{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:08:12Z","timestamp":1782601692203,"version":"3.54.5"},"publisher-location":"New York, NY","reference-count":134,"publisher":"Springer New York","isbn-type":[{"value":"9781493971947","type":"print"},{"value":"9781493971961","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/978-1-4939-7196-1_9","type":"book-chapter","created":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T14:24:07Z","timestamp":1502634247000},"page":"113-135","source":"Crossref","is-referenced-by-count":33,"title":["An Overview of Thrombophilia and Associated Laboratory Testing"],"prefix":"10.1007","author":[{"given":"Martina","family":"Montagnana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Danese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"9_CR1","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","volume":"133","author":"D Mozaffarian","year":"2016","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, American Heart Association Statistics Committee and Stroke Statistics Subcommittee et al (2016) Heart disease and stroke statistics-2016 update: a report from the American heart association. Circulation 133:e38\u2013e360","journal-title":"Circulation"},{"key":"9_CR2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11239-009-0365-8","volume":"29","author":"M Montagnana","year":"2010","unstructured":"Montagnana M, Favaloro EJ, Franchini M, Guidi GC, Lippi G (2010) The role of ethnicity, age and gender in venous thromboembolism. J Thromb Thrombolysis 29:489\u2013496","journal-title":"J Thromb Thrombolysis"},{"key":"9_CR3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0029-1145257","volume":"34","author":"G Lippi","year":"2008","unstructured":"Lippi G, Franchini M (2008) Pathogenesis of venous thromboembolism: when the cup runneth over. Semin Thromb Hemost 34:747\u2013761","journal-title":"Semin Thromb Hemost"},{"key":"9_CR4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1055\/s-0029-1242713","volume":"35","author":"G Lippi","year":"2009","unstructured":"Lippi G, Franchini M, Favaloro EJ (2009) Unsuspected triggers of venous thromboembolism\u2013trivial or not so trivial? Semin Thromb Hemost 35:597\u2013604","journal-title":"Semin Thromb Hemost"},{"key":"9_CR5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1055\/s-0029-1242723","volume":"35","author":"EJ Favaloro","year":"2009","unstructured":"Favaloro EJ, McDonald D, Lippi G (2009) Laboratory investigation of thrombophilia: the good, the bad, and the ugly. Semin Thromb Hemost 35:695\u2013710","journal-title":"Semin Thromb Hemost"},{"key":"9_CR6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1538-7933.2004.00660.x","volume":"2","author":"JA Heit","year":"2004","unstructured":"Heit JA et al (2004) Familial segregation of venous thromboembolism. J Thromb Haemost 2:731\u2013736","journal-title":"J Thromb Haemost"},{"key":"9_CR7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.7326\/0003-4819-138-2-200301210-00014","volume":"138","author":"MA Crowther","year":"2003","unstructured":"Crowther MA, Kelton JG (2003) Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system. Ann Intern Med 138:128\u2013134","journal-title":"Ann Intern Med"},{"key":"9_CR8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1055\/s-0038-1656297","volume":"13","author":"O Egeberg","year":"1965","unstructured":"Egeberg O (1965) Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 13:516\u2013530","journal-title":"Thromb Diath Haemorrh"},{"key":"9_CR9","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI110385","volume":"68","author":"JH Griffin","year":"1981","unstructured":"Griffin JH, Evatt B, Zimmerman T, Kleiss A, Wideman C (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68:1370\u20131373","journal-title":"J Clin Invest"},{"key":"9_CR10","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJM198412133112401","volume":"311","author":"PC Comp","year":"1984","unstructured":"Comp PC, Esmon CT (1984) Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 311:1525\u20131528","journal-title":"N Engl J Med"},{"key":"9_CR11","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.90.3.1004","volume":"90","author":"B Dahlb\u00e4ck","year":"1993","unstructured":"Dahlb\u00e4ck B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 90:1004\u20131008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9_CR12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","volume":"369","author":"RM Bertina","year":"1994","unstructured":"Bertina RM, Koeleman BPC, Koster T et al (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64\u201367","journal-title":"Nature"},{"key":"9_CR13","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"SR Poort","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PM, Bertina RM (1996) A common genetic variation in the 3\u2032 untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698\u20133703","journal-title":"Blood"},{"key":"9_CR14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrcardio.2013.211","volume":"11","author":"I Martinelli","year":"2014","unstructured":"Martinelli I, De Stefano V, Mannucci PM (2014) Inherited risk factors for venous thromboembolism. Nat Rev Cardiol 11:140\u2013156","journal-title":"Nat Rev Cardiol"},{"key":"9_CR15","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/ajh.21893","volume":"85","author":"B Khor","year":"2010","unstructured":"Khor B, Van Cott EM (2010) Laboratory tests for antithrombin deficiency. Am J Hematol 85:947\u2013950","journal-title":"Am J Hematol"},{"key":"9_CR16","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/00001721-199212000-00008","volume":"3","author":"E Melissari","year":"1992","unstructured":"Melissari E, Monte G, Lindo VS, Pemberton KD, Wilson NV, Edmondson R et al (1992) Congenital thrombophilia among patients with venous thromboembolism. Blood Coagul Fibrinolysis 3:749\u2013758","journal-title":"Blood