat.1005372","volume":"12","author":"K Yasuma","year":"2016","unstructured":"Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M (2016) HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT). PLoS Pathog 12(1):e1005372","journal-title":"PLoS Pathog"},{"key":"15_CR53","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","volume":"79","author":"M Shimoyama","year":"1991","unstructured":"Shimoyama M (1991) Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984\u201387). Br J Haematol 79:428\u2013437","journal-title":"Br J Haematol"},{"key":"15_CR54","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","volume":"27","author":"K Tsukasaki","year":"2009","unstructured":"Tsukasaki K et al (2009) Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol 27:453\u2013459","journal-title":"J Clin Oncol"},{"key":"15_CR55","first-page":"932175","volume":"2012","author":"A Mar\u00e7ais","year":"2012","unstructured":"Mar\u00e7ais A, Suarez F, Sibon D, Bazarbachi A, Hermine O (2012) Clinical trials of adult T-cell leukaemia\/lymphoma treatment. Leuk Res Treat 2012:932175","journal-title":"Leuk Res Treat"},{"key":"15_CR56","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1182\/blood-2009-09-242347","volume":"115","author":"Y Takasaki","year":"2010","unstructured":"Takasaki Y et al (2010) Long-term study of indolent adult T-cell leukemia lymphoma. Blood 115:433","journal-title":"Blood"},{"key":"15_CR57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1200\/JCO.1988.6.1.128","volume":"6","author":"M Shimoyama","year":"1988","unstructured":"Shimoyama M, Ota K, Kikuchi M et al (1988) Chemotherapeutic results and prognostic factors of patients with advanced non-Hodgkin\u2019s lymphoma treated with VEPA or VEPA-M. J Clin Oncol 6:128\u2013141","journal-title":"J Clin Oncol"},{"key":"15_CR58","unstructured":"Tobinai M, Shimoyama K, Minato. et al. (1994) Japan clinical oncology group phase II trial of second-generation LSG4 protocol in aggressive T- and B-lymphoma: a new predictive model for T- and B-lymphoma. Proc Am Soc Clin Oncol 13: 378."},{"key":"15_CR59","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02983215","volume":"77","author":"K Tsukasaki","year":"2003","unstructured":"Tsukasaki K et al (2003) Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). Int J Hematol 77:164\u2013170","journal-title":"Int J Hematol"},{"key":"15_CR60","doi-asserted-by":"crossref","unstructured":"Yamada Yet al. (2001) A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol 113:375\u2013382.","DOI":"10.1046\/j.1365-2141.2001.02737.x"},{"key":"15_CR61","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1200\/JCO.2007.11.9958","volume":"25","author":"K Tsukasaki","year":"2007","unstructured":"Tsukasaki K et al (2007) VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol 25:5458\u20135464","journal-title":"J Clin Oncol"},{"key":"15_CR62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.bmt.1701533","volume":"23","author":"K Tsukasaki","year":"1999","unstructured":"Tsukasaki K, Maeda T, Arimura K et al (1999) Poor outcome of autologous stem cell transplantation for adult T cell leukemia\/lymphoma: a case report and review of the literature. Bone Marrow Transplant 23:87\u201389","journal-title":"Bone Marrow Transplant"},{"key":"15_CR63","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/10428190902887571","volume":"50","author":"AA Phillips","year":"2009","unstructured":"Phillips AA, Willim RD, Savage DG et al (2009) A multi-institutional experience of autologous stem cell transplantation in North American patients with human T-cell lymphotropic virus type-1 adult T-cell leukemia\/lymphoma suggests ineffective salvage of relapsed patients. Leuk Lymphoma 50:1039\u20131042","journal-title":"Leuk Lymphoma"},{"key":"15_CR64","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1182\/blood-2009-10-247510","volume":"116","author":"M Hishizawa","year":"2010","unstructured":"Hishizawa M et al (2010) Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 116:1369","journal-title":"Blood"},{"key":"15_CR65","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1186\/1742-4690-8-S1-A33","volume":"8","author":"N Uike","year":"2011","unstructured":"Uike N, Tanosaki R, Utsunomiya A, Choi I, Okamura J (2011) Can allo-SCTwith RIC cure ATLL? long-term survivors with excellent PS and with heterogenous HTLV-1 proviral load level. Retrovirology 8:A33","journal-title":"Retrovirology"},{"issue":"10","key":"15_CR66","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/bmt.2014.143","volume":"49","author":"A Bazarbachi","year":"2014","unstructured":"Bazarbachi