Coagul Fibrinolysis"},{"key":"9_CR17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-0038-1655930","volume":"77","author":"DA Lane","year":"1997","unstructured":"Lane DA, Bayston T, Olds RJ, Fitches AC, Cooper DN, Millar DS et al (1997) Antithrombin mutation database: 2nd (1997) update. For the plasma coagulation inhibitors subcommittee of the scientific and standardization committee of the international society on thrombosis and haemostasis. Thromb Haemost 77:197\u2013211","journal-title":"Thromb Haemost"},{"key":"9_CR18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2005-863805","volume":"31","author":"EJ Favaloro","year":"2005","unstructured":"Favaloro EJ, Bonar R, Sioufi J, Wheeler M, Low J, Aboud M, RCPA QAP in haematology et al (2005) Multilaboratory testing of thrombophilia: current and past practice in Australasia as assessed through the royal college of pathologists of Australasia quality assurance program for hematology. Semin Thromb Hemost 31:49\u201358","journal-title":"Semin Thromb Hemost"},{"key":"9_CR19","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1182\/blood.V85.10.2756.bloodjournal85102756","volume":"85","author":"T Koster","year":"1995","unstructured":"Koster T, Rosendaal FR, Bri\u00ebt E, van der Meer FJ, Colly LP, Trienekens PH et al (1995) Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden thrombophilia study). Blood 85:2756\u20132761","journal-title":"Blood"},{"key":"9_CR20","doi-asserted-by":"crossref","first-page":"e365","DOI":"10.1161\/CIRCULATIONAHA.111.044412","volume":"124","author":"B Lipe","year":"2011","unstructured":"Lipe B, Ornstein DL (2011) Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin. Circulation 124:e365\u2013e368","journal-title":"Circulation"},{"key":"9_CR21","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/CIRCULATIONAHA.108.780759","volume":"118","author":"BK Mahmoodi","year":"2008","unstructured":"Mahmoodi BK, Brouwer JL, Veeger NJ, van der Meer J (2008) Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study. Circulation 118:1659\u20131667","journal-title":"Circulation"},{"key":"9_CR22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1751-553X.2012.01401.x","volume":"34","author":"PC Cooper","year":"2012","unstructured":"Cooper PC, Hill M, Maclean RM (2012) The phenotypic and genetic assessment of protein C deficiency. Int J Lab Hematol 34:336\u2013346","journal-title":"Int J Lab Hematol"},{"key":"9_CR23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0038-1642378","volume":"71","author":"G Finazzi","year":"1994","unstructured":"Finazzi G, Barbui T (1994) Different incidence of venous thrombosis in patients with inherited deficiencies of antithrombin III, protein C and protein S. Thromb Haemost 71:15\u201318","journal-title":"Thromb Haemost"},{"key":"9_CR24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood.V65.1.15.15","volume":"65","author":"E Marciniak","year":"1985","unstructured":"Marciniak E, Wilson HD, Marlar RA (1985) Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. Blood 65:15\u201320","journal-title":"Blood"},{"key":"9_CR25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/dx-2014-0054","volume":"1","author":"G Lippi","year":"2014","unstructured":"Lippi G, Mattiuzzi C, Favaloro EJ (2014) Thrombophilia testing in patients taking direct oral anticoagulants. Handle with care. Diagnosis 1:311\u2013312","journal-title":"Diagnosis"},{"key":"9_CR26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/ajh.21893","volume":"85","author":"B Khor","year":"2010","unstructured":"Khor B, Van Cott EM (2010) Laboratory tests for protein C deficiency. Am J Hematol 85:440\u2013442","journal-title":"Am J Hematol"},{"key":"9_CR27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2141.2009.08022.x","volume":"149","author":"T Baglin","year":"2010","unstructured":"Baglin T, Gray E, Greaves M, Hunt BJ, Keeling D, Machin S, British Committee for Standards in Haematology et al (2010) Clinical guidelines for testing for heritable thrombophilia. Br J Haematol 149:209\u2013220","journal-title":"Br J Haematol"},{"key":"9_CR28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/MOH.0b013e328309ec97","volume":"15","author":"E Castoldi","year":"2008","unstructured":"Castoldi E, Hackeng TM (2008) Regulation of coagulation by protein S. Curr Opin Hematol 15:529\u2013536","journal-title":"Curr Opin Hematol"},{"key":"9_CR29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1160\/TH07-03-0199","volume":"98","author":"P Garcia de Frutos","year":"2007","unstructured":"Garcia de Frutos P, Fuentes-Prior P, Hurtado B et al (2007) Molecular basis of protein S deficiency. Thromb Haemost 98:543\u2013545","journal-title":"Thromb Haemost"},{"key":"9_CR30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2141.2004.04961.x","volume":"125","author":"NJ Beauchamp","year":"2004","unstructured":"Beauchamp NJ, Dykes AC, Parikh N, Campbell Tait R, Daly ME (2004) The prevalence of, and molecular defects underlying, inherited protein S deficiency in the general population. Br J Haematol 125:647\u2013654","journal-title":"Br J Haematol"},{"key":"9_CR31","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2008-08-174128","volume":"113","author":"WM Lijfering","year":"2009","unstructured":"Lijfering WM, Mulder R, Ten Kate MK et al (2009) Clinical relevance of decreased free protein S levels: results from a retrospective family cohort study involving 1143 relatives. Blood 113:1225\u20131230","journal-title":"Blood"},{"key":"9_CR32","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3324\/haematol.2010.021923","volume":"95","author":"E Castoldi","year":"2010","unstructured":"Castoldi E, Maurissen LF, Tormene D, Spiezia L, Gavasso S, Radu C et al (2010) Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I\/III protein S deficiency. Haematologica 95:1563\u20131571","journal-title":"Haematologica"},{"key":"9_CR33","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ajh.21992","volume":"86","author":"RA Marlar","year":"2011","unstructured":"Marlar RA, Gausman JN (2011) Protein S abnormalities: a diagnostic nightmare. Am J Hematol 86:418\u2013421","journal-title":"Am J Hematol"},{"key":"9_CR34","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1021\/bi00457a004","volume":"29","author":"DD Monkovic","year":"1990","unstructured":"Monkovic DD, Tracy PB (1990) Activation of human factor V by factor Xa and thrombin. Biochemistry 29:1118\u20131128","journal-title":"Biochemistry"},{"key":"9_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/blood-2008-01-077909","volume":"112","author":"B Dahlback","year":"2008","unstructured":"Dahlback B (2008) Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood 112:19\u201327","journal-title":"Blood"},{"key":"9_CR36","first-page":"314","volume":"19","author":"HV Ioannou","year":"2000","unstructured":"Ioannou HV, Mitsis M, Eleftheriou A, Matsagas M, Nousias V, Rigopoulos C et al (2000) The prevalence of factor V Leiden as a risk factor for venous thromboembolism in the population of north-western Greece. Int Angiol 19:314\u2013318","journal-title":"Int Angiol"},{"key":"9_CR37","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.thromres.2015.10.019","volume":"136","author":"MR Meyer","year":"2015","unstructured":"Meyer MR, Witt DM, Delate T, Johnson SG, Fang M, Go A et al (2015) Thrombophilia testing patterns amongst patients with acute venous thromboembolism. Thromb Res 136:1160\u20131164","journal-title":"Thromb Res"},{"key":"9_CR38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/ajh.24222","volume":"91","author":"EM Cott Van","year":"2016","unstructured":"Van Cott EM, Khor B, Zehnder JL (2016) Factor V Leiden. Am J Hematol 91:46\u201349","journal-title":"Am J Hematol"},{"key":"9_CR39","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/hc5001.100793","volume":"104","author":"SM Boekholdt","year":"2001","unstructured":"Boekholdt SM, Bijsterveld NR, Moons AH et al (2001) Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review. Circulation 104:3063\u20133068","journal-title":"Circulation"},{"key":"9_CR40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(06)68263-9","volume":"367","author":"Z Ye","year":"2006","unstructured":"Ye Z, Liu EH, Higgins JP et al (2006) Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 367:651\u2013658","journal-title":"Lancet"},{"key":"9_CR41","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ajh.23867","volume":"89","author":"S Kadauke","year":"2014","unstructured":"Kadauke S, Khor B, Van Cott EM (2014) Activated protein C resistance testing for factor V Leiden. Am J Hematol 89:1147\u20131150","journal-title":"Am J Hematol"},{"key":"9_CR42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2005-863803","volume":"31","author":"MS Hertzberg","year":"2005","unstructured":"Hertzberg MS (2005) Genetic testing for thrombophilia mutations. Semin Thromb Hemost 31:33\u201338","journal-title":"Semin Thromb Hemost"},{"key":"9_CR43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1055\/s-0032-1321491","volume":"38","author":"PC Cooper","year":"2012","unstructured":"Cooper PC, Goodeve AC, Beauchamp NJ (2012) Quality in molecular biology testing for inherited thrombophilia disorders. Semin Thromb Hemost 38:600\u2013612","journal-title":"Semin Thromb Hemost"},{"key":"9_CR44","volume":"3","author":"MM Jadaon","year":"2011","unstructured":"Jadaon MM (2011) Epidemiology of prothrombin G20210A mutation in the mediterranean region. Mediterr J Hematol Infect Dis 3:e2011054","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"9_CR45","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1182\/blood-2002-02-0412","volume":"100","author":"ES Pollak","year":"2002","unstructured":"Pollak ES, Lam HS, Russell JE (2002) The G20210A mutation does not affect the stability of prothrombin mRNA in vivo. Blood 100:359\u2013362","journal-title":"Blood"},{"key":"9_CR46","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bmj.287.6399.1088","volume":"287","author":"GR Hughes","year":"1983","unstructured":"Hughes GR (1983) Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br Med J (Clin Res Ed) 287:1088\u20131089","journal-title":"Br Med J (Clin Res Ed)"},{"key":"9_CR47","doi-asserted-by":"crossref","unstructured":"([No authors listed] (2010) Raising awareness of antiphospholipid antibody syndrome. Lancet 375:778","DOI":"10.1016\/S0140-6736(10)60326-1"},{"key":"9_CR48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jaut.2014.01.006","volume":"48-49","author":"JA G\u00f3mez-Puerta","year":"2014","unstructured":"G\u00f3mez-Puerta JA, Cervera R (2014) Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun 48-49:20\u201325","journal-title":"J Autoimmun"},{"key":"9_CR49","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/j.1538-7836.2005.01485.x","volume":"3","author":"PG Groot de","year":"2005","unstructured":"de Groot PG, Derksen RH (2005) Pathophysiology of the antiphospholipid syndrome. J Thromb Haemost 3:1854\u20131860","journal-title":"J Thromb Haemost"},{"key":"9_CR50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.autrev.2015.08.011","volume":"15","author":"LL Hoogen van den","year":"2016","unstructured":"van den Hoogen LL, van Roon JA, Radstake TR, Fritsch-Stork RD, Derksen RH (2016) Delineating the deranged immune system in the antiphospholipid syndrome. Autoimmun Rev 15:50\u201360","journal-title":"Autoimmun Rev"},{"key":"9_CR51","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/MOH.0000000000000067","volume":"21","author":"S Chaturvedi","year":"2014","unstructured":"Chaturvedi S, McCrae KR (2014) Recent advances in the antiphospholipid antibody syndrome. Curr Opin Hematol 21:371\u2013379","journal-title":"Curr Opin Hematol"},{"key":"9_CR52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11926-014-0485-9","volume":"17","author":"R