A, Cwynarski K, Boumendil A, Finel H, Fields P, Raj K, Nagler A, Mohty M, Sureda A, Dreger P, Hermine O (2014) Outcome of patients with HTLV-1-associated adult T-cell leukemia\/lymphoma after SCT: a retrospective study by the EBMT LWP. Bone Marrow Transplant 49(10):1266\u20131268","journal-title":"Bone Marrow Transplant"},{"key":"15_CR67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood-2012-07-444372","volume":"121","author":"H Itonaga","year":"2013","unstructured":"Itonaga H et al (2013) Treatment of relapsed adult T-cell leukemia\/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience. Blood 121:219\u2013225","journal-title":"Blood"},{"key":"15_CR68","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1056\/NEJM199506293322603","volume":"332","author":"PS Gill","year":"1995","unstructured":"Gill PS et al (1995) Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N Engl J Med 332:1744\u20131748","journal-title":"N Engl J Med"},{"key":"15_CR69","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJM199506293322604","volume":"332","author":"O Hermine","year":"1995","unstructured":"Hermine O et al (1995) Brief report: treatment of adult T-cell leukemialymphoma with zidovudine and interferon alfa. N Engl J Med 332:1749\u20131751","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"15_CR70","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/00042560-199600001-00028","volume":"13","author":"A Bazarbachi","year":"1996","unstructured":"Bazarbachi A, Hermine O (1996) Treatment with a combination of zidovudine and alpha-interferon in naive and pretreated adult T-cell leukemia\/lymphoma patients. J Acquir Immune Defic Syndr Hum Retrovirol 13(Suppl 1):S186\u2013S190","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"15_CR71","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.thj.6200195","volume":"3","author":"O Hermine","year":"2002","unstructured":"Hermine O et al (2002) A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia\/lymphoma. Hematol J 3:276\u2013282","journal-title":"Hematol J"},{"key":"15_CR72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10428190109057927","volume":"40","author":"JD White","year":"2001","unstructured":"White JD et al (2001) The combination of zidovudine and interferon alpha-2B in the treatment of adult T-cell leukemia\/lymphoma. Leuk Lymphoma 40:287\u2013294","journal-title":"Leuk Lymphoma"},{"key":"15_CR73","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2141.2001.02794.x","volume":"113","author":"E Matutes","year":"2001","unstructured":"Matutes E, Taylor GP, Cavenagh J et al (2001) Interferon alpha and zidovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients. Br J Haematol 113:779\u2013784","journal-title":"Br J Haematol"},{"key":"15_CR74","doi-asserted-by":"crossref","first-page":"e4420","DOI":"10.1371\/journal.pone.0004420","volume":"4","author":"L Ratner","year":"2009","unstructured":"Ratner L, Harrington W, Feng X et al (2009) Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One 4:e4420","journal-title":"PLoS One"},{"key":"15_CR75","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1080\/1042819021000039983","volume":"43","author":"C Besson","year":"2002","unstructured":"Besson C, Panelatti G, Delaunay C et al (2002) Treatment of adult T-cell leukemia-lymphoma by CHOP followed by therapy with antinucleosides, alpha interferon and oral etoposide. Leuk Lymphoma 43:2275\u20132279","journal-title":"Leuk Lymphoma"},{"key":"15_CR76","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2010.28.0669","volume":"28","author":"A Bazarbachi","year":"2010","unstructured":"Bazarbachi A et al (2010) Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia\/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol 28:4177\u20134183","journal-title":"J Clin Oncol"},{"issue":"21","key":"15_CR77","doi-asserted-by":"crossref","first-page":"Abstr 3961","DOI":"10.1182\/blood.V116.21.3961.3961","volume":"116","author":"A Hodson","year":"2010","unstructured":"Hodson A et al (2010) Addition of anti-viral therapy to chemotherapy improves overall survival in acute and lymphomatous adult T-cell leukaemia\/lymphoma (ATLL). Blood 116(21):Abstr 3961","journal-title":"Blood"},{"key":"15_CR78","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood-2006-01-0067","volume":"108","author":"A Datta","year":"2006","unstructured":"Datta A et al (2006) Persistent inhibition of telomerase reprograms adult Tcell leukemia to p53-dependent senescence. Blood 108:1021\u20131029","journal-title":"Blood"},{"key":"15_CR79","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood.V93.1.278","volume":"93","author":"A