Willis","year":"2015","unstructured":"Willis R, Gonzalez EB, Brasier AR (2015) The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome. Curr Rheumatol Rep 17:16","journal-title":"Curr Rheumatol Rep"},{"key":"9_CR53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMra1112830","volume":"368","author":"B Giannakopoulos","year":"2013","unstructured":"Giannakopoulos B, Krilis SA (2013) The pathogenesis of the antiphospholipid syndrome. N Engl J Med 368:1033\u20131044","journal-title":"N Engl J Med"},{"key":"9_CR54","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.autrev.2012.11.007","volume":"12","author":"M Bazzan","year":"2013","unstructured":"Bazzan M, Vaccarino A, Stella S, Bertero MT, Carignola R, Montaruli B, Piedmont APS Consortium et al (2013) Thrombotic recurrences and bleeding events in APS vascular patients: a review from the literature and a comparison with the APS piedmont cohort. Autoimmun Rev 12:826\u2013831","journal-title":"Autoimmun Rev"},{"key":"9_CR55","doi-asserted-by":"crossref","first-page":"28418","DOI":"10.3390\/ijms161226104","volume":"16","author":"LE Simcox","year":"2015","unstructured":"Simcox LE, Ormesher L, Tower C, Greer IA (2015) Thrombophilia and pregnancy complications. Int J Mol Sci 16:28418\u201328428","journal-title":"Int J Mol Sci"},{"key":"9_CR56","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1258\/jrsm.95.7.336","volume":"95","author":"SC Keswani","year":"2002","unstructured":"Keswani SC, Chauhan N (2002) Antiphospholipid syndrome. J R Soc Med 95:336\u2013342","journal-title":"J R Soc Med"},{"key":"9_CR57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295\u2013306","journal-title":"J Thromb Haemost"},{"key":"9_CR58","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1182\/blood-2007-12-129627","volume":"113","author":"B Giannakopoulos","year":"2009","unstructured":"Giannakopoulos B, Passam F, Ioannou Y, Krilis SA (2009) How we diagnose the antiphospholipid syndrome. Blood 113:985\u2013994","journal-title":"Blood"},{"key":"9_CR59","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","volume":"7","author":"V Pengo","year":"2009","unstructured":"Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis et al (2009) Update of the guidelines for lupus anticoagulant detection. Subcommittee on lupus anticoagulant\/antiphospholipid antibody of the scientific and standardisation committee of the international society on thrombosis and haemostasis. J Thromb Haemost 7:1737\u20131740","journal-title":"J Thromb Haemost"},{"key":"9_CR60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2141.2012.09037.x","volume":"157","author":"D Keeling","year":"2012","unstructured":"Keeling D, Mackie I, Moore GW, Greer IA, Greaves M, British Committee for Standards in Haematology (2012) Guidelines on the investigation and management of antiphospholipid syndrome. Br J Haematol 157:47\u201358","journal-title":"Br J Haematol"},{"key":"9_CR61","unstructured":"Ledford-Kraemer MR, Moore GW, Bottenus R, Daniele C, de Groot PG, Exner T, et al (2014) Laboratory testing for the lupus anticoagulant. Approved guideline\u20131st edn. CLSI document H60. Wayne, PA: Clinical and Laboratory Standards Institute"},{"key":"9_CR62","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/ijlh.12227","volume":"36","author":"GW Moore","year":"2014","unstructured":"Moore GW (2014) Commonalities and contrasts in recent guidelines for lupus anticoagulant detection. Int J Lab Hematol 36:364\u2013373","journal-title":"Int J Lab Hematol"},{"key":"9_CR63","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/PAT.0000000000000142","volume":"46","author":"EJ Favaloro","year":"2014","unstructured":"Favaloro EJ, Wong RCW (2014) Antiphospholipid antibody testing for the antiphospholipid syndrome: a synopsis of challenges and recent guidelines. Pathology 46:481\u2013495","journal-title":"Pathology"},{"issue":"Suppl 1","key":"9_CR64","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.thromres.2012.08.283","volume":"130","author":"V Pengo","year":"2012","unstructured":"Pengo V (2012) ISTH guidelines on lupus anticoagulant testing. Thromb Res 130(Suppl 1):S76\u2013S77","journal-title":"Thromb Res"},{"key":"9_CR65","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-0033-1364185","volume":"40","author":"GW Moore","year":"2014","unstructured":"Moore GW (2014) Recent guidelines and recommendations for laboratory detection of lupus anticoagulants. Semin Thromb Hemost 40:163\u2013171","journal-title":"Semin Thromb Hemost"},{"key":"9_CR66","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-0033-1334864","volume":"39","author":"M Adams","year":"2013","unstructured":"Adams M (2013) Measurement of lupus anticoagulants: an update on quality in laboratory testing. Semin Thromb Hemost 39:267\u2013271","journal-title":"Semin Thromb Hemost"},{"key":"9_CR67","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4939-0326-9_17","volume":"1134","author":"C Pericleous","year":"2014","unstructured":"Pericleous C, Ripoll VM, Giles I, Ioannou Y (2014) Laboratory tests for the antiphospholipid syndrome. Methods Mol Biol 1134:221\u2013235","journal-title":"Methods Mol Biol"},{"key":"9_CR68","doi-asserted-by":"crossref","unstructured":"Krilis SA, Giannakopoulos B (2014) Laboratory methods to detect antiphospholipid antibodies. Hematology Am Soc Hematol Educ Program 2014:321\u2013328","DOI":"10.1182\/asheducation-2014.1.321"},{"key":"9_CR69","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/blood-2002-02-0441","volume":"101","author":"M Galli","year":"2003","unstructured":"Galli M, Luciani D, Bertolini G, Barbui T (2003) Lupus anticoagulants are stronger risk factors of thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101:1827\u20131832","journal-title":"Blood"},{"key":"9_CR70","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/s-0033-1364184","volume":"40","author":"EJ Favaloro","year":"2014","unstructured":"Favaloro