Bazarbachi","year":"1999","unstructured":"Bazarbachi A et al (1999) Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood 93:278\u2013283","journal-title":"Blood"},{"key":"15_CR80","first-page":"2849","volume":"96","author":"ME El-Sabban","year":"2000","unstructured":"El-Sabban ME et al (2000) Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation. Blood 96:2849\u20132855","journal-title":"Blood"},{"key":"15_CR81","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1182\/blood-2002-09-2986","volume":"101","author":"R Nasr","year":"2003","unstructured":"Nasr R et al (2003) Arsenic\/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. Blood 101:4576\u20134582","journal-title":"Blood"},{"key":"15_CR82","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1084\/jem.20101095","volume":"207","author":"H El Hajj","year":"2010","unstructured":"El Hajj H et al (2010) Therapy-induced selective loss of leukemia-initiating activity in murine adult Tcell leukemia. J Exp Med 207:2785\u20132792","journal-title":"J Exp Med"},{"key":"15_CR83","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1182\/blood-2009-03-211821","volume":"113","author":"G Kchour","year":"2009","unstructured":"Kchour G et al (2009) Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia\/lymphoma (ATL). Blood 113:6528\u20136532","journal-title":"Blood"},{"key":"15_CR84","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1742-4690-10-91","volume":"10","author":"G Kchour","year":"2013","unstructured":"Kchour G, Rezaee R, Farid R et al (2013) The combination of arsenic, interferon alpha, and zidovudine restores an \u201cimmunocompetent-like\u201d cytokine expression profile in patients with adult T-cell leukemia lymphoma. Retrovirology 10:91","journal-title":"Retrovirology"},{"key":"15_CR85","doi-asserted-by":"crossref","first-page":"A59","DOI":"10.1186\/1742-4690-8-S1-A59","volume":"8","author":"F Suarez","year":"2011","unstructured":"Suarez F et al (2011) Arsenic trioxyde in the treatment of HTLV1 associated ATLL. Retrovirology 8:A59","journal-title":"Retrovirology"},{"key":"15_CR86","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1182\/blood.V82.6.1701.1701","volume":"82","author":"TA Waldmann","year":"1993","unstructured":"Waldmann TA et al (1993) The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I induced adult T-cell leukemia. Blood 82:1701\u20131712","journal-title":"Blood"},{"key":"15_CR87","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1182\/blood.V86.11.4063.bloodjournal86114063","volume":"86","author":"TA Waldmann","year":"1995","unstructured":"Waldmann TA et al (1995) Radioimmunotherapy of interleukin-2R alpha expressing adult T-cell leukemia with yttrium-90-labeled anti-Tac. Blood 86:4063\u20134075","journal-title":"Blood"},{"key":"15_CR88","doi-asserted-by":"crossref","first-page":"A60","DOI":"10.1186\/1742-4690-8-S1-A60","volume":"8","author":"I Moura","year":"2011","unstructured":"Moura I et al (2011) A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients. Retrovirology 8:A60","journal-title":"Retrovirology"},{"key":"15_CR89","doi-asserted-by":"crossref","first-page":"A40","DOI":"10.1186\/1742-4690-8-S1-A40","volume":"8","author":"A Utsunomiya","year":"2011","unstructured":"Utsunomiya A et al (2011) Promising results of an anti-CCR4 antibody, KW-0761, for relapsed adult T-cell leukemia-lymphoma (ATL). Retrovirology 8:A40","journal-title":"Retrovirology"},{"key":"15_CR90","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1200\/JCO.2011.37.3472","volume":"30","author":"T Ishida","year":"2012","unstructured":"Ishida T et al (2012) Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30:837\u2013842","journal-title":"J Clin Oncol"},{"issue":"5","key":"15_CR91","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/bjh.13338","volume":"169","author":"T Ishida","year":"2015","unstructured":"Ishida T, Jo T, Takemoto S, Suzushima H, Uozumi K, Yamamoto K, Uike N, Saburi Y, Nosaka K, Utsunomiya A, Tobinai K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Moriuchi Y, Imada K, Miyamoto T, Akinaga S, Tomonaga M, Ueda R (2015) Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Br J Haematol 169(5):672\u2013682","journal-title":"Br J Haematol"},{"key":"15_CR92","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1200\/JCO.2006.10.2434","volume":"25","author":"EA Olsen","year":"2007","unstructured":"Olsen EA et al (2007) Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 25:3109\u20133115","journal-title":"J Clin