EJ, Plebani M, Lippi G (2014) Standardization and harmonization of antiphospholipid antibody assays. Semin Thromb Hemost 40:161\u2013162","journal-title":"Semin Thromb Hemost"},{"key":"9_CR71","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/jth.12537","volume":"12","author":"KM Devreese","year":"2014","unstructured":"Devreese KM, Pierangeli SS, de Laat B, Tripodi A, Atsumi T, Ortel TL, Subcommittee on Lupus Anticoagulant\/Phospholipid\/Dependent Antibodies (2014) Testing for antiphospholipid antibodies with solid phase assays: guidance from the SSC of the ISTH. J Thromb Haemost 12:792\u2013795","journal-title":"J Thromb Haemost"},{"key":"9_CR72","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/ijlh.12234","volume":"36","author":"KM Devreese","year":"2014","unstructured":"Devreese KM (2014) Antiphospholipid antibody testing and standardization. Int J Lab Hematol 36:352\u2013363","journal-title":"Int J Lab Hematol"},{"key":"9_CR73","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/CCLM.2011.064","volume":"49","author":"EJ Favaloro","year":"2011","unstructured":"Favaloro EJ, Wong RC (2011) Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays. Clin Chem Lab Med 49:447\u2013461","journal-title":"Clin Chem Lab Med"},{"key":"9_CR74","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/0961203310395055","volume":"20","author":"SS Pierangeli","year":"2011","unstructured":"Pierangeli SS, de Groot PG, Dlott J, Favaloro E, Harris EN, Lakos G et al (2011) \u2018Criteria\u2019 aPL tests: report task force and preconference workshop at the 13th international congress on antiphospholipid antibodies, Galveston, Texas, April 2010. Lupus 20:182\u2013190","journal-title":"Lupus"},{"key":"9_CR75","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1177\/0961203312439335","volume":"21","author":"KM Devreese","year":"2012","unstructured":"Devreese KM (2012) Standardization of antiphospholipid antibody assay. Where do we stand? Lupus 21:718\u2013721","journal-title":"Lupus"},{"issue":"Suppl 1","key":"9_CR76","first-page":"S89","volume":"48","author":"M Bo\u017ei\u010d-Mijovski","year":"2010","unstructured":"Bo\u017ei\u010d-Mijovski M (2010) Hyperhomocysteinemia and thrombophilia. Clin Chem Lab Med 48(Suppl 1):S89\u2013S95","journal-title":"Clin Chem Lab Med"},{"key":"9_CR77","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MBC.0b013e3283436401","volume":"22","author":"F Cacciapuoti","year":"2011","unstructured":"Cacciapuoti F (2011) Some considerations about the hypercoagulable states and their treatments. Blood Coagul Fibrinolysis 22:155\u2013159","journal-title":"Blood Coagul Fibrinolysis"},{"key":"9_CR78","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.5858\/2002-126-1367-HAT","volume":"126","author":"NS Key","year":"2002","unstructured":"Key NS, McGlennen RC (2002) Hyperhomocyst(e)inemia and thrombophilia. Arch Pathol Lab Med 126:1367\u20131375","journal-title":"Arch Pathol Lab Med"},{"key":"9_CR79","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2000-8469","volume":"26","author":"A Coppola","year":"2000","unstructured":"Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G (2000) Homocysteine, coagulation, platelet function, and thrombosis. Semin Thromb Hemost 26:243\u2013254","journal-title":"Semin Thromb Hemost"},{"key":"9_CR80","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1538-7836.2006.02275.x","volume":"5","author":"KB Holven","year":"2007","unstructured":"Holven KB, Aukrust P, Pedersen TM, Ose L, Nenseter MS (2007) Enhanced platelet activation in hyperhomocysteinemic individuals. J Thromb Haemost 5:193\u2013195","journal-title":"J Thromb Haemost"},{"key":"9_CR81","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/clinchem\/39.9.1764","volume":"39","author":"PM Ueland","year":"1993","unstructured":"Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH (1993) Total homocysteine in plasma or serum. Methods and clinical applications. Clin Chem 39:1764\u20131779","journal-title":"Clin Chem"},{"key":"9_CR82","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1570-0232(02)00497-X","volume":"781","author":"V Ducros","year":"2002","unstructured":"Ducros V, Demuth K, Sauvant MP, Quillard M, Causse E, Candito M et al (2002) Methods for homocysteine analysis and biological relevance of the results. J Chromatogr B Analyt Technol Biomed Life Sci 781:207\u2013226","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"9_CR83","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J et\u00a0al (2004) Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50:3\u201332","journal-title":"Clin Chem"},{"key":"9_CR84","first-page":"349","volume":"11","author":"MB Streiff","year":"2013","unstructured":"Streiff MB (2013) Association between cancer types, cancer treatments, and venous thromboembolism in medical oncology patients. Clin Adv Hematol Oncol 11:349\u2013357","journal-title":"Clin Adv Hematol Oncol"},{"key":"9_CR85","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1055\/s-0029-1242718","volume":"35","author":"M Franchini","year":"2009","unstructured":"Franchini M, Montagnana M, Favaloro EJ, Lippi G (2009) The bidirectional relationship of cancer and hemostasis and the potential role of anticoagulant therapy in moderating thrombosis and cancer spread. Semin Thromb Hemost 35:644\u2013653","journal-title":"Semin Thromb Hemost"},{"key":"9_CR86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11239-007-0028-6","volume":"24","author":"M Franchini","year":"2007","unstructured":"Franchini M, Montagnana M, Targher G, Manzato F, Lippi G (2007) Pathogenesis, clinical and laboratory aspects of thrombosis in cancer. J Thromb Thrombolysis 24:29\u201338","journal-title":"J Thromb Thrombolysis"},{"key":"9_CR87","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-0-387-79962-9_3","volume":"148","author":"FR Rickles","year":"2009","unstructured":"Rickles FR, Falanga A (2009) Activation of clotting factors in cancer. Cancer Treat Res 148:31\u201341","journal-title":"Cancer Treat Res"},{"key":"9_CR88","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF01307181","volume":"11","author":"LV Rao","year":"1992","unstructured":"Rao LV (1992) Tissue factor as a tumor procoagulant. Cancer Metastasis Rev 11:249\u2013266","journal-title":"Cancer Metastasis Rev"},{"key":"9_CR89","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/s-2006-933341","volume":"32","author":"J Rak","year":"2006","unstructured":"Rak J, Milsom C, May L, Klement P, Yu J (2006) Tissue factor in cancer and angiogenesis: the molecular link between genetic tumor progression, tumor neovascularization, and cancer coagulopathy. Semin Thromb Hemost 32:54\u201370","journal-title":"Semin Thromb Hemost"},{"key":"9_CR90","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1586\/14737140.8.8.1247","volume":"8","author":"L Borsig","year":"2008","unstructured":"Borsig L (2008) The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 8:1247\u20131255","journal-title":"Expert Rev Anticancer Ther"},{"key":"9_CR91","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1055\/s-2007-991540","volume":"33","author":"E Sierko","year":"2007","unstructured":"Sierko E, Wojtukiewicz MZ (2007) Inhibition of platelet function: does it offer a chance of better cancer progression control? Semin Thromb Hemost 33:712\u2013721","journal-title":"Semin Thromb Hemost"},{"key":"9_CR92","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1055\/s-2005-863812","volume":"31","author":"A Falanga","year":"2005","unstructured":"Falanga A (2005) Thrombophilia in cancer. Semin Thromb Hemost 31:104\u2013110","journal-title":"Semin Thromb Hemost"},{"key":"9_CR93","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1200\/JCO.2014.59.7351","volume":"33","author":"GH Lyman","year":"2015","unstructured":"Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, American Society of Clinical Oncology et al (2015) Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014. J Clin Oncol 33:654\u2013656","journal-title":"J Clin Oncol"},{"key":"9_CR94","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/jth.12265","volume":"11","author":"A Casini","year":"2013","unstructured":"Casini A, Fontana P, Lecompte TP (2013) Thrombotic complications of myeloproliferative neoplasms: risk assessment and risk-guided management. J Thromb Haemost 11:1215\u20131227","journal-title":"J Thromb Haemost"},{"key":"9_CR95","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1200\/JCO.2005.07.062","volume":"23","author":"R Marchioli","year":"2005","unstructured":"Marchioli R, Finazzi G, Landolfi R, Kutti J, Gisslinger H, Patrono C, Marilus R, Villega s A, Tognoni G, Barbui T (2005) Vascular and neoplastic risk in a large cohort of patients with polycythemia vera. J Clin Oncol 23:2224\u20132232","journal-title":"J Clin Oncol"},{"key":"9_CR96","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/leu.2011.314","volume":"26","author":"H Reikvam","year":"2012","unstructured":"Reikvam H, Tiu RV (2012) Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera. Leukemia 26:563\u2013571","journal-title":"Leukemia"},{"key":"9_CR97","doi-asserted-by":"crossref","unstructured":"Falanga A, Marchetti M (2012) Thrombotic disease in the myeloproliferative neoplasms. Hematology Am Soc Hematol Educ Program 2012:571\u2013581","DOI":"10.1182\/asheducation.V2012.1.571.3798557"},{"key":"9_CR98","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1055\/s-0034-1370794","volume":"40","author":"A Falanga","year":"2014","unstructured":"Falanga A, Marchetti M (2014) Thrombosis in myeloproliferative neoplasms. Semin Thromb Hemost 40:348\u2013358","journal-title":"Semin Thromb Hemost"},{"key":"9_CR99","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/leu.2008.72","volume":"22","author":"F Cervantes","year":"2008","unstructured":"Cervantes F, Passamonti F, Barosi G (2008) Life expectancy and prognostic factors in the classic BCR\/ABL-negative myeloproliferative disorders. Leukemia 22:905\u2013914","journal-title":"Leukemia"},{"key":"9_CR100","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1055\/s-2006-939439","volume":"32","author":"G Finazzi","year":"2006","unstructured":"Finazzi G (2006) Risk stratification, staging, and treatment of patients with polycythemia vera: Italian and European collaboration on low-dose aspirin in polycythemia data. Semin Thromb Hemost 32:276\u2013282","journal-title":"Semin Thromb Hemost"},{"key":"9_CR101","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ajh.23135","volume":"87","author":"A Tefferi","year":"2012","unstructured":"Tefferi A (2012) Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management. Am J Hematol 87:285\u2013293","journal-title":"Am J Hematol"},{"key":"9_CR102","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.beha.2014.07.005","volume":"27","author":"F Passamonti","year":"2014","unstructured":"Passamonti F, Caramazza D, Mora B, Casalone R, Maffioli M (2014) It is time to change thrombosis risk assessment for PV and ET? Best Pract Res Clin Haematol 27:121\u2013127","journal-title":"Best Pract Res Clin Haematol"},{"key":"9_CR103","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00277-014-2224-8","volume":"93","author":"S Kreher","year":"2014","unstructured":"Kreher S, Ochsenreither S, Trappe RU, Pabinger I, Bergmann F, Petrides PE, Haemostasis Working Party of the German Society of Hematology and Oncology, Austrian Society of Hematology and Oncology, Society of Thrombosis and Haemostasis Research et al (2014) Prophylaxis and management of venous thromboembolism in patients with myeloproliferative neoplasms: consensus statement of the haemostasis working party of the German society of hematology and oncology (DGHO), the Austrian society of hematology and oncology (\u00d6GHO) and society of thrombosis and