Oncol"},{"key":"15_CR93","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1200\/JCO.2010.28.9066","volume":"28","author":"SJ Whittaker","year":"2010","unstructured":"Whittaker SJ et al (2010) Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J Clin Oncol 28:4485\u20134491","journal-title":"J Clin Oncol"},{"key":"15_CR94","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1182\/blood-2010-10-312603","volume":"117","author":"RL Piekarz","year":"2011","unstructured":"Piekarz RL et al (2011) Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma. Blood 117:5827","journal-title":"Blood"},{"key":"15_CR95","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1200\/JCO.2011.37.4223","volume":"30","author":"B Coiffier","year":"2012","unstructured":"Coiffier B et al (2012) Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy. J Clin Oncol 30:631\u2013636","journal-title":"J Clin Oncol"},{"key":"15_CR96","doi-asserted-by":"crossref","first-page":"A48","DOI":"10.1186\/1742-4690-8-S1-A48","volume":"8","author":"J Ramos","year":"2011","unstructured":"Ramos J et al (2011) Targeting HTLV-I latency in adult T-cell leukemia\/lymphoma. Retrovirology 8:A48","journal-title":"Retrovirology"},{"key":"15_CR97","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1182\/blood-2010-02-270751","volume":"116","author":"PV Afonso","year":"2010","unstructured":"Afonso PV et al (2010) Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors. Blood 116:3802\u20133808","journal-title":"Blood"},{"key":"15_CR98","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1182\/blood.V98.6.1721","volume":"98","author":"CE Dearden","year":"2001","unstructured":"Dearden CE et al (2001) High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H. Blood 98:1721\u20131726","journal-title":"Blood"},{"key":"15_CR99","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1182\/blood-2005-01-0335","volume":"106","author":"A Mone","year":"2005","unstructured":"Mone A et al (2005) Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine\/IFN-a-refractory adult T-cell leukemia. Blood 106:3380\u20133382","journal-title":"Blood"},{"key":"15_CR100","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1200\/JCO.2009.22.6688","volume":"27","author":"F Ravandi","year":"2009","unstructured":"Ravandi F et al (2009) Phase II study of alemtuzumab in combination with pentostatin in patients with T-cell neoplasms. J Clin Oncol 27:5425\u20135430","journal-title":"J Clin Oncol"},{"key":"15_CR101","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1349-7006.2009.01354.x","volume":"101","author":"N Maeda","year":"2010","unstructured":"Maeda N, Muta H, Oflazoglu E, Yoshikai Y (2010) Susceptibility of human T cell leukemia virus type I-infected cells to humanized anti-CD30 monoclonal antibodies in vitro and in vivo. Cancer Sci 101:224\u2013230","journal-title":"Cancer Sci"},{"key":"15_CR102","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S1470-2045(04)01608-0","volume":"5","author":"A Bazarbachi","year":"2004","unstructured":"Bazarbachi A, Ghez D, Lepelletier Y et al (2004) New therapeutic approaches for adult T-cell leukaemia. Lancet Oncol 5:664\u2013672","journal-title":"Lancet Oncol"},{"key":"15_CR103","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2165\/00063030-199810060-00003","volume":"10","author":"O Hermine","year":"1998","unstructured":"Hermine O, Wattel E, Gessain A, Bazarbachi A (1998) Adult T cell leukaemia: a review of established and new treatments. BioDrugs 10:447\u2013462","journal-title":"BioDrugs"},{"key":"15_CR104","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1182\/blood-2011-03-345702","volume":"118","author":"A Bazarbachi","year":"2011","unstructured":"Bazarbachi A, Suarez F, Fields P, Hermine O (2011) How I treat adult T-cell leukemia\/lymphoma. Blood 118:1736\u20131745","journal-title":"Blood"},{"key":"15_CR105","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1073\/pnas.92.9.3963","volume":"92","author":"JM Flaman","year":"1995","unstructured":"Flaman JM et al (1995) A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci U S A 92:3963\u20133967","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Methods in Molecular Biology","Human T-Lymphotropic Viruses"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-6872-5_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:27:54Z","timestamp":1692728874000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-6872-5_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493968701","9781493968725"],"references-count":105,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-6872-5_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}