haemostasis research (GTH e.V.) Ann Hematol 93:1953\u20131563","journal-title":"Ann Hematol"},{"key":"9_CR104","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3109\/10428194.2011.580474","volume":"52","author":"K Lechner","year":"2011","unstructured":"Lechner K, Simonitsch I, Haselb\u00f6ck J, J\u00e4ger U, Pabinger I (2011) Acquired immune-mediated thrombophilia in lymphoproliferative disorders. Leuk Lymphoma 52:1836\u20131843","journal-title":"Leuk Lymphoma"},{"key":"9_CR105","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/jth.12724","volume":"12","author":"M Hultcrantz","year":"2014","unstructured":"Hultcrantz M, Pfeiffer RM, Bj\u00f6rkholm M, Goldin LR, Turesson I, Schulman S et al (2014) Elevated risk of venous but not arterial thrombosis in Waldenstr\u00f6m macroglobulinemia\/lymphoplasmacytic lymphoma. J Thromb Haemost 12:1816\u20131821","journal-title":"J Thromb Haemost"},{"key":"9_CR106","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/sj.bjc.6602504","volume":"92","author":"M Mohren","year":"2005","unstructured":"Mohren M, Markmann I, Jentsch-Ullrich K, Koenigsmann M, Lutze G, Franke A (2005) Increased risk of thromboembolism in patients with malignant lymphoma: a single-centre analysis. Br J Cancer 92:1349\u20131351","journal-title":"Br J Cancer"},{"key":"9_CR107","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-0609.1995.tb00214.x","volume":"54","author":"H Ottinger","year":"1995","unstructured":"Ottinger H, Belka C, Kozole G et al (1995) Deep venous thrombosis and pulmonary artery embolism in high-grade non Hodgkin\u2019s lymphoma: incidence, causes and prognostic relevance. Eur J Haematol 54:186\u2013194","journal-title":"Eur J Haematol"},{"key":"9_CR108","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.beha.2009.01.003","volume":"22","author":"U Nowak-G\u00f6ttl","year":"2009","unstructured":"Nowak-G\u00f6ttl U, Kenet G, Mitchell LG (2009) Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, aetiology, diagnosis, prevention and treatment. Best Pract Res Clin Haematol 22:103\u2013114","journal-title":"Best Pract Res Clin Haematol"},{"issue":"1","key":"9_CR109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MBC.0000000000000521","volume":"28","author":"MM Ismail","year":"2016","unstructured":"Ismail MM, Hamed GM (2016) Activity levels of natural anticoagulant proteins in childhood acute lymphoblastic leukemia: relation to thromboembolic complications and treatment. Blood Coagul Fibrinolysis 28(1):1\u20137. [Epub ahead of print]","journal-title":"Blood Coagul Fibrinolysis"},{"key":"9_CR110","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/pbc.25515","volume":"62","author":"C Merlen","year":"2015","unstructured":"Merlen C, Bonnefoy A, Wagner E, Dedeken L, Leclerc JM, Laverdi\u00e8re C, Rivard GE (2015) L-Asparaginase lowers plasma antithrombin and mannan-binding-lectin levels: impact on thrombotic and infectious events in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 62:1381\u20131387","journal-title":"Pediatr Blood Cancer"},{"key":"9_CR111","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1076029614521280","volume":"20","author":"MP Crowley","year":"2014","unstructured":"Crowley MP, Eustace JA, O'Shea SI, Gilligan OM (2014) Venous thromboembolism in patients with myeloma: incidence and risk factors in a \u201creal-world\u201d population. Clin Appl Thromb Hemost 20:600\u2013606","journal-title":"Clin Appl Thromb Hemost"},{"key":"9_CR112","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11239-011-0636-z","volume":"33","author":"Y Ipek","year":"2012","unstructured":"Ipek Y, Fehmi H, Sevgi BK, Deniz S (2012) Thrombotic complications in multiple myeloma: a report of three cases and review of the literature. J Thromb Thrombolysis 33:197\u2013201","journal-title":"J Thromb Thrombolysis"},{"key":"9_CR113","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/asheducation-2010.1.437","volume":"2010","author":"SY Kristinsson","year":"2010","unstructured":"Kristinsson SY (2010) Thrombosis in multiple myeloma. Hematology Am Soc Hematol Educ Program 2010:437\u2013444","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"9_CR114","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3324\/haematol.2012.064444","volume":"97","author":"SY Kristinsson","year":"2012","unstructured":"Kristinsson SY, Pfeiffer RM, Bj\u00f6rkholm M, Schulman S, Landgren O (2012) Thrombosis is associated with inferior survival in multiple myeloma. Haematologica 97:1603\u20131607","journal-title":"Haematologica"},{"key":"9_CR115","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.thromres.2014.02.014","volume":"133","author":"S Ornaghi","year":"2014","unstructured":"Ornaghi S, Barnhart KT, Frieling J, Streisand J, Paidas MJ (2014) Clinical syndromes associated with acquired antithrombin deficiency via microvascular leakage and the related risk of thrombosis. Thromb Res 133:972\u2013984","journal-title":"Thromb Res"},{"key":"9_CR116","first-page":"272","volume":"38","author":"R Hoffmann","year":"1991","unstructured":"Hoffmann R (1991) The thrombo-embolic risk in surgery. Hepatogastroenterology 38:272\u2013278","journal-title":"Hepatogastroenterology"},{"key":"9_CR117","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0049-3848(81)90045-1","volume":"24","author":"AK Rao","year":"1981","unstructured":"Rao AK, Niewiarowski S, Guzzo J, Day HJ (1981) Antithrombin III levels during heparin therapy. Thromb Res 24:181\u2013186","journal-title":"Thromb Res"},{"key":"9_CR118","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1055\/s-0034-1398383","volume":"41","author":"M Ranucci","year":"2015","unstructured":"Ranucci M (2015) Hemostatic and thrombotic issues in cardiac surgery. Semin Thromb Hemost 41:84\u201390","journal-title":"Semin Thromb Hemost"},{"key":"9_CR119","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF00442583","volume":"142","author":"B Roth","year":"1984","unstructured":"Roth B, von Lilien T, Busch B, Gillor A, Bulla M (1984) Deficiency of antithrombin III in children with hemolytic-uremic syndrome. Eur J Pediatr 142:16\u201320","journal-title":"Eur J Pediatr"},{"key":"9_CR120","first-page":"497","volume":"8","author":"B Gordon","year":"1991","unstructured":"Gordon B, Haire W, Kessinger A, Duggan M, Armitage J (1991) High frequency of antithrombin 3 and protein C deficiency following autologous bone marrow transplantation for lymphoma. Bone Marrow Transplant 8:497\u2013502","journal-title":"Bone Marrow Transplant"},{"key":"9_CR121","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/leu.2012.290","volume":"27","author":"E Truelove","year":"2013","unstructured":"Truelove E, Fielding AK, Hunt BJ (2013) The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia. Leukemia 27:553\u2013559","journal-title":"Leukemia"},{"key":"9_CR122","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/1097-0142(19820801)50:3<451::AID-CNCR2820500312>3.0.CO;2-4","volume":"50","author":"HA Liebman","year":"1982","unstructured":"Liebman HA, Wada JK, Patch MJ, McGehee W (1982) Depression of functional and antigenic plasma antithrombin III (AT-III) due to therapy with L-asparaginase. Cancer 50:451\u2013456","journal-title":"Cancer"},{"key":"9_CR123","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0140-6736(95)90166-3","volume":"345","author":"T Koster","year":"1995","unstructured":"Koster T, Blann AD, Briet E et al (1995) Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 345:152\u2013155","journal-title":"Lancet"},{"key":"9_CR124","doi-asserted-by":"crossref","first-page":"I9","DOI":"10.1161\/01.CIR.0000046771.12875.6C","volume":"107","author":"FA Anderson Jr","year":"2003","unstructured":"Anderson FA Jr, Spencer FA (2003) Risk factors for venous thromboembolism. Circulation 107:I9\u2013I16","journal-title":"Circulation"},{"key":"9_CR125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1613747","volume":"83","author":"RA Kraaijenhagen","year":"2000","unstructured":"Kraaijenhagen RA, Anker PS, Koopman MM et al (2000) High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost 83:5\u20139","journal-title":"Thromb Haemost"},{"key":"9_CR126","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0037-1614471","volume":"81","author":"T Kawasaki","year":"1999","unstructured":"Kawasaki T, Kaida T, Arnout J, Vermylen J, Hoylaerts MF (1999) A new animal model of thrombophilia confirms that high plasma factor VIII levels are thrombogenic. Thromb Haemost 81:306\u2013311","journal-title":"Thromb Haemost"},{"key":"9_CR127","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1365-2141.2001.03146.x","volume":"115","author":"J O'Donnell","year":"2001","unstructured":"O'Donnell J, Mumford AD, Manning RA, Laffan MA (2001) Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism. Br J Haematol 115:687\u2013691","journal-title":"Br J Haematol"},{"key":"9_CR128","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0248-8663(02)00806-8","volume":"24","author":"K Benjaber","year":"2003","unstructured":"Benjaber K, Constans J, Cougnard A et al (2003) High levels of factor VIIIc and risk of venous thrombosis: critical analysis of case control studies [in French]. Rev Med Interne 24:366\u2013371","journal-title":"Rev Med Interne"},{"key":"9_CR129","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-0037-1614553","volume":"81","author":"PW Kamphuisen","year":"1999","unstructured":"Kamphuisen PW, Eikenboom JC, Vos HL, Pablo R, Sturk A, Bertina RM et al (1999) Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions. Thromb Haemost 81:680\u2013683","journal-title":"Thromb Haemost"},{"key":"9_CR130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0035-1552588","volume":"42","author":"W Shou","year":"2016","unstructured":"Shou W, Chen Q, Wu W, Cui W (2016) Biological variations of lupus anticoagulant, antithrombin, protein C, protein S, and von Willebrand factor assays. Semin Thromb Hemost 42:87\u201392","journal-title":"Semin Thromb Hemost"},{"key":"9_CR131","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1055\/s-0035-1556732","volume":"41","author":"S Boyce","year":"2015","unstructured":"Boyce S, Eren E, Lwaleed BA, Kazmi RS (2015) The activation of complement and its role in the pathogenesis of thromboembolism. Semin Thromb Hemost 41:665\u2013672","journal-title":"Semin Thromb Hemost"},{"key":"9_CR132","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-0035-1556589","volume":"41","author":"J Thachil","year":"2015","unstructured":"Thachil J (2015) Platelets in inflammatory disorders: a pathophysiological and clinical perspective. Semin Thromb Hemost 41:572\u2013581","journal-title":"Semin Thromb Hemost"},{"key":"9_CR133","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1055\/s-0035-1556587","volume":"41","author":"K Matevosyan","year":"2015","unstructured":"Matevosyan K, Sarode R (2015) Thrombosis, microangiopathies, and inflammation. Semin Thromb Hemost 41:556\u2013562","journal-title":"Semin Thromb Hemost"},{"key":"9_CR134","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1055\/s-0035-1556726","volume":"41","author":"MA Albayati","year":"2015","unstructured":"Albayati MA, Grover SP, Saha P, Lwaleed BA, Modarai B, Smith A (2015) Postsurgical inflammation as a causative mechanism of venous thromboembolism. Semin Thromb Hemost 41:615\u2013620","journal-title":"Semin Thromb Hemost"}],"container-title":["Methods in Molecular Biology","Hemostasis and Thrombosis"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-4939-7196-1_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T01:07:29Z","timestamp":1692925649000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-4939-7196-1_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9781493971947","9781493971961"],"references-count":134,"URL":"https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}